Mus musculus

15 known processes

Tank

TRAF family member-associated Nf-kappa B activator

(Aliases: C86182,I-TRAF,E430026L09Rik)

Tank biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside phosphate metabolic process GO:0006753 338 0.272
positive regulation of secretion GO:0051047 130 0.254
regulation of secretion GO:0051046 274 0.186
positive regulation of secretion by cell GO:1903532 114 0.183
macromolecule catabolic process GO:0009057 281 0.176
purine ribonucleotide catabolic process GO:0009154 208 0.159
nucleobase containing small molecule metabolic process GO:0055086 352 0.132
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.132
protein modification by small protein conjugation GO:0032446 187 0.122
purine nucleoside metabolic process GO:0042278 241 0.122
regulation of interferon beta biosynthetic process GO:0045357 4 0.120
positive regulation of programmed cell death GO:0043068 218 0.119
activation of innate immune response GO:0002218 56 0.118
negative regulation of secretion GO:0051048 61 0.117
lymphocyte homeostasis GO:0002260 64 0.115
cell type specific apoptotic process GO:0097285 268 0.105
regulation of hydrolase activity GO:0051336 246 0.105
purine containing compound metabolic process GO:0072521 311 0.099
purine ribonucleoside metabolic process GO:0046128 241 0.097
protein ubiquitination GO:0016567 171 0.097
positive regulation of interferon alpha production GO:0032727 4 0.094
male gamete generation GO:0048232 285 0.090
positive regulation of endopeptidase activity GO:0010950 43 0.090
nucleoside triphosphate catabolic process GO:0009143 205 0.089
regulation of secretion by cell GO:1903530 249 0.089
activation of immune response GO:0002253 138 0.086
positive regulation of hydrolase activity GO:0051345 148 0.080
cytokine production GO:0001816 319 0.080
protein catabolic process GO:0030163 221 0.080
positive regulation of apoptotic process GO:0043065 217 0.078
positive regulation of cytokine biosynthetic process GO:0042108 40 0.078
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.077
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.077
modification dependent macromolecule catabolic process GO:0043632 133 0.074
nucleotide metabolic process GO:0009117 332 0.074
organophosphate catabolic process GO:0046434 232 0.073
cation transport GO:0006812 399 0.073
nucleoside phosphate catabolic process GO:1901292 222 0.073
gtp catabolic process GO:0006184 143 0.073
regulation of proteolysis GO:0030162 164 0.073
ribonucleoside metabolic process GO:0009119 245 0.072
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.070
positive regulation of defense response GO:0031349 124 0.069
developmental maturation GO:0021700 193 0.069
positive regulation of cell death GO:0010942 224 0.067
negative regulation of cell proliferation GO:0008285 296 0.065
cytokine biosynthetic process GO:0042089 68 0.064
dendritic cell proliferation GO:0044565 2 0.063
nucleoside metabolic process GO:0009116 246 0.063
guanosine containing compound catabolic process GO:1901069 144 0.062
microtubule based process GO:0007017 236 0.061
regulation of cytokine production GO:0001817 266 0.061
regulation of t cell activation GO:0050863 170 0.061
interferon beta biosynthetic process GO:0045350 4 0.060
regulation of peptidase activity GO:0052547 96 0.059
modification dependent protein catabolic process GO:0019941 133 0.059
glycosyl compound metabolic process GO:1901657 246 0.059
organic cyclic compound catabolic process GO:1901361 295 0.059
aromatic compound catabolic process GO:0019439 286 0.059
spermatid development GO:0007286 108 0.058
positive regulation of proteolysis GO:0045862 85 0.057
protein modification by small protein conjugation or removal GO:0070647 207 0.057
positive regulation of cytokine production GO:0001819 174 0.057
nucleoside triphosphate metabolic process GO:0009141 230 0.056
i kappab kinase nf kappab signaling GO:0007249 85 0.055
epithelial cell proliferation GO:0050673 174 0.055
mapk cascade GO:0000165 281 0.053
