|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.947
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.878
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.877
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.865
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.861
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.769
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.748
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.729
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.719
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.696
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.690
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.684
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.617
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.615
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.599
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.592
|
|
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.577
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.550
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.524
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.501
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.489
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.487
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.479
|
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.453
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.451
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.449
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.446
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.425
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.425
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.424
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.416
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
59 |
0.416
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.414
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.411
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.411
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.411
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.410
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.409
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.398
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.398
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.391
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.389
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.379
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.374
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.371
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.358
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.354
|
|
|
|
mast cell proliferation
|
GO:0070662 |
4 |
0.341
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
0.334
|
|
|
|
regulation of natural killer cell activation
|
GO:0032814 |
22 |
0.327
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.321
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.316
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.306
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.304
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.300
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
88 |
0.299
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.297
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.296
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.296
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.294
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
23 |
0.294
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.291
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.291
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.273
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.271
|
Worm |
|
|
progesterone metabolic process
|
GO:0042448 |
4 |
0.265
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.264
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.264
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.260
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.258
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.256
|
|
|
|
regulation of mast cell proliferation
|
GO:0070666 |
4 |
0.254
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.251
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.247
|
|
|
|
regulation of natural killer cell differentiation
|
GO:0032823 |
11 |
0.247
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.239
|
|
|
|
negative regulation of erythrocyte differentiation
|
GO:0045647 |
5 |
0.239
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.238
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.238
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.236
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.232
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.231
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.231
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.230
|
|
|
|
cell recognition
|
GO:0008037 |
83 |
0.230
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.223
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.222
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.221
|
|
|
|
leukocyte cell cell adhesion
|
GO:0007159 |
14 |
0.219
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.219
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.216
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.216
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.215
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.215
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.215
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.214
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.212
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.211
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.210
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.210
|
|
|
|
positive regulation of gamma delta t cell differentiation
|
GO:0045588 |
6 |
0.209
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.206
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.201
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.201
|
Worm |
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.200
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.194
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.193
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.192
|
|
|
|
gonad development
|
GO:0008406 |
141 |
0.189
|
Worm |
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.186
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.185
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.185
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.184
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.183
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.182
|
|
|
|
response to granulocyte macrophage colony stimulating factor
|
GO:0097012 |
3 |
0.181
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.180
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.180
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.179
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.179
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.178
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.173
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.173
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.172
|
Mouse |
|
|
cognition
|
GO:0050890 |
149 |
0.167
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.167
|
|
|
|
neuron migration
|
GO:0001764 |
122 |
0.162
|
Fly |
|
|
positive regulation of growth
