Mus musculus

0 known processes

Klhl30

kelch-like 30 (Drosophila)

(Aliases: MGC143856,4631423F02Rik)

Klhl30 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 20 0.080
cellular amino acid metabolic process GO:0006520 103 0.072
muscle tissue development GO:0060537 308 0.071
cellular amine metabolic process GO:0044106 44 0.069
amine metabolic process GO:0009308 45 0.059
actin cytoskeleton organization GO:0030036 220 0.056
striated muscle tissue development GO:0014706 293 0.055
cellular ketone metabolic process GO:0042180 84 0.054
regulation of cellular ketone metabolic process GO:0010565 66 0.054
muscle cell development GO:0055001 133 0.052
regulation of cellular amino acid metabolic process GO:0006521 5 0.051
regulation of system process GO:0044057 200 0.050
cation transport GO:0006812 399 0.047
nucleobase containing small molecule metabolic process GO:0055086 352 0.045
cellular macromolecule catabolic process GO:0044265 206 0.043
purine nucleotide metabolic process GO:0006163 302 0.042
muscle cell differentiation GO:0042692 261 0.040
transmembrane transport GO:0055085 412 0.040
cellular protein catabolic process GO:0044257 155 0.039
protein modification by small protein conjugation or removal GO:0070647 207 0.039
purine containing compound metabolic process GO:0072521 311 0.039
heterocycle catabolic process GO:0046700 280 0.039
macromolecule catabolic process GO:0009057 281 0.037
blood circulation GO:0008015 195 0.037
cation transmembrane transport GO:0098655 266 0.036
organelle assembly GO:0070925 177 0.036
skeletal system development GO:0001501 356 0.036
muscle system process GO:0003012 141 0.036
cytoplasmic transport GO:0016482 234 0.035
skeletal muscle organ development GO:0060538 163 0.035
aromatic compound catabolic process GO:0019439 286 0.034
ribonucleotide metabolic process GO:0009259 291 0.034
protein modification by small protein conjugation GO:0032446 187 0.034
cell adhesion GO:0007155 329 0.034
ribose phosphate metabolic process GO:0019693 291 0.033
negative regulation of intracellular signal transduction GO:1902532 167 0.033
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.032
sequestering of calcium ion GO:0051208 18 0.032
protein ubiquitination GO:0016567 171 0.032
oxidation reduction process GO:0055114 342 0.031
striated muscle cell development GO:0055002 125 0.031
ribonucleoside metabolic process GO:0009119 245 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
protein catabolic process GO:0030163 221 0.031
ion transmembrane transport GO:0034220 361 0.030
regulation of cellular catabolic process GO:0031329 242 0.030
peptidyl amino acid modification GO:0018193 336 0.029
nucleoside phosphate metabolic process GO:0006753 338 0.029
homeostasis of number of cells GO:0048872 210 0.029
Mouse
apoptotic signaling pathway GO:0097190 306 0.029
Mouse
positive regulation of nervous system development GO:0051962 221 0.029
carbohydrate metabolic process GO:0005975 230 0.029
regulation of organelle organization GO:0033043 289 0.028
purine nucleoside metabolic process GO:0042278 241 0.028
cell type specific apoptotic process GO:0097285 268 0.028
muscle contraction GO:0006936 101 0.028
modification dependent macromolecule catabolic process GO:0043632 133 0.028
rho protein signal transduction GO:0007266 32 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.028
purine ribonucleoside metabolic process GO:0046128 241 0.027
circulatory system process GO:0003013 197 0.027
anatomical structure homeostasis GO:0060249 145 0.027
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.027
response to organonitrogen compound GO:0010243 246 0.027
nitrogen compound transport GO:0071705 271 0.027
cellular nitrogen compound catabolic process GO:0044270 280 0.026
regulation of hydrolase activity GO:0051336 246 0.026
nucleotide metabolic process GO:0009117 332 0.026
organonitrogen compound biosynthetic process GO:1901566 192 0.026
purine ribonucleotide metabolic process GO:0009150 290 0.026
angiogenesis GO:0001525 201 0.026
ras protein signal transduction GO:0007265 77 0.026
organonitrogen compound catabolic process GO:1901565 264 0.025
nucleoside metabolic process GO:0009116 246 0.025
nucleoside triphosphate metabolic process GO:0009141 230 0.025
epithelial tube morphogenesis GO:0060562 303 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