response to organonitrogen compound GO:0010243 246 0.053
ribonucleotide metabolic process GO:0009259 291 0.052
regulation of innate immune response GO:0045088 91 0.052
ribonucleoside triphosphate metabolic process GO:0009199 220 0.051
homeostasis of number of cells GO:0048872 210 0.048
cellular protein catabolic process GO:0044257 155 0.046
regulation of organelle organization GO:0033043 289 0.046
peptidyl amino acid modification GO:0018193 336 0.046
regulation of defense response GO:0031347 233 0.046
regulation of lymphocyte activation GO:0051249 240 0.045
carbohydrate derivative catabolic process GO:1901136 231 0.045
lactation GO:0007595 25 0.044
mammary gland lobule development GO:0061377 22 0.044
regulation of cysteine type endopeptidase activity GO:2000116 65 0.044
spermatogenesis GO:0007283 284 0.044
response to peptide GO:1901652 136 0.043
purine containing compound catabolic process GO:0072523 213 0.043
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.043
rhythmic process GO:0048511 174 0.043
cytokine metabolic process GO:0042107 71 0.042
positive regulation of peptidase activity GO:0010952 49 0.042
ribose phosphate metabolic process GO:0019693 291 0.042
t cell activation GO:0042110 289 0.042
leukocyte homeostasis GO:0001776 79 0.041
spermatid differentiation GO:0048515 115 0.041
regulation of cell cycle GO:0051726 281 0.041
lymphocyte proliferation GO:0046651 164 0.041
positive regulation of innate immune response GO:0045089 80 0.040
ion transmembrane transport GO:0034220 361 0.039
ubiquitin dependent protein catabolic process GO:0006511 129 0.039
leukocyte proliferation GO:0070661 172 0.039
innate immune response GO:0045087 157 0.039
nucleoside catabolic process GO:0009164 206 0.039
b cell homeostasis GO:0001782 34 0.038
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.038
ribonucleoside triphosphate catabolic process GO:0009203 199 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
regulation of exocytosis GO:0017157 61 0.037
heterocycle catabolic process GO:0046700 280 0.036
establishment of synaptic vesicle localization GO:0097480 57 0.035
transmembrane transport GO:0055085 412 0.035
regulation of stress activated mapk cascade GO:0032872 69 0.035
positive regulation of sodium ion transport GO:0010765 13 0.034
body fluid secretion GO:0007589 53 0.034
cellular response to cytokine stimulus GO:0071345 189 0.034
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.033
regulation of body fluid levels GO:0050878 162 0.033
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.032
defense response to gram positive bacterium GO:0050830 50 0.032
regulation of hormone levels GO:0010817 211 0.032
negative regulation of intracellular signal transduction GO:1902532 167 0.032
regulation of cell activation GO:0050865 289 0.032
morphogenesis of embryonic epithelium GO:0016331 159 0.032
response to insulin GO:0032868 100 0.031
muscle tissue development GO:0060537 308 0.031
gland development GO:0048732 330 0.030
nucleotide catabolic process GO:0009166 217 0.030
regulation of cellular catabolic process GO:0031329 242 0.030
microtubule cytoskeleton organization GO:0000226 157 0.029
positive regulation of cellular catabolic process GO:0031331 148 0.029
regulation of endopeptidase activity GO:0052548 89 0.029
purine ribonucleotide metabolic process GO:0009150 290 0.029
protein autophosphorylation GO:0046777 61 0.028
protein polyubiquitination GO:0000209 33 0.028
cellular nitrogen compound catabolic process GO:0044270 280 0.027
carbohydrate metabolic process GO:0005975 230 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
cytoplasmic transport GO:0016482 234 0.027
purine nucleoside catabolic process GO:0006152 205 0.027
establishment of vesicle localization GO:0051650 81 0.026
positive regulation of apoptotic signaling pathway GO:2001235 95 0.026
synaptic transmission GO:0007268 329 0.026
ribonucleoside monophosphate metabolic process GO:0009161 80 0.025
interferon beta production GO:0032608 16 0.025
cell division GO:0051301 120 0.025
