Mus musculus

39 known processes

Tk1

thymidine kinase 1

(Aliases: Tk1a,Tk1b,Tk-1,D530002A18Rik)

Tk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.491
cellular response to dna damage stimulus GO:0006974 207 0.415
dna replication GO:0006260 52 0.290
nucleobase containing small molecule metabolic process GO:0055086 352 0.236
aromatic compound catabolic process GO:0019439 286 0.231
chromosome segregation GO:0007059 48 0.202
purine nucleoside triphosphate metabolic process GO:0009144 226 0.185
deoxyribonucleotide metabolic process GO:0009262 14 0.169
purine ribonucleotide metabolic process GO:0009150 290 0.161
heterocycle catabolic process GO:0046700 280 0.150
nucleotide metabolic process GO:0009117 332 0.148
nucleoside phosphate metabolic process GO:0006753 338 0.143
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.128
cellular nitrogen compound catabolic process GO:0044270 280 0.123
ribonucleoside metabolic process GO:0009119 245 0.121
purine ribonucleoside metabolic process GO:0046128 241 0.117
purine containing compound metabolic process GO:0072521 311 0.113
regulation of cell cycle GO:0051726 281 0.112
protein ubiquitination GO:0016567 171 0.112
dna repair GO:0006281 107 0.109
organic cyclic compound catabolic process GO:1901361 295 0.107
organelle localization GO:0051640 179 0.102
nucleoside triphosphate metabolic process GO:0009141 230 0.101
mitotic sister chromatid segregation GO:0000070 14 0.096
translesion synthesis GO:0019985 1 0.095
nucleoside monophosphate metabolic process GO:0009123 85 0.093
purine nucleoside metabolic process GO:0042278 241 0.089
proteasomal protein catabolic process GO:0010498 98 0.089
dna endoreduplication GO:0042023 4 0.089
covalent chromatin modification GO:0016569 163 0.087
organonitrogen compound catabolic process GO:1901565 264 0.086
lateral inhibition GO:0046331 1 0.083
asymmetric stem cell division GO:0098722 3 0.082
protein processing GO:0016485 163 0.082
cellular protein catabolic process GO:0044257 155 0.080
cellular amino acid metabolic process GO:0006520 103 0.078
histone modification GO:0016570 159 0.076
purine nucleotide metabolic process GO:0006163 302 0.076
nucleoside catabolic process GO:0009164 206 0.074
nuclear dna replication GO:0033260 3 0.073
purine containing compound catabolic process GO:0072523 213 0.073
dna dependent dna replication GO:0006261 24 0.070
macromolecule catabolic process GO:0009057 281 0.070
ubiquitin dependent protein catabolic process GO:0006511 129 0.069
protein modification by small protein conjugation or removal GO:0070647 207 0.067
ribonucleoside triphosphate catabolic process GO:0009203 199 0.067
ribonucleotide metabolic process GO:0009259 291 0.066
meiotic cell cycle process GO:1903046 77 0.066
modification dependent protein catabolic process GO:0019941 133 0.065
cellular homeostasis GO:0019725 240 0.065
ribonucleoside triphosphate metabolic process GO:0009199 220 0.064
nucleoside metabolic process GO:0009116 246 0.064
purine ribonucleoside catabolic process GO:0046130 205 0.063
purine nucleotide catabolic process GO:0006195 211 0.061
regulation of cellular ketone metabolic process GO:0010565 66 0.060
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.059
mitotic cell cycle GO:0000278 195 0.059
modification dependent macromolecule catabolic process GO:0043632 133 0.059
amine metabolic process GO:0009308 45 0.059
mitotic chromosome condensation GO:0007076 1 0.058
nucleoside phosphate catabolic process GO:1901292 222 0.058
deoxyribonucleotide biosynthetic process GO:0009263 6 0.057
cleavage furrow formation GO:0036089 2 0.057
meiotic nuclear division GO:0007126 115 0.056
ribose phosphate metabolic process GO:0019693 291 0.055
response to oxidative stress GO:0006979 123 0.055
cellular ketone metabolic process GO:0042180 84 0.054
regulation of cellular amino acid metabolic process GO:0006521 5 0.052
ribonucleoside monophosphate metabolic process GO:0009161 80 0.051
peptidyl amino acid modification GO:0018193 336 0.051
organelle assembly GO:0070925 177 0.050
nucleoside phosphate biosynthetic process GO:1901293 79 0.049
carbohydrate derivative biosynthetic process GO:1901137 183 0.048
regulation of cellular amine metabolic process GO:0033238 20 0.047
