|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.806
|
Mouse |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.572
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.491
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.491
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.481
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.477
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.474
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.460
|
|
|
|
activation of rac gtpase activity
|
GO:0032863 |
2 |
0.445
|
Fly |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.442
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.422
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.419
|
|
|
|
vesicle fusion
|
GO:0006906 |
16 |
0.416
|
|
|
|
organelle fusion
|
GO:0048284 |
28 |
0.396
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.396
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.393
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.391
|
Fly |
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.384
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.384
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.384
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.381
|
|
|
|
membrane fusion
|
GO:0061025 |
38 |
0.380
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.363
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.359
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.357
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.355
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.353
|
|
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.352
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.338
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.330
|
Fly |
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.326
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.323
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.299
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.297
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.295
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.286
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.285
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.284
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.275
|
Mouse |
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.274
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.270
|
Mouse |
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.265
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.264
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.263
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.260
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.258
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.254
|
Fly |
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.251
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.250
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.247
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.237
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.235
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.235
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.228
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.228
|
Fly |
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.220
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.220
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
21 |
0.219
|
Fly |
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.219
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.218
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.215
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.212
|
|
|
|
cell growth involved in cardiac muscle cell development
|
GO:0061049 |
3 |
0.204
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.201
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.200
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.198
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.198
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.191
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.190
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.186
|
Fly |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.186
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.184
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.183
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.178
|
|
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.177
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.174
|
|
|
|
oxidation reduction process
|
GO:0055114 |
342 |
0.174
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.173
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.173
|
|
|
|
phenol containing compound metabolic process
|
GO:0018958 |
60 |
0.172
|
Fly |
|
|
immune effector process
|
GO:0002252 |
321 |
0.172
|
Fly |
|
|
superoxide metabolic process
|
GO:0006801 |
27 |
0.172
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.171
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.171
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.170
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.168
|
Mouse |
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.167
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.166
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.164
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.162
|
|
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
11 |
0.158
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.158
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.156
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.155
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.153
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
121 |
0.153
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.151
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
57 |
0.150
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.149
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
39 |
0.148
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.147
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.146
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.144
|
|
|
|
neutrophil migration
|
GO:1990266 |
37 |
0.144
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.144
|
|
|
|
activation of ras gtpase activity
|
GO:0032856 |
11 |
0.144
|
Fly |
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.141
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.141
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.140
|
|
|
|
renal system development
|
GO:0072001 |
225 |
0.139
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.138
|
Mouse |
|
|
regulation of activation of jak2 kinase activity
|
GO:0010534 |
1 |
0.138
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
80 |
0.138
|
|
|
|
wound healing
|
GO:0042060 |
157 |
0.137
|
|
|
|
physiological cardiac muscle hypertrophy
|
GO:0003301 |
3 |
0.136
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.136
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.134
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
2 |
0.134
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.131
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.131
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.130
|
|
|
|
lamellipodium organization
|
GO:0097581 |
29 |
0.130
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.130
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.130
