Mus musculus

53 known processes

Melk

maternal embryonic leucine zipper kinase

(Aliases: AI327312,MPK38,mKIAA0175)

Melk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear division GO:0000280 158 0.627
dna metabolic process GO:0006259 303 0.552
chromosome segregation GO:0007059 48 0.545
organelle fission GO:0048285 170 0.494
modification dependent protein catabolic process GO:0019941 133 0.391
sister chromatid segregation GO:0000819 20 0.388
ubiquitin dependent protein catabolic process GO:0006511 129 0.319
dna replication GO:0006260 52 0.317
cellular protein catabolic process GO:0044257 155 0.308
regulation of cell cycle GO:0051726 281 0.291
meiotic nuclear division GO:0007126 115 0.273
regulation of chromosome segregation GO:0051983 21 0.247
cellular response to dna damage stimulus GO:0006974 207 0.241
mitotic cell cycle process GO:1903047 159 0.240
regulation of mitotic cell cycle phase transition GO:1901990 73 0.229
regulation of cellular protein catabolic process GO:1903362 61 0.213
cellular macromolecule catabolic process GO:0044265 206 0.206
mitotic nuclear division GO:0007067 48 0.204
meiotic cell cycle GO:0051321 122 0.196
microtubule based process GO:0007017 236 0.193
regulation of cell cycle process GO:0010564 160 0.183
dna endoreduplication GO:0042023 4 0.175
mitotic cell cycle GO:0000278 195 0.169
positive regulation of chromosome segregation GO:0051984 4 0.167
regulation of organelle organization GO:0033043 289 0.156
regulation of cellular catabolic process GO:0031329 242 0.154
Mouse
mitotic sister chromatid segregation GO:0000070 14 0.152
double strand break repair GO:0006302 48 0.150
regulation of cell cycle phase transition GO:1901987 77 0.141
macromolecule catabolic process GO:0009057 281 0.136
regulation of protein kinase activity GO:0045859 232 0.128
meiosis i GO:0007127 60 0.126
dna repair GO:0006281 107 0.126
regulation of cellular ketone metabolic process GO:0010565 66 0.124
regulation of exit from mitosis GO:0007096 1 0.120
microtubule cytoskeleton organization GO:0000226 157 0.116
regulation of chromosome organization GO:0033044 83 0.110
positive regulation of cell cycle GO:0045787 92 0.110
germ cell development GO:0007281 185 0.105
positive regulation of protein phosphorylation GO:0001934 242 0.100
mitotic sister chromatid cohesion GO:0007064 1 0.099
purine nucleotide metabolic process GO:0006163 302 0.099
intrinsic apoptotic signaling pathway GO:0097193 132 0.098
chromosome separation GO:0051304 14 0.098
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.091
regulation of proteasomal protein catabolic process GO:0061136 46 0.091
regulation of protein localization GO:0032880 231 0.091
mitotic sister chromatid separation GO:0051306 9 0.090
response to organic cyclic compound GO:0014070 198 0.090
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.089
meiotic cell cycle process GO:1903046 77 0.082
regulation of cell division GO:0051302 76 0.079
organonitrogen compound catabolic process GO:1901565 264 0.076
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.075
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.074
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.071
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.070
negative regulation of cellular protein metabolic process GO:0032269 247 0.070
regulation of proteolysis GO:0030162 164 0.068
negative regulation of cellular component organization GO:0051129 194 0.067
protein catabolic process GO:0030163 221 0.065
positive regulation of protein modification process GO:0031401 299 0.065
cell division GO:0051301 120 0.065
Worm
ribonucleoside catabolic process GO:0042454 206 0.065
cellular amino acid metabolic process GO:0006520 103 0.064
proteasomal protein catabolic process GO:0010498 98 0.064
organic cyclic compound catabolic process GO:1901361 295 0.062
ribose phosphate metabolic process GO:0019693 291 0.060
purine containing compound metabolic process GO:0072521 311 0.060
positive regulation of cellular catabolic process GO:0031331 148 0.060
Mouse
chromatin organization GO:0006325 206 0.060
Mouse
