Mus musculus

0 known processes

Adam4

a disintegrin and metallopeptidase domain 4

(Aliases: tMDCV,AV274654)

Adam4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of thymocyte migration GO:2000412 2 0.441
negative regulation of protein activation cascade GO:2000258 3 0.369
positive regulation of protein kinase b signaling GO:0051897 32 0.229
negative regulation of complement activation GO:0045916 3 0.161
regulation of cellular amine metabolic process GO:0033238 20 0.148
gliogenesis GO:0042063 141 0.101
regulation of complement activation classical pathway GO:0030450 1 0.100
regulation of eosinophil migration GO:2000416 2 0.096
positive regulation of eosinophil migration GO:2000418 2 0.079
multicellular organismal signaling GO:0035637 91 0.079
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.078
apoptotic signaling pathway GO:0097190 306 0.074
positive regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000309 1 0.071
entry into cell of other organism involved in symbiotic interaction GO:0051806 15 0.069
regulation of secretion by cell GO:1903530 249 0.068
protein kinase b signaling GO:0043491 74 0.067
neuronal action potential GO:0019228 54 0.067
t helper 2 cell cytokine production GO:0035745 4 0.066
cell maturation GO:0048469 127 0.064
thymocyte migration GO:0072679 2 0.063
transmembrane transport GO:0055085 412 0.063
amine metabolic process GO:0009308 45 0.059
regulation of cellular amino acid metabolic process GO:0006521 5 0.057
activation of mapk activity involved in innate immune response GO:0035419 2 0.054
negative regulation of neuron apoptotic process GO:0043524 92 0.054
neural precursor cell proliferation GO:0061351 121 0.053
regulation of lymphocyte activation GO:0051249 240 0.049
cellular ketone metabolic process GO:0042180 84 0.046
pma inducible membrane protein ectodomain proteolysis GO:0051088 1 0.045
regulation of organelle organization GO:0033043 289 0.045
sequestering of calcium ion GO:0051208 18 0.044
entry into host GO:0044409 15 0.043
eosinophil migration GO:0072677 3 0.043
negative regulation of t cell cytokine production GO:0002725 1 0.042
cell type specific apoptotic process GO:0097285 268 0.041
germ cell development GO:0007281 185 0.041
cytoplasmic transport GO:0016482 234 0.041
regulation of thymocyte migration GO:2000410 2 0.040
peptidyl amino acid modification GO:0018193 336 0.039
learning GO:0007612 98 0.039
regulation of neuron apoptotic process GO:0043523 122 0.039
leukocyte differentiation GO:0002521 342 0.039
positive regulation of cellular catabolic process GO:0031331 148 0.038
mesenchyme development GO:0060485 152 0.037
regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000307 1 0.036
stem cell differentiation GO:0048863 268 0.036
substrate dependent cell migration GO:0006929 18 0.036
extracellular matrix dependent thymocyte migration GO:0072680 1 0.035
prevention of polyspermy GO:0060468 4 0.034
myelination GO:0042552 74 0.034
regulation of apoptotic signaling pathway GO:2001233 197 0.034
synaptic transmission GO:0007268 329 0.034
negative regulation of protein complex disassembly GO:0043242 22 0.034
protein import GO:0017038 101 0.033
asymmetric stem cell division GO:0098722 3 0.033
ensheathment of neurons GO:0007272 76 0.033
regulation of cytoskeleton organization GO:0051493 122 0.033
regulation of membrane potential GO:0042391 192 0.032
b cell differentiation GO:0030183 78 0.032
protein localization to organelle GO:0033365 185 0.031
protein polymerization GO:0051258 57 0.031
negative regulation of immune effector process GO:0002698 55 0.031
second messenger mediated signaling GO:0019932 73 0.030
calcium mediated signaling GO:0019722 46 0.030
cellular amine metabolic process GO:0044106 44 0.029
positive regulation of fibronectin dependent thymocyte migration GO:2000415 1 0.029
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.028
cellular response to dna damage stimulus GO:0006974 207 0.028
transmission of nerve impulse GO:0019226 76 0.028
cognition GO:0050890 149 0.027
activation of immune response GO:0002253 138 0.027
negative regulation of immune system process GO:0002683 209 0.027
regulation of protein import into nucleus GO:0042306 52 0.027
monocyte extravasation GO:0035696 2 0.026
mitochondrion organization GO:0007005 134 0.026
purine nucleotide metabolic process GO:0006163 302 0.026
regulation of protein depolymerization GO:1901879 26 0.026
cellular amino acid metabolic process GO:0006520 103 0.026
regulation of establishment of protein localization GO:0070201 181 0.026
anion transport GO:0006820 177 0.025
carbohydrate derivative biosynthetic process GO:1901137 183 0.025
axon ensheathment GO:0008366 76 0.025
tumor necrosis factor ligand superfamily member 11 production GO:0072535 1 0.025
stem cell development GO:0048864 219 0.024
response to inorganic substance GO:0010035 96 0.024
renal system development GO:0072001 225 0.024
protein localization to membrane GO:0072657 108 0.024
positive regulation of protein modification process GO:0031401 299 0.024
regulation of cellular catabolic process GO:0031329 242 0.023
regulation of ion transmembrane transporter activity GO:0032412 54 0.023
regulation of monocyte extravasation GO:2000437 2 0.023
regulation of protein kinase b signaling GO:0051896 56 0.023
intracellular protein transport GO:0006886 204 0.023
asymmetric neuroblast division GO:0055059 1 0.022
