Mus musculus

12 known processes

Serpina1e

serine (or cysteine) peptidase inhibitor, clade A, member 1E

(Aliases: Spi1-5,Dom5,PI5)

Serpina1e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 323 0.484
Mouse
oxidation reduction process GO:0055114 342 0.285
inflammatory response GO:0006954 244 0.269
Mouse Rat
regulation of secretion by cell GO:1903530 249 0.215
Mouse
organic hydroxy compound metabolic process GO:1901615 203 0.171
Mouse
regulation of hormone levels GO:0010817 211 0.171
Mouse
response to peptide hormone GO:0043434 127 0.167
acylglycerol metabolic process GO:0006639 55 0.166
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.162
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.159
Human Mouse Rat
regulation of hydrolase activity GO:0051336 246 0.152
Human Mouse Rat
cellular amino acid metabolic process GO:0006520 103 0.149
regulation of defense response GO:0031347 233 0.149
Mouse
positive regulation of secretion GO:0051047 130 0.146
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.124
Mouse
regulation of response to wounding GO:1903034 189 0.122
Mouse
response to organic cyclic compound GO:0014070 198 0.118
Rat
glycerolipid metabolic process GO:0046486 122 0.110
Mouse
small molecule biosynthetic process GO:0044283 132 0.105
Mouse
fatty acid metabolic process GO:0006631 121 0.103
Mouse
blood circulation GO:0008015 195 0.101
Mouse
regulation of endopeptidase activity GO:0052548 89 0.099
Human Mouse Rat
response to peptide GO:1901652 136 0.098
neutral lipid metabolic process GO:0006638 57 0.098
Mouse
regulation of secretion GO:0051046 274 0.097
Mouse
alcohol metabolic process GO:0006066 116 0.095
Mouse
negative regulation of protein maturation GO:1903318 79 0.094
Human Mouse Rat
organic acid biosynthetic process GO:0016053 86 0.093
Mouse
regulation of inflammatory response GO:0050727 147 0.093
Mouse
positive regulation of secretion by cell GO:1903532 114 0.090
Mouse
regulation of anatomical structure size GO:0090066 178 0.086
Mouse
negative regulation of proteolysis GO:0045861 74 0.085
Human Mouse Rat
single organismal cell cell adhesion GO:0016337 131 0.083
negative regulation of protein processing GO:0010955 79 0.082
Human Mouse Rat
negative regulation of molecular function GO:0044092 258 0.081
Human Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 5 0.079
organic hydroxy compound biosynthetic process GO:1901617 77 0.078
regulation of system process GO:0044057 200 0.078
angiogenesis GO:0001525 201 0.076
establishment of blood nerve barrier GO:0008065 3 0.075
Mouse
regulation of protein maturation GO:1903317 96 0.075
Human Mouse Rat
lipid catabolic process GO:0016042 69 0.075
muscle tissue development GO:0060537 308 0.074
cellular response to hormone stimulus GO:0032870 150 0.074
Mouse
regulation of protein localization GO:0032880 231 0.072
Mouse
cell adhesion GO:0007155 329 0.070
Mouse
protein maturation GO:0051604 176 0.068
Mouse Rat
cellular response to peptide GO:1901653 92 0.068
Mouse
regulation of body fluid levels GO:0050878 162 0.068
lipid biosynthetic process GO:0008610 179 0.067
Mouse
cholesterol metabolic process GO:0008203 56 0.067
Mouse
cellular amine metabolic process GO:0044106 44 0.067
monocarboxylic acid metabolic process GO:0032787 191 0.066
Mouse
regulation of proteolysis GO:0030162 164 0.066
Human Mouse Rat
negative regulation of endopeptidase activity GO:0010951 44 0.066
Human Mouse Rat
male gamete generation GO:0048232 285 0.066
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.065
Human Mouse Rat
regulation of insulin receptor signaling pathway GO:0046626 21 0.065
Mouse
regulation of protein transport GO:0051223 163 0.064
Mouse
negative regulation of hydrolase activity GO:0051346 71 0.063
Human Mouse Rat
regulation of transferase activity GO:0051338 263 0.061
Mouse