glycosyl compound catabolic process GO:1901658 206 0.059
nucleotide metabolic process GO:0009117 332 0.059
male gamete generation GO:0048232 285 0.058
purine ribonucleotide metabolic process GO:0009150 290 0.057
regulation of mitotic sister chromatid segregation GO:0033047 12 0.056
negative regulation of mitosis GO:0045839 10 0.056
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.055
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.055
cleavage furrow formation GO:0036089 2 0.054
synapsis GO:0007129 34 0.052
regulation of transferase activity GO:0051338 263 0.051
nucleoside phosphate catabolic process GO:1901292 222 0.051
nucleobase containing small molecule metabolic process GO:0055086 352 0.050
cell fate commitment GO:0045165 210 0.049
Worm
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.048
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.048
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.047
mitotic cytokinesis GO:0000281 4 0.047
organelle assembly GO:0070925 177 0.046
spindle assembly involved in mitosis GO:0090307 4 0.046
covalent chromatin modification GO:0016569 163 0.046
Mouse
protein ubiquitination GO:0016567 171 0.045
establishment of organelle localization GO:0051656 122 0.045
modification dependent macromolecule catabolic process GO:0043632 133 0.044
positive regulation of apoptotic process GO:0043065 217 0.044
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.043
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.043
organelle localization GO:0051640 179 0.043
ribonucleotide metabolic process GO:0009259 291 0.043
response to radiation GO:0009314 165 0.043
Mouse
purine nucleoside metabolic process GO:0042278 241 0.043
cell cycle g1 s phase transition GO:0044843 57 0.043
regulation of protein catabolic process GO:0042176 108 0.042
translesion synthesis GO:0019985 1 0.042
nucleoside triphosphate metabolic process GO:0009141 230 0.042
nucleoside catabolic process GO:0009164 206 0.041
cellular amine metabolic process GO:0044106 44 0.041
purine ribonucleoside metabolic process GO:0046128 241 0.041
positive regulation of hydrolase activity GO:0051345 148 0.041
maintenance of location GO:0051235 89 0.041
nucleoside metabolic process GO:0009116 246 0.041
cellular response to growth factor stimulus GO:0071363 197 0.040
positive regulation of cell death GO:0010942 224 0.039
regulation of mitotic cell cycle GO:0007346 126 0.039
attachment of spindle microtubules to kinetochore GO:0008608 4 0.039
response to organonitrogen compound GO:0010243 246 0.039
Mouse
dna recombination GO:0006310 92 0.038
chromatin modification GO:0016568 187 0.038
Mouse
nucleoside triphosphate catabolic process GO:0009143 205 0.038
cytokinesis GO:0000910 17 0.038
ribonucleoside metabolic process GO:0009119 245 0.038
negative regulation of cellular protein catabolic process GO:1903363 22 0.038
cytokinetic process GO:0032506 2 0.037
heterocycle catabolic process GO:0046700 280 0.037
regulation of microtubule cytoskeleton organization GO:0070507 37 0.037
histone threonine phosphorylation GO:0035405 1 0.036
negative regulation of phosphorus metabolic process GO:0010563 184 0.036
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.036
protein processing GO:0016485 163 0.036
dna dependent dna replication GO:0006261 24 0.035
negative regulation of protein metabolic process GO:0051248 282 0.035
placenta development GO:0001890 140 0.035
purine nucleoside triphosphate catabolic process GO:0009146 203 0.035
cell type specific apoptotic process GO:0097285 268 0.035
positive regulation of organelle organization GO:0010638 128 0.034
protein localization to organelle GO:0033365 185 0.034
protein modification by small protein conjugation or removal GO:0070647 207 0.033
regulation of nuclear division GO:0051783 56 0.033
positive regulation of cell division GO:0051781 31 0.033
negative regulation of proteolysis GO:0045861 74 0.033
female gamete generation GO:0007292 74 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.032
regulation of cellular amino acid metabolic process GO:0006521 5 0.032
