Mus musculus

123 known processes

Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

(Aliases: PAI1,PAI-1,Planh1)

Serpine1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of protein modification process GO:0031401 299 0.690
leukocyte differentiation GO:0002521 342 0.547
reactive oxygen species metabolic process GO:0072593 84 0.520
cell adhesion GO:0007155 329 0.507
Human Mouse
regulation of mapk cascade GO:0043408 248 0.452
intussusceptive angiogenesis GO:0002041 2 0.445
regulation of transferase activity GO:0051338 263 0.429
cellular response to growth factor stimulus GO:0071363 197 0.429
regulation of peptidase activity GO:0052547 96 0.407
single organismal cell cell adhesion GO:0016337 131 0.380
Mouse
wound healing GO:0042060 157 0.374
positive regulation of mapk cascade GO:0043410 170 0.359
positive regulation of neutrophil mediated killing of symbiont cell GO:0070961 1 0.349
striated muscle tissue development GO:0014706 293 0.333
positive regulation of sphingolipid biosynthetic process GO:0090154 1 0.318
response to growth factor GO:0070848 198 0.303
placenta development GO:0001890 140 0.301
Rat
skeletal muscle organ development GO:0060538 163 0.301
regulation of apoptotic signaling pathway GO:2001233 197 0.297
Human
regulation of reactive oxygen species metabolic process GO:2000377 40 0.292
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.283
connective tissue development GO:0061448 179 0.279
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.268
positive regulation of cell death GO:0010942 224 0.263
regulation of kinase activity GO:0043549 249 0.258
single organism cell adhesion GO:0098602 156 0.255
Mouse
positive regulation of programmed cell death GO:0043068 218 0.250
response to radiation GO:0009314 165 0.247
apoptotic signaling pathway GO:0097190 306 0.243
Human
positive regulation of cell adhesion GO:0045785 80 0.242
regulation of response to wounding GO:1903034 189 0.230
rhombomere 5 development GO:0021571 4 0.222
extracellular matrix organization GO:0030198 147 0.222
positive regulation of proteolysis GO:0045862 85 0.221
sphingolipid biosynthetic process GO:0030148 26 0.220
positive regulation of cytokine production GO:0001819 174 0.219
Human
protein maturation GO:0051604 176 0.219
regulation of cell motility GO:2000145 236 0.218
Human Rat
positive regulation of leukocyte differentiation GO:1902107 86 0.213
blood vessel morphogenesis GO:0048514 285 0.210
skeletal system development GO:0001501 356 0.209
regulation of cellular response to stress GO:0080135 159 0.207
response to fibroblast growth factor GO:0071774 47 0.203
Rat
gland development GO:0048732 330 0.201
Mouse
sphingolipid metabolic process GO:0006665 45 0.200
regulation of sphingolipid biosynthetic process GO:0090153 1 0.197
positive regulation of apoptotic process GO:0043065 217 0.197
regulation of protein serine threonine kinase activity GO:0071900 157 0.183
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.183
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.179
negative regulation of protein metabolic process GO:0051248 282 0.179
regulation of ceramide biosynthetic process GO:2000303 1 0.178
muscle tissue development GO:0060537 308 0.175
t cell activation GO:0042110 289 0.173
cell chemotaxis GO:0060326 81 0.169
Human
regulation of angiogenesis GO:0045765 81 0.167
regulation of rhodopsin gene expression GO:0007468 3 0.163
regulation of map kinase activity GO:0043405 120 0.162
regulation of endopeptidase activity GO:0052548 89 0.158
regulation of hydrolase activity GO:0051336 246 0.155
mapk cascade GO:0000165 281 0.152
neutrophil mediated killing of gram negative bacterium GO:0070945 4 0.152
response to transforming growth factor beta GO:0071559 88 0.151
nucleobase containing small molecule metabolic process GO:0055086 352 0.149
regulation of protein transport GO:0051223 163 0.147
lung development GO:0030324 164 0.146
regulation of cellular catabolic process GO:0031329 242 0.144