cation homeostasis GO:0055080 212 0.024
blood vessel morphogenesis GO:0048514 285 0.024
cytokine production GO:0001816 319 0.024
organophosphate catabolic process GO:0046434 232 0.024
cardiac muscle tissue development GO:0048738 130 0.024
positive regulation of protein modification process GO:0031401 299 0.024
regulation of hormone levels GO:0010817 211 0.024
cardiac chamber development GO:0003205 108 0.024
organic hydroxy compound metabolic process GO:1901615 203 0.024
glycosyl compound metabolic process GO:1901657 246 0.023
modification dependent protein catabolic process GO:0019941 133 0.023
myotube differentiation GO:0014902 105 0.023
cellular chemical homeostasis GO:0055082 215 0.023
cellular component assembly involved in morphogenesis GO:0010927 139 0.023
purine nucleoside triphosphate metabolic process GO:0009144 226 0.023
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.023
regulation of purine nucleotide metabolic process GO:1900542 169 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.023
negative regulation of cellular amine metabolic process GO:0033239 1 0.023
sensory perception GO:0007600 245 0.023
cellular homeostasis GO:0019725 240 0.022
spermatogenesis GO:0007283 284 0.022
Mouse
regulation of anatomical structure size GO:0090066 178 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
positive regulation of cell development GO:0010720 237 0.022
heart morphogenesis GO:0003007 178 0.022
regulation of cell motility GO:2000145 236 0.022
regulation of nucleotide metabolic process GO:0006140 169 0.022
regulation of interleukin 8 production GO:0032677 3 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
regulation of cell cycle GO:0051726 281 0.022
purine containing compound catabolic process GO:0072523 213 0.022
extracellular structure organization GO:0043062 148 0.021
ubiquitin dependent protein catabolic process GO:0006511 129 0.021
ribonucleotide catabolic process GO:0009261 208 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
regulation of proteolysis GO:0030162 164 0.021
nucleoside phosphate catabolic process GO:1901292 222 0.021
renal system development GO:0072001 225 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.021
myosin filament organization GO:0031033 3 0.021
gland development GO:0048732 330 0.021
heart process GO:0003015 94 0.021
myosin filament assembly GO:0031034 2 0.020
immune effector process GO:0002252 321 0.020
cell substrate adhesion GO:0031589 130 0.020
purine nucleotide catabolic process GO:0006195 211 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
sensory organ morphogenesis GO:0090596 242 0.020
synaptic transmission GO:0007268 329 0.020
carbohydrate derivative biosynthetic process GO:1901137 183 0.020
sequestering of metal ion GO:0051238 19 0.020
nucleoside catabolic process GO:0009164 206 0.020
organelle fission GO:0048285 170 0.019
myeloid cell differentiation GO:0030099 233 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
cardiac ventricle development GO:0003231 83 0.019
regulation of intracellular transport GO:0032386 159 0.019
urogenital system development GO:0001655 261 0.019
cellular protein complex assembly GO:0043623 116 0.019
forebrain development GO:0030900 302 0.019
negative regulation of molecular function GO:0044092 258 0.019
purine ribonucleoside catabolic process GO:0046130 205 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.019
regulation of response to wounding GO:1903034 189 0.019
regulation of secretion GO:0051046 274 0.019
skeletal myofibril assembly GO:0014866 4 0.019
positive regulation of programmed cell death GO:0043068 218 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
regulation of cell adhesion GO:0030155 154 0.018
cellular lipid metabolic process GO:0044255 323 0.018
regulation of cellular component biogenesis GO:0044087 181 0.018
positive regulation of nucleotide metabolic process GO:0045981 114 0.018
camera type eye development GO:0043010 266 0.018
regulation of defense response GO:0031347 233 0.018
regulation of homeostatic process GO:0032844 182 0.018
inorganic cation transmembrane transport GO:0098662 207 0.018
connective tissue development GO:0061448 179 0.018
maintenance of location GO:0051235 89 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