regulation of protein maturation GO:1903317 96 0.032
regulation of mitotic sister chromatid separation GO:0010965 12 0.032
nucleoside monophosphate metabolic process GO:0009123 85 0.032
cell cycle g2 m phase transition GO:0044839 20 0.032
meiosis ii GO:0007135 7 0.032
synaptonemal complex assembly GO:0007130 13 0.031
regulation of kinase activity GO:0043549 249 0.031
lateral inhibition GO:0046331 1 0.031
male meiosis GO:0007140 37 0.031
regulation of nucleocytoplasmic transport GO:0046822 73 0.031
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.031
carbohydrate derivative catabolic process GO:1901136 231 0.031
cellular homeostasis GO:0019725 240 0.031
negative regulation of protein maturation GO:1903318 79 0.031
negative regulation of mitotic cell cycle GO:0045930 58 0.031
regulation of sister chromatid segregation GO:0033045 13 0.030
sister chromatid cohesion GO:0007062 12 0.030
negative regulation of cell cycle GO:0045786 123 0.029
nucleotide catabolic process GO:0009166 217 0.029
negative regulation of sister chromatid segregation GO:0033046 7 0.029
positive regulation of kinase activity GO:0033674 155 0.029
apoptotic signaling pathway GO:0097190 306 0.029
positive regulation of protein kinase activity GO:0045860 144 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
peptidyl serine phosphorylation GO:0018105 74 0.027
Mouse
female meiotic division GO:0007143 21 0.027
purine nucleotide catabolic process GO:0006195 211 0.027
positive regulation of programmed cell death GO:0043068 218 0.027
nucleoside monophosphate catabolic process GO:0009125 59 0.027
female meiosis chromosome segregation GO:0016321 1 0.027
purine ribonucleoside catabolic process GO:0046130 205 0.027
gland development GO:0048732 330 0.027
regulation of hydrolase activity GO:0051336 246 0.026
purine nucleoside catabolic process GO:0006152 205 0.026
wnt signaling pathway GO:0016055 188 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.026
oogenesis GO:0048477 56 0.026
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.026
purine containing compound catabolic process GO:0072523 213 0.026
cellular response to lipid GO:0071396 145 0.025
cellular ketone metabolic process GO:0042180 84 0.025
embryonic epithelial tube formation GO:0001838 130 0.025
cell adhesion GO:0007155 329 0.025
regulation of mitosis GO:0007088 29 0.025
spindle checkpoint GO:0031577 12 0.025
amine metabolic process GO:0009308 45 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.025
mitotic spindle checkpoint GO:0071174 9 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
synaptonemal complex organization GO:0070193 15 0.025
aromatic compound catabolic process GO:0019439 286 0.024
regulation of cell size GO:0008361 72 0.024
cellular nitrogen compound catabolic process GO:0044270 280 0.024
positive regulation of exit from mitosis GO:0031536 1 0.024
response to acid chemical GO:0001101 111 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
endocytosis GO:0006897 168 0.024
regulation of protein processing GO:0070613 96 0.023
regulation of cytoplasmic transport GO:1903649 112 0.023
positive regulation of meiotic cell cycle GO:0051446 15 0.023
mapk cascade GO:0000165 281 0.023
regulation of response to wounding GO:1903034 189 0.023
negative regulation of cellular catabolic process GO:0031330 47 0.023
leukocyte homeostasis GO:0001776 79 0.023
regulation of protein serine threonine kinase activity GO:0071900 157 0.023
muscle cell differentiation GO:0042692 261 0.023
peptidyl amino acid modification GO:0018193 336 0.023
Human Mouse
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 9 0.023
microtubule anchoring GO:0034453 9 0.023
g1 s transition of mitotic cell cycle GO:0000082 57 0.022
oocyte differentiation GO:0009994 35 0.022
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.022
positive regulation of proteolysis GO:0045862 85 0.022
cellular lipid metabolic process GO:0044255 323 0.022
Mouse
ribonucleoside monophosphate metabolic process GO:0009161 80 0.022
regulation of cellular response to stress GO:0080135 159 0.022
cellularization GO:0007349 1 0.021