cartilage development GO:0051216 140 0.142
extracellular structure organization GO:0043062 148 0.140
carbohydrate metabolic process GO:0005975 230 0.139
axonogenesis GO:0007409 274 0.139
regulation of cell adhesion GO:0030155 154 0.138
Human Mouse
inflammatory response GO:0006954 244 0.138
Human
muscle cell development GO:0055001 133 0.136
nucleoside phosphate metabolic process GO:0006753 338 0.136
wound healing involved in inflammatory response GO:0002246 4 0.136
regulation of thymocyte migration GO:2000410 2 0.135
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.134
regulation of nucleotide metabolic process GO:0006140 169 0.133
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.131
regulation of cell cycle GO:0051726 281 0.130
regulation of proteolysis GO:0030162 164 0.128
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.127
thymocyte migration GO:0072679 2 0.127
cellular amine metabolic process GO:0044106 44 0.126
camera type eye development GO:0043010 266 0.124
cellular amino acid metabolic process GO:0006520 103 0.124
positive regulation of hematopoietic stem cell proliferation GO:1902035 2 0.123
regulation of cytokine production GO:0001817 266 0.120
Human
response to inorganic substance GO:0010035 96 0.118
Rat
negative regulation of intracellular signal transduction GO:1902532 167 0.118
Mouse
membrane lipid biosynthetic process GO:0046467 32 0.117
respiratory tube development GO:0030323 167 0.116
cell substrate adhesion GO:0031589 130 0.116
Human
response to organic cyclic compound GO:0014070 198 0.115
Rat
muscle cell differentiation GO:0042692 261 0.114
regulation of organelle organization GO:0033043 289 0.112
basement membrane organization GO:0071711 8 0.111
multicellular organismal homeostasis GO:0048871 164 0.111
myeloid cell differentiation GO:0030099 233 0.110
positive regulation of phospholipase activity GO:0010518 3 0.108
fat cell differentiation GO:0045444 160 0.107
chemotaxis GO:0006935 247 0.107
Human
inflammatory response to wounding GO:0090594 4 0.107
intrinsic apoptotic signaling pathway GO:0097193 132 0.106
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.106
positive regulation of protein kinase activity GO:0045860 144 0.106
cytokine production GO:0001816 319 0.105
Human
embryonic placenta development GO:0001892 98 0.104
regulation of defense response GO:0031347 233 0.102
Human
regulation of fat cell differentiation GO:0045598 81 0.102
positive regulation of b cell chemotaxis GO:2000538 2 0.101
negative regulation of molecular function GO:0044092 258 0.100
lens development in camera type eye GO:0002088 62 0.100
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.098
response to ionizing radiation GO:0010212 42 0.097
brain segmentation GO:0035284 3 0.097
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.097
cation homeostasis GO:0055080 212 0.097
regulation of cell growth GO:0001558 91 0.097
Mouse
chondroblast differentiation GO:0060591 2 0.096
regulation of system process GO:0044057 200 0.095
skeletal system morphogenesis GO:0048705 203 0.093
regulation of neuron death GO:1901214 134 0.092
regulation of cellular amino acid metabolic process GO:0006521 5 0.092
cell growth GO:0016049 130 0.092
Mouse
synaptic transmission GO:0007268 329 0.091
Mouse
cellular response to extracellular stimulus GO:0031668 81 0.090
regulation of chondrocyte differentiation GO:0032330 33 0.090
regulation of leukocyte differentiation GO:1902105 159 0.090
positive regulation of rhodopsin gene expression GO:0045872 2 0.089
negative regulation of cellular protein metabolic process GO:0032269 247 0.088
carbohydrate derivative biosynthetic process GO:1901137 183 0.088
positive regulation of peptidase activity GO:0010952 49 0.088
respiratory system development GO:0060541 190 0.087
positive regulation of protein phosphorylation GO:0001934 242 0.085
cation transport GO:0006812 399 0.085
Mouse Rat
regulation of homeostatic process GO:0032844 182 0.085