negative regulation of exocytosis GO:0045920 12 0.025
response to molecule of bacterial origin GO:0002237 143 0.025
exocytosis GO:0006887 121 0.025
guanosine containing compound metabolic process GO:1901068 144 0.024
glycosyl compound catabolic process GO:1901658 206 0.024
mammary gland epithelial cell proliferation GO:0033598 24 0.024
insulin secretion GO:0030073 89 0.024
defense response to other organism GO:0098542 197 0.024
nucleoside monophosphate metabolic process GO:0009123 85 0.024
nitrogen compound transport GO:0071705 271 0.024
vesicle organization GO:0016050 60 0.024
synaptic vesicle localization GO:0097479 59 0.024
negative regulation of t cell activation GO:0050868 65 0.023
canonical wnt signaling pathway GO:0060070 130 0.023
meiotic cell cycle GO:0051321 122 0.023
regulation of cell size GO:0008361 72 0.023
carbohydrate homeostasis GO:0033500 128 0.023
regulation of mapk cascade GO:0043408 248 0.023
regulation of ion transmembrane transporter activity GO:0032412 54 0.023
cellular lipid metabolic process GO:0044255 323 0.023
regulation of cellular response to stress GO:0080135 159 0.023
stress activated protein kinase signaling cascade GO:0031098 81 0.023
negative regulation of molecular function GO:0044092 258 0.023
mammary gland alveolus development GO:0060749 22 0.023
regulation of cellular component size GO:0032535 121 0.022
striated muscle tissue development GO:0014706 293 0.022
i kappab phosphorylation GO:0007252 6 0.022
type i interferon production GO:0032606 29 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.022
regulation of multi organism process GO:0043900 111 0.022
maintenance of location GO:0051235 89 0.022
neuron apoptotic process GO:0051402 142 0.022
respiratory tube development GO:0030323 167 0.022
regulation of cellular ketone metabolic process GO:0010565 66 0.022
positive regulation of gtpase activity GO:0043547 85 0.022
positive regulation of protein modification process GO:0031401 299 0.021
regulation of kinase activity GO:0043549 249 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
stress activated mapk cascade GO:0051403 80 0.021
response to peptide hormone GO:0043434 127 0.021
cellular response to interleukin 15 GO:0071350 2 0.021
myelination GO:0042552 74 0.021
neuronal action potential GO:0019228 54 0.020
organelle localization GO:0051640 179 0.020
meiotic cell cycle process GO:1903046 77 0.020
negative regulation of secretion by cell GO:1903531 54 0.020
peptide secretion GO:0002790 114 0.020
rap protein signal transduction GO:0032486 3 0.020
ribonucleoside catabolic process GO:0042454 206 0.020
hexose metabolic process GO:0019318 98 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
regulation of protein kinase activity GO:0045859 232 0.020
myeloid leukocyte differentiation GO:0002573 119 0.020
purine nucleoside triphosphate catabolic process GO:0009146 203 0.020
regulation of cellular amine metabolic process GO:0033238 20 0.020
mitochondrion organization GO:0007005 134 0.020
single organism cell adhesion GO:0098602 156 0.019
mammary gland epithelium development GO:0061180 65 0.019
odontogenesis of dentin containing tooth GO:0042475 66 0.019
myeloid cell differentiation GO:0030099 233 0.019
calcium ion dependent exocytosis GO:0017156 35 0.019
regulation of interferon beta production GO:0032648 13 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
negative regulation of neuron death GO:1901215 98 0.018
cellular response to organonitrogen compound GO:0071417 145 0.018
epithelial tube morphogenesis GO:0060562 303 0.018
positive regulation of antimicrobial humoral response GO:0002760 2 0.018
glucose homeostasis GO:0042593 128 0.018
immune response regulating signaling pathway GO:0002764 125 0.018
regulation of metal ion transport GO:0010959 106 0.018
positive regulation of protein transport GO:0051222 93 0.018
positive regulation of sequestering of triglyceride GO:0010890 4 0.018
nuclear division GO:0000280 158 0.018
lipid transport GO:0006869 98 0.018
regulation of transferase activity GO:0051338 263 0.018