histone modification GO:0016570 159 0.021
Mouse
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.021
negative regulation of protein processing GO:0010955 79 0.021
protein maturation GO:0051604 176 0.021
regulation of cell projection organization GO:0031344 206 0.021
negative regulation of molecular function GO:0044092 258 0.021
oocyte maturation GO:0001556 18 0.021
intracellular mrna localization GO:0008298 4 0.020
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.020
organophosphate catabolic process GO:0046434 232 0.020
mitotic spindle organization GO:0007052 10 0.020
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.020
ribonucleoside monophosphate catabolic process GO:0009158 57 0.020
muscle cell development GO:0055001 133 0.020
regulation of defense response GO:0031347 233 0.019
purine nucleoside monophosphate catabolic process GO:0009128 58 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
regulation of double strand break repair via homologous recombination GO:0010569 2 0.019
negative regulation of protein dephosphorylation GO:0035308 2 0.019
response to oxidative stress GO:0006979 123 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
negative regulation of protein modification process GO:0031400 163 0.019
response to inorganic substance GO:0010035 96 0.019
Mouse
regulation of intracellular transport GO:0032386 159 0.019
mitotic spindle assembly checkpoint GO:0007094 7 0.019
organism emergence from protective structure GO:0071684 4 0.019
negative regulation of protein phosphorylation GO:0001933 126 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
negative regulation of cell cycle phase transition GO:1901988 48 0.018
histone serine phosphorylation GO:0035404 5 0.018
Mouse
response to metal ion GO:0010038 47 0.018
purine nucleoside monophosphate metabolic process GO:0009126 81 0.018
positive regulation of mitotic cell cycle GO:0045931 41 0.018
negative regulation of organelle organization GO:0010639 90 0.018
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.018
muscle tissue development GO:0060537 308 0.017
spindle assembly involved in meiosis GO:0090306 4 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.017
mrna metabolic process GO:0016071 84 0.017
positive regulation of nuclear division GO:0051785 27 0.017
negative regulation of cell cycle process GO:0010948 69 0.017
digestive tract development GO:0048565 190 0.017
oxidation reduction process GO:0055114 342 0.017
Mouse
metaphase plate congression GO:0051310 2 0.017
regulation of establishment of protein localization GO:0070201 181 0.017
ras protein signal transduction GO:0007265 77 0.017
dephosphorylation GO:0016311 129 0.017
negative regulation of nuclear division GO:0051784 19 0.016
spindle assembly involved in female meiosis GO:0007056 3 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
rho protein signal transduction GO:0007266 32 0.016
actomyosin structure organization GO:0031032 56 0.016
atp metabolic process GO:0046034 75 0.016
protein localization to chromosome GO:0034502 6 0.016
regulation of neuron death GO:1901214 134 0.016
positive regulation of transferase activity GO:0051347 167 0.016
positive regulation of cell development GO:0010720 237 0.015
cell maturation GO:0048469 127 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
regulation of protein transport GO:0051223 163 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
regulation of lymphocyte activation GO:0051249 240 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.015
dna replication independent nucleosome assembly GO:0006336 1 0.015
regulation of chromatin modification GO:1903308 57 0.015
regulation of homeostatic process GO:0032844 182 0.015
inflammatory response GO:0006954 244 0.015
spermatogenesis GO:0007283 284 0.015
cellular response to organic cyclic compound GO:0071407 87 0.015
positive regulation of chromosome organization GO:2001252 33 0.015
folic acid containing compound metabolic process GO:0006760 3 0.015
dna conformation change GO:0071103 37 0.015
positive regulation of nervous system development GO:0051962 221 0.015