placenta blood vessel development GO:0060674 31 0.084
covalent chromatin modification GO:0016569 163 0.084
negative regulation of phosphorus metabolic process GO:0010563 184 0.082
positive regulation of endopeptidase activity GO:0010950 43 0.082
myeloid leukocyte differentiation GO:0002573 119 0.081
negative regulation of protein phosphorylation GO:0001933 126 0.081
regulation of cell migration GO:0030334 219 0.080
Human Rat
cell type specific apoptotic process GO:0097285 268 0.080
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.080
cellular response to inorganic substance GO:0071241 37 0.079
Rat
translation GO:0006412 93 0.079
response to decreased oxygen levels GO:0036293 59 0.079
Rat
regulation of cell substrate adhesion GO:0010810 73 0.079
Human
muscle system process GO:0003012 141 0.077
cell recognition GO:0008037 83 0.076
cellular response to oxidative stress GO:0034599 76 0.075
Rat
regulation of cyclin dependent protein serine threonine kinase activity involved in g2 m transition of mitotic cell cycle GO:0031660 1 0.075
regulation of secretion by cell GO:1903530 249 0.075
stem cell differentiation GO:0048863 268 0.074
positive regulation of cell development GO:0010720 237 0.074
urogenital system development GO:0001655 261 0.073
glycoprotein biosynthetic process GO:0009101 89 0.073
regulation of cartilage development GO:0061035 44 0.073
epithelial cell proliferation GO:0050673 174 0.072
positive regulation of kinase activity GO:0033674 155 0.072
positive regulation of eosinophil migration GO:2000418 2 0.071
positive regulation of hydrolase activity GO:0051345 148 0.071
purine nucleotide metabolic process GO:0006163 302 0.071
positive regulation of epithelial cell proliferation GO:0050679 68 0.070
response to organonitrogen compound GO:0010243 246 0.070
Rat
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.070
Rat
glycoprotein metabolic process GO:0009100 116 0.070
anion transport GO:0006820 177 0.070
purine containing compound metabolic process GO:0072521 311 0.069
response to steroid hormone GO:0048545 56 0.069
Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.069
macromolecule deacylation GO:0098732 37 0.068
keratinocyte migration GO:0051546 3 0.067
Rat
regulation of neuron projection development GO:0010975 169 0.067
regulation of cell activation GO:0050865 289 0.067
Mouse
nucleotide metabolic process GO:0009117 332 0.067
regulation of neutrophil mediated killing of fungus GO:0070953 1 0.067
regulation of neuron apoptotic process GO:0043523 122 0.066
positive regulation of stem cell proliferation GO:2000648 59 0.066
t cell differentiation GO:0030217 174 0.066
ossification GO:0001503 216 0.065
anatomical structure homeostasis GO:0060249 145 0.065
regulation of bmp signaling pathway GO:0030510 60 0.065
negative regulation of fat cell differentiation GO:0045599 36 0.065
striated muscle cell development GO:0055002 125 0.065
regulation of erk1 and erk2 cascade GO:0070372 71 0.064
regulation of histone deacetylation GO:0031063 12 0.064
regulation of eosinophil migration GO:2000416 2 0.064
erk1 and erk2 cascade GO:0070371 77 0.063
extrinsic apoptotic signaling pathway GO:0097191 126 0.063
Human
cellular ketone metabolic process GO:0042180 84 0.063
labyrinthine layer morphogenesis GO:0060713 21 0.063
regulation of protein kinase activity GO:0045859 232 0.063
regulation of neuron differentiation GO:0045664 281 0.062
eye photoreceptor cell development GO:0042462 31 0.062
response to light stimulus GO:0009416 135 0.061
positive regulation of lipid biosynthetic process GO:0046889 18 0.061
regulation of secretion GO:0051046 274 0.061
chromatin organization GO:0006325 206 0.061
eosinophil migration GO:0072677 3 0.061
response to peptide GO:1901652 136 0.060
Rat
immune effector process GO:0002252 321 0.060
purine ribonucleotide metabolic process GO:0009150 290 0.060
negative regulation of response to wounding GO:1903035 77 0.060
metal ion homeostasis GO:0055065 189 0.060
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.060