|
Mouse |
|
|
peptide secretion
|
GO:0002790 |
114 |
0.130
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.127
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.126
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.126
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.125
|
Mouse |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.122
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.122
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.119
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.119
|
|
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.119
|
|
|
|
secondary metabolic process
|
GO:0019748 |
18 |
0.116
|
Fly |
|
|
muscle adaptation
|
GO:0043500 |
39 |
0.115
|
|
|
|
muscle contraction
|
GO:0006936 |
101 |
0.115
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.115
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.114
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.112
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.111
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.109
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.109
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.108
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.108
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.107
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.107
|
|
|
|
neurotransmitter transport
|
GO:0006836 |
76 |
0.105
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.105
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.103
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.103
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.103
|
|
|
|
response to corticosterone
|
GO:0051412 |
1 |
0.102
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.101
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.100
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.098
|
|
|
|
organ regeneration
|
GO:0031100 |
2 |
0.098
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.096
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.096
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.095
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.095
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.094
|
Fly |
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
40 |
0.093
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.093
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.093
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.092
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.090
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.088
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.088
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.087
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.086
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.086
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.086
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.085
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.085
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.084
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.082
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.082
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
143 |
0.082
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.081
|
|
|
|
catecholamine metabolic process
|
GO:0006584 |
30 |
0.081
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.081
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
118 |
0.081
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.080
|
|
|
|
neurotrophin trk receptor signaling pathway
|
GO:0048011 |
8 |
0.080
|
|
|
|
vesicle localization
|
GO:0051648 |
86 |
0.079
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.078
|
|
|
|
respiratory tube development
|
GO:0030323 |
167 |
0.078
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.078
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.076
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.076
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.076
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.075
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.075
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.075
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.075
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.074
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.073
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.073
|
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.073
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.073
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
211 |
0.073
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.072
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.071
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.070
|
|
|
|
circulatory system process
|
GO:0003013 |
197 |
0.070
|
|
|
|
hormone metabolic process
|
GO:0042445 |
86 |
0.070
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.069
|
|
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.069
|
|
|
|
placenta development
|
GO:0001890 |
140 |
0.069
|
|
|
|
hemostasis
|
GO:0007599 |
78 |
0.068
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.068
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
179 |
0.068
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
59 |
0.068
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.067
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.067
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
37 |
0.067
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.066
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.066
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
234 |
0.065
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.065
|
|
|
|
physiological muscle hypertrophy
|
GO:0003298 |
3 |
0.065
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.065
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.065
|
|
|
|
camera type eye development
|
GO:0043010 |
266 |
0.065
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.064
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.064
|
|
|
|
heart morphogenesis
|
GO:0003007 |
178 |
0.064
|
|
|
|
regulation of fat cell differentiation
|
GO:0045598 |
81 |
0.064
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.063
|
|
|
|
negative regulation of synaptic vesicle transport
|
GO:1902804 |
3 |
0.062
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.062
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
127 |
0.062
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.062
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.061
|
|
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.061
|
|
|
|
pigmentation
|
GO:0043473 |
71 |
0.061
|
|
|
|
exocytosis
|
GO:0006887 |
121 |
0.061
|
|
|
|
heart process
|
GO:0003015 |
94 |
0.060
|
|
|
|
regulation of circadian sleep wake cycle sleep
|
GO:0045187 |
3 |
0.060
|
|
|
|
connective tissue development
|
GO:0061448 |
179 |
0.060
|
|
|
|
adipose tissue development
|
GO:0060612 |
25 |
0.060
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.060
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
0 |
0.059
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
130 |
0.059
|
|
|
|
regulation of neurotransmitter levels
|
GO:0001505 |
87 |
0.059
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.058
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
100 |
0.058