dna recombination GO:0006310 92 0.046
chromatin modification GO:0016568 187 0.046
endocytosis GO:0006897 168 0.046
germ cell development GO:0007281 185 0.046
purine nucleoside catabolic process GO:0006152 205 0.045
oxidation reduction process GO:0055114 342 0.045
regulation of secretion GO:0051046 274 0.045
regulation of mitotic cell cycle phase transition GO:1901990 73 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
cellular lipid metabolic process GO:0044255 323 0.044
negative regulation of chromatin silencing GO:0031936 1 0.043
organophosphate catabolic process GO:0046434 232 0.042
cellular amine metabolic process GO:0044106 44 0.042
male gamete generation GO:0048232 285 0.041
protein oligomerization GO:0051259 67 0.041
Human
microtubule based process GO:0007017 236 0.040
regulation of cellular response to stress GO:0080135 159 0.040
regulation of organelle organization GO:0033043 289 0.039
nucleoside triphosphate catabolic process GO:0009143 205 0.039
regulation of hydrolase activity GO:0051336 246 0.039
regulation of dna replication GO:0006275 17 0.039
carbohydrate derivative catabolic process GO:1901136 231 0.039
regulation of cell cycle process GO:0010564 160 0.038
regulation of cellular catabolic process GO:0031329 242 0.038
spindle midzone assembly GO:0051255 1 0.038
development of primary sexual characteristics GO:0045137 143 0.037
double strand break repair GO:0006302 48 0.037
regulation of cellular protein catabolic process GO:1903362 61 0.036
meiosis i GO:0007127 60 0.036
cation transport GO:0006812 399 0.036
sister chromatid cohesion GO:0007062 12 0.036
sister chromatid segregation GO:0000819 20 0.035
synapsis GO:0007129 34 0.035
nucleotide catabolic process GO:0009166 217 0.034
purine nucleoside monophosphate catabolic process GO:0009128 58 0.034
ribonucleoside catabolic process GO:0042454 206 0.034
regulation of dna dependent dna replication initiation GO:0030174 3 0.034
positive regulation of cellular amine metabolic process GO:0033240 5 0.033
circulatory system process GO:0003013 197 0.033
organonitrogen compound biosynthetic process GO:1901566 192 0.033
nuclear division GO:0000280 158 0.033
cellular protein complex assembly GO:0043623 116 0.033
mitotic nuclear division GO:0007067 48 0.033
synaptonemal complex assembly GO:0007130 13 0.032
positive regulation of chromosome segregation GO:0051984 4 0.032
response to organonitrogen compound GO:0010243 246 0.031
glycosyl compound metabolic process GO:1901657 246 0.031
apoptotic signaling pathway GO:0097190 306 0.031
protein catabolic process GO:0030163 221 0.031
gene silencing GO:0016458 38 0.031
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.031
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
cyclin catabolic process GO:0008054 1 0.030
regulation of mitotic cell cycle GO:0007346 126 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.030
mitotic cytokinesis GO:0000281 4 0.029
mitotic cell cycle process GO:1903047 159 0.029
regulation of chromosome segregation GO:0051983 21 0.028
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.028
ribonucleotide catabolic process GO:0009261 208 0.028
mitotic sister chromatid cohesion GO:0007064 1 0.028
nucleoside monophosphate catabolic process GO:0009125 59 0.028
atp metabolic process GO:0046034 75 0.028
regulation of defense response GO:0031347 233 0.028
positive regulation of cellular catabolic process GO:0031331 148 0.028
positive regulation of protein phosphorylation GO:0001934 242 0.027
protein localization to organelle GO:0033365 185 0.027
peptidyl serine phosphorylation GO:0018105 74 0.027
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
chromatin organization GO:0006325 206 0.026
cell type specific apoptotic process GO:0097285 268 0.026
gonad development GO:0008406 141 0.026
regulation of transferase activity GO:0051338 263 0.025
anion transport GO:0006820 177 0.025
female gamete generation GO:0007292 74 0.025
blood circulation GO:0008015 195 0.025
response to iron ion GO:0010039 4 0.025
protein maturation GO:0051604 176 0.025
regulation of spindle organization GO:0090224 2 0.025
spindle assembly involved in mitosis GO:0090307 4 0.025
microtubule based movement GO:0007018 84 0.024