|
GO:0045927 |
104 |
0.159
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.157
|
|
|
|
natural killer cell proliferation
|
GO:0001787 |
3 |
0.157
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.157
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.156
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.155
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.155
|
|
|
|
lamellipodium organization
|
GO:0097581 |
29 |
0.154
|
Mouse |
|
|
urogenital system development
|
GO:0001655 |
261 |
0.153
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.153
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.152
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.151
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.151
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.149
|
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.149
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.147
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.147
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.146
|
|
|
|
cellular lactam metabolic process
|
GO:0072338 |
3 |
0.143
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.142
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.141
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.141
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.139
|
Worm Fly |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.139
|
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.139
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.137
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.137
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.136
|
|
|
|
leukocyte mediated cytotoxicity
|
GO:0001909 |
62 |
0.136
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.135
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.135
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.133
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.132
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.131
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.131
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.130
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.129
|
|
|
|
t cell selection
|
GO:0045058 |
34 |
0.128
|
|
|
|
positive regulation of gamma delta t cell activation
|
GO:0046645 |
6 |
0.128
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
13 |
0.128
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation
|
GO:2000721 |
2 |
0.127
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.126
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.126
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.125
|
|
|
|
creatine metabolic process
|
GO:0006600 |
4 |
0.123
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.123
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.122
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.120
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.120
|
|
|
|
regulation of type 2 immune response
|
GO:0002828 |
18 |
0.120
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
38 |
0.119
|
|
|
|
negative regulation of syncytium formation by plasma membrane fusion
|
GO:0034242 |
5 |
0.119
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.119
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.118
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.117
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.116
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.114
|
|
|
|
memory
|
GO:0007613 |
58 |
0.111
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.111
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.110
|
Mouse |
|
|
gliogenesis
|
GO:0042063 |
141 |
0.110
|
|
|
|
regulation of mast cell apoptotic process
|
GO:0033025 |
5 |
0.107
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.106
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.105
|
|
|
|
response to interleukin 15
|
GO:0070672 |
3 |
0.104
|
|
|
|
natural killer cell differentiation
|
GO:0001779 |
21 |
0.103
|
|
|
|
positive t cell selection
|
GO:0043368 |
23 |
0.103
|
|
|
|
phospholipid homeostasis
|
GO:0055091 |
6 |
0.102
|
|
|
|
eye photoreceptor cell differentiation
|
GO:0001754 |
41 |
0.101
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.101
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.101
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.100
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.100
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.099
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.098
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.098
|
|
|
|
regulation of natural killer cell proliferation
|
GO:0032817 |
2 |
0.098
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.097
|
Fly |
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.097
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.096
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.096
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.095
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.094
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
56 |
0.094
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.094
|
|
|
|
dendritic spine maintenance
|
GO:0097062 |
4 |
0.094
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.094
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.093
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.093
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.093
|
|
|
|
prolactin signaling pathway
|
GO:0038161 |
5 |
0.091
|
|
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
25 |
0.091
|
|
|
|
development of secondary male sexual characteristics
|
GO:0046544 |
3 |
0.091
|
|
|
|
b cell activation involved in immune response
|
GO:0002312 |
50 |
0.091
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
234 |
0.091
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.090
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
61 |
0.089
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.089
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.089
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.089
|
Fly |
|
|
endomembrane system organization
|
GO:0010256 |
147 |
0.089
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.089
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.088
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.087
|
|
|
|
calcium ion transport from endoplasmic reticulum to cytosol
|
GO:1903514 |
12 |
0.087
|
|
|
|
membrane invagination
|
GO:0010324 |
17 |
0.087
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.087
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.087
|
|
|
|
negative regulation of leukocyte mediated immunity
|
GO:0002704 |
29 |
0.087
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.086
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.086
|
|
|
|
citrate metabolic process
|
GO:0006101 |
3 |
0.085
|
|
|
|
cellular response to interleukin 4
|
GO:0071353 |
21 |
0.085
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.084
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.084
|
|
|
|
post embryonic organ development
|
GO:0048569 |
17 |
0.083
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.083
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.082
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.082
|
|
|
|
negative regulation of humoral immune response
|
GO:0002921 |
6 |
0.082
|
|
|
|
regulation of erythrocyte differentiation
|
GO:0045646 |
23 |
0.082
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.082
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
143 |
0.081
|
