Mus musculus

0 known processes

Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

(Aliases: ASM3A,ASML3A,0610010C24Rik,AI529588,ASML3)

Smpdl3a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 44 0.110
immune effector process GO:0002252 321 0.082
amine metabolic process GO:0009308 45 0.074
cellular amino acid metabolic process GO:0006520 103 0.067
cellular ketone metabolic process GO:0042180 84 0.055
protein processing GO:0016485 163 0.055
protein maturation GO:0051604 176 0.051
maintenance of location GO:0051235 89 0.050
oxidation reduction process GO:0055114 342 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.048
cellular lipid metabolic process GO:0044255 323 0.047
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
regulation of apoptotic signaling pathway GO:2001233 197 0.045
aromatic compound catabolic process GO:0019439 286 0.045
apoptotic signaling pathway GO:0097190 306 0.045
regulation of membrane potential GO:0042391 192 0.044
nucleoside phosphate metabolic process GO:0006753 338 0.043
leukocyte mediated immunity GO:0002443 174 0.042
heterocycle catabolic process GO:0046700 280 0.041
cellular lipid catabolic process GO:0044242 52 0.041
cation transport GO:0006812 399 0.040
positive regulation of cell death GO:0010942 224 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
positive regulation of apoptotic process GO:0043065 217 0.039
regulation of defense response GO:0031347 233 0.039
ras protein signal transduction GO:0007265 77 0.039
regulation of secretion GO:0051046 274 0.038
adaptive immune response GO:0002250 155 0.038
regulation of leukocyte mediated immunity GO:0002703 104 0.037
small molecule catabolic process GO:0044282 71 0.036
positive regulation of programmed cell death GO:0043068 218 0.036
nucleotide metabolic process GO:0009117 332 0.036
negative regulation of phosphorus metabolic process GO:0010563 184 0.035
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.035
macromolecule catabolic process GO:0009057 281 0.035
organic hydroxy compound metabolic process GO:1901615 203 0.034
transmembrane transport GO:0055085 412 0.034
defense response to other organism GO:0098542 197 0.034
regulation of cellular ketone metabolic process GO:0010565 66 0.033
mapk cascade GO:0000165 281 0.033
regulation of protein maturation GO:1903317 96 0.033
regulation of protein transport GO:0051223 163 0.033
negative regulation of protein metabolic process GO:0051248 282 0.032
lymphocyte mediated immunity GO:0002449 139 0.032
regulation of cellular catabolic process GO:0031329 242 0.031
negative regulation of phosphate metabolic process GO:0045936 184 0.031
organophosphate biosynthetic process GO:0090407 122 0.031
ribonucleoside metabolic process GO:0009119 245 0.031
small gtpase mediated signal transduction GO:0007264 97 0.030
organonitrogen compound catabolic process GO:1901565 264 0.030
ion transmembrane transport GO:0034220 361 0.030
inflammatory response GO:0006954 244 0.030
t cell activation GO:0042110 289 0.029
regulation of hydrolase activity GO:0051336 246 0.029
regulation of establishment of protein localization GO:0070201 181 0.029
lipid modification GO:0030258 65 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
negative regulation of phosphorylation GO:0042326 166 0.028
negative regulation of intracellular signal transduction GO:1902532 167 0.028
cytoplasmic transport GO:0016482 234 0.028
glycerolipid metabolic process GO:0046486 122 0.028
regulation of transferase activity GO:0051338 263 0.028
protein catabolic process GO:0030163 221 0.028
regulation of secretion by cell GO:1903530 249 0.028
regulation of mapk cascade GO:0043408 248 0.027
organic cyclic compound catabolic process GO:1901361 295 0.027
spermatogenesis GO:0007283 284 0.027
nucleoside metabolic process GO:0009116 246 0.027
cytokine production GO:0001816 319 0.027
regulation of intracellular transport GO:0032386 159 0.027
regulation of lymphocyte mediated immunity GO:0002706 84 0.026
anatomical structure homeostasis GO:0060249 145 0.026
cellular response to hormone stimulus GO:0032870 150 0.025
response to lipopolysaccharide GO:0032496 128 0.025
glycerophospholipid metabolic process GO:0006650 71 0.025
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.025
cellular macromolecule catabolic process GO:0044265 206 0.025
male gamete generation GO:0048232 285 0.025
regulation of protein localization GO:0032880 231 0.025
purine containing compound metabolic process GO:0072521 311 0.024
regulation of inflammatory response GO:0050727 147 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
monocarboxylic acid catabolic process GO:0072329 27 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
response to organonitrogen compound GO:0010243 246 0.024
cellular response to cytokine stimulus GO:0071345 189 0.024
cation transmembrane transport GO:0098655 266 0.023