regulation of cholesterol metabolic process GO:0090181 14 0.060
Mouse
phosphatidylinositol mediated signaling GO:0048015 41 0.060
Mouse
blood vessel morphogenesis GO:0048514 285 0.059
cellular ketone metabolic process GO:0042180 84 0.059
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.059
Mouse
defense response to other organism GO:0098542 197 0.058
retinoid metabolic process GO:0001523 24 0.058
alpha amino acid metabolic process GO:1901605 59 0.057
negative regulation of serine type endopeptidase activity GO:1900004 2 0.056
Rat
response to metal ion GO:0010038 47 0.055
Rat
cell type specific apoptotic process GO:0097285 268 0.053
Mouse
lipid transport GO:0006869 98 0.052
regulation of protein processing GO:0070613 96 0.052
Human Mouse Rat
hormone secretion GO:0046879 128 0.051
hexose biosynthetic process GO:0019319 39 0.051
Mouse
glycosylation GO:0070085 62 0.050
Mouse
positive regulation of hormone secretion GO:0046887 38 0.050
glucose metabolic process GO:0006006 92 0.049
Mouse
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.049
Mouse
amide transport GO:0042886 138 0.049
activation of membrane attack complex GO:0001905 4 0.049
immune effector process GO:0002252 321 0.047
regulation of hormone secretion GO:0046883 88 0.047
steroid metabolic process GO:0008202 119 0.047
Mouse
macromolecule catabolic process GO:0009057 281 0.045
cellular response to peptide hormone stimulus GO:0071375 92 0.045
Mouse
regulation of lipid metabolic process GO:0019216 118 0.044
Mouse
kidney development GO:0001822 213 0.044
Mouse
renal system development GO:0072001 225 0.044
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
cellular response to cadmium ion GO:0071276 3 0.043
morphogenesis of a branching structure GO:0001763 203 0.043
Mouse
energy derivation by oxidation of organic compounds GO:0015980 77 0.043
glucocorticoid metabolic process GO:0008211 9 0.042
Mouse
macromolecule glycosylation GO:0043413 55 0.042
Mouse
fatty acid biosynthetic process GO:0006633 41 0.041
Mouse
organic acid catabolic process GO:0016054 51 0.041
positive regulation of fatty acid biosynthetic process GO:0045723 3 0.041
Mouse
blood coagulation GO:0007596 76 0.040
hormone metabolic process GO:0042445 86 0.040
Mouse
drug metabolic process GO:0017144 4 0.040
regulation of gluconeogenesis GO:0006111 30 0.040
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.038
Mouse
negative regulation of cell proliferation GO:0008285 296 0.038
Mouse
cellular amino acid catabolic process GO:0009063 25 0.038
inositol lipid mediated signaling GO:0048017 41 0.038
Mouse
regulation of carbohydrate biosynthetic process GO:0043255 40 0.038
Mouse
regulation of kinase activity GO:0043549 249 0.036
Mouse
circulatory system process GO:0003013 197 0.036
Mouse
cellular response to insulin stimulus GO:0032869 78 0.036
Mouse
positive regulation of programmed cell death GO:0043068 218 0.036
gluconeogenesis GO:0006094 39 0.036
Mouse
single organism cell adhesion GO:0098602 156 0.035
response to organonitrogen compound GO:0010243 246 0.035
sterol metabolic process GO:0016125 58 0.035
Mouse
positive regulation of nervous system development GO:0051962 221 0.035
regulation of glucose metabolic process GO:0010906 60 0.035
Mouse
protein processing GO:0016485 163 0.035
Mouse Rat
cellular lipid catabolic process GO:0044242 52 0.034
cellular chemical homeostasis GO:0055082 215 0.034
cytokine secretion GO:0050663 72 0.033
Mouse
regulation of carbohydrate metabolic process GO:0006109 75 0.033
Mouse
protein glycosylation GO:0006486 55 0.033
Mouse
peptide transport GO:0015833 133 0.033
amine metabolic process GO:0009308 45 0.032
nitrogen compound transport GO:0071705 271 0.032
regulation of establishment of protein localization GO:0070201 181 0.032
Mouse
organic hydroxy compound transport GO:0015850 93 0.032
