Mus musculus

50 known processes

Palb2

partner and localizer of BRCA2

(Aliases: BC066140,4732427B05)

Palb2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.315
cellular response to dna damage stimulus GO:0006974 207 0.194
dna repair GO:0006281 107 0.193
meiotic cell cycle process GO:1903046 77 0.127
dna recombination GO:0006310 92 0.120
double strand break repair GO:0006302 48 0.108
meiotic nuclear division GO:0007126 115 0.078
organelle fission GO:0048285 170 0.067
chromosome organization involved in meiosis GO:0070192 39 0.064
purine containing compound metabolic process GO:0072521 311 0.062
regulation of cell cycle GO:0051726 281 0.058
nuclear division GO:0000280 158 0.057
cellular amino acid metabolic process GO:0006520 103 0.057
organic cyclic compound catabolic process GO:1901361 295 0.056
purine ribonucleoside metabolic process GO:0046128 241 0.056
nucleobase containing small molecule metabolic process GO:0055086 352 0.052
regulation of organelle organization GO:0033043 289 0.049
amine metabolic process GO:0009308 45 0.048
recombinational repair GO:0000725 21 0.047
response to radiation GO:0009314 165 0.046
meiotic cell cycle GO:0051321 122 0.045
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
glycosyl compound metabolic process GO:1901657 246 0.042
cellular amine metabolic process GO:0044106 44 0.042
nucleoside monophosphate metabolic process GO:0009123 85 0.042
ribonucleotide metabolic process GO:0009259 291 0.041
ribose phosphate metabolic process GO:0019693 291 0.040
purine nucleoside catabolic process GO:0006152 205 0.040
cellular macromolecule catabolic process GO:0044265 206 0.039
nucleoside metabolic process GO:0009116 246 0.039
atp metabolic process GO:0046034 75 0.039
cellular nitrogen compound catabolic process GO:0044270 280 0.039
organophosphate catabolic process GO:0046434 232 0.038
regulation of cellular amine metabolic process GO:0033238 20 0.038
glycosyl compound catabolic process GO:1901658 206 0.038
chromosome segregation GO:0007059 48 0.038
protein catabolic process GO:0030163 221 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.036
purine ribonucleotide metabolic process GO:0009150 290 0.036
purine nucleoside metabolic process GO:0042278 241 0.036
aromatic compound catabolic process GO:0019439 286 0.036
purine nucleoside triphosphate metabolic process GO:0009144 226 0.036
atp catabolic process GO:0006200 55 0.036
ribonucleoside triphosphate catabolic process GO:0009203 199 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.035
nucleoside phosphate metabolic process GO:0006753 338 0.035
purine nucleotide metabolic process GO:0006163 302 0.035
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.034
carbohydrate derivative catabolic process GO:1901136 231 0.034
intrinsic apoptotic signaling pathway GO:0097193 132 0.034
purine nucleoside triphosphate catabolic process GO:0009146 203 0.034
nucleoside triphosphate catabolic process GO:0009143 205 0.033
purine containing compound catabolic process GO:0072523 213 0.032
male gamete generation GO:0048232 285 0.032
cellular ketone metabolic process GO:0042180 84 0.031
ribonucleoside metabolic process GO:0009119 245 0.031
regulation of cell cycle process GO:0010564 160 0.031
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
purine ribonucleoside catabolic process GO:0046130 205 0.031
heterocycle catabolic process GO:0046700 280 0.031
purine ribonucleotide catabolic process GO:0009154 208 0.030
chromatin modification GO:0016568 187 0.030
chromatin organization GO:0006325 206 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
ribonucleoside catabolic process GO:0042454 206 0.029
nucleoside catabolic process GO:0009164 206 0.029
ribonucleoside triphosphate metabolic process GO:0009199 220 0.029
cell division GO:0051301 120 0.028
nucleoside phosphate catabolic process GO:1901292 222 0.028
negative regulation of protein metabolic process GO:0051248 282 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.027
nucleoside triphosphate metabolic process GO:0009141 230 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.027
nucleotide metabolic process GO:0009117 332 0.027
negative regulation of cellular component organization GO:0051129 194 0.026
regulation of cellular catabolic process GO:0031329 242 0.026
purine nucleotide catabolic process GO:0006195 211 0.026
spermatogenesis GO:0007283 284 0.026
cell cycle checkpoint GO:0000075 47 0.026
nucleotide catabolic process GO:0009166 217 0.026
protein ubiquitination GO:0016567 171 0.025
protein modification by small protein conjugation or removal GO:0070647 207 0.024