regulation of inflammatory response GO:0050727 147 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.014
regulation of meiotic cell cycle GO:0051445 34 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
membrane organization GO:0061024 245 0.014
positive regulation of protein catabolic process GO:0045732 60 0.014
response to decreased oxygen levels GO:0036293 59 0.014
citrate metabolic process GO:0006101 3 0.014
regulation of sister chromatid cohesion GO:0007063 5 0.014
carbohydrate homeostasis GO:0033500 128 0.014
Mouse
regulation of secretion GO:0051046 274 0.014
neural tube development GO:0021915 160 0.014
neuron apoptotic process GO:0051402 142 0.014
positive regulation of intracellular transport GO:0032388 70 0.014
negative regulation of protein catabolic process GO:0042177 36 0.014
developmental maturation GO:0021700 193 0.013
cellular response to radiation GO:0071478 28 0.013
mitotic chromosome condensation GO:0007076 1 0.013
asymmetric stem cell division GO:0098722 3 0.013
Worm
nucleotide biosynthetic process GO:0009165 78 0.013
myosin filament assembly GO:0031034 2 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
dna packaging GO:0006323 30 0.013
neuron death GO:0070997 154 0.013
spindle midzone assembly GO:0051255 1 0.013
striated muscle tissue development GO:0014706 293 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
Mouse
spindle organization GO:0007051 28 0.012
centromere complex assembly GO:0034508 3 0.012
positive regulation of mitosis GO:0045840 14 0.012
regulation of secretion by cell GO:1903530 249 0.012
epithelial tube formation GO:0072175 130 0.012
response to ionizing radiation GO:0010212 42 0.012
Mouse
liver development GO:0001889 66 0.012
digestive system development GO:0055123 200 0.012
regulation of neuron differentiation GO:0045664 281 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
cervix development GO:0060067 2 0.012
regulation of neuron projection development GO:0010975 169 0.012
meiotic cytokinesis GO:0033206 5 0.012
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.012
regulation of cell activation GO:0050865 289 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.011
t cell activation GO:0042110 289 0.011
protein localization to chromosome centromeric region GO:0071459 1 0.011
endomembrane system organization GO:0010256 147 0.011
meiotic dna repair synthesis GO:0000711 4 0.011
regulation of t cell activation GO:0050863 170 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.011
regulation of binding GO:0051098 111 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
dna ligation GO:0006266 3 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
positive regulation of cell cycle process GO:0090068 61 0.011
regulation of mapk cascade GO:0043408 248 0.011
regulation of protein targeting GO:1903533 61 0.011
response to growth factor GO:0070848 198 0.011
glucose homeostasis GO:0042593 128 0.011
Mouse
nitrogen compound transport GO:0071705 271 0.011
cytoplasmic transport GO:0016482 234 0.011
anatomical structure homeostasis GO:0060249 145 0.011
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 8 0.011
cellular response to abiotic stimulus GO:0071214 56 0.011
neural tube formation GO:0001841 108 0.011
gastrulation GO:0007369 116 0.011
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.011
fibroblast proliferation GO:0048144 35 0.011
response to reactive oxygen species GO:0000302 56 0.011
Mouse
tube closure GO:0060606 91 0.010
mrna processing GO:0006397 63 0.010
genitalia development GO:0048806 37 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.010
immune effector process GO:0002252 321 0.010
regulation of purine nucleotide metabolic process GO:1900542 169 0.010
rna processing GO:0006396 105 0.010
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.010
meiotic chromosome segregation GO:0045132 19 0.010

Melk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.101
cancer DOID:162 0 0.051
organ system cancer DOID:0050686 0 0.044
thoracic cancer DOID:5093 0 0.033
breast cancer DOID:1612 0 0.026
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.018