response to phenylpropanoid GO:0080184 22 0.032
lipid localization GO:0010876 126 0.032
hematopoietic progenitor cell differentiation GO:0002244 143 0.032
muscle cell differentiation GO:0042692 261 0.031
Mouse
regulation of vesicle mediated transport GO:0060627 139 0.031
peptide secretion GO:0002790 114 0.031
regulation of lipid biosynthetic process GO:0046890 54 0.031
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.031
response to insulin GO:0032868 100 0.031
Mouse
positive regulation of transferase activity GO:0051347 167 0.031
Mouse
response to inorganic substance GO:0010035 96 0.030
Rat
muscle system process GO:0003012 141 0.030
Mouse
tissue homeostasis GO:0001894 115 0.030
monosaccharide biosynthetic process GO:0046364 44 0.030
Mouse
positive regulation of leukocyte mediated immunity GO:0002705 70 0.030
cellular response to lipid GO:0071396 145 0.030
leukocyte mediated immunity GO:0002443 174 0.029
myeloid leukocyte differentiation GO:0002573 119 0.029
skeletal system development GO:0001501 356 0.029
nucleoside phosphate metabolic process GO:0006753 338 0.029
cellular carbohydrate metabolic process GO:0044262 119 0.029
Mouse
response to nutrient levels GO:0031667 109 0.029
negative regulation of peptidase activity GO:0010466 46 0.029
Human Mouse Rat
carboxylic acid catabolic process GO:0046395 51 0.029
mesonephros development GO:0001823 97 0.029
Mouse
organ regeneration GO:0031100 2 0.028
adaptive immune response GO:0002250 155 0.028
myeloid cell differentiation GO:0030099 233 0.028
response to molecule of bacterial origin GO:0002237 143 0.028
Rat
endocytosis GO:0006897 168 0.028
regulation of intracellular transport GO:0032386 159 0.028
type b pancreatic cell proliferation GO:0044342 10 0.028
rhythmic process GO:0048511 174 0.027
Mouse
response to lipopolysaccharide GO:0032496 128 0.027
Rat
heart contraction GO:0060047 93 0.027
lymphocyte mediated immunity GO:0002449 139 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
female sex differentiation GO:0046660 84 0.026
Mouse
kidney epithelium development GO:0072073 121 0.026
Mouse
response to acid chemical GO:0001101 111 0.026
Rat
muscle contraction GO:0006936 101 0.026
Mouse
respiratory tube development GO:0030323 167 0.026
extracellular matrix organization GO:0030198 147 0.026
Mouse
aromatic compound catabolic process GO:0019439 286 0.026
negative regulation of response to wounding GO:1903035 77 0.026
glucose homeostasis GO:0042593 128 0.025
icosanoid metabolic process GO:0006690 33 0.025
complement activation GO:0006956 16 0.025
peptide hormone secretion GO:0030072 109 0.025
rho protein signal transduction GO:0007266 32 0.025
fertilization GO:0009566 127 0.025
positive regulation of protein modification process GO:0031401 299 0.025
Mouse
extracellular structure organization GO:0043062 148 0.025
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.025
coagulation GO:0050817 78 0.025
nephron tubule development GO:0072080 84 0.025
Mouse
positive regulation of fatty acid metabolic process GO:0045923 8 0.024
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.024
Mouse
carbohydrate homeostasis GO:0033500 128 0.024
one carbon metabolic process GO:0006730 1 0.024
regulation of fatty acid metabolic process GO:0019217 28 0.024
Mouse
unsaturated fatty acid metabolic process GO:0033559 31 0.024
protein secretion GO:0009306 111 0.024
Mouse
transmembrane transport GO:0055085 412 0.024
leukocyte activation involved in immune response GO:0002366 126 0.024
cellular alcohol metabolic process GO:0044107 3 0.023
regulation of ossification GO:0030278 112 0.023
striated muscle tissue development GO:0014706 293 0.023
apoptotic signaling pathway GO:0097190 306 0.023
cellular protein catabolic process GO:0044257 155 0.023
cellular homeostasis GO:0019725 240 0.023