response to organonitrogen compound GO:0010243 246 0.024
ribonucleoside monophosphate catabolic process GO:0009158 57 0.024
double strand break repair via homologous recombination GO:0000724 21 0.024
meiosis i GO:0007127 60 0.024
methylation GO:0032259 134 0.023
regulation of mitotic cell cycle phase transition GO:1901990 73 0.023
ribonucleotide catabolic process GO:0009261 208 0.023
regulation of cell cycle phase transition GO:1901987 77 0.023
macromolecule methylation GO:0043414 120 0.023
macromolecule catabolic process GO:0009057 281 0.023
organonitrogen compound catabolic process GO:1901565 264 0.022
spermatid development GO:0007286 108 0.022
nucleoside monophosphate catabolic process GO:0009125 59 0.022
cellular protein catabolic process GO:0044257 155 0.021
anatomical structure homeostasis GO:0060249 145 0.021
peptidyl amino acid modification GO:0018193 336 0.021
mitotic cell cycle GO:0000278 195 0.021
purine nucleoside monophosphate metabolic process GO:0009126 81 0.021
response to ionizing radiation GO:0010212 42 0.020
regulation of chromosome organization GO:0033044 83 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
regulation of mitotic cell cycle GO:0007346 126 0.020
negative regulation of cell cycle GO:0045786 123 0.019
germ cell development GO:0007281 185 0.019
purine nucleoside monophosphate catabolic process GO:0009128 58 0.019
lipid biosynthetic process GO:0008610 179 0.019
immune effector process GO:0002252 321 0.019
oxidation reduction process GO:0055114 342 0.018
cation transport GO:0006812 399 0.018
protein maturation GO:0051604 176 0.018
cellular lipid metabolic process GO:0044255 323 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.018
regulation of proteolysis GO:0030162 164 0.018
cellular response to cytokine stimulus GO:0071345 189 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
regulation of membrane potential GO:0042391 192 0.017
membrane organization GO:0061024 245 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.016
cell type specific apoptotic process GO:0097285 268 0.016
regulation of cellular response to stress GO:0080135 159 0.016
spermatid differentiation GO:0048515 115 0.016
regulation of transferase activity GO:0051338 263 0.016
protein processing GO:0016485 163 0.016
production of molecular mediator of immune response GO:0002440 103 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
multicellular organismal signaling GO:0035637 91 0.016
sister chromatid segregation GO:0000819 20 0.016
positive regulation of protein modification process GO:0031401 299 0.016
regulation of cell activation GO:0050865 289 0.015
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.015
ion transmembrane transport GO:0034220 361 0.015
histone modification GO:0016570 159 0.015
cytokine production GO:0001816 319 0.015
response to organic cyclic compound GO:0014070 198 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
cytoplasmic transport GO:0016482 234 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
lateral inhibition GO:0046331 1 0.015
t cell activation GO:0042110 289 0.015
positive regulation of cell death GO:0010942 224 0.015
covalent chromatin modification GO:0016569 163 0.015
regulation of defense response GO:0031347 233 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.014
b cell activation GO:0042113 161 0.014
cell fate commitment GO:0045165 210 0.014
leukocyte differentiation GO:0002521 342 0.014
protein localization to organelle GO:0033365 185 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
transmembrane transport GO:0055085 412 0.014
nitrogen compound transport GO:0071705 271 0.014
protein modification by small protein conjugation GO:0032446 187 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
response to light stimulus GO:0009416 135 0.014
protein methylation GO:0006479 81 0.014
cellular homeostasis GO:0019725 240 0.014
regulation of secretion GO:0051046 274 0.014
gland development GO:0048732 330 0.014
regulation of sister chromatid segregation GO:0033045 13 0.014
female gamete generation GO:0007292 74 0.013
positive regulation of cell development GO:0010720 237 0.013
negative regulation of cellular catabolic process GO:0031330 47 0.013
regulation of nuclear division GO:0051783 56 0.013
microtubule based process GO:0007017 236 0.013
microtubule cytoskeleton organization GO:0000226 157 0.013
regulation of cytokine production GO:0001817 266 0.013
lymphocyte mediated immunity GO:0002449 139 0.013
mitotic nuclear division GO:0007067 48 0.013
developmental maturation GO:0021700 193 0.013