striated muscle myosin thick filament assembly GO:0071688 1 0.018
cellular ion homeostasis GO:0006873 165 0.018
bone development GO:0060348 120 0.018
regulation of cytokine production GO:0001817 266 0.018
positive regulation of cell adhesion GO:0045785 80 0.018
extracellular matrix organization GO:0030198 147 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
action potential GO:0001508 78 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
purine nucleoside catabolic process GO:0006152 205 0.018
nucleoside triphosphate catabolic process GO:0009143 205 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
regulation of ion transport GO:0043269 215 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
small molecule biosynthetic process GO:0044283 132 0.017
heart contraction GO:0060047 93 0.017
divalent metal ion transport GO:0070838 172 0.017
actin mediated cell contraction GO:0070252 15 0.017
metal ion homeostasis GO:0055065 189 0.017
male gamete generation GO:0048232 285 0.017
Mouse
regulation of neuron differentiation GO:0045664 281 0.017
inflammatory response GO:0006954 244 0.017
lipid biosynthetic process GO:0008610 179 0.017
response to organic cyclic compound GO:0014070 198 0.017
glycosyl compound catabolic process GO:1901658 206 0.016
respiratory system development GO:0060541 190 0.016
striated muscle contraction GO:0006941 45 0.016
response to oxidative stress GO:0006979 123 0.016
mitochondrion organization GO:0007005 134 0.016
regulation of membrane potential GO:0042391 192 0.016
positive regulation of cell death GO:0010942 224 0.016
mitotic cell cycle GO:0000278 195 0.016
negative regulation of immune system process GO:0002683 209 0.016
regulation of muscle system process GO:0090257 80 0.016
divalent inorganic cation transport GO:0072511 178 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
locomotory behavior GO:0007626 195 0.016
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.016
placenta development GO:0001890 140 0.016
response to inorganic substance GO:0010035 96 0.016
regulation of cell migration GO:0030334 219 0.016
regulation of cell projection organization GO:0031344 206 0.016
carbohydrate homeostasis GO:0033500 128 0.016
regulation of feeding behavior GO:0060259 3 0.016
response to growth factor GO:0070848 198 0.016
central nervous system neuron differentiation GO:0021953 162 0.016
skeletal system morphogenesis GO:0048705 203 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
generation of precursor metabolites and energy GO:0006091 103 0.015
neural tube development GO:0021915 160 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
interleukin 8 production GO:0032637 4 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
embryonic organ morphogenesis GO:0048562 276 0.015
membrane organization GO:0061024 245 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
Mouse
fertilization GO:0009566 127 0.015
Mouse
dephosphorylation GO:0016311 129 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
negative regulation of apoptotic signaling pathway GO:2001234 104 0.015
Mouse
muscle tissue morphogenesis GO:0060415 53 0.015
proteasomal protein catabolic process GO:0010498 98 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.015
regulation of purine nucleotide catabolic process GO:0033121 122 0.015
cardiac muscle cell development GO:0055013 39 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
regulation of multi organism process GO:0043900 111 0.015
mesoderm development GO:0007498 100 0.015
skin development GO:0043588 220 0.015
ossification GO:0001503 216 0.015
amide transport GO:0042886 138 0.015
adult behavior GO:0030534 135 0.015
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.015
alcohol metabolic process GO:0006066 116 0.015
nuclear division GO:0000280 158 0.014
stem cell differentiation GO:0048863 268 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
skeletal muscle cell differentiation GO:0035914 66 0.014
cardiac chamber morphogenesis GO:0003206 93 0.014
respiratory tube development GO:0030323 167 0.014
actin filament organization GO:0007015 113 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
organic anion transport GO:0015711 137 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
tissue homeostasis GO:0001894 115 0.014