cellular ion homeostasis GO:0006873 165 0.023
regulation of protein processing GO:0070613 96 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
regulation of organelle organization GO:0033043 289 0.023
organophosphate catabolic process GO:0046434 232 0.023
peptidyl amino acid modification GO:0018193 336 0.023
positive regulation of protein modification process GO:0031401 299 0.023
metal ion homeostasis GO:0055065 189 0.023
regulation of hormone levels GO:0010817 211 0.023
ribonucleoside triphosphate metabolic process GO:0009199 220 0.023
regulation of kinase activity GO:0043549 249 0.023
cellular chemical homeostasis GO:0055082 215 0.022
response to organic cyclic compound GO:0014070 198 0.022
nitrogen compound transport GO:0071705 271 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.022
carbohydrate metabolic process GO:0005975 230 0.022
regulation of cytokine production GO:0001817 266 0.022
negative regulation of molecular function GO:0044092 258 0.022
cellular response to lipid GO:0071396 145 0.022
nucleotide catabolic process GO:0009166 217 0.022
positive regulation of secretion GO:0051047 130 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
regulation of cell cycle GO:0051726 281 0.021
t cell mediated immunity GO:0002456 50 0.021
extrinsic apoptotic signaling pathway GO:0097191 126 0.021
alcohol metabolic process GO:0006066 116 0.021
lipid biosynthetic process GO:0008610 179 0.021
regulation of complement activation classical pathway GO:0030450 1 0.021
positive regulation of protein phosphorylation GO:0001934 242 0.021
regulation of response to wounding GO:1903034 189 0.020
transmission of nerve impulse GO:0019226 76 0.020
striated muscle tissue development GO:0014706 293 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
lymphocyte proliferation GO:0046651 164 0.020
regulation of peptidase activity GO:0052547 96 0.020
positive regulation of protein transport GO:0051222 93 0.020
response to oxidative stress GO:0006979 123 0.020
regulation of proteolysis GO:0030162 164 0.020
negative regulation of cell proliferation GO:0008285 296 0.019
negative regulation of glycoprotein metabolic process GO:1903019 3 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
reactive oxygen species metabolic process GO:0072593 84 0.019
nucleoside catabolic process GO:0009164 206 0.019
protein ubiquitination GO:0016567 171 0.019
divalent metal ion transport GO:0070838 172 0.019
positive regulation of cytokine production GO:0001819 174 0.019
positive regulation of secretion by cell GO:1903532 114 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
negative regulation of protein modification process GO:0031400 163 0.018
cell type specific apoptotic process GO:0097285 268 0.018
intracellular protein transport GO:0006886 204 0.018
sequestering of metal ion GO:0051238 19 0.018
protein localization to organelle GO:0033365 185 0.018
response to molecule of bacterial origin GO:0002237 143 0.018
carboxylic acid catabolic process GO:0046395 51 0.018
muscle tissue development GO:0060537 308 0.018
monocarboxylic acid metabolic process GO:0032787 191 0.018
phospholipid metabolic process GO:0006644 87 0.018
sequestering of calcium ion GO:0051208 18 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
lipid localization GO:0010876 126 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.018
compound eye development GO:0048749 1 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.018
leukocyte differentiation GO:0002521 342 0.018
cellular metal ion homeostasis GO:0006875 151 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
positive regulation of hydrolase activity GO:0051345 148 0.018
ribonucleotide metabolic process GO:0009259 291 0.018
defense response to bacterium GO:0042742 119 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.018
purine nucleoside metabolic process GO:0042278 241 0.018
multicellular organismal signaling GO:0035637 91 0.018
ossification GO:0001503 216 0.018
cell killing GO:0001906 67 0.018
sensory perception GO:0007600 245 0.018
regulation of cell activation GO:0050865 289 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
homeostasis of number of cells GO:0048872 210 0.017
glucose homeostasis GO:0042593 128 0.017
regulation of homeostatic process GO:0032844 182 0.017
cellular homeostasis GO:0019725 240 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
organic acid biosynthetic process GO:0016053 86 0.017
leukocyte mediated cytotoxicity GO:0001909 62 0.017
g protein coupled receptor signaling pathway GO:0007186 243 0.017
cation homeostasis GO:0055080 212 0.017
positive regulation of defense response GO:0031349 124 0.017
nucleoside triphosphate catabolic process GO:0009143 205 0.017
regulation of lymphocyte proliferation GO:0050670 117 0.017
glycerolipid biosynthetic process GO:0045017 50 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
