Mus musculus

0 known processes

Spag4

sperm associated antigen 4

(Aliases: MNCb-0953,KIAA4118,mKIAA4118,1700041K21Rik,Sun4,MGC130280)

Spag4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 44 0.100
chemotaxis GO:0006935 247 0.080
spermatogenesis GO:0007283 284 0.071
cellular amino acid metabolic process GO:0006520 103 0.070
action potential GO:0001508 78 0.068
germ cell development GO:0007281 185 0.064
muscle tissue development GO:0060537 308 0.062
skeletal system development GO:0001501 356 0.062
positive regulation of programmed cell death GO:0043068 218 0.061
positive regulation of apoptotic process GO:0043065 217 0.060
smoothened signaling pathway GO:0007224 105 0.057
male gamete generation GO:0048232 285 0.056
forebrain development GO:0030900 302 0.056
amine metabolic process GO:0009308 45 0.054
ear development GO:0043583 200 0.053
cation transport GO:0006812 399 0.052
renal system development GO:0072001 225 0.051
epithelial tube morphogenesis GO:0060562 303 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.049
positive regulation of cellular amine metabolic process GO:0033240 5 0.046
transmission of nerve impulse GO:0019226 76 0.046
positive regulation of cell death GO:0010942 224 0.046
regulation of cell cycle GO:0051726 281 0.045
telencephalon development GO:0021537 186 0.044
lymphocyte differentiation GO:0030098 242 0.043
muscle cell differentiation GO:0042692 261 0.041
sensory perception of sound GO:0007605 97 0.041
cellular response to external stimulus GO:0071496 88 0.038
axonogenesis GO:0007409 274 0.038
macromolecule catabolic process GO:0009057 281 0.038
stem cell differentiation GO:0048863 268 0.037
locomotory behavior GO:0007626 195 0.037
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.037
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.036
striated muscle tissue development GO:0014706 293 0.036
glycerolipid metabolic process GO:0046486 122 0.036
cell type specific apoptotic process GO:0097285 268 0.035
cell fate commitment GO:0045165 210 0.034
response to extracellular stimulus GO:0009991 127 0.034
cellular ketone metabolic process GO:0042180 84 0.033
regulation of organ morphogenesis GO:2000027 144 0.033
protein maturation GO:0051604 176 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
organic hydroxy compound metabolic process GO:1901615 203 0.033
sensory perception GO:0007600 245 0.032
regulation of cellular response to stress GO:0080135 159 0.032
peptidyl serine modification GO:0018209 83 0.032
lateral inhibition GO:0046331 1 0.030
muscle cell development GO:0055001 133 0.030
extracellular matrix organization GO:0030198 147 0.030
organelle fission GO:0048285 170 0.030
regulation of cellular amino acid metabolic process GO:0006521 5 0.029
mesenchyme development GO:0060485 152 0.029
negative regulation of molecular function GO:0044092 258 0.029
metencephalon development GO:0022037 89 0.029
morphogenesis of a branching epithelium GO:0061138 193 0.029
spermatid differentiation GO:0048515 115 0.028
glycoprotein metabolic process GO:0009100 116 0.028
regulation of membrane potential GO:0042391 192 0.027
regulation of cellular ketone metabolic process GO:0010565 66 0.027
t cell activation GO:0042110 289 0.027
cell proliferation in forebrain GO:0021846 30 0.026
cation transmembrane transport GO:0098655 266 0.026
neuronal action potential GO:0019228 54 0.026
neural tube development GO:0021915 160 0.026
cellular response to hormone stimulus GO:0032870 150 0.025
transmembrane transport GO:0055085 412 0.025
developmental maturation GO:0021700 193 0.025
negative regulation of cell development GO:0010721 169 0.025
meiotic nuclear division GO:0007126 115 0.025
regulation of apoptotic signaling pathway GO:2001233 197 0.025
stem cell proliferation GO:0072089 117 0.024
response to nutrient levels GO:0031667 109 0.024
inflammatory response GO:0006954 244 0.024
ion transmembrane transport GO:0034220 361 0.024
camera type eye development GO:0043010 266 0.024
kidney development GO:0001822 213 0.024
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
circulatory system process GO:0003013 197 0.023
mesenchymal cell differentiation GO:0048762 107 0.023
cellular response to extracellular stimulus GO:0031668 81 0.023
leukocyte migration GO:0050900 124 0.022
endoderm development GO:0007492 45 0.022
ensheathment of neurons GO:0007272 76 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.022
blood vessel morphogenesis GO:0048514 285 0.022
meiotic cell cycle GO:0051321 122 0.022
urogenital system development GO:0001655 261 0.022
response to oxygen levels GO:0070482 62 0.022
homeostasis of number of cells GO:0048872 210 0.022
regulation of epithelial cell proliferation GO:0050678 141 0.022
cellular homeostasis GO:0019725 240 0.021
regulation of stem cell proliferation GO:0072091 78 0.021
protein modification by small protein conjugation or removal GO:0070647 207 0.021
leukocyte proliferation GO:0070661 172 0.021
