Mus musculus

96 known processes

Ttc8

tetratricopeptide repeat domain 8

(Aliases: BBS8,AV001447,0610012F22Rik)

Ttc8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intraciliary retrograde transport GO:0035721 3 0.956
cilium morphogenesis GO:0060271 102 0.942
cilium assembly GO:0042384 81 0.928
cellular component assembly involved in morphogenesis GO:0010927 139 0.559
establishment of melanosome localization GO:0032401 11 0.492
smoothened signaling pathway GO:0007224 105 0.388
organelle assembly GO:0070925 177 0.274
melanosome transport GO:0032402 11 0.236
pigment granule localization GO:0051875 13 0.226
melanosome localization GO:0032400 12 0.211
microtubule based movement GO:0007018 84 0.203
Worm
sensory organ morphogenesis GO:0090596 242 0.159
intraciliary transport GO:0042073 9 0.147
Worm
nonmotile primary cilium assembly GO:0035058 8 0.145
Worm
appendage development GO:0048736 166 0.135
pigmentation GO:0043473 71 0.131
axoneme assembly GO:0035082 15 0.124
regulation of cilium assembly GO:1902017 7 0.096
microtubule based transport GO:0010970 50 0.086
Worm
limb development GO:0060173 166 0.085
protein localization to organelle GO:0033365 185 0.084
establishment of vesicle localization GO:0051650 81 0.075
nucleoside phosphate metabolic process GO:0006753 338 0.075
leptin mediated signaling pathway GO:0033210 4 0.073
skeletal system development GO:0001501 356 0.069
regulation of smoothened signaling pathway GO:0008589 58 0.069
retina development in camera type eye GO:0060041 119 0.067
camera type eye development GO:0043010 266 0.064
neural tube development GO:0021915 160 0.062
purine nucleotide metabolic process GO:0006163 302 0.061
cellular amino acid metabolic process GO:0006520 103 0.061
cytoskeleton dependent intracellular transport GO:0030705 50 0.061
Worm
eye photoreceptor cell differentiation GO:0001754 41 0.058
epithelial tube formation GO:0072175 130 0.058
pigment granule transport GO:0051904 12 0.055
vesicle localization GO:0051648 86 0.053
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.051
heterocycle catabolic process GO:0046700 280 0.050
cellular ketone metabolic process GO:0042180 84 0.049
establishment of pigment granule localization GO:0051905 12 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.048
regulation of cellular amine metabolic process GO:0033238 20 0.048
fat cell differentiation GO:0045444 160 0.048
embryonic epithelial tube formation GO:0001838 130 0.047
spermatogenesis GO:0007283 284 0.047
cellular amine metabolic process GO:0044106 44 0.046
cellular nitrogen compound catabolic process GO:0044270 280 0.045
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
ribonucleoside triphosphate catabolic process GO:0009203 199 0.044
cellular response to leptin stimulus GO:0044320 6 0.044
positive regulation of cellular amine metabolic process GO:0033240 5 0.043
regulation of response to food GO:0032095 10 0.043
purine containing compound metabolic process GO:0072521 311 0.043
purine nucleotide catabolic process GO:0006195 211 0.043
organonitrogen compound catabolic process GO:1901565 264 0.043
organelle localization GO:0051640 179 0.043
purine nucleoside metabolic process GO:0042278 241 0.043
tube formation GO:0035148 140 0.042
nucleoside metabolic process GO:0009116 246 0.042
amine metabolic process GO:0009308 45 0.041
primary neural tube formation GO:0014020 95 0.041
carbohydrate derivative catabolic process GO:1901136 231 0.041
negative regulation of cell proliferation GO:0008285 296 0.041
nucleoside triphosphate metabolic process GO:0009141 230 0.040
nucleotide metabolic process GO:0009117 332 0.040
digestive tract development GO:0048565 190 0.040
notch signaling pathway GO:0007219 71 0.039
telencephalon development GO:0021537 186 0.039
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.039
microtubule based process GO:0007017 236 0.039
Worm
