|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
0.997
|
|
|
|
b cell receptor signaling pathway
|
GO:0050853 |
20 |
0.987
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.984
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.966
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.952
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.931
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.919
|
Fly |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.899
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.889
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.881
|
Fly |
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.877
|
|
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
29 |
0.866
|
|
|
|
syncytium formation
|
GO:0006949 |
43 |
0.865
|
Fly |
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.843
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.832
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.827
|
Mouse |
|
|
activation of immune response
|
GO:0002253 |
138 |
0.808
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.787
|
|
|
|
granulocyte migration
|
GO:0097530 |
43 |
0.766
|
|
|
|
integrin mediated signaling pathway
|
GO:0007229 |
27 |
0.723
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
39 |
0.714
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.705
|
|
|
|
leukocyte cell cell adhesion
|
GO:0007159 |
14 |
0.686
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.677
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.675
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.673
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.657
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.656
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.648
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.641
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.638
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.633
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.632
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.622
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.622
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.615
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.608
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.590
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.587
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.586
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.581
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
17 |
0.579
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.579
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.575
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.557
|
Mouse |
|
|
innate immune response
|
GO:0045087 |
157 |
0.549
|
Fly |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.548
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.542
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.541
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.538
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.534
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.532
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.522
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.519
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.517
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.495
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.493
|
Mouse |
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.491
|
|
|
|
lamellipodium organization
|
GO:0097581 |
29 |
0.486
|
Mouse |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.469
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.466
|
|
|
|
regulation of cell shape
|
GO:0008360 |
39 |
0.456
|
Fly |
|
|
regulation of cell adhesion mediated by integrin
|
GO:0033628 |
13 |
0.452
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.452
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.448
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.448
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.444
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.444
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.440
|
|
|
|
activation of rac gtpase activity
|
GO:0032863 |
2 |
0.440
|
Fly |
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.438
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.435
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.434
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.429
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.418
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
118 |
0.413
|
Mouse |
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.408
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.405
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.404
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.400
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.398
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.398
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.397
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.390
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.388
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.381
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
42 |
0.377
|
Fly |
|
|
leukocyte chemotaxis
|
GO:0030595 |
69 |
0.370
|
|
|
|
blood coagulation
|
GO:0007596 |
76 |
0.369
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.357
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.356
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.355
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.353
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.353
|
|
|
|
hemostasis
|
GO:0007599 |
78 |
0.352
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.351
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.350
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.349
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.342
|
Mouse |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.342
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.340
|
Mouse |
|
|
positive regulation of gamma delta t cell differentiation
|
GO:0045588 |
6 |
0.339
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.337
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.334
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.328
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.325
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.325
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.323
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.321
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
57 |
0.318
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.318
|
Mouse |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.317
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.315
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.296
|
|
|
|
neutrophil migration
|
GO:1990266 |
37 |
0.295
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.293
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.292
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.291
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.290
|
|
|
|
regulation of coagulation
|
GO:0050818 |
31 |
0.284
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.284
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.280
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.279
|
Mouse |
|
|
membrane organization
|
GO:0061024 |
245 |
0.273
|
Mouse |
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.272