connective tissue development GO:0061448 179 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.023
Mouse
positive regulation of hydrolase activity GO:0051345 148 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
intracellular receptor signaling pathway GO:0030522 74 0.023
regulation of blood pressure GO:0008217 93 0.023
Mouse
cellular ion homeostasis GO:0006873 165 0.023
mesonephric epithelium development GO:0072163 94 0.023
Mouse
actin filament organization GO:0007015 113 0.023
carbohydrate biosynthetic process GO:0016051 74 0.022
Mouse
hemostasis GO:0007599 78 0.022
response to monosaccharide GO:0034284 67 0.022
monocarboxylic acid biosynthetic process GO:0072330 61 0.022
Mouse
insulin secretion GO:0030073 89 0.022
regulation of epithelial cell proliferation GO:0050678 141 0.022
positive regulation of cellular component biogenesis GO:0044089 94 0.022
exocytosis GO:0006887 121 0.022
heterocycle catabolic process GO:0046700 280 0.022
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway GO:0010579 3 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.022
regulation of lymphocyte mediated immunity GO:0002706 84 0.021
protein catabolic process GO:0030163 221 0.021
hexose metabolic process GO:0019318 98 0.021
Mouse
regulation of protein kinase activity GO:0045859 232 0.021
Mouse
regulation of actin cytoskeleton organization GO:0032956 84 0.021
monosaccharide metabolic process GO:0005996 106 0.021
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.021
vascular process in circulatory system GO:0003018 62 0.021
Mouse
cell substrate adhesion GO:0031589 130 0.021
Mouse
regulation of peptidase activity GO:0052547 96 0.021
Human Mouse Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.021
regulation of peptide hormone secretion GO:0090276 75 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
regulation of blood coagulation GO:0030193 28 0.020
positive regulation of cellular amine metabolic process GO:0033240 5 0.020
muscle cell proliferation GO:0033002 52 0.020
Mouse
positive regulation of activation of membrane attack complex GO:0001970 2 0.020
lipoprotein metabolic process GO:0042157 43 0.020
cellular macromolecule catabolic process GO:0044265 206 0.020
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.020
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.020
embryonic placenta development GO:0001892 98 0.020
positive regulation of kinase activity GO:0033674 155 0.020
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.020
vitamin d biosynthetic process GO:0042368 3 0.020
epithelial tube morphogenesis GO:0060562 303 0.020
Mouse
positive regulation of lipid metabolic process GO:0045834 40 0.020
Mouse
sensory perception GO:0007600 245 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
neuron death GO:0070997 154 0.019
Mouse
diterpenoid metabolic process GO:0016101 24 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
epithelial cell proliferation GO:0050673 174 0.019
lung development GO:0030324 164 0.019
cell matrix adhesion GO:0007160 68 0.019
Mouse
regulation of cell activation GO:0050865 289 0.019
positive regulation of cell development GO:0010720 237 0.019
regulation of blood circulation GO:1903522 93 0.019
fibrinolysis GO:0042730 3 0.019
lipid homeostasis GO:0055088 63 0.019
cognition GO:0050890 149 0.019
nucleotide metabolic process GO:0009117 332 0.019
negative regulation of vasculature development GO:1901343 26 0.018
mapk cascade GO:0000165 281 0.018
Mouse
establishment of vesicle localization GO:0051650 81 0.018
cellular protein complex assembly GO:0043623 116 0.018
positive regulation of fatty acid oxidation GO:0046321 4 0.018
generation of precursor metabolites and energy GO:0006091 103 0.018
glycoprotein metabolic process GO:0009100 116 0.018
Mouse
purine ribonucleoside metabolic process GO:0046128 241 0.018