labyrinthine layer development GO:0060711 49 0.059
branching morphogenesis of an epithelial tube GO:0048754 159 0.059
negative regulation of neuron apoptotic process GO:0043524 92 0.059
mitotic cell cycle process GO:1903047 159 0.058
lipid biosynthetic process GO:0008610 179 0.058
regulation of stem cell proliferation GO:0072091 78 0.058
divalent metal ion transport GO:0070838 172 0.057
Rat
response to metal ion GO:0010038 47 0.057
Rat
myotube differentiation GO:0014902 105 0.057
regulation of neutrophil mediated cytotoxicity GO:0070948 2 0.057
chromatin modification GO:0016568 187 0.056
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.055
morphogenesis of a branching structure GO:0001763 203 0.055
regulation of establishment of protein localization GO:0070201 181 0.055
ribonucleotide metabolic process GO:0009259 291 0.055
regulation of neutrophil mediated killing of bacterium GO:0070950 1 0.054
i kappab kinase nf kappab signaling GO:0007249 85 0.054
mitotic cell cycle GO:0000278 195 0.054
regulation of lipase activity GO:0060191 15 0.054
circulatory system process GO:0003013 197 0.054
positive regulation of cell migration GO:0030335 109 0.054
Human Rat
neutrophil chemotaxis GO:0030593 36 0.054
peptidyl amino acid modification GO:0018193 336 0.053
response to molecule of bacterial origin GO:0002237 143 0.053
Human Rat
cellular metal ion homeostasis GO:0006875 151 0.053
axon regeneration GO:0031103 12 0.053
negative regulation of protein maturation GO:1903318 79 0.053
regulation of histone modification GO:0031056 56 0.052
response to oxidative stress GO:0006979 123 0.052
Rat
adult behavior GO:0030534 135 0.052
positive regulation of angiogenesis GO:0045766 46 0.052
cellular response to metal ion GO:0071248 31 0.051
Rat
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.051
smooth muscle contraction GO:0006939 44 0.051
calcium ion homeostasis GO:0055074 127 0.051
regulation of chromosome organization GO:0033044 83 0.051
skin development GO:0043588 220 0.051
regulation of cell projection organization GO:0031344 206 0.050
ceramide biosynthetic process GO:0046513 20 0.050
response to calcium ion GO:0051592 20 0.049
elastic fiber assembly GO:0048251 4 0.049
regulation of myotube differentiation GO:0010830 62 0.049
response to peptide hormone GO:0043434 127 0.049
Rat
regulation of inflammatory response GO:0050727 147 0.049
Human
morphogenesis of a branching epithelium GO:0061138 193 0.049
granulocyte migration GO:0097530 43 0.049
chondrocyte differentiation GO:0002062 72 0.048
regulation of protein localization GO:0032880 231 0.048
positive regulation of lymphocyte activation GO:0051251 140 0.048
developmental cell growth GO:0048588 84 0.048
rhythmic process GO:0048511 174 0.047
response to insulin GO:0032868 100 0.047
Rat
lung alveolus development GO:0048286 45 0.047
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.046
organonitrogen compound biosynthetic process GO:1901566 192 0.046
regulation of cysteine type endopeptidase activity GO:2000116 65 0.046
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.046
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.046
cardiac septum development GO:0003279 59 0.046
eye photoreceptor cell differentiation GO:0001754 41 0.046
negative regulation of striated muscle cell differentiation GO:0051154 14 0.046
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.046
regulation of fibrinolysis GO:0051917 1 0.045
Human
cognition GO:0050890 149 0.045
chorio allantoic fusion GO:0060710 8 0.045
leukocyte migration GO:0050900 124 0.044
Human
regulation of ossification GO:0030278 112 0.044
wound healing spreading of cells GO:0044319 8 0.044
positive regulation of cell motility GO:2000147 116 0.044
Human Rat
angiogenesis GO:0001525 201 0.044
cellular response to lipid GO:0071396 145 0.043
Human Rat
positive regulation of map kinase activity GO:0043406 84 0.043
positive regulation of cell activation GO:0050867 158 0.043