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.024
dephosphorylation GO:0016311 129 0.024
mapk cascade GO:0000165 281 0.024
spermatogenesis GO:0007283 284 0.024
cytokine production GO:0001816 319 0.024
genitalia development GO:0048806 37 0.023
guanosine containing compound metabolic process GO:1901068 144 0.023
regulation of proteolysis GO:0030162 164 0.023
cellular chemical homeostasis GO:0055082 215 0.023
dna unwinding involved in dna replication GO:0006268 5 0.023
glycosyl compound catabolic process GO:1901658 206 0.023
gland development GO:0048732 330 0.023
leukocyte homeostasis GO:0001776 79 0.022
negative regulation of cell proliferation GO:0008285 296 0.022
lymphocyte differentiation GO:0030098 242 0.022
purine deoxyribonucleoside triphosphate metabolic process GO:0009215 7 0.022
histone serine phosphorylation GO:0035404 5 0.022
regulation of mitotic spindle organization GO:0060236 2 0.021
sensory perception GO:0007600 245 0.021
gtp metabolic process GO:0046039 144 0.021
regulation of mapk cascade GO:0043408 248 0.021
mitochondrion organization GO:0007005 134 0.021
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.021
myosin filament assembly GO:0031034 2 0.020
single fertilization GO:0007338 82 0.020
synaptic transmission GO:0007268 329 0.020
response to organic cyclic compound GO:0014070 198 0.020
microtubule cytoskeleton organization GO:0000226 157 0.020
energy derivation by oxidation of organic compounds GO:0015980 77 0.020
positive regulation of protein modification process GO:0031401 299 0.020
spindle assembly involved in female meiosis GO:0007056 3 0.020
protein polymerization GO:0051258 57 0.020
cytokinetic process GO:0032506 2 0.020
cellular response to biotic stimulus GO:0071216 92 0.019
ion transmembrane transport GO:0034220 361 0.019
positive regulation of protein kinase activity GO:0045860 144 0.019
cofactor metabolic process GO:0051186 80 0.019
protein tetramerization GO:0051262 23 0.019
Human
regulation of response to wounding GO:1903034 189 0.019
regulation of dna dependent dna replication GO:0090329 8 0.019
positive regulation of exit from mitosis GO:0031536 1 0.019
neural tube development GO:0021915 160 0.019
regulation of inflammatory response GO:0050727 147 0.019
establishment of organelle localization GO:0051656 122 0.018
cell cycle g1 s phase transition GO:0044843 57 0.018
organelle fission GO:0048285 170 0.018
mitotic sister chromatid separation GO:0051306 9 0.018
negative regulation of protein modification process GO:0031400 163 0.018
cellular amino acid catabolic process GO:0009063 25 0.018
carbohydrate metabolic process GO:0005975 230 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
spindle assembly involved in meiosis GO:0090306 4 0.018
nitrogen compound transport GO:0071705 271 0.018
nucleotide biosynthetic process GO:0009165 78 0.018
regulation of transcription by chromatin organization GO:0034401 0 0.018
muscle cell development GO:0055001 133 0.018
regulation of protein serine threonine kinase activity GO:0071900 157 0.018
transmembrane transport GO:0055085 412 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.018
cytoplasmic transport GO:0016482 234 0.018
regulation of exit from mitosis GO:0007096 1 0.018
female meiotic division GO:0007143 21 0.017
leukocyte differentiation GO:0002521 342 0.017
regulation of cell motility GO:2000145 236 0.017
myeloid cell differentiation GO:0030099 233 0.017
fibroblast proliferation GO:0048144 35 0.017
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.017
negative regulation of gene silencing GO:0060969 2 0.017
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
fertilization GO:0009566 127 0.017
regulation of cell cycle phase transition GO:1901987 77 0.017
response to lipopolysaccharide GO:0032496 128 0.017
cell adhesion GO:0007155 329 0.017
synaptonemal complex organization GO:0070193 15 0.017
response to inorganic substance GO:0010035 96 0.017
positive regulation of hydrolase activity GO:0051345 148 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
negative regulation of molecular function GO:0044092 258 0.017
embryonic epithelial tube formation GO:0001838 130 0.017
protein heterotetramerization GO:0051290 4 0.017
