Mus musculus

14 known processes

Hmgcl

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

(Aliases: AW476067,HL)

Hmgcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.205
cellular lipid metabolic process GO:0044255 323 0.170
monocarboxylic acid metabolic process GO:0032787 191 0.104
cellular lipid catabolic process GO:0044242 52 0.089
cellular ketone metabolic process GO:0042180 84 0.088
cellular amino acid metabolic process GO:0006520 103 0.077
regulation of cellular ketone metabolic process GO:0010565 66 0.069
carboxylic acid catabolic process GO:0046395 51 0.065
regulation of cellular amino acid metabolic process GO:0006521 5 0.061
amine metabolic process GO:0009308 45 0.058
cofactor metabolic process GO:0051186 80 0.055
small molecule catabolic process GO:0044282 71 0.050
cellular amine metabolic process GO:0044106 44 0.046
regulation of cellular amine metabolic process GO:0033238 20 0.041
lipid modification GO:0030258 65 0.039
sulfur compound metabolic process GO:0006790 100 0.037
cation transport GO:0006812 399 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
lipid catabolic process GO:0016042 69 0.030
maintenance of location GO:0051235 89 0.030
nitrogen compound transport GO:0071705 271 0.030
organonitrogen compound biosynthetic process GO:1901566 192 0.029
transmembrane transport GO:0055085 412 0.029
small molecule biosynthetic process GO:0044283 132 0.029
spermatogenesis GO:0007283 284 0.029
fatty acid metabolic process GO:0006631 121 0.029
lipid biosynthetic process GO:0008610 179 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
inorganic ion transmembrane transport GO:0098660 234 0.028
cation transmembrane transport GO:0098655 266 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
purine ribonucleotide metabolic process GO:0009150 290 0.028
response to organic cyclic compound GO:0014070 198 0.027
regulation of hormone levels GO:0010817 211 0.027
male gamete generation GO:0048232 285 0.027
macromolecule catabolic process GO:0009057 281 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
organic hydroxy compound metabolic process GO:1901615 203 0.027
nucleoside phosphate metabolic process GO:0006753 338 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
cytokine production GO:0001816 319 0.025
ion transmembrane transport GO:0034220 361 0.024
proteasomal protein catabolic process GO:0010498 98 0.024
cellular amide metabolic process GO:0043603 58 0.024
regulation of cellular catabolic process GO:0031329 242 0.024
negative regulation of protein metabolic process GO:0051248 282 0.024
organic acid biosynthetic process GO:0016053 86 0.024
response to organonitrogen compound GO:0010243 246 0.024
carbohydrate metabolic process GO:0005975 230 0.023
apoptotic signaling pathway GO:0097190 306 0.023
mapk cascade GO:0000165 281 0.023
regulation of mapk cascade GO:0043408 248 0.023
organic anion transport GO:0015711 137 0.023
regulation of organelle organization GO:0033043 289 0.023
peptidyl amino acid modification GO:0018193 336 0.022
membrane organization GO:0061024 245 0.022
germ cell development GO:0007281 185 0.022
immune effector process GO:0002252 321 0.022
nucleotide metabolic process GO:0009117 332 0.022
cellular chemical homeostasis GO:0055082 215 0.022
purine containing compound metabolic process GO:0072521 311 0.022
lateral inhibition GO:0046331 1 0.021
fatty acid oxidation GO:0019395 28 0.021
inorganic cation transmembrane transport GO:0098662 207 0.021
regulation of secretion GO:0051046 274 0.021
g protein coupled receptor signaling pathway GO:0007186 243 0.020
regulation of secretion by cell GO:1903530 249 0.020
anion transport GO:0006820 177 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.020
organic acid catabolic process GO:0016054 51 0.020
reactive nitrogen species metabolic process GO:2001057 0 0.020
carboxylic acid biosynthetic process GO:0046394 86 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
regulation of membrane potential GO:0042391 192 0.019
protein processing GO:0016485 163 0.019
protein maturation GO:0051604 176 0.019
regulation of defense response GO:0031347 233 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
cellular homeostasis GO:0019725 240 0.018
regulation of cytokine production GO:0001817 266 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
regulation of cell cycle GO:0051726 281 0.018
cell type specific apoptotic process GO:0097285 268 0.018
protein ubiquitination GO:0016567 171 0.018
response to nutrient levels GO:0031667 109 0.018
response to extracellular stimulus GO:0009991 127 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
endomembrane system organization GO:0010256 147 0.018
protein catabolic process GO:0030163 221 0.018
developmental maturation GO:0021700 193 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.017
reactive oxygen species metabolic process GO:0072593 84 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
regulation of protein localization GO:0032880 231 0.017
cation homeostasis GO:0055080 212 0.017
inflammatory response GO:0006954 244 0.017
sensory perception GO:0007600 245 0.017
positive regulation of secretion GO:0051047 130 0.017
lipid oxidation GO:0034440 29 0.017
chromatin modification GO:0016568 187 0.017
thioester metabolic process GO:0035383 19 0.017
microtubule based process GO:0007017 236 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
response to molecule of bacterial origin GO:0002237 143 0.016
cellular protein catabolic process GO:0044257 155 0.016
multicellular organismal homeostasis GO:0048871 164 0.016
negative regulation of cellular amine metabolic process GO:0033239 1 0.016
multicellular organismal signaling GO:0035637 91 0.016
positive regulation of cell death GO:0010942 224 0.016
neuronal action potential GO:0019228 54 0.016
regulation of kinase activity GO:0043549 249 0.016
positive regulation of protein modification process GO:0031401 299 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
nucleoside metabolic process GO:0009116 246 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
peptide metabolic process GO:0006518 46 0.015
regulation of cellular component biogenesis GO:0044087 181 0.015
cellular carbohydrate metabolic process GO:0044262 119 0.015
glycerolipid metabolic process GO:0046486 122 0.015
cellular response to nutrient levels GO:0031669 64 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
homeostasis of number of cells GO:0048872 210 0.015