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.043
tissue homeostasis GO:0001894 115 0.042
regulation of hematopoietic stem cell proliferation GO:1902033 3 0.042
cellular response to organic cyclic compound GO:0071407 87 0.042
Rat
osteoclast differentiation GO:0030316 62 0.042
heart morphogenesis GO:0003007 178 0.041
neuron projection regeneration GO:0031102 14 0.041
t cell differentiation in thymus GO:0033077 77 0.041
protein secretion GO:0009306 111 0.041
purine nucleoside triphosphate metabolic process GO:0009144 226 0.041
sequestering of calcium ion GO:0051208 18 0.040
myeloid leukocyte migration GO:0097529 57 0.040
Human
transforming growth factor beta2 production GO:0032906 2 0.040
metanephric glomerular mesangium development GO:0072223 3 0.040
cellular lipid metabolic process GO:0044255 323 0.040
cellular nitrogen compound catabolic process GO:0044270 280 0.040
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.040
embryonic placenta morphogenesis GO:0060669 25 0.039
granulocyte chemotaxis GO:0071621 39 0.039
calcium ion transport GO:0006816 159 0.039
Rat
regulation of leukocyte mediated immunity GO:0002703 104 0.039
negative regulation of phosphorylation GO:0042326 166 0.039
regulation of cellular component biogenesis GO:0044087 181 0.039
ventricular septum development GO:0003281 42 0.039
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.039
cellular calcium ion homeostasis GO:0006874 119 0.039
negative regulation of proteolysis GO:0045861 74 0.039
mature dendritic cell differentiation GO:0097029 3 0.039
regulation of protein processing GO:0070613 96 0.038
regulation of protein maturation GO:1903317 96 0.038
negative regulation of myoblast differentiation GO:0045662 18 0.038
lymphocyte differentiation GO:0030098 242 0.038
regulation of lipid biosynthetic process GO:0046890 54 0.038
reactive oxygen species biosynthetic process GO:1903409 8 0.038
muscle contraction GO:0006936 101 0.038
oxidation reduction process GO:0055114 342 0.038
neutrophil migration GO:1990266 37 0.037
hexose metabolic process GO:0019318 98 0.037
positive regulation of lipid metabolic process GO:0045834 40 0.037
organic acid transport GO:0015849 101 0.037
protein glycosylation GO:0006486 55 0.037
skeletal muscle cell differentiation GO:0035914 66 0.037
phagocytosis GO:0006909 66 0.037
integrin mediated signaling pathway GO:0007229 27 0.036
multicellular organismal macromolecule metabolic process GO:0044259 19 0.036
jnk cascade GO:0007254 72 0.036
sensory system development GO:0048880 3 0.036
negative regulation of endopeptidase activity GO:0010951 44 0.036
purine ribonucleotide catabolic process GO:0009154 208 0.036
purine containing compound catabolic process GO:0072523 213 0.036
interleukin 12 secretion GO:0072610 3 0.036
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.036
divalent inorganic cation homeostasis GO:0072507 138 0.036
positive regulation of vasoconstriction GO:0045907 4 0.036
protein kinase b signaling GO:0043491 74 0.036
negative regulation of myotube differentiation GO:0010832 9 0.036
cellular response to dna damage stimulus GO:0006974 207 0.035
compound eye development GO:0048749 1 0.035
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.035
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.035
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.035
superoxide metabolic process GO:0006801 27 0.035
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
tumor necrosis factor production GO:0032640 50 0.034
negative regulation of neuron death GO:1901215 98 0.034
cellular response to biotic stimulus GO:0071216 92 0.034
Human
circadian behavior GO:0048512 13 0.034
carbohydrate biosynthetic process GO:0016051 74 0.034
regulation of cell cycle process GO:0010564 160 0.034
regulation of stress activated mapk cascade GO:0032872 69 0.034
regulation of action potential GO:0098900 4 0.034
posttranscriptional regulation of gene expression GO:0010608 155 0.034