regulation of purine nucleotide catabolic process GO:0033121 122 0.018
cell maturation GO:0048469 127 0.017
negative regulation of fatty acid transport GO:2000192 1 0.017
response to lipopolysaccharide GO:0032496 128 0.017
membrane fusion GO:0061025 38 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
monosaccharide metabolic process GO:0005996 106 0.017
regulation of ion transport GO:0043269 215 0.017
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.017
leukocyte mediated immunity GO:0002443 174 0.017
actin cytoskeleton organization GO:0030036 220 0.016
apoptotic signaling pathway GO:0097190 306 0.016
lipid localization GO:0010876 126 0.016
protein maturation GO:0051604 176 0.016
hematopoietic progenitor cell differentiation GO:0002244 143 0.016
protein localization to organelle GO:0033365 185 0.016
wnt signaling pathway GO:0016055 188 0.016
golgi to endosome transport GO:0006895 3 0.016
regulation of cell cycle process GO:0010564 160 0.016
organonitrogen compound catabolic process GO:1901565 264 0.016
regulation of neuron projection development GO:0010975 169 0.016
cellular amino acid metabolic process GO:0006520 103 0.015
osteoclast differentiation GO:0030316 62 0.015
amine metabolic process GO:0009308 45 0.015
regulation of cytoskeleton organization GO:0051493 122 0.015
regulation of protein transport GO:0051223 163 0.015
membrane organization GO:0061024 245 0.015
transmission of nerve impulse GO:0019226 76 0.015
axon target recognition GO:0007412 4 0.015
t cell differentiation in thymus GO:0033077 77 0.015
embryonic epithelial tube formation GO:0001838 130 0.015
type i interferon biosynthetic process GO:0045351 9 0.015
regulation of protein localization GO:0032880 231 0.015
regulation of nucleotide catabolic process GO:0030811 122 0.015
hormone secretion GO:0046879 128 0.015
neurotransmitter secretion GO:0007269 62 0.014
cellular response to biotic stimulus GO:0071216 92 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.014
cellular ketone metabolic process GO:0042180 84 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
regulation of neuronal synaptic plasticity GO:0048168 30 0.014
gtp metabolic process GO:0046039 144 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
protein processing GO:0016485 163 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
multi organism behavior GO:0051705 62 0.014
muscle cell differentiation GO:0042692 261 0.014
b cell activation GO:0042113 161 0.014
positive regulation of interferon beta production GO:0032728 8 0.014
regulation of ion transmembrane transport GO:0034765 119 0.013
anion transport GO:0006820 177 0.013
sperm individualization GO:0007291 1 0.013
immune response activating signal transduction GO:0002757 116 0.013
immune effector process GO:0002252 321 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
negative regulation of icosanoid secretion GO:0032304 1 0.013
innate immune response activating signal transduction GO:0002758 50 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
positive regulation of growth GO:0045927 104 0.013
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
regulation of membrane potential GO:0042391 192 0.013
positive regulation of cell activation GO:0050867 158 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.013
establishment of protein localization to vacuole GO:0072666 4 0.013
microtubule based movement GO:0007018 84 0.013
dna metabolic process GO:0006259 303 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
positive regulation of protein secretion GO:0050714 52 0.013
protein secretion GO:0009306 111 0.013
endomembrane system organization GO:0010256 147 0.013
regulation of neuron differentiation GO:0045664 281 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
learning GO:0007612 98 0.013
mitotic cell cycle GO:0000278 195 0.013
multicellular organismal signaling GO:0035637 91 0.013
peptide hormone secretion GO:0030072 109 0.013
regulation of lymphocyte differentiation GO:0045619 107 0.013