Worm |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.080
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.080
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.080
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.080
|
|
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.080
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
52 |
0.079
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.079
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.077
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.076
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.076
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.076
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.075
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.075
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.074
|
|
|
|
smooth muscle contraction
|
GO:0006939 |
44 |
0.074
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.074
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.073
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.073
|
|
|
|
regulation of cd4 positive alpha beta t cell activation
|
GO:2000514 |
24 |
0.073
|
|
|
|
substrate dependent cell migration
|
GO:0006929 |
18 |
0.073
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.073
|
|
|
|
cellular response to granulocyte macrophage colony stimulating factor stimulus
|
GO:0097011 |
3 |
0.072
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.072
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.072
|
|
|
|
microglia differentiation
|
GO:0014004 |
2 |
0.072
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
8 |
0.071
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.071
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.071
|
|
|
|
positive regulation of natural killer cell mediated immunity
|
GO:0002717 |
16 |
0.070
|
|
|
|
positive regulation of immunoglobulin production
|
GO:0002639 |
28 |
0.070
|
|
|
|
jak stat cascade involved in growth hormone signaling pathway
|
GO:0060397 |
4 |
0.070
|
|
|
|
interleukin 2 biosynthetic process
|
GO:0042094 |
15 |
0.070
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.069
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.069
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.069
|
|
|
|
oogenesis
|
GO:0048477 |
56 |
0.068
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
32 |
0.068
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.068
|
|
|
|
mast cell apoptotic process
|
GO:0033024 |
5 |
0.068
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.067
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.067
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.067
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.067
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.065
|
|
|
|
response to interleukin 4
|
GO:0070670 |
23 |
0.065
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.065
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
169 |
0.065
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.065
|
|
|
|
regulation of mast cell differentiation
|
GO:0060375 |
3 |
0.065
|
|
|
|
regulation of leukocyte mediated cytotoxicity
|
GO:0001910 |
38 |
0.065
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.064
|
|
|
|
regulation of cell shape
|
GO:0008360 |
39 |
0.063
|
Fly |
|
|
cell killing
|
GO:0001906 |
67 |
0.063
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.063
|
|
|
|
positive regulation of cell killing
|
GO:0031343 |
33 |
0.063
|
|
|
|
positive regulation of b cell activation
|
GO:0050871 |
49 |
0.062
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.060
|
|
|
|
protein polymerization
|
GO:0051258 |
57 |
0.059
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.059
|
|
|
|
stem cell development
|
GO:0048864 |
219 |
0.059
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.059
|
|
|
|
muscle contraction
|
GO:0006936 |
101 |
0.058
|
|
|
|
oocyte axis specification
|
GO:0007309 |
2 |
0.058
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.058
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.058
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.058
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.058
|
|
|
|
taurine metabolic process
|
GO:0019530 |
4 |
0.057
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.057
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.056
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.056
|
|
|
|
negative regulation of synapse assembly
|
GO:0051964 |
3 |
0.056
|
|
|
|
activation of rac gtpase activity
|
GO:0032863 |
2 |
0.056
|
|
|
|
oocyte development
|
GO:0048599 |
33 |
0.056
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.055
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
61 |
0.055
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.055
|
|
|
|
negative regulation of macrophage fusion
|
GO:0034240 |
1 |
0.055
|
|
|
|
positive regulation of t cell extravasation
|
GO:2000409 |
2 |
0.055
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
143 |
0.055
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.055
|
|
|
|
cell adhesion mediated by integrin
|
GO:0033627 |
18 |
0.054
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.054
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.054
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.054
|
|
|
|
positive regulation of hematopoietic stem cell migration
|
GO:2000473 |
1 |
0.054
|
|
|
|
natural killer cell mediated cytotoxicity
|
GO:0042267 |
29 |
0.054
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.054
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.053
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.053
|
Mouse |
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.053
|
|
|
|
negative regulation of type 2 immune response
|
GO:0002829 |
8 |
0.053
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
42 |
0.053
|
Fly |
|
|
natural killer cell activation
|
GO:0030101 |
44 |
0.052
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.052
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.052
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.051
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.051
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.051
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.050
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.050
|
|
|
|
regulation of phagocytosis
|
GO:0050764 |
33 |
0.050
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.050
|
|
|
|
gamma delta t cell differentiation
|
GO:0042492 |
11 |
0.049
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
69 |
0.048
|
|
|
|
platelet activation
|
GO:0030168 |
40 |
0.048
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.048
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.047
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.047
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.047
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.047
|
|
|
|
glucose homeostasis
|
GO:0042593 |
128 |
0.047
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
42 |
0.047
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
34 |
0.047
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.047
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.046
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
39 |
0.046
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.046
|
|
|
|
regulation of immunoglobulin mediated immune response
|
GO:0002889 |
37 |
0.046
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.046
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.046
|
|
|
|
renal system development
|
GO:0072001 |
225 |