forebrain development GO:0030900 302 0.039
nucleotide catabolic process GO:0009166 217 0.039
regionalization GO:0003002 337 0.037
determination of left right symmetry GO:0007368 80 0.037
gastrulation GO:0007369 116 0.037
nucleoside triphosphate catabolic process GO:0009143 205 0.037
ribonucleoside metabolic process GO:0009119 245 0.037
ribose phosphate metabolic process GO:0019693 291 0.037
organophosphate catabolic process GO:0046434 232 0.037
cilium movement involved in cell motility GO:0060294 5 0.036
male gamete generation GO:0048232 285 0.036
regulation of cilium beat frequency involved in ciliary motility GO:0060296 5 0.036
retina homeostasis GO:0001895 23 0.036
regulation of epithelial cell proliferation GO:0050678 141 0.036
glycosyl compound metabolic process GO:1901657 246 0.035
digestive system development GO:0055123 200 0.035
regulation of cellular catabolic process GO:0031329 242 0.034
ribonucleotide metabolic process GO:0009259 291 0.034
eye photoreceptor cell development GO:0042462 31 0.033
regulation of cilium movement involved in cell motility GO:0060295 5 0.033
nucleoside catabolic process GO:0009164 206 0.032
nucleobase containing small molecule metabolic process GO:0055086 352 0.032
sensory perception GO:0007600 245 0.032
regulation of cell projection organization GO:0031344 206 0.032
nucleoside phosphate catabolic process GO:1901292 222 0.032
urogenital system development GO:0001655 261 0.032
retina morphogenesis in camera type eye GO:0060042 45 0.031
small gtpase mediated signal transduction GO:0007264 97 0.031
purine ribonucleotide metabolic process GO:0009150 290 0.031
cellular response to hormone stimulus GO:0032870 150 0.031
microtubule cytoskeleton organization GO:0000226 157 0.031
cellular lipid metabolic process GO:0044255 323 0.031
purine ribonucleoside metabolic process GO:0046128 241 0.030
tube closure GO:0060606 91 0.030
ras protein signal transduction GO:0007265 77 0.030
photoreceptor cell differentiation GO:0046530 52 0.030
aromatic compound catabolic process GO:0019439 286 0.030
organic cyclic compound catabolic process GO:1901361 295 0.029
adult behavior GO:0030534 135 0.029
purine containing compound catabolic process GO:0072523 213 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.029
ribonucleoside triphosphate metabolic process GO:0009199 220 0.028
glycosyl compound catabolic process GO:1901658 206 0.028
photoreceptor cell maintenance GO:0045494 19 0.028
epithelial cell proliferation GO:0050673 174 0.028
multicellular organismal homeostasis GO:0048871 164 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
purine nucleoside triphosphate metabolic process GO:0009144 226 0.028
ribonucleoside catabolic process GO:0042454 206 0.027
cilium movement GO:0003341 28 0.027
regulation of cilium movement GO:0003352 6 0.027
skin development GO:0043588 220 0.026
axis elongation involved in somitogenesis GO:0090245 4 0.026
purine nucleoside catabolic process GO:0006152 205 0.026
visual perception GO:0007601 52 0.026
transmembrane transport GO:0055085 412 0.026
protein catabolic process GO:0030163 221 0.025
embryonic appendage morphogenesis GO:0035113 126 0.025
germ cell development GO:0007281 185 0.025
spermatid development GO:0007286 108 0.025
circulatory system process GO:0003013 197 0.025
kidney development GO:0001822 213 0.024
cilium dependent cell motility GO:0060285 6 0.024
neural retina development GO:0003407 41 0.024
membrane organization GO:0061024 245 0.024
ribonucleotide catabolic process GO:0009261 208 0.023
purine ribonucleoside catabolic process GO:0046130 205 0.023
photoreceptor cell development GO:0042461 40 0.023
anatomical structure homeostasis GO:0060249 145 0.023
regulation of organelle organization GO:0033043 289 0.023
cilium or flagellum dependent cell motility GO:0001539 6 0.023
glucose homeostasis GO:0042593 128 0.023