fat cell differentiation GO:0045444 160 0.021
lymphocyte proliferation GO:0046651 164 0.021
regulation of postsynaptic membrane potential GO:0060078 48 0.021
cardiac chamber development GO:0003205 108 0.021
nephron morphogenesis GO:0072028 69 0.021
regulation of cell adhesion GO:0030155 154 0.021
multicellular organismal signaling GO:0035637 91 0.020
gland development GO:0048732 330 0.020
regulation of leukocyte apoptotic process GO:2000106 56 0.020
blood circulation GO:0008015 195 0.020
regulation of neuron death GO:1901214 134 0.020
intracellular protein transport GO:0006886 204 0.020
negative regulation of neuron differentiation GO:0045665 101 0.020
embryonic skeletal system development GO:0048706 120 0.020
inorganic cation transmembrane transport GO:0098662 207 0.020
nuclear division GO:0000280 158 0.020
actin cytoskeleton organization GO:0030036 220 0.019
female gamete generation GO:0007292 74 0.019
cardiac muscle tissue development GO:0048738 130 0.019
response to acid chemical GO:0001101 111 0.019
positive regulation of lymphocyte activation GO:0051251 140 0.019
regulation of kinase activity GO:0043549 249 0.019
regulation of neural precursor cell proliferation GO:2000177 70 0.018
midgut development GO:0007494 4 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
development of primary sexual characteristics GO:0045137 143 0.018
skeletal muscle cell differentiation GO:0035914 66 0.018
bmp signaling pathway GO:0030509 93 0.018
regulation of organelle organization GO:0033043 289 0.018
regulation of lymphocyte apoptotic process GO:0070228 41 0.018
somitogenesis GO:0001756 69 0.018
muscle system process GO:0003012 141 0.018
epidermis development GO:0008544 187 0.018
cell matrix adhesion GO:0007160 68 0.018
connective tissue development GO:0061448 179 0.018
positive regulation of cell development GO:0010720 237 0.018
neuron apoptotic process GO:0051402 142 0.018
neural precursor cell proliferation GO:0061351 121 0.018
acylglycerol metabolic process GO:0006639 55 0.018
b cell activation GO:0042113 161 0.018
cytoplasmic transport GO:0016482 234 0.018
leukocyte apoptotic process GO:0071887 71 0.017
response to organonitrogen compound GO:0010243 246 0.017
apoptotic signaling pathway GO:0097190 306 0.017
cell adhesion GO:0007155 329 0.017
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.017
protein ubiquitination GO:0016567 171 0.017
endothelium development GO:0003158 45 0.017
oviduct development GO:0060066 3 0.017
reactive oxygen species metabolic process GO:0072593 84 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
regulation of lipid biosynthetic process GO:0046890 54 0.017
respiratory system development GO:0060541 190 0.017
chromatin modification GO:0016568 187 0.017
nucleocytoplasmic transport GO:0006913 139 0.017
positive regulation of organelle organization GO:0010638 128 0.017
rna interference GO:0016246 2 0.017
regulation of ion transport GO:0043269 215 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
negative regulation of hormone metabolic process GO:0032351 4 0.017
neuron projection guidance GO:0097485 141 0.016
spermatid development GO:0007286 108 0.016
response to radiation GO:0009314 165 0.016
positive regulation of epithelial cell proliferation GO:0050679 68 0.016
positive regulation of thymocyte migration GO:2000412 2 0.016
mesonephric epithelium development GO:0072163 94 0.016
cell substrate adhesion GO:0031589 130 0.016
digestive system development GO:0055123 200 0.016
regulation of eosinophil migration GO:2000416 2 0.016
response to oxidative stress GO:0006979 123 0.016
skeletal system morphogenesis GO:0048705 203 0.016
hindbrain development GO:0030902 128 0.016
negative regulation of endothelial cell migration GO:0010596 4 0.016
multicellular organism growth GO:0035264 161 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
circadian rhythm GO:0007623 114 0.016
leukocyte homeostasis GO:0001776 79 0.016
peptidyl amino acid modification GO:0018193 336 0.016
glycoprotein biosynthetic process GO:0009101 89 0.016
digestive tract development GO:0048565 190 0.016
regulation of hormone levels GO:0010817 211 0.016
sequestering of calcium ion GO:0051208 18 0.016
carbohydrate homeostasis GO:0033500 128 0.016
sensory perception of chemical stimulus GO:0007606 51 0.015
muscle contraction GO:0006936 101 0.015
regionalization GO:0003002 337 0.015
sulfur compound metabolic process GO:0006790 100 0.015
response to steroid hormone GO:0048545 56 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
t cell differentiation GO:0030217 174 0.015
negative regulation of nervous system development GO:0051961 156 0.015
mesonephros development GO:0001823 97 0.015
methylation GO:0032259 134 0.015
nuclear transport GO:0051169 139 0.015
positive regulation of leukocyte apoptotic process GO:2000108 21 0.015
neuromuscular process GO:0050905 99 0.015
sperm motility GO:0030317 47 0.015
pallium development GO:0021543 120 0.015