cell division GO:0051301 120 0.022
response to amino acid GO:0043200 37 0.022
nucleotide metabolic process GO:0009117 332 0.022
sequestering of metal ion GO:0051238 19 0.022
protein import into nucleus GO:0006606 95 0.022
striated muscle tissue development GO:0014706 293 0.022
small gtpase mediated signal transduction GO:0007264 97 0.021
regulation of multi organism process GO:0043900 111 0.021
regulation of fibronectin dependent thymocyte migration GO:2000413 1 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
response to radiation GO:0009314 165 0.021
neuron apoptotic process GO:0051402 142 0.021
lymphocyte differentiation GO:0030098 242 0.021
bronchiole morphogenesis GO:0060436 1 0.021
positive regulation of cell cycle GO:0045787 92 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.020
regulation of interleukin 5 secretion GO:2000662 2 0.020
regulation of cellular response to stress GO:0080135 159 0.020
regulation of cellular ketone metabolic process GO:0010565 66 0.020
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.020
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.020
nucleocytoplasmic transport GO:0006913 139 0.020
membrane organization GO:0061024 245 0.020
glial cell differentiation GO:0010001 131 0.020
cytokine production GO:0001816 319 0.020
mesenchymal epithelial cell signaling involved in lung development GO:0060496 1 0.019
regulation of t cell activation GO:0050863 170 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
action potential GO:0001508 78 0.019
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.019
sensory perception GO:0007600 245 0.019
protein targeting GO:0006605 143 0.019
regulation of response to wounding GO:1903034 189 0.019
cellular component assembly involved in morphogenesis GO:0010927 139 0.019
myelination in peripheral nervous system GO:0022011 19 0.019
cation transport GO:0006812 399 0.019
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
mitotic cell cycle process GO:1903047 159 0.019
organic acid transport GO:0015849 101 0.018
myeloid leukocyte migration GO:0097529 57 0.018
protein maturation GO:0051604 176 0.018
cell cell recognition GO:0009988 44 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
learning or memory GO:0007611 148 0.018
rho protein signal transduction GO:0007266 32 0.017
negative regulation of multi organism process GO:0043901 68 0.017
bone remodeling GO:0046849 53 0.017
neuron death GO:0070997 154 0.017
negative regulation of cytoskeleton organization GO:0051494 36 0.017
epidermis development GO:0008544 187 0.017
response to reactive oxygen species GO:0000302 56 0.017
regulation of protein complex disassembly GO:0043244 28 0.017
b cell activation GO:0042113 161 0.017
negative regulation of macrophage apoptotic process GO:2000110 3 0.017
regulation of t helper 2 cell cytokine production GO:2000551 3 0.016
regulation of organ morphogenesis GO:2000027 144 0.016
regulation of immunological synapse formation GO:2000520 2 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.016
nuclear transport GO:0051169 139 0.016
microtubule based process GO:0007017 236 0.016
ras protein signal transduction GO:0007265 77 0.016
divalent inorganic cation transport GO:0072511 178 0.016
regulation of relaxation of muscle GO:1901077 8 0.016
negative regulation of neuron death GO:1901215 98 0.016
embryonic genitalia morphogenesis GO:0030538 4 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of timing of cell differentiation GO:0048505 11 0.016
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.016
negative regulation of homeostatic process GO:0032845 71 0.015
innate immune response GO:0045087 157 0.015
regulation of actin nucleation GO:0051125 4 0.015
myeloid cell homeostasis GO:0002262 114 0.015
purine nucleotide biosynthetic process GO:0006164 65 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
regulation of neuron death GO:1901214 134 0.015
regulation of protein localization GO:0032880 231 0.015
negative regulation of protein depolymerization GO:1901880 21 0.015
entry into host cell GO:0030260 15 0.015
visual learning GO:0008542 44 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
divalent inorganic cation homeostasis GO:0072507 138 0.015
glial cell development GO:0021782 54 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.015
schwann cell development GO:0014044 22 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
developmental maturation GO:0021700 193 0.015
regulation of epithelial cell proliferation GO:0050678 141 0.015
cellular metal ion homeostasis GO:0006875 151 0.014
positive regulation of atpase activity GO:0032781 3 0.014
cellularization GO:0007349 1 0.014
locomotory behavior GO:0007626 195 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.014
protein depolymerization GO:0051261 34 0.014
regulation of leukocyte differentiation GO:1902105 159 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
organic cyclic compound catabolic process GO:1901361 295 0.014
spermatid development GO:0007286 108 0.014
rhythmic process GO:0048511 174 0.014
regulation of leukocyte mediated immunity GO:0002703 104 0.014
establishment of neuroblast polarity GO:0045200 1 0.014
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.014
regulation of cell migration GO:0030334 219 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
regulation of secretion GO:0051046 274 0.013