cellular amine metabolic process GO:0044106 44 0.013
amide transport GO:0042886 138 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
regulation of protein secretion GO:0050708 82 0.013
response to interleukin 15 GO:0070672 3 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
lung development GO:0030324 164 0.012
neural tube formation GO:0001841 108 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
multi multicellular organism process GO:0044706 109 0.012
endocytic recycling GO:0032456 7 0.012
endocytosis GO:0006897 168 0.012
leukocyte differentiation GO:0002521 342 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
regulation of protein maturation GO:1903317 96 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
regulation of response to wounding GO:1903034 189 0.012
sodium ion transport GO:0006814 73 0.012
negative regulation of cellular protein metabolic process GO:0032269 247 0.012
response to radiation GO:0009314 165 0.012
organelle fission GO:0048285 170 0.012
vesicle localization GO:0051648 86 0.012
regulation of cell adhesion GO:0030155 154 0.012
regulation of protein complex assembly GO:0043254 83 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 1 0.011
protein retention in golgi apparatus GO:0045053 1 0.011
regulation of production of molecular mediator of immune response GO:0002700 65 0.011
protein targeting GO:0006605 143 0.011
positive regulation of protein autophosphorylation GO:0031954 4 0.011
positive regulation of cell development GO:0010720 237 0.011
learning or memory GO:0007611 148 0.011
ossification GO:0001503 216 0.011
immunoglobulin transcytosis in epithelial cells GO:0002414 2 0.011
neurotransmitter transport GO:0006836 76 0.011
peptidyl serine modification GO:0018209 83 0.011
respiratory system development GO:0060541 190 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
regulation of type i interferon production GO:0032479 22 0.011
actin filament organization GO:0007015 113 0.011
regulation of sodium ion transport GO:0002028 29 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
mitochondrion distribution GO:0048311 4 0.011
organic acid transport GO:0015849 101 0.011
negative regulation of cell development GO:0010721 169 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
cognition GO:0050890 149 0.011
inflammatory response GO:0006954 244 0.011
neuron death GO:0070997 154 0.011
positive regulation of ion transport GO:0043270 65 0.011
glucose metabolic process GO:0006006 92 0.011
antigen receptor mediated signaling pathway GO:0050851 64 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
negative regulation of wnt signaling pathway GO:0030178 73 0.011
centrosome separation GO:0051299 4 0.011
organelle fusion GO:0048284 28 0.011
circadian regulation of gene expression GO:0032922 48 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.010
synaptic vesicle transport GO:0048489 57 0.010
regulation of carbohydrate biosynthetic process GO:0043255 40 0.010
regulation of interferon alpha production GO:0032647 5 0.010
lipid storage GO:0019915 36 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
regulation of calcium ion dependent exocytosis GO:0017158 16 0.010
positive regulation of cell adhesion GO:0045785 80 0.010
odontogenesis GO:0042476 78 0.010
action potential GO:0001508 78 0.010
positive regulation of nervous system development GO:0051962 221 0.010
regulation of reactive oxygen species metabolic process GO:2000377 40 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.010
response to light stimulus GO:0009416 135 0.010
retrograde transport endosome to golgi GO:0042147 2 0.010
regulation of protein processing GO:0070613 96 0.010

Tank disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.013
retinal degeneration DOID:8466 0 0.013
cone rod dystrophy DOID:0050572 0 0.013
sensory system disease DOID:0050155 0 0.013
disease of anatomical entity DOID:7 0 0.013
eye and adnexa disease DOID:1492 0 0.013
nervous system disease DOID:863 0 0.013
eye disease DOID:5614 0 0.013