cytokinesis GO:0000910 17 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
positive regulation of cell cycle GO:0045787 92 0.016
hepaticobiliary system development GO:0061008 67 0.016
meiotic cell cycle GO:0051321 122 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
ras protein signal transduction GO:0007265 77 0.016
regulation of secretion by cell GO:1903530 249 0.016
striated muscle myosin thick filament assembly GO:0071688 1 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of cell migration GO:0030334 219 0.016
peptidyl serine modification GO:0018209 83 0.016
inflammatory response GO:0006954 244 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
cellular metal ion homeostasis GO:0006875 151 0.016
positive regulation of proteolysis GO:0045862 85 0.016
regulation of cell projection organization GO:0031344 206 0.016
asymmetric neuroblast division GO:0055059 1 0.015
cellular response to lipid GO:0071396 145 0.015
regulation of cell division GO:0051302 76 0.015
muscle cell differentiation GO:0042692 261 0.015
dna integrity checkpoint GO:0031570 28 0.015
carbohydrate homeostasis GO:0033500 128 0.015
response to metal ion GO:0010038 47 0.015
response to acid chemical GO:0001101 111 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
cellular component assembly involved in morphogenesis GO:0010927 139 0.015
regulation of cytokine production GO:0001817 266 0.015
regulation of kinase activity GO:0043549 249 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
regulation of mitotic sister chromatid segregation GO:0033047 12 0.015
camera type eye development GO:0043010 266 0.014
rho protein signal transduction GO:0007266 32 0.014
t cell activation GO:0042110 289 0.014
cell maturation GO:0048469 127 0.014
heart contraction GO:0060047 93 0.014
response to oxygen levels GO:0070482 62 0.014
atp catabolic process GO:0006200 55 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
membrane organization GO:0061024 245 0.014
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.014
peptide transport GO:0015833 133 0.014
protein kinase b signaling GO:0043491 74 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
negative regulation of cell cycle GO:0045786 123 0.014
cell division GO:0051301 120 0.014
myosin filament organization GO:0031033 3 0.014
neuron apoptotic process GO:0051402 142 0.014
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
homeostasis of number of cells GO:0048872 210 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
positive regulation of nervous system development GO:0051962 221 0.014
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.014
positive regulation of protein transport GO:0051222 93 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
glucose homeostasis GO:0042593 128 0.014
developmental maturation GO:0021700 193 0.014
cellular ion homeostasis GO:0006873 165 0.013
cofactor biosynthetic process GO:0051188 41 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
positive regulation of viral genome replication GO:0045070 2 0.013
organic anion transport GO:0015711 137 0.013
angiogenesis GO:0001525 201 0.013
anatomical structure homeostasis GO:0060249 145 0.013
deoxyribonucleotide catabolic process GO:0009264 5 0.013
heart process GO:0003015 94 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
base excision repair GO:0006284 9 0.013
organ growth GO:0035265 117 0.013
reciprocal meiotic recombination GO:0007131 16 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
cellular response to hexose stimulus GO:0071331 47 0.013
b cell activation GO:0042113 161 0.013
g1 s transition of mitotic cell cycle GO:0000082 57 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
mrna metabolic process GO:0016071 84 0.013
chromosome condensation GO:0030261 10 0.013
chromosome movement towards spindle pole GO:0051305 3 0.013
protein localization to chromosome centromeric region GO:0071459 1 0.012
striated muscle tissue development GO:0014706 293 0.012
regulation of cell activation GO:0050865 289 0.012
rna processing GO:0006396 105 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
cognition GO:0050890 149 0.012
positive regulation of ubiquitin protein transferase activity GO:0051443 4 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