regulation of lymphocyte activation GO:0051249 240 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
action potential GO:0001508 78 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
carbohydrate derivative catabolic process GO:1901136 231 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
hematopoietic progenitor cell differentiation GO:0002244 143 0.015
innate immune response GO:0045087 157 0.015
cellular ion homeostasis GO:0006873 165 0.015
mitochondrion organization GO:0007005 134 0.014
regulation of transferase activity GO:0051338 263 0.014
epithelial cell development GO:0002064 159 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
cellular response to extracellular stimulus GO:0031668 81 0.014
ribonucleoside metabolic process GO:0009119 245 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
endocytosis GO:0006897 168 0.014
purine nucleoside triphosphate metabolic process GO:0009144 226 0.014
regulation of proteolysis GO:0030162 164 0.014
metal ion homeostasis GO:0055065 189 0.014
t cell activation GO:0042110 289 0.014
chromatin organization GO:0006325 206 0.014
cellular response to external stimulus GO:0071496 88 0.014
regulation of protein kinase activity GO:0045859 232 0.014
ossification GO:0001503 216 0.014
positive regulation of cell development GO:0010720 237 0.014
response to starvation GO:0042594 65 0.014
cellular metal ion homeostasis GO:0006875 151 0.013
amide transport GO:0042886 138 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
glycoprotein metabolic process GO:0009100 116 0.013
gland development GO:0048732 330 0.013
response to lipopolysaccharide GO:0032496 128 0.013
cytoplasmic transport GO:0016482 234 0.013
urogenital system development GO:0001655 261 0.013
transmission of nerve impulse GO:0019226 76 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
response to acid chemical GO:0001101 111 0.013
hexose metabolic process GO:0019318 98 0.013
bone development GO:0060348 120 0.013
skeletal system development GO:0001501 356 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
renal system development GO:0072001 225 0.013
organelle localization GO:0051640 179 0.013
regulation of binding GO:0051098 111 0.013
response to peptide GO:1901652 136 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
cellular response to starvation GO:0009267 57 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
regulation of cell activation GO:0050865 289 0.012
dna metabolic process GO:0006259 303 0.012
alcohol metabolic process GO:0006066 116 0.012
negative regulation of protein modification process GO:0031400 163 0.012
coenzyme metabolic process GO:0006732 52 0.012
protein oligomerization GO:0051259 67 0.012
carbohydrate homeostasis GO:0033500 128 0.012
protein secretion GO:0009306 111 0.012
very long chain fatty acid catabolic process GO:0042760 2 0.012
cellular response to lipid GO:0071396 145 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
divalent metal ion transport GO:0070838 172 0.012
synaptic transmission GO:0007268 329 0.012
covalent chromatin modification GO:0016569 163 0.012
regulation of ion transport GO:0043269 215 0.012
divalent inorganic cation transport GO:0072511 178 0.012
defense response to other organism GO:0098542 197 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
negative regulation of immune system process GO:0002683 209 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
calcium ion transport GO:0006816 159 0.012
defense response to bacterium GO:0042742 119 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
regulation of protein catabolic process GO:0042176 108 0.012
intracellular protein transport GO:0006886 204 0.012
cell division GO:0051301 120 0.012
regulation of t cell activation GO:0050863 170 0.012
organelle fission GO:0048285 170 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
neuron death GO:0070997 154 0.012
sequestering of metal ion GO:0051238 19 0.012
fatty acid beta oxidation GO:0006635 16 0.012
forebrain development GO:0030900 302 0.012
asymmetric stem cell division GO:0098722 3 0.012
erk1 and erk2 cascade GO:0070371 77 0.011
striated muscle tissue development GO:0014706 293 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
muscle tissue development GO:0060537 308 0.011
circulatory system process GO:0003013 197 0.011
aromatic compound catabolic process GO:0019439 286 0.011
cell maturation GO:0048469 127 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
positive regulation of kinase activity GO:0033674 155 0.011
nucleotide catabolic process GO:0009166 217 0.011
peptide transport GO:0015833 133 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
plasma membrane organization GO:0007009 90 0.011
lipid localization GO:0010876 126 0.011
leukocyte migration GO:0050900 124 0.011
regulation of neuron differentiation GO:0045664 281 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
ras protein signal transduction GO:0007265 77 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
ribonucleoside triphosphate metabolic process GO:0009199 220 0.011
response to peptide hormone GO:0043434 127 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
histone modification GO:0016570 159 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
acyl coa metabolic process GO:0006637 19 0.011
digestive system development GO:0055123 200 0.011
myeloid cell differentiation GO:0030099 233 0.010
gonad development GO:0008406 141 0.010
muscle cell differentiation GO:0042692 261 0.010
response to insulin GO:0032868 100 0.010
positive regulation of cytokine production GO:0001819 174 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
monosaccharide metabolic process GO:0005996 106 0.010
leukocyte differentiation GO:0002521 342 0.010
fat cell differentiation GO:0045444 160 0.010
cell adhesion GO:0007155 329 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.010
digestive tract development GO:0048565 190 0.010
positive regulation of transferase activity GO:0051347 167 0.010
protein localization to membrane GO:0072657 108 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
development of primary male sexual characteristics GO:0046546 88 0.010

Hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.025
inherited metabolic disorder DOID:655 0 0.019
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
central nervous system disease DOID:331 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
immune system disease DOID:2914 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
sensory system disease DOID:0050155 0 0.010