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.058
|
|
|
|
heart contraction
|
GO:0060047 |
93 |
0.058
|
|
|
|
negative regulation of synaptic vesicle exocytosis
|
GO:2000301 |
3 |
0.058
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.058
|
|
|
|
bone development
|
GO:0060348 |
120 |
0.057
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.057
|
|
|
|
negative regulation of cellular response to insulin stimulus
|
GO:1900077 |
16 |
0.057
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
32 |
0.057
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.057
|
|
|
|
norepinephrine transport
|
GO:0015874 |
2 |
0.057
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
31 |
0.057
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.056
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.056
|
Human |
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
17 |
0.056
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.055
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.055
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.055
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.055
|
|
|
|
kidney development
|
GO:0001822 |
213 |
0.055
|
|
|
|
kidney epithelium development
|
GO:0072073 |
121 |
0.055
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
28 |
0.054
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.054
|
Fly |
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.054
|
|
|
|
dephosphorylation
|
GO:0016311 |
129 |
0.054
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
191 |
0.054
|
|
|
|
chondrocyte differentiation
|
GO:0002062 |
72 |
0.054
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.054
|
|
|
|
pigment metabolic process
|
GO:0042440 |
32 |
0.053
|
Fly |
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
207 |
0.053
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.053
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.053
|
Mouse |
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.053
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.052
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
116 |
0.052
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
79 |
0.052
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.052
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.052
|
|
|
|
neutrophil chemotaxis
|
GO:0030593 |
36 |
0.052
|
|
|
|
cognition
|
GO:0050890 |
149 |
0.052
|
|
|
|
glucocorticoid biosynthetic process
|
GO:0006704 |
5 |
0.051
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.051
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.051
|
|
|
|
negative regulation of neurotransmitter transport
|
GO:0051589 |
7 |
0.050
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
8 |
0.050
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
109 |
0.050
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
28 |
0.050
|
|
|
|
response to inactivity
|
GO:0014854 |
4 |
0.050
|
|
|
|
regulation of muscle hypertrophy
|
GO:0014743 |
13 |
0.050
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.049
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.049
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
78 |
0.049
|
|
|
|
peptide metabolic process
|
GO:0006518 |
46 |
0.049
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
42 |
0.048
|
Fly |
|
|
multi multicellular organism process
|
GO:0044706 |
109 |
0.048
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
87 |
0.048
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.048
|
|
|
|
organic acid transport
|
GO:0015849 |
101 |
0.048
|
|
|
|
positive regulation of growth
|
GO:0045927 |
104 |
0.048
|
|
|
|
fibroblast migration
|
GO:0010761 |
21 |
0.048
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.047
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.047
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.047
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.047
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
128 |
0.047
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.047
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.047
|
|
|
|
monoamine transport
|
GO:0015844 |
33 |
0.047
|
|
|
|
phenol containing compound biosynthetic process
|
GO:0046189 |
21 |
0.047
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.047
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.047
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.046
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.046
|
|
|
|
modification by symbiont of host morphology or physiology
|
GO:0044003 |
4 |
0.046
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.045
|
Human |
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.045
|
Human |
|
|
sensory perception of light stimulus
|
GO:0050953 |
54 |
0.045
|
|
|
|
glucose homeostasis
|
GO:0042593 |
128 |
0.045
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.045
|
|
|
|
lung development
|
GO:0030324 |
164 |
0.045
|
|
|
|
protein localization to membrane
|
GO:0072657 |
108 |
0.044
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.044
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.044
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.044
|
|
|
|
amino acid transport
|
GO:0006865 |
61 |
0.044
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.044
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.044
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.044
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.044
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.044
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.043
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.043
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
64 |
0.042
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.042
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
91 |
0.042
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.042
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
54 |
0.042
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.042
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
122 |
0.041
|
|
|
|
response to amino acid
|
GO:0043200 |
37 |
0.041
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
39 |
0.041
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.041
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
26 |
0.041
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.041
|
Fly |
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.041
|
|
|
|
respiratory system development
|
GO:0060541 |
190 |
0.041
|
Fly |
|
|
negative regulation of neuron death
|
GO:1901215 |
98 |
0.041
|
|
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
4 |
0.041
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.041
|
|
|
|
smooth muscle contraction
|
GO:0006939 |
44 |
0.041
|
|
|
|
carbohydrate homeostasis
|
GO:0033500 |
128 |
0.040
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.040
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.040
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.040
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.040
|
|
|
|
response to osmotic stress
|
GO:0006970 |
21 |
0.040
|
|
|
|
chromatin mediated maintenance of transcription
|
GO:0048096 |
2 |
0.040
|
|
|
|
mesonephros development
|
GO:0001823 |
97 |
0.040
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.040
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.040
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.040
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