nephron epithelium morphogenesis GO:0072088 68 0.018
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.018
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.018
Mouse
regulation of cytokine production GO:0001817 266 0.018
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.018
steroid biosynthetic process GO:0006694 47 0.018
negative regulation of coagulation GO:0050819 11 0.018
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.018
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.018
Mouse
regulation of peptide secretion GO:0002791 77 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
nucleoside triphosphate catabolic process GO:0009143 205 0.017
positive regulation of cell activation GO:0050867 158 0.017
tissue remodeling GO:0048771 102 0.017
ossification GO:0001503 216 0.017
sulfur compound metabolic process GO:0006790 100 0.017
positive regulation of organ growth GO:0046622 29 0.017
Mouse
organophosphate biosynthetic process GO:0090407 122 0.017
testosterone biosynthetic process GO:0061370 2 0.017
negative regulation of neuron death GO:1901215 98 0.017
Mouse
multicellular organismal homeostasis GO:0048871 164 0.017
response to chromate GO:0046687 1 0.017
Rat
development of primary sexual characteristics GO:0045137 143 0.017
Mouse
regulation of serine type endopeptidase activity GO:1900003 2 0.017
Rat
appendage morphogenesis GO:0035107 149 0.017
establishment of organelle localization GO:0051656 122 0.017
negative regulation of lipid metabolic process GO:0045833 30 0.017
Mouse
ribose phosphate metabolic process GO:0019693 291 0.017
response to steroid hormone GO:0048545 56 0.017
Rat
alcohol biosynthetic process GO:0046165 43 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
regulation of neuron differentiation GO:0045664 281 0.016
regulation of mapk cascade GO:0043408 248 0.016
Mouse
t cell activation GO:0042110 289 0.016
regulation of blood vessel size GO:0050880 56 0.016
Mouse
regulation of protein secretion GO:0050708 82 0.016
Mouse
folic acid containing compound metabolic process GO:0006760 3 0.016
cellular response to biotic stimulus GO:0071216 92 0.016
wound healing GO:0042060 157 0.016
regulation of actin filament based process GO:0032970 99 0.016
regulation of organ growth GO:0046620 61 0.016
Mouse
regulation of cellular response to insulin stimulus GO:1900076 30 0.016
Mouse
positive regulation of apoptotic process GO:0043065 217 0.016
cellular glucose homeostasis GO:0001678 52 0.016
protein activation cascade GO:0072376 19 0.016
cytokine production GO:0001816 319 0.016
Mouse
myeloid leukocyte activation GO:0002274 83 0.016
cellular modified amino acid metabolic process GO:0006575 63 0.016
response to corticosterone GO:0051412 1 0.016
membrane organization GO:0061024 245 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
Mouse
cell maturation GO:0048469 127 0.015
response to growth factor GO:0070848 198 0.015
body fluid secretion GO:0007589 53 0.015
somatotropin secreting cell differentiation GO:0060126 4 0.015
platelet activation GO:0030168 40 0.015
regulation of cytoplasmic transport GO:1903649 112 0.015
insulin receptor signaling pathway GO:0008286 49 0.015
Mouse
regulation of vasculature development GO:1901342 88 0.015
glycoprotein biosynthetic process GO:0009101 89 0.015
Mouse
regulation of heart contraction GO:0008016 77 0.015
peptidyl amino acid modification GO:0018193 336 0.015
Mouse
arachidonic acid metabolic process GO:0019369 14 0.015
negative regulation of ossification GO:0030279 49 0.015
dibenzo p dioxin metabolic process GO:0018894 1 0.015
actin cytoskeleton organization GO:0030036 220 0.015
methylation GO:0032259 134 0.015
placenta development GO:0001890 140 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
leukocyte apoptotic process GO:0071887 71 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
