Mus musculus

23 known processes

Psmb10

proteasome (prosome, macropain) subunit, beta type 10

(Aliases: Mecl1)

Psmb10 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
antigen processing and presentation of exogenous antigen GO:0019884 26 0.717
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.654
antigen processing and presentation GO:0019882 47 0.628
innate immune response GO:0045087 157 0.402
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.368
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 9 0.326
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.255
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.216
interspecies interaction between organisms GO:0044419 83 0.186
regulation of t cell activation GO:0050863 170 0.179
antigen processing and presentation of exogenous peptide antigen via mhc class ib GO:0002477 3 0.175
regulation of defense response GO:0031347 233 0.171
leukocyte mediated cytotoxicity GO:0001909 62 0.160
t cell proliferation GO:0042098 120 0.158
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.148
positive regulation of innate immune response GO:0045089 80 0.129
regulation of intracellular transport GO:0032386 159 0.117
regulation of defense response to virus by host GO:0050691 8 0.111
regulation of cellular ketone metabolic process GO:0010565 66 0.103
regulation of type i interferon mediated signaling pathway GO:0060338 7 0.100
positive regulation of proteolysis GO:0045862 85 0.098
negative regulation of cell proliferation GO:0008285 296 0.098
positive regulation of peptidase activity GO:0010952 49 0.097
lymphocyte mediated immunity GO:0002449 139 0.093
leukocyte proliferation GO:0070661 172 0.087
fat cell differentiation GO:0045444 160 0.080
ribose phosphate metabolic process GO:0019693 291 0.076
cellular amine metabolic process GO:0044106 44 0.076
regulation of myd88 independent toll like receptor signaling pathway GO:0034127 1 0.076
carbohydrate derivative catabolic process GO:1901136 231 0.075
cellular amino acid metabolic process GO:0006520 103 0.074
cellular ketone metabolic process GO:0042180 84 0.074
purine ribonucleotide catabolic process GO:0009154 208 0.069
protein polymerization GO:0051258 57 0.069
peptide metabolic process GO:0006518 46 0.068
regulation of endopeptidase activity GO:0052548 89 0.068
regulation of proteolysis GO:0030162 164 0.068
cation transport GO:0006812 399 0.067
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 3 0.066
response to lipopolysaccharide GO:0032496 128 0.063
intracellular protein transport GO:0006886 204 0.062
positive regulation of hydrolase activity GO:0051345 148 0.060
cellular chemical homeostasis GO:0055082 215 0.060
myosin filament organization GO:0031033 3 0.059
negative regulation of molecular function GO:0044092 258 0.058
t cell activation GO:0042110 289 0.057
regulation of peptidase activity GO:0052547 96 0.055
actin filament polymerization GO:0030041 44 0.055
regulation of hormone levels GO:0010817 211 0.053
regulation of hydrolase activity GO:0051336 246 0.053
female sex differentiation GO:0046660 84 0.052
gland development GO:0048732 330 0.051
arp2 3 complex mediated actin nucleation GO:0034314 3 0.050
negative regulation of protein modification process GO:0031400 163 0.049
epidermis development GO:0008544 187 0.049
negative regulation of immune system process GO:0002683 209 0.049
organic cyclic compound catabolic process GO:1901361 295 0.048
glycosyl compound metabolic process GO:1901657 246 0.047
cytoplasmic transport GO:0016482 234 0.047
natural killer cell mediated immunity GO:0002228 29 0.046
leukocyte differentiation GO:0002521 342 0.046
nucleobase containing small molecule metabolic process GO:0055086 352 0.044
regulation of cellular component biogenesis GO:0044087 181 0.044
purine containing compound catabolic process GO:0072523 213 0.044
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
protein catabolic process GO:0030163 221 0.042
Yeast
aromatic compound catabolic process GO:0019439 286 0.042
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.042
regulation of lymphocyte activation GO:0051249 240 0.041
negative regulation of phosphorus metabolic process GO:0010563 184 0.040
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.039
nucleotide catabolic process GO:0009166 217 0.039
positive regulation of cellular amine metabolic process GO:0033240 5 0.039
rac protein signal transduction GO:0016601 13 0.038
regulation of cellular amine metabolic process GO:0033238 20 0.038
muscle tissue development GO:0060537 308 0.038
cell adhesion GO:0007155 329 0.038
metal ion homeostasis GO:0055065 189 0.037
guanosine containing compound metabolic process GO:1901068 144 0.037
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.037
phagocytosis GO:0006909 66 0.036
antigen processing and presentation of peptide antigen GO:0048002 29 0.036
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
regulation of cytoplasmic transport GO:1903649 112 0.035
