Mus musculus

117 known processes

Pias1

protein inhibitor of activated STAT 1

(Aliases: 2900068C24Rik,Ddxbp1,GBP)

Pias1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule catabolic process GO:0044265 206 0.846
regulation of transcription from rna polymerase ii promoter by galactose GO:0000431 1 0.755
appendage development GO:0048736 166 0.543
leukocyte mediated cytotoxicity GO:0001909 62 0.507
histone modification GO:0016570 159 0.501
modification dependent protein catabolic process GO:0019941 133 0.387
histone lysine methylation GO:0034968 50 0.372
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.361
dna alkylation GO:0006305 43 0.358
protein modification by small protein conjugation GO:0032446 187 0.348
covalent chromatin modification GO:0016569 163 0.326
macromolecule methylation GO:0043414 120 0.294
modification dependent macromolecule catabolic process GO:0043632 133 0.253
skeletal system development GO:0001501 356 0.245
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.238
Mouse
cellular protein catabolic process GO:0044257 155 0.238
dna methylation GO:0006306 43 0.236
protein methylation GO:0006479 81 0.236
histone methylation GO:0016571 71 0.224
protein modification by small protein conjugation or removal GO:0070647 207 0.211
negative regulation of protein metabolic process GO:0051248 282 0.197
chromatin organization GO:0006325 206 0.188
cytoplasmic transport GO:0016482 234 0.174
regulation of response to drug GO:2001023 2 0.171
regulation of cellular protein catabolic process GO:1903362 61 0.164
embryonic organ morphogenesis GO:0048562 276 0.157
methylation GO:0032259 134 0.144
positive regulation of transcription from rna polymerase ii promoter by galactose GO:0000435 1 0.136
lymphocyte mediated immunity GO:0002449 139 0.134
peptidyl amino acid modification GO:0018193 336 0.128
gene silencing GO:0016458 38 0.123
histone h3 k9 methylation GO:0051567 17 0.122
protein localization to organelle GO:0033365 185 0.116
peptidyl lysine methylation GO:0018022 29 0.110
skeletal muscle organ development GO:0060538 163 0.105
immune effector process GO:0002252 321 0.100
smoothened signaling pathway GO:0007224 105 0.097
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.096
innate immune response GO:0045087 157 0.096
Fly
protein catabolic process GO:0030163 221 0.096
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.095
Mouse
ventral spinal cord interneuron differentiation GO:0021514 16 0.090
protein import into nucleus GO:0006606 95 0.086
central nervous system neuron differentiation GO:0021953 162 0.084
protein localization to nucleus GO:0034504 121 0.084
apoptotic signaling pathway GO:0097190 306 0.078
Mouse
carbon catabolite activation of transcription GO:0045991 4 0.075
regulation of protein localization GO:0032880 231 0.073
activation of immune response GO:0002253 138 0.072
chromatin modification GO:0016568 187 0.071
germ cell development GO:0007281 185 0.071
spinal cord development GO:0021510 81 0.069
lens development in camera type eye GO:0002088 62 0.069
cellular response to dna damage stimulus GO:0006974 207 0.067
Mouse Worm Fly
embryonic epithelial tube formation GO:0001838 130 0.067
rna catabolic process GO:0006401 29 0.066
tube closure GO:0060606 91 0.065
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.064
regulation of histone modification GO:0031056 56 0.064
limb morphogenesis GO:0035108 149 0.063
regulation of chromatin silencing GO:0031935 2 0.062
regulation of cellular catabolic process GO:0031329 242 0.061
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.061
histone h3 k36 methylation GO:0010452 6 0.061
regulation of keratinocyte differentiation GO:0045616 11 0.060
natural killer cell mediated immunity GO:0002228 29 0.060
protein ubiquitination GO:0016567 171 0.059
intracellular protein transport GO:0006886 204 0.059
female sex differentiation GO:0046660 84 0.058
histone h3 k9 trimethylation GO:0036124 6 0.055
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.054
limb development GO:0060173 166 0.050
internal protein amino acid acetylation GO:0006475 42 0.050
positive regulation of programmed cell death GO:0043068 218 0.050
Mouse
camera type eye development GO:0043010 266 0.050
negative regulation of molecular function GO:0044092 258 0.049
Mouse
macromolecule catabolic process GO:0009057 281 0.049
muscle tissue development GO:0060537 308 0.048
ventral spinal cord interneuron specification GO:0021521 11 0.048
regulation of protein processing GO:0070613 96 0.048
regionalization GO:0003002 337 0.045
immune response activating signal transduction GO:0002757 116 0.045
peptidyl lysine modification GO:0018205 77 0.044
vesicle organization GO:0016050 60 0.042
cytokine production GO:0001816 319 0.042