small gtpase mediated signal transduction GO:0007264 97 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.014
cellular response to carbohydrate stimulus GO:0071322 50 0.014
regulation of cytokine secretion GO:0050707 61 0.014
Mouse
regulation of peptide transport GO:0090087 91 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
response to extracellular stimulus GO:0009991 127 0.014
mesonephric tubule development GO:0072164 94 0.014
Mouse
regulation of cell adhesion GO:0030155 154 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
regulation of cell projection organization GO:0031344 206 0.014
astrocyte activation GO:0048143 2 0.014
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
regulation of endocytosis GO:0030100 69 0.014
positive regulation of peptide hormone secretion GO:0090277 31 0.014
ureteric bud development GO:0001657 94 0.014
Mouse
biomineral tissue development GO:0031214 64 0.014
toxin metabolic process GO:0009404 5 0.014
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.014
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.014
skeletal muscle organ development GO:0060538 163 0.014
multi multicellular organism process GO:0044706 109 0.014
purine containing compound metabolic process GO:0072521 311 0.014
regulation of lipoprotein lipase activity GO:0051004 4 0.014
regulation of map kinase activity GO:0043405 120 0.014
membrane lipid metabolic process GO:0006643 53 0.014
purine nucleoside triphosphate metabolic process GO:0009144 226 0.014
organelle localization GO:0051640 179 0.014
renal tubule morphogenesis GO:0061333 72 0.014
Mouse
regulation of cell cycle GO:0051726 281 0.014
alpha amino acid catabolic process GO:1901606 18 0.014
regulation of ion homeostasis GO:2000021 64 0.014
positive regulation of cytokine production GO:0001819 174 0.014
Mouse
carbohydrate metabolic process GO:0005975 230 0.013
Mouse
interleukin 8 production GO:0032637 4 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
forebrain development GO:0030900 302 0.013
porphyrin containing compound metabolic process GO:0006778 22 0.013
regulation of cell growth GO:0001558 91 0.013
hepaticobiliary system development GO:0061008 67 0.013
calcium ion homeostasis GO:0055074 127 0.013
medium chain fatty acid metabolic process GO:0051791 1 0.013
positive regulation of peptide secretion GO:0002793 33 0.013
metal ion homeostasis GO:0055065 189 0.013
sensory perception of pain GO:0019233 47 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.013
Mouse
regulation of blood vessel size by renin angiotensin GO:0002034 5 0.013
Mouse
calcitriol biosynthetic process from calciol GO:0036378 3 0.013
digestive system development GO:0055123 200 0.013
cholesterol transport GO:0030301 38 0.013
gland development GO:0048732 330 0.013
cardiocyte differentiation GO:0035051 87 0.013
leukocyte differentiation GO:0002521 342 0.013
regulation of organelle organization GO:0033043 289 0.013
regulation of protein kinase c activity GO:1900019 1 0.013
Mouse
positive regulation of protein activation cascade GO:2000259 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
liver development GO:0001889 66 0.013
osteoclast differentiation GO:0030316 62 0.013
positive regulation of cell death GO:0010942 224 0.012
camera type eye development GO:0043010 266 0.012
regulation of angiogenesis GO:0045765 81 0.012
oxygen homeostasis GO:0032364 2 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
learning or memory GO:0007611 148 0.012
tetrapyrrole metabolic process GO:0033013 22 0.012
long chain fatty acid metabolic process GO:0001676 26 0.012
bone mineralization GO:0030282 54 0.012
negative regulation of cell adhesion mediated by integrin GO:0033629 2 0.012
protein homooligomerization GO:0051260 43 0.012
cellular response to hexose stimulus GO:0071331 47 0.012