nitrogen compound transport GO:0071705 271 0.034
monosaccharide biosynthetic process GO:0046364 44 0.034
regulation of lipid metabolic process GO:0019216 118 0.033
positive regulation of killing of cells of other organism GO:0051712 3 0.033
cell activation involved in immune response GO:0002263 126 0.033
cellular response to cytokine stimulus GO:0071345 189 0.033
Rat
cellular response to amino acid stimulus GO:0071230 29 0.033
negative regulation of neuron projection regeneration GO:0070571 3 0.033
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.033
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.033
regulation of removal of superoxide radicals GO:2000121 4 0.033
homeostasis of number of cells GO:0048872 210 0.033
positive regulation of striated muscle cell differentiation GO:0051155 35 0.033
regulation of blood circulation GO:1903522 93 0.032
regulation of phospholipase activity GO:0010517 9 0.032
regulation of gliogenesis GO:0014013 50 0.032
positive regulation of cell killing GO:0031343 33 0.032
ceramide metabolic process GO:0006672 31 0.032
vitellogenesis GO:0007296 2 0.032
forebrain development GO:0030900 302 0.032
regulation of killing of cells of other organism GO:0051709 4 0.032
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.032
organic anion transport GO:0015711 137 0.032
response to interleukin 1 GO:0070555 11 0.032
Rat
negative regulation of protein processing GO:0010955 79 0.032
dna metabolic process GO:0006259 303 0.032
cellular chemical homeostasis GO:0055082 215 0.032
Rat
positive regulation of cardiac muscle contraction GO:0060452 2 0.032
cellular ion homeostasis GO:0006873 165 0.031
skeletal muscle fiber development GO:0048741 58 0.031
cellular homeostasis GO:0019725 240 0.031
Rat
leukocyte homeostasis GO:0001776 79 0.031
glucose homeostasis GO:0042593 128 0.031
Rat
neuron projection extension GO:1990138 64 0.031
regulation of purine nucleotide metabolic process GO:1900542 169 0.031
fertilization GO:0009566 127 0.031
plasma membrane long chain fatty acid transport GO:0015911 1 0.031
nucleoside triphosphate metabolic process GO:0009141 230 0.031
hindbrain development GO:0030902 128 0.031
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.031
regulation of fibroblast proliferation GO:0048145 34 0.031
Rat
response to alcohol GO:0097305 48 0.031
Rat
positive regulation of protein deacetylation GO:0090312 9 0.030
nucleotide catabolic process GO:0009166 217 0.030
t cell proliferation GO:0042098 120 0.030
protein deacylation GO:0035601 36 0.030
negative regulation of protein modification process GO:0031400 163 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
membrane lipid metabolic process GO:0006643 53 0.030
positive regulation of fibroblast proliferation GO:0048146 20 0.030
Rat
regulation of protein kinase b signaling GO:0051896 56 0.030
regulation of vasculature development GO:1901342 88 0.030
cellular response to insulin stimulus GO:0032869 78 0.030
Rat
cellular response to organonitrogen compound GO:0071417 145 0.030
Rat
response to drug GO:0042493 75 0.030
Rat
hematopoietic progenitor cell differentiation GO:0002244 143 0.030
axon guidance GO:0007411 141 0.030
sensory organ morphogenesis GO:0090596 242 0.030
epithelial tube morphogenesis GO:0060562 303 0.030
development of primary female sexual characteristics GO:0046545 73 0.029
Rat
positive regulation of organelle organization GO:0010638 128 0.029
epidermis development GO:0008544 187 0.029
positive regulation of histone modification GO:0031058 28 0.029
positive regulation of neutrophil mediated killing of fungus GO:0070965 1 0.029
stem cell proliferation GO:0072089 117 0.029
positive regulation of secretion GO:0051047 130 0.029
negative regulation of macrophage apoptotic process GO:2000110 3 0.029
positive regulation of stress activated mapk cascade GO:0032874 48 0.029
positive regulation of protein transport GO:0051222 93 0.029
glial cell differentiation GO:0010001 131 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