0.046
|
|
|
|
microglia development
|
GO:0014005 |
2 |
0.046
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
31 |
0.046
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.045
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.045
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
32 |
0.045
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.045
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
130 |
0.045
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.045
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.044
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
45 |
0.044
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
46 |
0.044
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.044
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.044
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
138 |
0.044
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.044
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.044
|
|
|
|
carbohydrate homeostasis
|
GO:0033500 |
128 |
0.043
|
|
|
|
myeloid cell apoptotic process
|
GO:0033028 |
22 |
0.043
|
|
|
|
smooth muscle cell chemotaxis
|
GO:0071670 |
2 |
0.043
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.043
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
22 |
0.043
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
57 |
0.042
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.042
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.042
|
|
|
|
regulation of gamma delta t cell activation
|
GO:0046643 |
9 |
0.042
|
|
|
|
stem cell differentiation
|
GO:0048863 |
268 |
0.041
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.041
|
|
|
|
macrophage fusion
|
GO:0034238 |
3 |
0.041
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.041
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.041
|
|
|
|
positive regulation of monocyte chemotaxis
|
GO:0090026 |
2 |
0.041
|
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.041
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.041
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.041
|
|
|
|
regulated secretory pathway
|
GO:0045055 |
32 |
0.040
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.040
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.040
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.040
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.040
|
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.040
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.039
|
|
|
|
neuron projection extension
|
GO:1990138 |
64 |
0.039
|
|
|
|
regulation of natural killer cell mediated immunity
|
GO:0002715 |
19 |
0.039
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.039
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
54 |
0.039
|
|
|
|
detection of stimulus
|
GO:0051606 |
84 |
0.039
|
|
|
|
cd4 positive alpha beta t cell lineage commitment
|
GO:0043373 |
6 |
0.038
|
|
|
|
t helper 1 type immune response
|
GO:0042088 |
25 |
0.038
|
|
|
|
positive regulation of response to wounding
|
GO:1903036 |
66 |
0.038
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.038
|
|
|
|
epithelial cell differentiation involved in prostate gland development
|
GO:0060742 |
13 |
0.038
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.038
|
|
|
|
t helper cell lineage commitment
|
GO:0002295 |
6 |
0.037
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.037
|
|
|
|
cellular response to x ray
|
GO:0071481 |
2 |
0.037
|
|
|
|
response to ethanol
|
GO:0045471 |
18 |
0.037
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.037
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
15 |
0.037
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.037
|
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.036
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.036
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.036
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.036
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.036
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.035
|
|
|
|
positive regulation of monocyte extravasation
|
GO:2000439 |
1 |
0.035
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.035
|
|
|
|
negative regulation of myeloid cell apoptotic process
|
GO:0033033 |
11 |
0.035
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.035
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.035
|
|
|
|
cellular component maintenance
|
GO:0043954 |
11 |
0.035
|
|
|
|
positive regulation of cd8 positive alpha beta t cell extravasation
|
GO:2000451 |
2 |
0.035
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.034
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.034
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
25 |
0.034
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.034
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.034
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.034
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.034
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.033
|
|
|
|
natural killer cell mediated immunity
|
GO:0002228 |
29 |
0.033
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.033
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
68 |
0.033
|
|
|
|
regulation of actin nucleation
|
GO:0051125 |
4 |
0.033
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.033
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.033
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.033
|
|
|
|
isotype switching to ige isotypes
|
GO:0048289 |
7 |
0.032
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.032
|
|
|
|
sulfur compound metabolic process
|
GO:0006790 |
100 |
0.032
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
45 |
0.032
|
|
|
|
regulation of interleukin 2 biosynthetic process
|
GO:0045076 |
13 |
0.032
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
10 |
0.032
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.032
|
Mouse |
|
|
oocyte construction
|
GO:0007308 |
2 |
0.032
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.031
|
|
|
|
microglial cell activation involved in immune response
|
GO:0002282 |
1 |
0.031
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.031
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.031
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.031
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.031
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.031
|
|
|
|
negative regulation of t cell mediated immunity
|
GO:0002710 |
9 |
0.031
|
|
|
|
synapse assembly
|
GO:0007416 |
56 |
0.031
|
|
|
|
iron ion homeostasis
|
GO:0055072 |
36 |
0.030
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.030
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.030
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.030
|
|
|
|
mast cell homeostasis
|
GO:0033023 |
5 |
0.030
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.030
|
|
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.030
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.030
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.030
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
61 |
0.030
|
|
|
|
tissue homeostasis
|
GO:0001894 |
115 |
0.030
|
|
|
|
creatinine metabolic process
|
GO:0046449 |
3 |
0.030
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.029
|
|
|
|
immunoglobulin production involved in immunoglobulin mediated immune response
|
GO:0002381 |
43 |
0.029
|
|
|
|
eating behavior
|
GO:0042755 |
15 |
0.029
|
|
|
|
membrane tubulation
|
GO:0097320 |
4 |
0.029
|
|
|
|
somatic diversification of immunoglobulins
|
GO:0016445 |
43 |
0.029
|
|