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.014
mapk cascade GO:0000165 281 0.014
cell fate commitment GO:0045165 210 0.014
organelle localization GO:0051640 179 0.014
leukocyte differentiation GO:0002521 342 0.014
regulation of protein localization GO:0032880 231 0.014
negative regulation of organelle organization GO:0010639 90 0.014
tube formation GO:0035148 140 0.014
protein maturation GO:0051604 176 0.014
calcium ion transport GO:0006816 159 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
endomembrane system organization GO:0010256 147 0.013
regulation of secretion by cell GO:1903530 249 0.013
nucleotide catabolic process GO:0009166 217 0.013
epidermis development GO:0008544 187 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
Mouse
developmental maturation GO:0021700 193 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
protein localization to organelle GO:0033365 185 0.013
fat cell differentiation GO:0045444 160 0.013
regulation of cell substrate adhesion GO:0010810 73 0.013
stem cell development GO:0048864 219 0.013
anion transport GO:0006820 177 0.013
monocarboxylic acid metabolic process GO:0032787 191 0.013
energy derivation by oxidation of organic compounds GO:0015980 77 0.013
neuron apoptotic process GO:0051402 142 0.013
cardiocyte differentiation GO:0035051 87 0.013
engulfment of apoptotic cell GO:0043652 3 0.013
glucose homeostasis GO:0042593 128 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of kinase activity GO:0043549 249 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
positive regulation of cellular catabolic process GO:0031331 148 0.013
regulation of ion homeostasis GO:2000021 64 0.013
regulation of actin filament based process GO:0032970 99 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.013
branching morphogenesis of an epithelial tube GO:0048754 159 0.012
innate immune response GO:0045087 157 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
t cell activation GO:0042110 289 0.012
tissue remodeling GO:0048771 102 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
mitotic cell cycle process GO:1903047 159 0.012
steroid metabolic process GO:0008202 119 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of cellular response to stress GO:0080135 159 0.012
regulation of protein catabolic process GO:0042176 108 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
regulation of neuron projection development GO:0010975 169 0.012
multicellular organism growth GO:0035264 161 0.012
lipid localization GO:0010876 126 0.012
response to radiation GO:0009314 165 0.012
protein processing GO:0016485 163 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
regionalization GO:0003002 337 0.012
neuromuscular process GO:0050905 99 0.012
kidney development GO:0001822 213 0.012
neuron death GO:0070997 154 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
chemotaxis GO:0006935 247 0.012
regulation of myotube differentiation GO:0010830 62 0.012
regulation of cell activation GO:0050865 289 0.012
cytosolic calcium ion transport GO:0060401 48 0.012
lung development GO:0030324 164 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
ear development GO:0043583 200 0.012
regulation of organ morphogenesis GO:2000027 144 0.012
actin polymerization or depolymerization GO:0008154 54 0.012
hormone secretion GO:0046879 128 0.012
hexose metabolic process GO:0019318 98 0.012
somite development GO:0061053 81 0.012
neural precursor cell proliferation GO:0061351 121 0.012
pharynx development GO:0060465 1 0.012
microtubule based process GO:0007017 236 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.011
single organism cell adhesion GO:0098602 156 0.011
regulation of blood pressure GO:0008217 93 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
glycoprotein metabolic process GO:0009100 116 0.011
cardiac muscle cell differentiation GO:0055007 69 0.011
sarcomere organization GO:0045214 24 0.011
ventricular cardiac muscle cell action potential GO:0086005 4 0.011
lymphocyte differentiation GO:0030098 242 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
organic hydroxy compound transport GO:0015850 93 0.011
calcium ion homeostasis GO:0055074 127 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
neural tube closure GO:0001843 90 0.011
cytosolic calcium ion homeostasis GO:0051480 70 0.011
