Mus musculus

0 known processes

Smpd1

sphingomyelin phosphodiesterase 1, acid lysosomal

(Aliases: aSMase,Zn-SMase,A-SMase,ASM)

Smpd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of secretion GO:0051046 274 0.081
nucleoside phosphate metabolic process GO:0006753 338 0.079
regulation of cellular amine metabolic process GO:0033238 20 0.069
cellular lipid metabolic process GO:0044255 323 0.067
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.066
cellular amino acid metabolic process GO:0006520 103 0.066
glycoprotein biosynthetic process GO:0009101 89 0.058
amine metabolic process GO:0009308 45 0.047
carbohydrate metabolic process GO:0005975 230 0.043
cellular response to extracellular stimulus GO:0031668 81 0.043
regulation of cellular ketone metabolic process GO:0010565 66 0.041
vacuole organization GO:0007033 38 0.040
organophosphate catabolic process GO:0046434 232 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
cellular amine metabolic process GO:0044106 44 0.037
transmembrane transport GO:0055085 412 0.036
sensory system development GO:0048880 3 0.036
sulfur compound metabolic process GO:0006790 100 0.036
carbohydrate derivative biosynthetic process GO:1901137 183 0.036
cation transmembrane transport GO:0098655 266 0.034
intracellular protein transport GO:0006886 204 0.033
negative regulation of molecular function GO:0044092 258 0.033
Human
positive regulation of protein modification process GO:0031401 299 0.033
Human
glycoprotein metabolic process GO:0009100 116 0.032
peptidyl amino acid modification GO:0018193 336 0.032
skin development GO:0043588 220 0.031
endomembrane system organization GO:0010256 147 0.031
lipid transport GO:0006869 98 0.030
renal system development GO:0072001 225 0.030
cation transport GO:0006812 399 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
anatomical structure homeostasis GO:0060249 145 0.029
lipid localization GO:0010876 126 0.028
cellular response to growth factor stimulus GO:0071363 197 0.028
negative regulation of intracellular signal transduction GO:1902532 167 0.027
Human
rho protein signal transduction GO:0007266 32 0.027
action potential GO:0001508 78 0.027
nucleotide metabolic process GO:0009117 332 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
heterocycle catabolic process GO:0046700 280 0.026
leukocyte differentiation GO:0002521 342 0.025
cellular ketone metabolic process GO:0042180 84 0.025
mapk cascade GO:0000165 281 0.025
Human
positive regulation of apoptotic process GO:0043065 217 0.025
axonogenesis GO:0007409 274 0.025
ossification GO:0001503 216 0.024
negative regulation of cellular amine metabolic process GO:0033239 1 0.024
inorganic cation transmembrane transport GO:0098662 207 0.024
inorganic ion transmembrane transport GO:0098660 234 0.024
heart morphogenesis GO:0003007 178 0.023
purine containing compound catabolic process GO:0072523 213 0.023
protein glycosylation GO:0006486 55 0.023
organelle assembly GO:0070925 177 0.023
cellular homeostasis GO:0019725 240 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.022
endocytosis GO:0006897 168 0.022
macroautophagy GO:0016236 21 0.021
lipid biosynthetic process GO:0008610 179 0.021
Human
urogenital system development GO:0001655 261 0.021
apoptotic signaling pathway GO:0097190 306 0.021
circulatory system process GO:0003013 197 0.021
myelination GO:0042552 74 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
positive regulation of leukocyte differentiation GO:1902107 86 0.020
plasma membrane organization GO:0007009 90 0.020
dna metabolic process GO:0006259 303 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
Human
oxidation reduction process GO:0055114 342 0.019
cellular divalent inorganic cation homeostasis GO:0072503 127 0.019
response to extracellular stimulus GO:0009991 127 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
developmental maturation GO:0021700 193 0.019
regulation of leukocyte differentiation GO:1902105 159 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
inflammatory response GO:0006954 244 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
ion transmembrane transport GO:0034220 361 0.019
cellular response to nutrient levels GO:0031669 64 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
cellular response to external stimulus GO:0071496 88 0.019
regulation of cell activation GO:0050865 289 0.018
maintenance of location GO:0051235 89 0.018
response to organonitrogen compound GO:0010243 246 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.018