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.267
|
Fly |
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
21 |
0.266
|
Fly |
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.265
|
Fly |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.264
|
|
|
|
cell adhesion mediated by integrin
|
GO:0033627 |
18 |
0.258
|
|
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
46 |
0.258
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.254
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.253
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.253
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.252
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.252
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.245
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.242
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.235
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.234
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
21 |
0.233
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.232
|
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.231
|
|
|
|
pigment metabolic process
|
GO:0042440 |
32 |
0.226
|
Fly |
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.221
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.221
|
|
|
|
b cell activation involved in immune response
|
GO:0002312 |
50 |
0.216
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.214
|
|
|
|
activation of ras gtpase activity
|
GO:0032856 |
11 |
0.213
|
Fly |
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.208
|
|
|
|
positive t cell selection
|
GO:0043368 |
23 |
0.206
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.205
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.205
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.202
|
|
|
|
vesicle fusion
|
GO:0006906 |
16 |
0.200
|
Mouse |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.200
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.199
|
|
|
|
apical constriction
|
GO:0003383 |
4 |
0.197
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.197
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.195
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.192
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.191
|
|
|
|
platelet aggregation
|
GO:0070527 |
20 |
0.191
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.190
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.183
|
|
|
|
thymic t cell selection
|
GO:0045061 |
22 |
0.178
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.177
|
|
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
0.177
|
|
|
|
regulation of phosphatidylinositol 3 kinase activity
|
GO:0043551 |
14 |
0.176
|
Mouse |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.174
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.170
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.170
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.169
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.165
|
|
|
|
neutrophil chemotaxis
|
GO:0030593 |
36 |
0.165
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.163
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.162
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
32 |
0.161
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.158
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.157
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.157
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.157
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.155
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.155
|
|
|
|
regulation of b cell receptor signaling pathway
|
GO:0050855 |
9 |
0.155
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.153
|
|
|
|
exocytosis
|
GO:0006887 |
121 |
0.152
|
|
|
|
dephosphorylation
|
GO:0016311 |
129 |
0.151
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.151
|
|
|
|
regulation of natural killer cell activation
|
GO:0032814 |
22 |
0.149
|
|
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
11 |
0.148
|
Mouse |
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.144
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.141
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.141
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.141
|
|
|
|
homotypic cell cell adhesion
|
GO:0034109 |
28 |
0.141
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.140
|
|
|
|
negative regulation of b cell receptor signaling pathway
|
GO:0050859 |
4 |
0.140
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.140
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.138
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.137
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.134
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.133
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.132
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.132
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.131
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.131
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.130
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.130
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.130
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.129
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.128
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.128
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
234 |
0.125
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
40 |
0.125
|
Mouse |
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.124
|
|
|
|
t cell selection
|
GO:0045058 |
34 |
0.124
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.123
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.123
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.122
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.122
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.121
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.120
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.120
|
|
|
|
zygotic determination of anterior posterior axis embryo
|
GO:0007354 |
3 |
0.120
|
|
|
|
negative thymic t cell selection
|
GO:0045060 |
12 |
0.117
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.117
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
93 |
0.116
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.114
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.110
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.110
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.110
|
Fly |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.109
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.108
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.107
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.106
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.106
|
|
|
|
wound healing
|
GO:0042060 |
157 |
0.105
|
|
|
|
positive regulation of b cell activation
|
GO:0050871 |
49 |
0.104
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.104
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.104
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.103
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
28 |
0.103
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.102
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.102
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.101
|
|
|
|
neutrophil degranulation
|
GO:0043312 |
6 |
0.101
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.101