mature dendritic cell differentiation GO:0097029 3 0.011
transmission of nerve impulse GO:0019226 76 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
development of primary sexual characteristics GO:0045137 143 0.011
Mouse
adult locomotory behavior GO:0008344 91 0.011
Mouse
leukocyte migration GO:0050900 124 0.011
rna interference GO:0016246 2 0.011
regulation of heart contraction GO:0008016 77 0.011
peptide transport GO:0015833 133 0.011
mitochondrion distribution GO:0048311 4 0.011
bmp signaling pathway GO:0030509 93 0.011
ear morphogenesis GO:0042471 118 0.011
positive regulation of proteolysis GO:0045862 85 0.011
carboxylic acid transport GO:0046942 100 0.011
multicellular organismal signaling GO:0035637 91 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
regulation of binding GO:0051098 111 0.011
digestive tract development GO:0048565 190 0.011
regulation of mapk cascade GO:0043408 248 0.011
regulation of inflammatory response GO:0050727 147 0.011
nephron development GO:0072006 109 0.011
actomyosin structure organization GO:0031032 56 0.011
renal tubule morphogenesis GO:0061333 72 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
intracellular receptor signaling pathway GO:0030522 74 0.011
regulation of vasculature development GO:1901342 88 0.011
epithelial cell proliferation GO:0050673 174 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
stem cell proliferation GO:0072089 117 0.011
cell growth GO:0016049 130 0.011
regulation of angiogenesis GO:0045765 81 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
dna metabolic process GO:0006259 303 0.011
glycerolipid metabolic process GO:0046486 122 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
axonogenesis GO:0007409 274 0.011
response to lipopolysaccharide GO:0032496 128 0.011
meiotic nuclear division GO:0007126 115 0.011
endocytosis GO:0006897 168 0.011
regulation of muscle contraction GO:0006937 49 0.011
multi multicellular organism process GO:0044706 109 0.011
epithelial cell development GO:0002064 159 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
positive regulation of interleukin 8 production GO:0032757 2 0.010
wound healing GO:0042060 157 0.010
cell division GO:0051301 120 0.010
rna processing GO:0006396 105 0.010
intracellular protein transport GO:0006886 204 0.010
cell maturation GO:0048469 127 0.010
positive regulation of vasoconstriction GO:0045907 4 0.010
regulation of transferase activity GO:0051338 263 0.010
cellular response to biotic stimulus GO:0071216 92 0.010
myeloid cell homeostasis GO:0002262 114 0.010
regulation of neurotransmitter levels GO:0001505 87 0.010
limb development GO:0060173 166 0.010
response to acid chemical GO:0001101 111 0.010
somitogenesis GO:0001756 69 0.010
hindbrain development GO:0030902 128 0.010
Mouse
single fertilization GO:0007338 82 0.010
actin filament based movement GO:0030048 23 0.010
monosaccharide metabolic process GO:0005996 106 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
atp metabolic process GO:0046034 75 0.010
organic hydroxy compound biosynthetic process GO:1901617 77 0.010
fatty acid metabolic process GO:0006631 121 0.010
organic acid transport GO:0015849 101 0.010
defense response to other organism GO:0098542 197 0.010
telencephalon development GO:0021537 186 0.010
learning or memory GO:0007611 148 0.010
leukocyte mediated immunity GO:0002443 174 0.010
adaptive immune response GO:0002250 155 0.010
embryonic limb morphogenesis GO:0030326 126 0.010
regulation of cellular component size GO:0032535 121 0.010
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.010

Klhl30 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
muscle tissue disease DOID:66 0 0.080
musculoskeletal system disease DOID:17 0 0.080
disease of anatomical entity DOID:7 0 0.080
muscular disease DOID:0080000 0 0.080
myopathy DOID:423 0 0.062
cardiomyopathy DOID:0050700 0 0.038
heart disease DOID:114 0 0.038
cardiovascular system disease DOID:1287 0 0.038
nervous system disease DOID:863 0 0.033
eye and adnexa disease DOID:1492 0 0.020
sensory system disease DOID:0050155 0 0.020
disease of metabolism DOID:0014667 0 0.019
intrinsic cardiomyopathy DOID:0060036 0 0.019
eye disease DOID:5614 0 0.016
retinal disease DOID:5679 0 0.011
central nervous system disease DOID:331 0 0.010