multicellular organism growth GO:0035264 161 0.013
lymphocyte differentiation GO:0030098 242 0.013
monocarboxylic acid metabolic process GO:0032787 191 0.012
apoptotic signaling pathway GO:0097190 306 0.012
regulation of cell division GO:0051302 76 0.012
cell adhesion GO:0007155 329 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
myeloid cell differentiation GO:0030099 233 0.012
regulation of protein maturation GO:1903317 96 0.012
sensory perception GO:0007600 245 0.012
positive regulation of cell cycle GO:0045787 92 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
intracellular protein transport GO:0006886 204 0.012
gene silencing GO:0016458 38 0.012
mitotic cell cycle process GO:1903047 159 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
heterochromatin organization GO:0070828 4 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
leukocyte mediated immunity GO:0002443 174 0.012
negative regulation of protein processing GO:0010955 79 0.012
cation transmembrane transport GO:0098655 266 0.011
negative regulation of transferase activity GO:0051348 85 0.011
organic anion transport GO:0015711 137 0.011
regulation of hydrolase activity GO:0051336 246 0.011
rhythmic process GO:0048511 174 0.011
negative regulation of nuclear division GO:0051784 19 0.011
locomotory behavior GO:0007626 195 0.011
histone methylation GO:0016571 71 0.011
negative regulation of molecular function GO:0044092 258 0.011
glucose homeostasis GO:0042593 128 0.011
cellular response to gamma radiation GO:0071480 4 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
divalent inorganic cation transport GO:0072511 178 0.011
protein alkylation GO:0008213 81 0.011
response to extracellular stimulus GO:0009991 127 0.011
inflammatory response GO:0006954 244 0.011
divalent metal ion transport GO:0070838 172 0.011
regulation of histone modification GO:0031056 56 0.011
lymphocyte proliferation GO:0046651 164 0.011
mapk cascade GO:0000165 281 0.011
cofactor metabolic process GO:0051186 80 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
leukocyte activation involved in immune response GO:0002366 126 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
regulation of mapk cascade GO:0043408 248 0.011
negative regulation of protein modification process GO:0031400 163 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
negative regulation of dna replication GO:0008156 4 0.011
regulation of dna recombination GO:0000018 34 0.011
action potential GO:0001508 78 0.011
response to acid chemical GO:0001101 111 0.011
cell cycle g1 s phase transition GO:0044843 57 0.011
cell activation involved in immune response GO:0002263 126 0.010
regulation of protein processing GO:0070613 96 0.010
mitotic cell cycle checkpoint GO:0007093 31 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
adaptive immune response GO:0002250 155 0.010
gonad development GO:0008406 141 0.010
regulation of secretion by cell GO:1903530 249 0.010
ossification GO:0001503 216 0.010
negative regulation of protein maturation GO:1903318 79 0.010
skeletal system development GO:0001501 356 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
camera type eye development GO:0043010 266 0.010
chromosome separation GO:0051304 14 0.010
forebrain development GO:0030900 302 0.010
organic hydroxy compound metabolic process GO:1901615 203 0.010
response to oxidative stress GO:0006979 123 0.010
regulation of t cell activation GO:0050863 170 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.010
cellular chemical homeostasis GO:0055082 215 0.010
nuclear transport GO:0051169 139 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
regulation of reactive oxygen species metabolic process GO:2000377 40 0.010

Palb2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.073
disease of cellular proliferation DOID:14566 0 0.073
organ system cancer DOID:0050686 0 0.073
immune system disease DOID:2914 0 0.034
disease of anatomical entity DOID:7 0 0.034
aplastic anemia DOID:12449 0 0.034
bone marrow disease DOID:4961 0 0.034
anemia DOID:2355 0 0.034
hematopoietic system disease DOID:74 0 0.034
nervous system disease DOID:863 0 0.022
thoracic cancer DOID:5093 0 0.016
congenital hypoplastic anemia DOID:1342 0 0.015
breast cancer DOID:1612 0 0.014
gastrointestinal system cancer DOID:3119 0 0.014
large intestine cancer DOID:5672 0 0.012
intestinal cancer DOID:10155 0 0.012
immune system cancer DOID:0060083 0 0.011
hematologic cancer DOID:2531 0 0.011
disease of metabolism DOID:0014667 0 0.010
central nervous system disease DOID:331 0 0.010