ribonucleotide catabolic process GO:0009261 208 0.017
regulation of t cell activation GO:0050863 170 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
dna metabolic process GO:0006259 303 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
purine containing compound catabolic process GO:0072523 213 0.016
regulation of adaptive immune response GO:0002819 90 0.016
cellular response to organonitrogen compound GO:0071417 145 0.016
regulation of body fluid levels GO:0050878 162 0.016
muscle cell differentiation GO:0042692 261 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.016
membrane organization GO:0061024 245 0.016
innate immune response GO:0045087 157 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
neuronal action potential GO:0019228 54 0.016
t cell proliferation GO:0042098 120 0.016
dephosphorylation GO:0016311 129 0.016
circulatory system process GO:0003013 197 0.016
small molecule biosynthetic process GO:0044283 132 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
leukocyte activation involved in immune response GO:0002366 126 0.015
fat cell differentiation GO:0045444 160 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
humoral immune response GO:0006959 57 0.015
negative regulation of protein processing GO:0010955 79 0.015
rho protein signal transduction GO:0007266 32 0.015
protein modification by small protein conjugation or removal GO:0070647 207 0.015
multi multicellular organism process GO:0044706 109 0.015
developmental maturation GO:0021700 193 0.015
organelle fission GO:0048285 170 0.015
autophagy GO:0006914 45 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
negative regulation of immune system process GO:0002683 209 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
activation of immune response GO:0002253 138 0.015
regulation of binding GO:0051098 111 0.015
regulation of nucleotide catabolic process GO:0030811 122 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
epithelial cell proliferation GO:0050673 174 0.015
regulation of vesicle mediated transport GO:0060627 139 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
tissue homeostasis GO:0001894 115 0.014
regulation of cytoplasmic transport GO:1903649 112 0.014
pyruvate transport GO:0006848 2 0.014
regulation of protein kinase activity GO:0045859 232 0.014
cell activation involved in immune response GO:0002263 126 0.014
glycoprotein metabolic process GO:0009100 116 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
negative regulation of protein maturation GO:1903318 79 0.014
response to growth factor GO:0070848 198 0.014
leukocyte proliferation GO:0070661 172 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
response to inorganic substance GO:0010035 96 0.014
blood circulation GO:0008015 195 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
cellular calcium ion homeostasis GO:0006874 119 0.014
carbohydrate homeostasis GO:0033500 128 0.014
action potential GO:0001508 78 0.014
positive regulation of organelle organization GO:0010638 128 0.014
signal transduction in absence of ligand GO:0038034 55 0.014
fertilization GO:0009566 127 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
peptide metabolic process GO:0006518 46 0.014
regulation of cellular response to stress GO:0080135 159 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
calcium ion transport GO:0006816 159 0.014
cellular response to thyroid hormone stimulus GO:0097067 1 0.014
lipid transport GO:0006869 98 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.013
protein targeting GO:0006605 143 0.013
divalent inorganic cation transport GO:0072511 178 0.013
negative regulation of cell activation GO:0050866 111 0.013
positive regulation of immune effector process GO:0002699 107 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
calcium ion homeostasis GO:0055074 127 0.013
positive regulation of apoptotic signaling pathway GO:2001235 95 0.013
exocytosis GO:0006887 121 0.013
protein import GO:0017038 101 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.013
single fertilization GO:0007338 82 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
meiotic cell cycle GO:0051321 122 0.013
positive regulation of transferase activity GO:0051347 167 0.013
wound healing GO:0042060 157 0.013
cellular protein complex assembly GO:0043623 116 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
peptide transport GO:0015833 133 0.013
phosphatidylethanolamine biosynthetic process GO:0006646 2 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
alpha beta t cell activation GO:0046631 91 0.012
regulation of multi organism process GO:0043900 111 0.012
hormone secretion GO:0046879 128 0.012
phospholipid biosynthetic process GO:0008654 36 0.012
protein secretion GO:0009306 111 0.012
glycerophospholipid biosynthetic process GO:0046474 32 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