cellular response to nutrient levels GO:0031669 64 0.015
embryonic organ morphogenesis GO:0048562 276 0.014
positive regulation of nervous system development GO:0051962 221 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.014
sensory organ morphogenesis GO:0090596 242 0.014
regulation of cell cycle process GO:0010564 160 0.014
endothelial cell differentiation GO:0045446 41 0.014
negative regulation of cell cycle GO:0045786 123 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
lymphocyte apoptotic process GO:0070227 54 0.014
heterocycle catabolic process GO:0046700 280 0.014
extracellular structure organization GO:0043062 148 0.014
regulation of neuron differentiation GO:0045664 281 0.014
mesoderm morphogenesis GO:0048332 64 0.014
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.014
response to peptide GO:1901652 136 0.014
regulation of homeostatic process GO:0032844 182 0.014
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.014
regulation of cell activation GO:0050865 289 0.014
negative regulation of neuron apoptotic process GO:0043524 92 0.014
glucose homeostasis GO:0042593 128 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
maintenance of location GO:0051235 89 0.014
cellular response to dna damage stimulus GO:0006974 207 0.014
protein catabolic process GO:0030163 221 0.014
divalent metal ion transport GO:0070838 172 0.014
regulation of protein kinase activity GO:0045859 232 0.014
mitotic cell cycle GO:0000278 195 0.014
response to transforming growth factor beta GO:0071559 88 0.014
thymocyte migration GO:0072679 2 0.014
myotube differentiation GO:0014902 105 0.014
lipid biosynthetic process GO:0008610 179 0.014
negative regulation of lipid metabolic process GO:0045833 30 0.013
mesenchymal cell development GO:0014031 93 0.013
male sex differentiation GO:0046661 109 0.013
regulation of proteolysis GO:0030162 164 0.013
sodium ion transport GO:0006814 73 0.013
mitochondrion organization GO:0007005 134 0.013
anatomical structure homeostasis GO:0060249 145 0.013
synaptic transmission GO:0007268 329 0.013
regulation of interleukin 1 alpha production GO:0032650 4 0.013
gonad development GO:0008406 141 0.013
leukocyte differentiation GO:0002521 342 0.013
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.013
dephosphorylation GO:0016311 129 0.013
response to hypoxia GO:0001666 58 0.013
macromolecule methylation GO:0043414 120 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.013
calcium ion transport GO:0006816 159 0.013
organic cyclic compound catabolic process GO:1901361 295 0.013
palate development GO:0060021 76 0.013
muscle tissue morphogenesis GO:0060415 53 0.013
nephron tubule morphogenesis GO:0072078 68 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
multi multicellular organism process GO:0044706 109 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.013
aromatic compound catabolic process GO:0019439 286 0.013
regulation of mitotic cell cycle GO:0007346 126 0.013
cellular response to oxidative stress GO:0034599 76 0.013
neutral lipid metabolic process GO:0006638 57 0.013
regulation of thymocyte migration GO:2000410 2 0.013
paramesonephric duct development GO:0061205 3 0.013
membrane organization GO:0061024 245 0.013
male gonad development GO:0008584 88 0.013
regulation of system process GO:0044057 200 0.013
regulation of tube size GO:0035150 57 0.013
mesoderm development GO:0007498 100 0.013
cell growth GO:0016049 130 0.012
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.012
organic anion transport GO:0015711 137 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
carbohydrate metabolic process GO:0005975 230 0.012
glycosylation GO:0070085 62 0.012
negative regulation of protein maturation GO:1903318 79 0.012
regulation of neural retina development GO:0061074 3 0.012
hepaticobiliary system development GO:0061008 67 0.012
ubiquitin dependent protein catabolic process GO:0006511 129 0.012
central nervous system projection neuron axonogenesis GO:0021952 21 0.012
motor neuron migration GO:0097475 4 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
development of primary male sexual characteristics GO:0046546 88 0.012
metanephric loop of henle development GO:0072236 4 0.012
mesodermal cell migration GO:0008078 4 0.012
activation of mapk activity involved in innate immune response GO:0035419 2 0.012
cerebellum development GO:0021549 77 0.012
negative regulation of hormone biosynthetic process GO:0032353 4 0.012
mesoderm formation GO:0001707 62 0.012
organophosphate catabolic process GO:0046434 232 0.012
insulin receptor signaling pathway GO:0008286 49 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
bundle of his development GO:0003166 4 0.012
nuclear export GO:0051168 34 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
positive regulation of cell cycle GO:0045787 92 0.012
mrna metabolic process GO:0016071 84 0.012
female gonad development GO:0008585 71 0.012