cell maturation GO:0048469 127 0.018
cellular nitrogen compound catabolic process GO:0044270 280 0.018
chemotaxis GO:0006935 247 0.018
cation homeostasis GO:0055080 212 0.018
multicellular organismal homeostasis GO:0048871 164 0.017
macromolecule glycosylation GO:0043413 55 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
nucleotide sugar metabolic process GO:0009225 4 0.017
nitrogen compound transport GO:0071705 271 0.017
negative regulation of growth GO:0045926 99 0.016
small gtpase mediated signal transduction GO:0007264 97 0.016
ribonucleotide metabolic process GO:0009259 291 0.016
response to inorganic substance GO:0010035 96 0.016
cellular chemical homeostasis GO:0055082 215 0.016
dephosphorylation GO:0016311 129 0.016
Human
ras protein signal transduction GO:0007265 77 0.016
protein maturation GO:0051604 176 0.016
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.016
positive regulation of cell death GO:0010942 224 0.016
regulation of cellular catabolic process GO:0031329 242 0.016
glycerolipid metabolic process GO:0046486 122 0.016
positive regulation of secretion by cell GO:1903532 114 0.016
negative regulation of nervous system development GO:0051961 156 0.016
macromolecule catabolic process GO:0009057 281 0.016
blood circulation GO:0008015 195 0.016
regulation of secretion by cell GO:1903530 249 0.015
cellular lipid catabolic process GO:0044242 52 0.015
glycosylation GO:0070085 62 0.015
extracellular structure organization GO:0043062 148 0.015
regulation of membrane potential GO:0042391 192 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
Human
sensory organ morphogenesis GO:0090596 242 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
nucleotide catabolic process GO:0009166 217 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
Human
response to nutrient levels GO:0031667 109 0.015
autophagy GO:0006914 45 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
regulation of cellular response to stress GO:0080135 159 0.015
ear development GO:0043583 200 0.015
pigmentation GO:0043473 71 0.015
camera type eye development GO:0043010 266 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
Human
t cell activation GO:0042110 289 0.015
immune effector process GO:0002252 321 0.015
lateral line system development GO:0048925 1 0.015
protein processing GO:0016485 163 0.015
respiratory system development GO:0060541 190 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
hair cell differentiation GO:0035315 40 0.014
aromatic compound catabolic process GO:0019439 286 0.014
attachment of spindle microtubules to kinetochore GO:0008608 4 0.014
protein kinase b signaling GO:0043491 74 0.014
interspecies interaction between organisms GO:0044419 83 0.014
fatty acid metabolic process GO:0006631 121 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
regulation of protein localization GO:0032880 231 0.014
regulation of cytokine production GO:0001817 266 0.014
regulation of cell cycle GO:0051726 281 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
lymphocyte differentiation GO:0030098 242 0.014
response to starvation GO:0042594 65 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
nucleoside catabolic process GO:0009164 206 0.014
epithelial cell proliferation GO:0050673 174 0.014
protein localization to plasma membrane GO:0072659 57 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
Human
organic cyclic compound catabolic process GO:1901361 295 0.013
nucleoside metabolic process GO:0009116 246 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
transmission of nerve impulse GO:0019226 76 0.013
negative regulation of cellular catabolic process GO:0031330 47 0.013
response to oxidative stress GO:0006979 123 0.013
regulation of t cell activation GO:0050863 170 0.013
positive regulation of secretion GO:0051047 130 0.013
negative regulation of synapse assembly GO:0051964 3 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
single organism cell adhesion GO:0098602 156 0.013
peptidyl tyrosine modification GO:0018212 145 0.013
autophagic vacuole assembly GO:0000045 13 0.013
regulation of hormone levels GO:0010817 211 0.013
epidermis development GO:0008544 187 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
alcohol metabolic process GO:0006066 116 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
response to monosaccharide GO:0034284 67 0.013
organelle fission GO:0048285 170 0.013
germ cell development GO:0007281 185 0.013
negative regulation of cell development GO:0010721 169 0.013