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.100
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.100
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.099
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.098
|
Mouse |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.098
|
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.098
|
|
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.096
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
23 |
0.096
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
70 |
0.096
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
32 |
0.096
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
128 |
0.095
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.095
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.095
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.093
|
|
|
|
peptidyl tyrosine dephosphorylation
|
GO:0035335 |
23 |
0.093
|
|
|
|
negative regulation of cellular response to insulin stimulus
|
GO:1900077 |
16 |
0.092
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.092
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.091
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.091
|
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.090
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.089
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.089
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.089
|
|
|
|
negative regulation of leukocyte mediated immunity
|
GO:0002704 |
29 |
0.088
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.087
|
|
|
|
leukotriene metabolic process
|
GO:0006691 |
7 |
0.087
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.087
|
|
|
|
positive regulation of antigen receptor mediated signaling pathway
|
GO:0050857 |
9 |
0.087
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.087
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.086
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.086
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.085
|
|
|
|
negative regulation of antigen receptor mediated signaling pathway
|
GO:0050858 |
16 |
0.085
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.083
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.083
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.081
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.080
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.080
|
|
|
|
gamma delta t cell differentiation
|
GO:0042492 |
11 |
0.080
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.079
|
Fly |
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.079
|
|
|
|
negative regulation of cell adhesion mediated by integrin
|
GO:0033629 |
2 |
0.079
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.079
|
|
|
|
phenol containing compound metabolic process
|
GO:0018958 |
60 |
0.079
|
Fly |
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
81 |
0.077
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.077
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
46 |
0.076
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.076
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.075
|
|
|
|
regulation of hemostasis
|
GO:1900046 |
28 |
0.075
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.074
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.074
|
|
|
|
gamma delta t cell activation
|
GO:0046629 |
13 |
0.073
|
|
|
|
regulation of t cell receptor signaling pathway
|
GO:0050856 |
21 |
0.073
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.072
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.072
|
|
|
|
regulation of immunoglobulin mediated immune response
|
GO:0002889 |
37 |
0.072
|
|
|
|
lipid transport
|
GO:0006869 |
98 |
0.072
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
20 |
0.071
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.071
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
73 |
0.071
|
|
|
|
membrane invagination
|
GO:0010324 |
17 |
0.071
|
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.070
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.069
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
42 |
0.069
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.069
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.068
|
|
|
|
negative regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002924 |
3 |
0.068
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.067
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.066
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.066
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.065
|
Fly |
|
|
t cell apoptotic process
|
GO:0070231 |
39 |
0.065
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.063
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.063
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.063
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
61 |
0.062
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.062
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.061
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.061
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.060
|
|
|
|
positive thymic t cell selection
|
GO:0045059 |
13 |
0.060
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.060
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.059
|
|
|
|
marginal zone b cell differentiation
|
GO:0002315 |
2 |
0.059
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.059
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.059
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
36 |
0.058
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.058
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.058
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.057
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.057
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
28 |
0.057
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
86 |
0.057
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.057
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.057
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.057
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.056
|
|
|
|
serotonin secretion involved in inflammatory response
|
GO:0002442 |
4 |
0.056
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.056
|
|
|
|
negative t cell selection
|
GO:0043383 |
13 |
0.056
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
2 |
0.055
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.055
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.055
|
|
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.055
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.054
|
|
|
|
skeletal muscle organ development
|
GO:0060538 |
163 |
0.054
|
|
|
|
negative regulation of t helper 1 cell differentiation
|
GO:0045626 |
3 |
0.054
|
|
|
|
regulation of interleukin 10 production
|
GO:0032653 |
21 |
0.054
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.054
|
|
|
|
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process
|
GO:0045425 |
2 |
0.054
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
57 |
0.053
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.052
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.052
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.052
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
121 |
0.051
|
|
|
|
regulation of homotypic cell cell adhesion
|
GO:0034110 |
13 |
0.051
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.051
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.051