regulation of homeostatic process GO:0032844 182 0.012
response to reactive oxygen species GO:0000302 56 0.012
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
muscle tissue development GO:0060537 308 0.012
negative regulation of hydrolase activity GO:0051346 71 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
regulation of protein processing GO:0070613 96 0.012
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
wnt signaling pathway GO:0016055 188 0.012
purine containing compound biosynthetic process GO:0072522 70 0.012
placenta development GO:0001890 140 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
response to radiation GO:0009314 165 0.012
locomotory behavior GO:0007626 195 0.012
metaphase plate congression GO:0051310 2 0.012
response to light stimulus GO:0009416 135 0.012
alpha amino acid biosynthetic process GO:1901607 15 0.012
regulation of protein kinase activity GO:0045859 232 0.012
positive regulation of cell death GO:0010942 224 0.012
negative regulation of cytoskeleton organization GO:0051494 36 0.012
regulation of protein transport GO:0051223 163 0.012
intracellular protein transport GO:0006886 204 0.012
apoptotic mitochondrial changes GO:0008637 48 0.012
innate immune response GO:0045087 157 0.011
regulation of hormone levels GO:0010817 211 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.011
mitotic centrosome separation GO:0007100 4 0.011
amide transport GO:0042886 138 0.011
purine nucleobase biosynthetic process GO:0009113 3 0.011
rna interference GO:0016246 2 0.011
neuron death GO:0070997 154 0.011
response to growth factor GO:0070848 198 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
positive regulation of transferase activity GO:0051347 167 0.011
hexose metabolic process GO:0019318 98 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
cell activation involved in immune response GO:0002263 126 0.011
lipid biosynthetic process GO:0008610 179 0.011
wound healing GO:0042060 157 0.011
epithelial tube formation GO:0072175 130 0.011
dendrite development GO:0016358 115 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
striated muscle cell development GO:0055002 125 0.011
t cell differentiation GO:0030217 174 0.011
negative regulation of protein maturation GO:1903318 79 0.011
activation of anaphase promoting complex activity GO:0051488 1 0.011
negative regulation of organelle organization GO:0010639 90 0.011
positive regulation of cell development GO:0010720 237 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
response to extracellular stimulus GO:0009991 127 0.011
respiratory tube development GO:0030323 167 0.011
leukocyte proliferation GO:0070661 172 0.010
regulation of intracellular transport GO:0032386 159 0.010
regulation of lipid metabolic process GO:0019216 118 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
rna catabolic process GO:0006401 29 0.010
myofibril assembly GO:0030239 34 0.010
guanosine containing compound catabolic process GO:1901069 144 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
stress activated mapk cascade GO:0051403 80 0.010
metal ion homeostasis GO:0055065 189 0.010
cellular response to oxidative stress GO:0034599 76 0.010
neural tube formation GO:0001841 108 0.010
epithelial cell proliferation GO:0050673 174 0.010
rhythmic process GO:0048511 174 0.010
lymphocyte homeostasis GO:0002260 64 0.010
humoral immune response GO:0006959 57 0.010
positive regulation of neuron projection development GO:0010976 79 0.010
protein secretion GO:0009306 111 0.010
oogenesis GO:0048477 56 0.010
reactive oxygen species metabolic process GO:0072593 84 0.010
liver development GO:0001889 66 0.010
peptidyl threonine phosphorylation GO:0018107 31 0.010
cardiocyte differentiation GO:0035051 87 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010

Tk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.104
inherited metabolic disorder DOID:655 0 0.104
disease of cellular proliferation DOID:14566 0 0.021
cancer DOID:162 0 0.016
gastrointestinal system cancer DOID:3119 0 0.014
organ system cancer DOID:0050686 0 0.014
intestinal cancer DOID:10155 0 0.011
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
carbohydrate metabolic disorder DOID:2978 0 0.010