cellular biogenic amine metabolic process GO:0006576 28 0.012
response to light stimulus GO:0009416 135 0.012
peptide hormone secretion GO:0030072 109 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
peptide secretion GO:0002790 114 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
establishment of vesicle localization GO:0051650 81 0.012
myelination GO:0042552 74 0.012
regulation of system process GO:0044057 200 0.012
nuclear division GO:0000280 158 0.012
regulation of lipid metabolic process GO:0019216 118 0.011
regulation of ossification GO:0030278 112 0.011
negative regulation of hydrolase activity GO:0051346 71 0.011
hexose metabolic process GO:0019318 98 0.011
endomembrane system organization GO:0010256 147 0.011
microtubule based process GO:0007017 236 0.011
synaptic transmission GO:0007268 329 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
selenium compound metabolic process GO:0001887 3 0.011
response to acid chemical GO:0001101 111 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
regulation of protein catabolic process GO:0042176 108 0.011
positive regulation of nervous system development GO:0051962 221 0.011
gland development GO:0048732 330 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
lipid catabolic process GO:0016042 69 0.011
male courtship behavior GO:0008049 2 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
locomotory behavior GO:0007626 195 0.011
purine ribonucleotide metabolic process GO:0009150 290 0.011
regulation of voltage gated calcium channel activity GO:1901385 4 0.011
ear development GO:0043583 200 0.011
cellular protein catabolic process GO:0044257 155 0.011
regulation of ion transport GO:0043269 215 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
skeletal system development GO:0001501 356 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of neuron projection development GO:0010975 169 0.011
spermatid differentiation GO:0048515 115 0.011
regulation of neuron differentiation GO:0045664 281 0.011
negative regulation of response to wounding GO:1903035 77 0.011
cytokine metabolic process GO:0042107 71 0.011
angiogenesis GO:0001525 201 0.011
response to radiation GO:0009314 165 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
ensheathment of neurons GO:0007272 76 0.011
respiratory tube development GO:0030323 167 0.011
blood coagulation GO:0007596 76 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
response to steroid hormone GO:0048545 56 0.011
muscle contraction GO:0006936 101 0.011
mitotic cell cycle process GO:1903047 159 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
fatty acid alpha oxidation GO:0001561 2 0.011
skin development GO:0043588 220 0.011
amide transport GO:0042886 138 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
zymogen activation GO:0031638 41 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
regulation of interleukin 8 secretion GO:2000482 2 0.011
organelle localization GO:0051640 179 0.011
regulation of leukocyte proliferation GO:0070663 121 0.011
response to drug GO:0042493 75 0.010
positive regulation of cell motility GO:2000147 116 0.010
negative regulation of complement activation GO:0045916 3 0.010
establishment of protein localization to organelle GO:0072594 118 0.010
tissue remodeling GO:0048771 102 0.010
coagulation GO:0050817 78 0.010
renal system development GO:0072001 225 0.010
lateral inhibition GO:0046331 1 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.010
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
negative regulation of immune effector process GO:0002698 55 0.010
monosaccharide metabolic process GO:0005996 106 0.010
microtubule cytoskeleton organization GO:0000226 157 0.010
organic hydroxy compound transport GO:0015850 93 0.010
urogenital system development GO:0001655 261 0.010
membrane lipid metabolic process GO:0006643 53 0.010
single organism nuclear import GO:1902593 95 0.010
myeloid cell differentiation GO:0030099 233 0.010
regulation of t cell proliferation GO:0042129 92 0.010
extracellular structure organization GO:0043062 148 0.010
regulation of interleukin 1 alpha production GO:0032650 4 0.010
germ cell development GO:0007281 185 0.010
regulation of nucleoside metabolic process GO:0009118 130 0.010
regulation of endopeptidase activity GO:0052548 89 0.010

Smpdl3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.101
inherited metabolic disorder DOID:655 0 0.069
disease of anatomical entity DOID:7 0 0.044
nervous system disease DOID:863 0 0.044
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.020
eye disease DOID:5614 0 0.020
central nervous system disease DOID:331 0 0.016
retinal disease DOID:5679 0 0.016
retinal degeneration DOID:8466 0 0.016
acquired metabolic disease DOID:0060158 0 0.012
brain disease DOID:936 0 0.011
lysosomal storage disease DOID:3211 0 0.010
neurodegenerative disease DOID:1289 0 0.010