cellular homeostasis GO:0019725 240 0.013
oligodendrocyte differentiation GO:0048709 53 0.013
response to light stimulus GO:0009416 135 0.013
organophosphate catabolic process GO:0046434 232 0.013
cellular chemical homeostasis GO:0055082 215 0.013
aromatic compound catabolic process GO:0019439 286 0.013
nucleoside metabolic process GO:0009116 246 0.013
skeletal muscle fiber development GO:0048741 58 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.013
purine ribonucleotide metabolic process GO:0009150 290 0.013
positive regulation of nervous system development GO:0051962 221 0.013
camera type eye development GO:0043010 266 0.013
negative regulation of organelle organization GO:0010639 90 0.013
positive regulation of cell death GO:0010942 224 0.013
response to organonitrogen compound GO:0010243 246 0.013
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
olfactory learning GO:0008355 2 0.012
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.012
regulation of cellular component size GO:0032535 121 0.012
maintenance of location GO:0051235 89 0.012
purine containing compound metabolic process GO:0072521 311 0.012
regulation of protein transport GO:0051223 163 0.012
cation homeostasis GO:0055080 212 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
regulation of inflammatory response GO:0050727 147 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
muscle tissue development GO:0060537 308 0.012
plasma membrane organization GO:0007009 90 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
entry into other organism involved in symbiotic interaction GO:0051828 15 0.012
natural killer cell activation GO:0030101 44 0.012
response to transforming growth factor beta GO:0071559 88 0.011
regulation of interleukin 13 secretion GO:2000665 2 0.011
organonitrogen compound catabolic process GO:1901565 264 0.011
adult locomotory behavior GO:0008344 91 0.011
regulation of cell cycle GO:0051726 281 0.011
actin mediated cell contraction GO:0070252 15 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
negative regulation of growth GO:0045926 99 0.011
negative regulation of interleukin 5 production GO:0032714 4 0.011
viral process GO:0016032 41 0.011
cellular protein complex disassembly GO:0043624 36 0.011
heterocycle catabolic process GO:0046700 280 0.011
muscle cell differentiation GO:0042692 261 0.011
negative regulation of protein processing GO:0010955 79 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
organic anion transport GO:0015711 137 0.011
axonogenesis GO:0007409 274 0.011
positive regulation of kinase activity GO:0033674 155 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
negative regulation of interleukin 13 secretion GO:2000666 1 0.011
sensory perception of chemical stimulus GO:0007606 51 0.011
rac protein signal transduction GO:0016601 13 0.011
spermatid differentiation GO:0048515 115 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
placenta development GO:0001890 140 0.011
positive regulation of transferase activity GO:0051347 167 0.011
methionine transport GO:0015821 1 0.011
actin filament polymerization GO:0030041 44 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
detection of chemical stimulus involved in sensory perception of smell GO:0050911 4 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
schwann cell differentiation GO:0014037 26 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
regulation of notch signaling pathway GO:0008593 35 0.011
negative regulation of cell size GO:0045792 3 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
regulation of t cell costimulation GO:2000523 2 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
cellular macromolecule catabolic process GO:0044265 206 0.011
fertilization GO:0009566 127 0.011
ribonucleotide metabolic process GO:0009259 291 0.011
macromolecule catabolic process GO:0009057 281 0.011
regulation of defense response GO:0031347 233 0.011
glycoprotein biosynthetic process GO:0009101 89 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.010
negative regulation of interleukin 13 production GO:0032696 2 0.010
positive regulation of antimicrobial humoral response GO:0002760 2 0.010
lymphocyte proliferation GO:0046651 164 0.010
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.010
striated muscle cell development GO:0055002 125 0.010
protein catabolic process GO:0030163 221 0.010
single organism nuclear import GO:1902593 95 0.010
glycoprotein metabolic process GO:0009100 116 0.010
mechanoreceptor differentiation GO:0042490 67 0.010
peptidyl tyrosine phosphorylation GO:0018108 143 0.010
regulation of protein maturation GO:1903317 96 0.010
sensory organ boundary specification GO:0008052 1 0.010
positive regulation of cell cycle process GO:0090068 61 0.010
regulation of transporter activity GO:0032409 57 0.010
glycosyl compound metabolic process GO:1901657 246 0.010
lymphocyte activation involved in immune response GO:0002285 93 0.010
respiratory system development GO:0060541 190 0.010

Adam4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
epilepsy syndrome DOID:1826 0 0.023
central nervous system disease DOID:331 0 0.023
brain disease DOID:936 0 0.023
electroclinical syndrome DOID:0050701 0 0.023
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.014
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
immune system cancer DOID:0060083 0 0.010
hematologic cancer DOID:2531 0 0.010