peptidyl lysine trimethylation GO:0018023 12 0.042
skeletal muscle cell differentiation GO:0035914 66 0.041
regulation of gene silencing GO:0060968 7 0.041
appendage morphogenesis GO:0035107 149 0.040
maintenance of location GO:0051235 89 0.040
cellular carbohydrate metabolic process GO:0044262 119 0.040
heterocycle catabolic process GO:0046700 280 0.040
negative regulation of intracellular protein transport GO:0090317 27 0.039
positive regulation of organelle organization GO:0010638 128 0.039
gland development GO:0048732 330 0.039
blastocyst development GO:0001824 80 0.039
positive regulation of apoptotic process GO:0043065 217 0.038
Mouse
leukocyte mediated immunity GO:0002443 174 0.038
internal peptidyl lysine acetylation GO:0018393 42 0.038
carbon catabolite regulation of transcription GO:0045990 4 0.038
negative regulation of chromatin silencing GO:0031936 1 0.037
embryonic heart tube morphogenesis GO:0003143 51 0.037
multicellular organism growth GO:0035264 161 0.036
Worm
chemotaxis GO:0006935 247 0.036
posttranscriptional regulation of gene expression GO:0010608 155 0.036
histone acetylation GO:0016573 41 0.036
neuron apoptotic process GO:0051402 142 0.036
cellular response to external stimulus GO:0071496 88 0.035
ventral spinal cord development GO:0021517 48 0.035
positive regulation of transcription by galactose GO:0000411 1 0.034
skin development GO:0043588 220 0.034
hematopoietic progenitor cell differentiation GO:0002244 143 0.034
nuclear division GO:0000280 158 0.034
neural tube closure GO:0001843 90 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.033
t cell proliferation GO:0042098 120 0.032
protein polyubiquitination GO:0000209 33 0.032
negative regulation of meiotic cell cycle GO:0051447 14 0.032
regulation of protein binding GO:0043393 60 0.031
lymphocyte differentiation GO:0030098 242 0.031
positive regulation of protein phosphorylation GO:0001934 242 0.031
regulation of establishment of protein localization GO:0070201 181 0.031
positive regulation of keratinocyte differentiation GO:0045618 3 0.030
spinal cord patterning GO:0021511 25 0.030
genitalia development GO:0048806 37 0.030
Worm
determination of heart left right asymmetry GO:0061371 48 0.030
regulation of organelle organization GO:0033043 289 0.030
striated muscle tissue development GO:0014706 293 0.030
regulation of embryonic development GO:0045995 71 0.029
positive regulation of cell development GO:0010720 237 0.029
regulation of smoothened signaling pathway GO:0008589 58 0.029
transmembrane transport GO:0055085 412 0.029
negative regulation of t cell activation GO:0050868 65 0.029
epithelial tube formation GO:0072175 130 0.028
mapk cascade GO:0000165 281 0.028
mrna metabolic process GO:0016071 84 0.028
regulation of transcription during meiosis GO:0051037 1 0.028
ventral spinal cord interneuron fate commitment GO:0060579 14 0.028
dna repair GO:0006281 107 0.028
ear development GO:0043583 200 0.027
positive regulation of protein modification process GO:0031401 299 0.027
Human
mrna catabolic process GO:0006402 22 0.027
negative regulation of protein catabolic process GO:0042177 36 0.027
negative regulation of intracellular transport GO:0032387 38 0.027
regulation of hydrolase activity GO:0051336 246 0.027
neural tube development GO:0021915 160 0.027
nucleocytoplasmic transport GO:0006913 139 0.026
negative regulation of smoothened signaling pathway GO:0045879 25 0.026
keratinocyte differentiation GO:0030216 48 0.026
positive regulation of chromatin modification GO:1903310 28 0.026
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 12 0.026
neural precursor cell proliferation GO:0061351 121 0.025
negative regulation of intracellular signal transduction GO:1902532 167 0.025
cell type specific apoptotic process GO:0097285 268 0.025
Mouse
regulation of protein transport GO:0051223 163 0.025
negative regulation of binding GO:0051100 39 0.024
response to nutrient levels GO:0031667 109 0.024
regulation of binding GO:0051098 111 0.023
female genitalia development GO:0030540 14 0.023
regulation of apoptotic signaling pathway GO:2001233 197 0.023
Mouse
axonogenesis GO:0007409 274 0.023
myeloid cell differentiation GO:0030099 233 0.023
cell killing GO:0001906 67 0.023
heart morphogenesis GO:0003007 178 0.023
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.023
regulation of neuron differentiation GO:0045664 281 0.022
lymphocyte proliferation GO:0046651 164 0.022
nuclear transport GO:0051169 139 0.022
positive regulation of apoptotic signaling pathway GO:2001235 95 0.022
Mouse
regulation of mapk cascade GO:0043408 248 0.022
regulation of chromosome organization GO:0033044 83 0.022
cellular response to drug GO:0035690 15 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