negative regulation of cellular amine metabolic process GO:0033239 1 0.035
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.034
cellular response to growth factor stimulus GO:0071363 197 0.034
uropod organization GO:0032796 2 0.034
response to organonitrogen compound GO:0010243 246 0.034
cell fate commitment GO:0045165 210 0.034
positive regulation of cellular component biogenesis GO:0044089 94 0.033
actin cytoskeleton organization GO:0030036 220 0.032
macromolecule catabolic process GO:0009057 281 0.032
Yeast
regulation of cellular amino acid metabolic process GO:0006521 5 0.031
kidney development GO:0001822 213 0.031
myeloid cell differentiation GO:0030099 233 0.031
negative regulation of phosphorylation GO:0042326 166 0.031
endocytosis GO:0006897 168 0.030
myeloid cell homeostasis GO:0002262 114 0.030
cellular metal ion homeostasis GO:0006875 151 0.030
regulation of protein ubiquitination GO:0031396 52 0.030
positive regulation of lymphocyte activation GO:0051251 140 0.029
cell substrate adhesion GO:0031589 130 0.029
molting cycle GO:0042303 90 0.029
calcium ion transport GO:0006816 159 0.029
positive regulation of endopeptidase activity GO:0010950 43 0.028
neuron death GO:0070997 154 0.027
regulation of t cell proliferation GO:0042129 92 0.027
sequestering of metal ion GO:0051238 19 0.027
regulation of cellular component size GO:0032535 121 0.027
regulation of protein localization GO:0032880 231 0.027
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 4 0.026
cellular nitrogen compound catabolic process GO:0044270 280 0.026
response to organic cyclic compound GO:0014070 198 0.026
response to radiation GO:0009314 165 0.026
actin polymerization or depolymerization GO:0008154 54 0.026
cellular homeostasis GO:0019725 240 0.026
cellular macromolecule catabolic process GO:0044265 206 0.025
Yeast
heterocycle catabolic process GO:0046700 280 0.025
regulation of neuron apoptotic process GO:0043523 122 0.025
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.025
i kappab kinase nf kappab signaling GO:0007249 85 0.025
histone modification GO:0016570 159 0.024
cellular ion homeostasis GO:0006873 165 0.024
regulation of homeostatic process GO:0032844 182 0.024
organelle assembly GO:0070925 177 0.024
regulation of cell motility GO:2000145 236 0.024
regulation of nucleotide metabolic process GO:0006140 169 0.024
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.024
homeostasis of number of cells GO:0048872 210 0.023
regulation of lipid metabolic process GO:0019216 118 0.023
regulation of myd88 dependent toll like receptor signaling pathway GO:0034124 2 0.023
adaptive immune response GO:0002250 155 0.023
cellular response to cytokine stimulus GO:0071345 189 0.023
protein localization to organelle GO:0033365 185 0.023
regulation of protein complex assembly GO:0043254 83 0.023
sequestering of calcium ion GO:0051208 18 0.023
protein ubiquitination GO:0016567 171 0.023
negative regulation of protein phosphorylation GO:0001933 126 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
response to protozoan GO:0001562 28 0.021
defense response to virus GO:0051607 68 0.021
germ cell development GO:0007281 185 0.021
carbohydrate homeostasis GO:0033500 128 0.021
antigen processing and presentation via mhc class ib GO:0002475 8 0.021
regulation of purine nucleotide metabolic process GO:1900542 169 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
guanosine containing compound catabolic process GO:1901069 144 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.021
amine metabolic process GO:0009308 45 0.021
small gtpase mediated signal transduction GO:0007264 97 0.020
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.020
apoptotic signaling pathway GO:0097190 306 0.020
response to light stimulus GO:0009416 135 0.020
positive regulation of actin filament polymerization GO:0030838 26 0.020
response to inorganic substance GO:0010035 96 0.020
keratinocyte differentiation GO:0030216 48 0.020
tube formation GO:0035148 140 0.020
defense response to protozoan GO:0042832 25 0.020
negative regulation of phosphate metabolic process GO:0045936 184 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
extrinsic apoptotic signaling pathway GO:0097191 126 0.019
calcium ion transport into cytosol GO:0060402 48 0.019
ras protein signal transduction GO:0007265 77 0.019
negative regulation of defense response to virus by host GO:0050689 1 0.019
oxidation reduction process GO:0055114 342 0.019
negative regulation of innate immune response GO:0045824 17 0.018
regulation of calcium ion transport into cytosol GO:0010522 31 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
skin development GO:0043588 220 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
sensory organ morphogenesis GO:0090596 242 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
response to growth factor GO:0070848 198 0.018
positive regulation of t cell activation GO:0050870 101 0.017
negative regulation of defense response GO:0031348 77 0.017