synapse organization GO:0050808 125 0.029
response to reactive oxygen species GO:0000302 56 0.029
Rat
protein processing GO:0016485 163 0.029
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.029
negative regulation of phosphate metabolic process GO:0045936 184 0.029
sensory perception GO:0007600 245 0.028
Mouse
regulation of wound healing GO:0061041 40 0.028
positive regulation of wound healing GO:0090303 17 0.028
Human
acetylcholine secretion neurotransmission GO:0014055 2 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
membrane organization GO:0061024 245 0.028
natural killer cell chemotaxis GO:0035747 1 0.028
regulation of multi organism process GO:0043900 111 0.028
macromolecule catabolic process GO:0009057 281 0.028
Mouse
glucose metabolic process GO:0006006 92 0.028
developmental maturation GO:0021700 193 0.028
mitochondrion organization GO:0007005 134 0.028
positive regulation of muscle cell differentiation GO:0051149 39 0.027
multi multicellular organism process GO:0044706 109 0.027
Mouse Rat
macromolecule glycosylation GO:0043413 55 0.027
tissue remodeling GO:0048771 102 0.027
muscle fiber development GO:0048747 76 0.027
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.027
regulation of skeletal muscle fiber development GO:0048742 36 0.027
negative regulation of muscle cell differentiation GO:0051148 33 0.027
response to estrogen GO:0043627 24 0.027
Rat
female sex differentiation GO:0046660 84 0.027
Rat
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.027
regulation of myeloid leukocyte differentiation GO:0002761 58 0.027
regulation of plasminogen activation GO:0010755 4 0.027
heart process GO:0003015 94 0.027
neuron death GO:0070997 154 0.027
regulation of osteoclast differentiation GO:0045670 36 0.027
purine nucleoside catabolic process GO:0006152 205 0.026
regionalization GO:0003002 337 0.026
regulation of vesicle mediated transport GO:0060627 139 0.026
Human Rat
negative regulation of endothelial cell migration GO:0010596 4 0.026
ear development GO:0043583 200 0.026
regulation of cellular ketone metabolic process GO:0010565 66 0.026
sequestering of metal ion GO:0051238 19 0.026
mesoderm development GO:0007498 100 0.026
regulation of b cell chemotaxis GO:2000537 2 0.026
positive regulation of homeostatic process GO:0032846 64 0.026
neuron apoptotic process GO:0051402 142 0.026
regulation of amine transport GO:0051952 21 0.026
photoreceptor cell development GO:0042461 40 0.026
cellular response to acid chemical GO:0071229 68 0.026
hexose biosynthetic process GO:0019319 39 0.026
ameboidal type cell migration GO:0001667 128 0.026
Rat
response to corticosteroid GO:0031960 20 0.026
Rat
peptidyl lysine modification GO:0018205 77 0.025
embryonic organ morphogenesis GO:0048562 276 0.025
positive regulation of t cell activation GO:0050870 101 0.025
hormone secretion GO:0046879 128 0.025
protein localization to cell junction GO:1902414 3 0.025
germ cell development GO:0007281 185 0.025
regulation of ion transport GO:0043269 215 0.025
Mouse Rat
ribose phosphate metabolic process GO:0019693 291 0.025
positive regulation of protein kinase b signaling GO:0051897 32 0.025
positive regulation of neuron projection development GO:0010976 79 0.025
regulation of neurotransmitter transport GO:0051588 35 0.025
positive regulation of leukocyte mediated immunity GO:0002705 70 0.025
positive regulation of defense response GO:0031349 124 0.024
Human
positive regulation of secretion by cell GO:1903532 114 0.024
regulation of stem cell differentiation GO:2000736 50 0.024

Serpine1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.145
nervous system disease DOID:863 0 0.145
sensory system disease DOID:0050155 0 0.052
neuromuscular disease DOID:440 0 0.052
neuropathy DOID:870 0 0.052
disease of metabolism DOID:0014667 0 0.036
charcot marie tooth disease DOID:10595 0 0.032
eye and adnexa disease DOID:1492 0 0.031
acquired metabolic disease DOID:0060158 0 0.025