regulation of systemic arterial blood pressure GO:0003073 61 0.012
Mouse
regulation of interleukin 8 production GO:0032677 3 0.012
cellular response to cytokine stimulus GO:0071345 189 0.012
response to radiation GO:0009314 165 0.012
kidney morphogenesis GO:0060993 83 0.012
Mouse
neuron apoptotic process GO:0051402 142 0.012
Mouse
cellular response to monosaccharide stimulus GO:0071326 47 0.012
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.012
ureteric bud morphogenesis GO:0060675 62 0.012
Mouse
multicellular organism growth GO:0035264 161 0.012
Mouse
cofactor metabolic process GO:0051186 80 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
respiratory system development GO:0060541 190 0.012
nuclear transport GO:0051169 139 0.012
skeletal system morphogenesis GO:0048705 203 0.012
skin development GO:0043588 220 0.012
maternal placenta development GO:0001893 20 0.012
glycogen metabolic process GO:0005977 32 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
negative regulation of immune system process GO:0002683 209 0.011
dna metabolic process GO:0006259 303 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
female gamete generation GO:0007292 74 0.011
Mouse
cellular response to organic cyclic compound GO:0071407 87 0.011
terpenoid metabolic process GO:0006721 25 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
septum primum development GO:0003284 4 0.011
cellular response to metal ion GO:0071248 31 0.011
embryonic appendage morphogenesis GO:0035113 126 0.011
response to mineralocorticoid GO:0051385 1 0.011
nucleoside catabolic process GO:0009164 206 0.011
positive regulation of cell growth GO:0030307 33 0.011
protein lipid complex subunit organization GO:0071825 12 0.011
nik nf kappab signaling GO:0038061 14 0.011
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
negative regulation of protein modification process GO:0031400 163 0.011
negative regulation of gluconeogenesis GO:0045721 9 0.011
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
response to stilbenoid GO:0035634 22 0.011
endothelial cell development GO:0001885 20 0.011
Mouse
female gonad development GO:0008585 71 0.011
Mouse
lipid oxidation GO:0034440 29 0.011
lymphocyte differentiation GO:0030098 242 0.011
response to light stimulus GO:0009416 135 0.011
sterol transport GO:0015918 38 0.011
mesonephric tubule morphogenesis GO:0072171 63 0.011
Mouse
purine nucleoside catabolic process GO:0006152 205 0.011
detection of stimulus GO:0051606 84 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
establishment of tissue polarity GO:0007164 28 0.011
endocrine process GO:0050886 39 0.011
Mouse
negative regulation of secretion GO:0051048 61 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
chondrocyte differentiation GO:0002062 72 0.011
vesicle localization GO:0051648 86 0.011
bone development GO:0060348 120 0.011
organelle assembly GO:0070925 177 0.011
myeloid leukocyte mediated immunity GO:0002444 42 0.010
developmental maturation GO:0021700 193 0.010
phospholipid metabolic process GO:0006644 87 0.010
response to oxidative stress GO:0006979 123 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
oogenesis GO:0048477 56 0.010
regulation of interleukin 8 secretion GO:2000482 2 0.010

Serpina1e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.107
Human
inherited metabolic disorder DOID:655 0 0.094
Human
disease of anatomical entity DOID:7 0 0.036
cardiovascular system disease DOID:1287 0 0.036
alpha 1 antitrypsin deficiency DOID:13372 0 0.034
Human
plasma protein metabolism disease DOID:2345 0 0.034
Human
immune system disease DOID:2914 0 0.013
acquired metabolic disease DOID:0060158 0 0.012
central nervous system disease DOID:331 0 0.012
neurodegenerative disease DOID:1289 0 0.012
nervous system disease DOID:863 0 0.012