organelle localization GO:0051640 179 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
regulation of cell motility GO:2000145 236 0.013
learning or memory GO:0007611 148 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
muscle system process GO:0003012 141 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
glucose homeostasis GO:0042593 128 0.012
ribose phosphate metabolic process GO:0019693 291 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
substantia nigra development GO:0021762 2 0.012
lipid catabolic process GO:0016042 69 0.012
neuronal action potential GO:0019228 54 0.012
mesoderm development GO:0007498 100 0.012
multicellular organism growth GO:0035264 161 0.012
skeletal system development GO:0001501 356 0.012
compound eye development GO:0048749 1 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
regulation of body fluid levels GO:0050878 162 0.012
lipoprotein metabolic process GO:0042157 43 0.012
acetate ester transport GO:1901374 2 0.012
modification by symbiont of host morphology or physiology GO:0044003 4 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
lysosome organization GO:0007040 21 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
multicellular organismal signaling GO:0035637 91 0.012
cellular response to oxidative stress GO:0034599 76 0.012
acetylcholine transport GO:0015870 2 0.012
male gamete generation GO:0048232 285 0.012
glycerophospholipid metabolic process GO:0006650 71 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
wnt signaling pathway GO:0016055 188 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
establishment of protein localization to membrane GO:0090150 54 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of organelle organization GO:0033043 289 0.012
glycerolipid biosynthetic process GO:0045017 50 0.012
muscle contraction GO:0006936 101 0.012
organic acid biosynthetic process GO:0016053 86 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
regulation of defense response GO:0031347 233 0.011
membrane organization GO:0061024 245 0.011
extracellular matrix organization GO:0030198 147 0.011
regulation of cell growth GO:0001558 91 0.011
sensory perception GO:0007600 245 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
wound healing GO:0042060 157 0.011
regulation of system process GO:0044057 200 0.011
positive regulation of cell activation GO:0050867 158 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
muscle tissue development GO:0060537 308 0.011
neutral lipid metabolic process GO:0006638 57 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
cellular response to starvation GO:0009267 57 0.011
response to epidermal growth factor GO:0070849 4 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
respiratory gaseous exchange GO:0007585 43 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
response to peptide GO:1901652 136 0.011
positive regulation of nervous system development GO:0051962 221 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
exocytosis GO:0006887 121 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010
regulation of lymphocyte differentiation GO:0045619 107 0.010
carboxylic acid biosynthetic process GO:0046394 86 0.010
positive regulation of organelle organization GO:0010638 128 0.010
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.010
regulation of multi organism process GO:0043900 111 0.010
organic hydroxy compound transport GO:0015850 93 0.010
negative regulation of protein modification process GO:0031400 163 0.010
Human
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
cytokine production GO:0001816 319 0.010
purine containing compound metabolic process GO:0072521 311 0.010
protein modification by small protein conjugation GO:0032446 187 0.010
locomotory behavior GO:0007626 195 0.010
regulation of transmembrane transport GO:0034762 128 0.010
nucleoside monophosphate catabolic process GO:0009125 59 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
cellular amide metabolic process GO:0043603 58 0.010
cellular polysaccharide metabolic process GO:0044264 38 0.010

Smpd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.157
Human
inherited metabolic disorder DOID:655 0 0.039
Human
central nervous system disease DOID:331 0 0.038
disease of anatomical entity DOID:7 0 0.038
Human
nervous system disease DOID:863 0 0.038
brain disease DOID:936 0 0.016
sensory system disease DOID:0050155 0 0.012
acquired metabolic disease DOID:0060158 0 0.010
cardiovascular system disease DOID:1287 0 0.010
immune system disease DOID:2914 0 0.010
Human