spinal cord dorsal ventral patterning GO:0021513 23 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
interferon gamma secretion GO:0072643 7 0.021
neural tube formation GO:0001841 108 0.021
negative regulation of gene silencing GO:0060969 2 0.021
protein autophosphorylation GO:0046777 61 0.021
negative regulation of cellular catabolic process GO:0031330 47 0.021
muscle cell differentiation GO:0042692 261 0.021
regulation of meiotic cell cycle GO:0051445 34 0.021
deoxyribonucleoside triphosphate biosynthetic process GO:0009202 2 0.020
positive regulation of dna templated transcription elongation GO:0032786 2 0.020
cellular response to nutrient levels GO:0031669 64 0.020
positive regulation of nervous system development GO:0051962 221 0.020
organelle fission GO:0048285 170 0.020
cell fate commitment involved in pattern specification GO:0060581 14 0.020
neuron fate specification GO:0048665 30 0.020
positive regulation of defense response GO:0031349 124 0.020
Fly
sensory perception of sound GO:0007605 97 0.019
regulation of mitotic cell cycle phase transition GO:1901990 73 0.019
Fly
regulation of glucose metabolic process GO:0010906 60 0.019
dorsal ventral neural tube patterning GO:0021904 28 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
lung development GO:0030324 164 0.019
protein acylation GO:0043543 64 0.019
regulation of carbohydrate metabolic process GO:0006109 75 0.019
endocytosis GO:0006897 168 0.019
cell proliferation in forebrain GO:0021846 30 0.019
regulation of protein kinase b signaling GO:0051896 56 0.019
hepaticobiliary system development GO:0061008 67 0.018
t cell activation GO:0042110 289 0.018
labyrinthine layer development GO:0060711 49 0.018
regulation of dna methylation GO:0044030 12 0.018
placenta development GO:0001890 140 0.018
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.018
regulation of protein targeting GO:1903533 61 0.018
neuronal action potential GO:0019228 54 0.018
negative regulation of transcription factor import into nucleus GO:0042992 13 0.018
renal tubule development GO:0061326 87 0.018
regulation of protein maturation GO:1903317 96 0.018
rna 3 end processing GO:0031123 20 0.018
cell aging GO:0007569 35 0.017
regulation of histone methylation GO:0031060 30 0.017
spermatogenesis GO:0007283 284 0.017
carbohydrate catabolic process GO:0016052 32 0.017
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.017
single organism nuclear import GO:1902593 95 0.017
regulation of transcription by galactose GO:0000409 1 0.017
regulation of lymphocyte proliferation GO:0050670 117 0.017
cellular amine metabolic process GO:0044106 44 0.017
lipid homeostasis GO:0055088 63 0.017
transcription from rna polymerase iii promoter GO:0006383 3 0.017
negative regulation of proteolysis GO:0045861 74 0.017
regulation of cytoplasmic mrna processing body assembly GO:0010603 2 0.017
digestive tract morphogenesis GO:0048546 147 0.017
natural killer cell mediated cytotoxicity GO:0042267 29 0.017
development of primary sexual characteristics GO:0045137 143 0.016
Worm
cell differentiation in spinal cord GO:0021515 53 0.016
b cell activation involved in immune response GO:0002312 50 0.016
negative regulation of protein localization to nucleus GO:1900181 23 0.016
digestive tract development GO:0048565 190 0.016
Worm
carbohydrate metabolic process GO:0005975 230 0.016
adaptive immune response GO:0002250 155 0.016
response to growth factor GO:0070848 198 0.016
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.016
histone h4 acetylation GO:0043967 10 0.016
compound eye development GO:0048749 1 0.016
Fly
male gamete generation GO:0048232 285 0.016
sensory organ morphogenesis GO:0090596 242 0.015
regulation of ion transmembrane transport GO:0034765 119 0.015
meiotic nuclear division GO:0007126 115 0.015
regulation of transcription factor import into nucleus GO:0042990 24 0.015
regulation of t cell proliferation GO:0042129 92 0.015
ion transmembrane transport GO:0034220 361 0.015
mitotic sister chromatid cohesion GO:0007064 1 0.015
regulation of nuclear division GO:0051783 56 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
determination of left right symmetry GO:0007368 80 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
regulation of protein import into nucleus GO:0042306 52 0.014
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.014
bone development GO:0060348 120 0.014
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.014
digestive system development GO:0055123 200 0.014
Worm
regulation of proteolysis GO:0030162 164 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
cytokine secretion GO:0050663 72 0.014
regulation of ossification GO:0030278 112 0.014
Mouse
positive regulation of chromosome organization GO:2001252 33 0.014