branching morphogenesis of an epithelial tube GO:0048754 159 0.012
sequestering of metal ion GO:0051238 19 0.012
negative regulation of protein modification process GO:0031400 163 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
cell maturation GO:0048469 127 0.012
regulation of anatomical structure size GO:0090066 178 0.012
cell chemotaxis GO:0060326 81 0.012
neurotransmitter transport GO:0006836 76 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
skin development GO:0043588 220 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
rna processing GO:0006396 105 0.012
cellular lipid metabolic process GO:0044255 323 0.012
odontogenesis of dentin containing tooth GO:0042475 66 0.012
mesonephric tubule development GO:0072164 94 0.011
visual perception GO:0007601 52 0.011
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.011
response to organic cyclic compound GO:0014070 198 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.011
positive regulation of stem cell proliferation GO:2000648 59 0.011
positive regulation of proteolysis GO:0045862 85 0.011
stem cell development GO:0048864 219 0.011
regulation of cell projection organization GO:0031344 206 0.011
protein glycosylation GO:0006486 55 0.011
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.011
placenta development GO:0001890 140 0.011
regulation of nuclear division GO:0051783 56 0.011
mesonephric duct morphogenesis GO:0072180 4 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
positive regulation of protein modification process GO:0031401 299 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
epithelial cell proliferation GO:0050673 174 0.011
central nervous system neuron differentiation GO:0021953 162 0.011
chromatin organization GO:0006325 206 0.011
adaptive immune response GO:0002250 155 0.011
response to monosaccharide GO:0034284 67 0.011
ear morphogenesis GO:0042471 118 0.011
response to light stimulus GO:0009416 135 0.011
nitrogen compound transport GO:0071705 271 0.011
skeletal muscle organ development GO:0060538 163 0.011
trabecula morphogenesis GO:0061383 40 0.011
odontogenesis GO:0042476 78 0.011
atp metabolic process GO:0046034 75 0.011
response to growth factor GO:0070848 198 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
purine nucleotide metabolic process GO:0006163 302 0.011
cation homeostasis GO:0055080 212 0.011
rho protein signal transduction GO:0007266 32 0.011
nephron development GO:0072006 109 0.011
metanephric nephron development GO:0072210 34 0.011
ribonucleotide metabolic process GO:0009259 291 0.011
endomembrane system organization GO:0010256 147 0.011
determination of left right symmetry GO:0007368 80 0.011
retina development in camera type eye GO:0060041 119 0.011
nucleoside phosphate metabolic process GO:0006753 338 0.011
b cell differentiation GO:0030183 78 0.011
midbrain development GO:0030901 35 0.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.011
regulation of angiotensin levels in blood GO:0002002 4 0.011
sensory perception of mechanical stimulus GO:0050954 107 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
regulation of cell migration GO:0030334 219 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
purine nucleoside catabolic process GO:0006152 205 0.010
cellular protein catabolic process GO:0044257 155 0.010
nucleoside metabolic process GO:0009116 246 0.010
microtubule based process GO:0007017 236 0.010
ribonucleoside monophosphate metabolic process GO:0009161 80 0.010
testosterone biosynthetic process GO:0061370 2 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
regulation of protein processing GO:0070613 96 0.010
ameboidal type cell migration GO:0001667 128 0.010
cartilage development GO:0051216 140 0.010
regulation of steroid metabolic process GO:0019218 39 0.010
muscle fiber development GO:0048747 76 0.010
limb morphogenesis GO:0035108 149 0.010
regulation of multi organism process GO:0043900 111 0.010
androgen biosynthetic process GO:0006702 4 0.010
regulation of organ growth GO:0046620 61 0.010
nucleoside triphosphate metabolic process GO:0009141 230 0.010
peptidyl serine phosphorylation GO:0018105 74 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
protein processing GO:0016485 163 0.010
positive regulation of map kinase activity GO:0043406 84 0.010
nerve development GO:0021675 67 0.010
neuron death GO:0070997 154 0.010
regulation of transmembrane transport GO:0034762 128 0.010
ventricular cardiac muscle tissue development GO:0003229 38 0.010
mucopolysaccharide metabolic process GO:1903510 25 0.010
cellular chemical homeostasis GO:0055082 215 0.010

Spag4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.029
disease of anatomical entity DOID:7 0 0.029
connective tissue disease DOID:65 0 0.014
musculoskeletal system disease DOID:17 0 0.014
bone disease DOID:0080001 0 0.014
central nervous system disease DOID:331 0 0.012
disease of cellular proliferation DOID:14566 0 0.011