62 |
0.040
|
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.039
|
|
|
|
hexose metabolic process
|
GO:0019318 |
98 |
0.039
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
69 |
0.039
|
|
|
|
response to vitamin d
|
GO:0033280 |
3 |
0.039
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.039
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.038
|
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.038
|
|
|
|
organelle assembly
|
GO:0070925 |
177 |
0.038
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.038
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.038
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
64 |
0.038
|
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.038
|
|
|
|
negative regulation of fibroblast migration
|
GO:0010764 |
2 |
0.038
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.037
|
|
|
|
body fluid secretion
|
GO:0007589 |
53 |
0.037
|
|
|
|
action potential
|
GO:0001508 |
78 |
0.037
|
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.037
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
58 |
0.037
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
88 |
0.037
|
|
|
|
regulation of systemic arterial blood pressure
|
GO:0003073 |
61 |
0.037
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.037
|
|
|
|
regulation of norepinephrine secretion
|
GO:0014061 |
2 |
0.037
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
78 |
0.036
|
|
|
|
regulation of notch signaling pathway
|
GO:0008593 |
35 |
0.036
|
Worm |
|
|
muscle system process
|
GO:0003012 |
141 |
0.036
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.036
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.036
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.036
|
|
|
|
negative regulation of insulin receptor signaling pathway
|
GO:0046627 |
14 |
0.035
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
69 |
0.035
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
3 |
0.035
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.035
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.034
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
94 |
0.034
|
|
|
|
photoreceptor cell development
|
GO:0042461 |
40 |
0.034
|
|
|
|
regulation of wound healing
|
GO:0061041 |
40 |
0.034
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
45 |
0.034
|
|
|
|
response to alcohol
|
GO:0097305 |
48 |
0.034
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
52 |
0.034
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
77 |
0.034
|
|
|
|
organ growth
|
GO:0035265 |
117 |
0.034
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.034
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
128 |
0.034
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.034
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.034
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
1 |
0.034
|
|
|
|
regulation of muscle adaptation
|
GO:0043502 |
31 |
0.033
|
|
|
|
schwann cell development
|
GO:0014044 |
22 |
0.033
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.033
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.033
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
61 |
0.033
|
|
|
|
myeloid leukocyte mediated immunity
|
GO:0002444 |
42 |
0.033
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
119 |
0.033
|
|
|
|
ureteric bud development
|
GO:0001657 |
94 |
0.033
|
|
|
|
blood coagulation
|
GO:0007596 |
76 |
0.033
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.032
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.032
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.032
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
14 |
0.032
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.032
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.032
|
|
|
|
regulation of hemostasis
|
GO:1900046 |
28 |
0.032
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
81 |
0.032
|
|
|
|
rap protein signal transduction
|
GO:0032486 |
3 |
0.032
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.031
|
|
|
|
central nervous system neuron differentiation
|
GO:0021953 |
162 |
0.031
|
|
|
|
sperm individualization
|
GO:0007291 |
1 |
0.031
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
92 |
0.031
|
|
|
|
regulation of coagulation
|
GO:0050818 |
31 |
0.031
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.031
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.031
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.031
|
|
|
|
regulation of circadian rhythm
|
GO:0042752 |
58 |
0.031
|
|
|
|
cell maturation
|
GO:0048469 |
127 |
0.030
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
49 |
0.030
|
|
|
|
learning
|
GO:0007612 |
98 |
0.030
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.030
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.030
|
|
|
|
microglia differentiation
|
GO:0014004 |
2 |
0.030
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.030
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.030
|
|
|
|
hormone secretion
|
GO:0046879 |
128 |
0.030
|
|
|
|
response to monosaccharide
|
GO:0034284 |
67 |
0.029
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.029
|
|
|
|
regulation of circadian sleep wake cycle
|
GO:0042749 |
3 |
0.029
|
|
|
|
regulation of gluconeogenesis
|
GO:0006111 |
30 |
0.029
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.029
|
|
|
|
nephron tubule development
|
GO:0072080 |
84 |
0.029
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.029
|
|
|
|
regulation of cell shape
|
GO:0008360 |
39 |
0.029
|
Fly |
|
|
rac protein signal transduction
|
GO:0016601 |
13 |
0.029
|
|
|
|
stem cell development
|
GO:0048864 |
219 |
0.029
|
|
|
|
steroid metabolic process
|
GO:0008202 |
119 |
0.029
|
|
|
|
renal tubule development
|
GO:0061326 |
87 |
0.029
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.029
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.029
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
11 |
0.029
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
2 |
0.029
|
|
|
|
cellular response to carbohydrate stimulus
|
GO:0071322 |
50 |
0.028
|
|
|
|
chromatin modification
|
GO:0016568 |
187 |
0.028
|
|
|
|
superoxide anion generation
|
GO:0042554 |
11 |
0.028
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
81 |
0.028
|
|
|
|
syncytium formation
|
GO:0006949 |
43 |
0.028
|
Fly |
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.028
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.028
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
70 |
0.028
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
59 |
0.028
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
59 |
0.028
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.028
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.028
|
|
|
|
mesonephric tubule development
|
GO:0072164 |
94 |
0.028
|
|
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.028
|
|
|
|
dopamine metabolic process
|
GO:0042417 |
23 |
0.028
|
|
|
|
regulation of neurotransmitter transport
|
GO:0051588 |
35 |
0.028
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.028
|
|
|
|
insulin secretion
|
GO:0030073 |
89 |
0.028
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.028
|
|
|
|
granulocyte migration
|
GO:0097530 |
43 |
0.028
|
|
|
|
neutrophil mediated immunity
|
GO:0002446 |
19 |
0.027
|
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.027
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.027
|
|