stress activated protein kinase signaling cascade GO:0031098 81 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
cellular lipid metabolic process GO:0044255 323 0.014
regulation of protein localization to nucleus GO:1900180 60 0.014
histone h3 k9 dimethylation GO:0036123 4 0.014
primary neural tube formation GO:0014020 95 0.014
negative regulation of cytoplasmic transport GO:1903650 29 0.014
regulation of cellular response to drug GO:2001038 1 0.014
regulation of cell migration GO:0030334 219 0.014
peptidyl lysine acetylation GO:0018394 45 0.014
positive regulation of cell death GO:0010942 224 0.014
Mouse
regulation of chromatin organization GO:1902275 57 0.014
cellular response to molecule of bacterial origin GO:0071219 83 0.014
negative regulation of nucleocytoplasmic transport GO:0046823 23 0.014
negative regulation of cell division GO:0051782 24 0.013
organelle localization GO:0051640 179 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
t cell apoptotic process GO:0070231 39 0.013
t cell differentiation GO:0030217 174 0.013
cellular amino acid metabolic process GO:0006520 103 0.013
cell division GO:0051301 120 0.013
regulation of transmembrane transport GO:0034762 128 0.013
connective tissue development GO:0061448 179 0.013
second messenger mediated signaling GO:0019932 73 0.013
organophosphate biosynthetic process GO:0090407 122 0.013
positive regulation of glial cell proliferation GO:0060252 4 0.013
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 14 0.013
rho protein signal transduction GO:0007266 32 0.013
cell cell recognition GO:0009988 44 0.013
protein maturation GO:0051604 176 0.013
steroid metabolic process GO:0008202 119 0.012
regulation of cell growth GO:0001558 91 0.012
regulation of membrane potential GO:0042391 192 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
regulation of intracellular transport GO:0032386 159 0.012
intrinsic apoptotic signaling pathway GO:0097193 132 0.012
Mouse
cartilage development GO:0051216 140 0.012
regulation of cell activation GO:0050865 289 0.012
glucose homeostasis GO:0042593 128 0.012
protein kinase b signaling GO:0043491 74 0.012
histone deacetylation GO:0016575 26 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
regulation of androgen receptor signaling pathway GO:0060765 3 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
negative regulation of organelle organization GO:0010639 90 0.012
development of secondary female sexual characteristics GO:0046543 8 0.012
alcohol metabolic process GO:0006066 116 0.012
negative regulation of cell development GO:0010721 169 0.012
positive regulation of histone modification GO:0031058 28 0.011
branching morphogenesis of an epithelial tube GO:0048754 159 0.011
regulation of protein ubiquitination GO:0031396 52 0.011
regulation of homeostatic process GO:0032844 182 0.011
respiratory system development GO:0060541 190 0.011
lipid localization GO:0010876 126 0.011
g1 s transition of mitotic cell cycle GO:0000082 57 0.011
renal system development GO:0072001 225 0.011
mammary gland morphogenesis GO:0060443 54 0.011
negative regulation of protein binding GO:0032091 17 0.011
regulation of stress activated mapk cascade GO:0032872 69 0.011
glucose metabolic process GO:0006006 92 0.011
protein processing GO:0016485 163 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
developmental maturation GO:0021700 193 0.011
positive regulation of homeostatic process GO:0032846 64 0.011
negative regulation of protein maturation GO:1903318 79 0.011
vagina development GO:0060068 11 0.011
respiratory tube development GO:0030323 167 0.011
regulation of response to wounding GO:1903034 189 0.011
wnt signaling pathway GO:0016055 188 0.011
spinal cord motor neuron differentiation GO:0021522 35 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
positive regulation of ras gtpase activity GO:0032320 65 0.010
cellular response to organic cyclic compound GO:0071407 87 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
establishment of protein localization to organelle GO:0072594 118 0.010
regulation of cytokine biosynthetic process GO:0042035 59 0.010
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.010
regulation of cellular amine metabolic process GO:0033238 20 0.010
metal ion homeostasis GO:0055065 189 0.010
epidermis development GO:0008544 187 0.010
protein alkylation GO:0008213 81 0.010
cation transport GO:0006812 399 0.010
histone h4 k16 acetylation GO:0043984 3 0.010

Pias1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.250
disease of cellular proliferation DOID:14566 0 0.250
organ system cancer DOID:0050686 0 0.226
nervous system cancer DOID:3093 0 0.181
central nervous system cancer DOID:3620 0 0.181
disease of anatomical entity DOID:7 0 0.046
nervous system disease DOID:863 0 0.046