|
|
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.051
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.050
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase activity
|
GO:0043552 |
11 |
0.050
|
Mouse |
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.050
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
40 |
0.050
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
35 |
0.050
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.049
|
|
|
|
neutral lipid metabolic process
|
GO:0006638 |
57 |
0.049
|
|
|
|
cd8 positive alpha beta t cell proliferation
|
GO:0035740 |
1 |
0.049
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
207 |
0.049
|
|
|
|
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002823 |
23 |
0.049
|
|
|
|
superoxide metabolic process
|
GO:0006801 |
27 |
0.048
|
|
|
|
platelet activation
|
GO:0030168 |
40 |
0.048
|
|
|
|
mesodermal cell migration
|
GO:0008078 |
4 |
0.048
|
|
|
|
myeloid cell activation involved in immune response
|
GO:0002275 |
34 |
0.048
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.048
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.048
|
|
|
|
secondary metabolic process
|
GO:0019748 |
18 |
0.048
|
Fly |
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.048
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.047
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
41 |
0.047
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.047
|
|
|
|
protein localization to membrane
|
GO:0072657 |
108 |
0.047
|
|
|
|
substrate adhesion dependent cell spreading
|
GO:0034446 |
30 |
0.047
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.046
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.046
|
|
|
|
dna recombination
|
GO:0006310 |
92 |
0.045
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
28 |
0.045
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.045
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.045
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.045
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.044
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.044
|
|
|
|
regulation of gamma delta t cell differentiation
|
GO:0045586 |
9 |
0.044
|
|
|
|
positive regulation of b cell receptor signaling pathway
|
GO:0050861 |
4 |
0.044
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.044
|
|
|
|
integrin activation
|
GO:0033622 |
8 |
0.044
|
|
|
|
organic acid transport
|
GO:0015849 |
101 |
0.044
|
|
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.043
|
|
|
|
hormone secretion
|
GO:0046879 |
128 |
0.042
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.042
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.042
|
|
|
|
interleukin 10 production
|
GO:0032613 |
23 |
0.042
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.042
|
Fly |
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.041
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.041
|
|
|
|
regulation of notch signaling pathway
|
GO:0008593 |
35 |
0.041
|
Worm |
|
|
dendrite development
|
GO:0016358 |
115 |
0.041
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.040
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.040
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
9 |
0.040
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.040
|
Fly |
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.040
|
|
|
|
neutrophil activation
|
GO:0042119 |
9 |
0.039
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
45 |
0.039
|
|
|
|
regulation of wound healing
|
GO:0061041 |
40 |
0.039
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.039
|
|
|
|
monoamine transport
|
GO:0015844 |
33 |
0.039
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.039
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.038
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.038
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.038
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
2 |
0.037
|
|
|
|
regulation of gamma delta t cell activation
|
GO:0046643 |
9 |
0.037
|
|
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.037
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.037
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
127 |
0.037
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.037
|
|
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
39 |
0.037
|
|
|
|
bone remodeling
|
GO:0046849 |
53 |
0.036
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.036
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.036
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.036
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
116 |
0.035
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.035
|
|
|
|
granulocyte macrophage colony stimulating factor biosynthetic process
|
GO:0042253 |
2 |
0.034
|
|
|
|
negative regulation of synapse assembly
|
GO:0051964 |
3 |
0.034
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.034
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.034
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.034
|
|
|
|
interleukin 4 production
|
GO:0032633 |
24 |
0.034
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.034
|
|
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
25 |
0.034
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.033
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
30 |
0.033
|
|
|
|
cell recognition
|
GO:0008037 |
83 |
0.033
|
|
|
|
membrane fusion
|
GO:0061025 |
38 |
0.033
|
Mouse |
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.033
|
|
|
|
positive regulation of interferon beta biosynthetic process
|
GO:0045359 |
3 |
0.033
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.033
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.032
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
57 |
0.032
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.032
|
|
|
|
placenta development
|
GO:0001890 |
140 |
0.032
|
|
|
|
serotonin secretion by platelet
|
GO:0002554 |
3 |
0.032
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.032
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.032
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.032
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.031
|
|
|
|
regulation of mast cell activation
|
GO:0033003 |
21 |
0.031
|
|
|
|
oocyte construction
|
GO:0007308 |
2 |
0.031
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.031
|
|
|
|
tissue migration
|
GO:0090130 |
68 |
0.031
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.031
|
|
|
|
triglyceride metabolic process
|
GO:0006641 |
51 |
0.031
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
41 |
0.031
|
|
|
|
epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade
|
GO:0038168 |
1 |
0.030
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.030
|
|
|
|
neurotrophin signaling pathway
|
GO:0038179 |
12 |
0.030
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
0 |
0.030
|
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.030
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.030
|
Fly |
|
|
regulation of bone resorption
|
GO:0045124 |
24 |
0.030
|
|
|
|
pallium development
|
GO:0021543 |
120 |
0.030
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
75 |
0.030
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
13 |
0.029
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
31 |
0.029
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
47 |
0.029
|
|
|
|
acylglycerol metabolic process
|
GO:0006639 |
55 |
0.029
|
|