regulation of actin filament length GO:0030832 45 0.017
maintenance of location GO:0051235 89 0.017
rna interference GO:0016246 2 0.017
positive regulation of apoptotic signaling pathway GO:2001235 95 0.017
regulation of actin filament based process GO:0032970 99 0.017
regulation of organelle organization GO:0033043 289 0.017
defense response to other organism GO:0098542 197 0.017
regulation of cell migration GO:0030334 219 0.017
negative regulation of vesicle fusion GO:0031339 1 0.017
regulation of cell activation GO:0050865 289 0.017
t cell homeostasis GO:0043029 35 0.017
peptidyl amino acid modification GO:0018193 336 0.017
cellular divalent inorganic cation homeostasis GO:0072503 127 0.017
positive regulation of interferon alpha production GO:0032727 4 0.017
regulation of actin polymerization or depolymerization GO:0008064 45 0.017
cellular response to dna damage stimulus GO:0006974 207 0.017
Fly
peptidyl lysine methylation GO:0018022 29 0.017
nucleotide metabolic process GO:0009117 332 0.017
intracellular transport of virus GO:0075733 1 0.017
positive regulation of protein complex assembly GO:0031334 45 0.017
negative regulation of protein ubiquitination GO:0031397 19 0.017
inflammatory response GO:0006954 244 0.017
neuron apoptotic process GO:0051402 142 0.016
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.016
dna metabolic process GO:0006259 303 0.016
progesterone metabolic process GO:0042448 4 0.016
tissue homeostasis GO:0001894 115 0.016
gtp metabolic process GO:0046039 144 0.016
t cell mediated immunity GO:0002456 50 0.016
striated muscle myosin thick filament assembly GO:0071688 1 0.016
cation homeostasis GO:0055080 212 0.016
glycoprotein metabolic process GO:0009100 116 0.016
transport of virus GO:0046794 1 0.016
protein localization to nucleus GO:0034504 121 0.016
positive regulation of rig i signaling pathway GO:1900246 1 0.016
leukocyte activation involved in immune response GO:0002366 126 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.016
cytokine production GO:0001816 319 0.016
nucleoside triphosphate catabolic process GO:0009143 205 0.015
nuclear import GO:0051170 95 0.015
central nervous system neuron differentiation GO:0021953 162 0.015
mitochondrion organization GO:0007005 134 0.015
regulation of leukocyte proliferation GO:0070663 121 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
nuclear transport GO:0051169 139 0.015
protection from natural killer cell mediated cytotoxicity GO:0042270 2 0.015
type i interferon production GO:0032606 29 0.015
regulation of neuron death GO:1901214 134 0.015
protein modification by small protein conjugation GO:0032446 187 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
leukocyte mediated immunity GO:0002443 174 0.015
regulation of actin filament polymerization GO:0030833 38 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
interleukin 1 production GO:0032612 31 0.015
regulation of lymphocyte proliferation GO:0050670 117 0.015
cellular protein complex assembly GO:0043623 116 0.015
regulation of cytokine biosynthetic process GO:0042035 59 0.014
cellular response to type i interferon GO:0071357 10 0.014
type i interferon signaling pathway GO:0060337 10 0.014
glucose homeostasis GO:0042593 128 0.014
t helper 17 cell lineage commitment GO:0072540 4 0.014
iron ion import into cell GO:0097459 4 0.014
regulation of leukocyte differentiation GO:1902105 159 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
anatomical structure homeostasis GO:0060249 145 0.014
striated muscle tissue development GO:0014706 293 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.014
cytosolic calcium ion transport GO:0060401 48 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
response to peptide GO:1901652 136 0.014
divalent inorganic cation transport GO:0072511 178 0.014
regulation of metal ion transport GO:0010959 106 0.014
regulation of actin nucleation GO:0051125 4 0.014
establishment of protein localization to organelle GO:0072594 118 0.013
viral life cycle GO:0019058 36 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
actin filament organization GO:0007015 113 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
purine ribonucleotide metabolic process GO:0009150 290 0.013
hormone secretion GO:0046879 128 0.013
protein targeting GO:0006605 143 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
positive regulation of kinase activity GO:0033674 155 0.013
positive regulation of leukocyte mediated immunity GO:0002705 70 0.013
cell killing GO:0001906 67 0.013
multicellular organism growth GO:0035264 161 0.013
cellular lipid metabolic process GO:0044255 323 0.013
regulation of dna templated transcription initiation GO:2000142 7 0.013
protein methylation GO:0006479 81 0.013
positive regulation of interferon gamma production GO:0032729 39 0.013
carbohydrate metabolic process GO:0005975 230 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
cell type specific apoptotic process GO:0097285 268 0.013
positive regulation of organelle organization GO:0010638 128 0.013
regulation of t cell mediated cytotoxicity GO:0001914 18 0.013
negative regulation of lymphocyte mediated immunity GO:0002707 21 0.013
renal system development GO:0072001 225 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
negative regulation of transferase activity GO:0051348 85 0.013
chromatin organization GO:0006325 206 0.013
protein import GO:0017038 101 0.013
negative regulation of kinase activity GO:0033673 81 0.013
negative regulation of homeostatic process GO:0032845 71 0.013
male gamete generation GO:0048232 285 0.012
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 2 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.012
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.012
regulation of binding GO:0051098 111 0.012
neural tube development GO:0021915 160 0.012
regulation of anatomical structure size GO:0090066 178 0.012
cellular response to peptide GO:1901653 92 0.012
negative regulation of intracellular protein transport GO:0090317 27 0.012
nitrogen compound transport GO:0071705 271 0.012
cellular calcium ion homeostasis GO:0006874 119 0.012
myosin filament assembly GO:0031034 2 0.012
blood vessel morphogenesis GO:0048514 285 0.012
lymphocyte proliferation GO:0046651 164 0.012
calcium ion homeostasis GO:0055074 127 0.012
regulation of protein kinase activity GO:0045859 232 0.012
negative regulation of regulatory t cell differentiation GO:0045590 2 0.012
purine nucleotide biosynthetic process GO:0006164 65 0.012
lymphocyte differentiation GO:0030098 242 0.012
membrane organization GO:0061024 245 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
positive regulation of t cell proliferation GO:0042102 52 0.012
ear development GO:0043583 200 0.012
positive regulation of actin nucleation GO:0051127 3 0.012
lysosomal transport GO:0007041 10 0.011
regulation of transferase activity GO:0051338 263 0.011
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.011
cellular response to abiotic stimulus GO:0071214 56 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
b cell mediated immunity GO:0019724 71 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
regulation of cell adhesion GO:0030155 154 0.011
regulation of membrane potential GO:0042391 192 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
purine nucleotide metabolic process GO:0006163 302 0.011
deoxyribonucleotide catabolic process GO:0009264 5 0.011
plasma cell differentiation GO:0002317 3 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
sensory perception GO:0007600 245 0.011
rhythmic process GO:0048511 174 0.011
chromatin modification GO:0016568 187 0.011
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
b cell activation GO:0042113 161 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
protein oligomerization GO:0051259 67 0.011
response to dsrna GO:0043331 30 0.011
regulation of lymphocyte mediated immunity GO:0002706 84 0.011
positive regulation of cell migration GO:0030335 109 0.011
immune response regulating signaling pathway GO:0002764 125 0.011
epithelial tube formation GO:0072175 130 0.011
regulation of cytokine production GO:0001817 266 0.011
regulation of kinase activity GO:0043549 249 0.010
regulation of ion homeostasis GO:2000021 64 0.010
epithelial cell proliferation GO:0050673 174 0.010
immune effector process GO:0002252 321 0.010
cellular response to interleukin 4 GO:0071353 21 0.010
extracellular matrix organization GO:0030198 147 0.010
translation GO:0006412 93 0.010
neuromuscular process GO:0050905 99 0.010
gonad development GO:0008406 141 0.010
leukocyte homeostasis GO:0001776 79 0.010
female gonad development GO:0008585 71 0.010
negative regulation of organelle organization GO:0010639 90 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
embryonic epithelial tube formation GO:0001838 130 0.010
locomotory behavior GO:0007626 195 0.010
synaptic transmission GO:0007268 329 0.010
protein localization to plasma membrane GO:0072659 57 0.010
response to peptide hormone GO:0043434 127 0.010
regulation of peptidyl serine phosphorylation GO:0033135 39 0.010
positive regulation of leukocyte proliferation GO:0070665 73 0.010
sulfur compound metabolic process GO:0006790 100 0.010
covalent chromatin modification GO:0016569 163 0.010
antigen processing and presentation of exogenous peptide antigen via mhc class i GO:0042590 6 0.010
regulation of protein heterodimerization activity GO:0043497 2 0.010
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.010
establishment of protein localization to membrane GO:0090150 54 0.010

Psmb10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.021
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.021
primary immunodeficiency disease DOID:612 0 0.013
immune system disease DOID:2914 0 0.013
disease of anatomical entity DOID:7 0 0.013
bone disease DOID:0080001 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
nervous system disease DOID:863 0 0.010