protein modification by small protein conjugation GO:0032446 187 0.023
cellular homeostasis GO:0019725 240 0.023
regulation of cell motility GO:2000145 236 0.023
cellular pigmentation GO:0033059 20 0.022
hematopoietic progenitor cell differentiation GO:0002244 143 0.022
spermatid differentiation GO:0048515 115 0.022
vasodilation GO:0042311 28 0.022
sensory perception of light stimulus GO:0050953 54 0.022
epidermis development GO:0008544 187 0.021
protein ubiquitination GO:0016567 171 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
limbic system development GO:0021761 72 0.021
gtp catabolic process GO:0006184 143 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
regulation of purine nucleotide catabolic process GO:0033121 122 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.021
purine ribonucleotide catabolic process GO:0009154 208 0.021
developmental growth involved in morphogenesis GO:0060560 138 0.021
regulation of purine nucleotide metabolic process GO:1900542 169 0.021
skeletal system morphogenesis GO:0048705 203 0.021
synapse organization GO:0050808 125 0.020
embryonic digit morphogenesis GO:0042733 56 0.020
response to nutrient levels GO:0031667 109 0.020
gtp metabolic process GO:0046039 144 0.020
cerebral cortex development GO:0021987 86 0.020
regulation of cellular response to growth factor stimulus GO:0090287 82 0.020
epithelial tube morphogenesis GO:0060562 303 0.020
dna metabolic process GO:0006259 303 0.020
maintenance of protein location in nucleus GO:0051457 2 0.020
digestive tract morphogenesis GO:0048546 147 0.020
renal system development GO:0072001 225 0.020
appendage morphogenesis GO:0035107 149 0.019
positive regulation of cellular catabolic process GO:0031331 148 0.019
connective tissue development GO:0061448 179 0.019
pallium development GO:0021543 120 0.019
regulation of hormone levels GO:0010817 211 0.019
response to extracellular stimulus GO:0009991 127 0.019
mitotic cytokinesis GO:0000281 4 0.019
nitrogen compound transport GO:0071705 271 0.019
organophosphate biosynthetic process GO:0090407 122 0.019
tissue homeostasis GO:0001894 115 0.019
embryonic organ morphogenesis GO:0048562 276 0.018
cognition GO:0050890 149 0.018
Worm
regulation of anatomical structure size GO:0090066 178 0.018
regulation of secretion GO:0051046 274 0.018
regulation of neuron differentiation GO:0045664 281 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
negative regulation of epithelial cell proliferation GO:0050680 64 0.018
proteasomal protein catabolic process GO:0010498 98 0.018
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
establishment of organelle localization GO:0051656 122 0.018
regulation of cell cycle GO:0051726 281 0.017
protein processing GO:0016485 163 0.017
microtubule anchoring at microtubule organizing center GO:0072393 5 0.017
hippocampus development GO:0021766 52 0.017
ear development GO:0043583 200 0.017
muscle tissue development GO:0060537 308 0.017
blood circulation GO:0008015 195 0.017
striated muscle tissue development GO:0014706 293 0.017
muscle contraction GO:0006936 101 0.017
mitotic cell cycle GO:0000278 195 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
rho protein signal transduction GO:0007266 32 0.017
negative regulation of growth GO:0045926 99 0.016
cellular protein catabolic process GO:0044257 155 0.016
atp metabolic process GO:0046034 75 0.016
response to organonitrogen compound GO:0010243 246 0.016
muscle system process GO:0003012 141 0.016
embryonic limb morphogenesis GO:0030326 126 0.016
multicellular organism growth GO:0035264 161 0.016
cytoplasmic transport GO:0016482 234 0.015
cation transport GO:0006812 399 0.015
regulation of membrane potential GO:0042391 192 0.015
regulation of cilium dependent cell motility GO:1902019 5 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
response to organic cyclic compound GO:0014070 198 0.015
protein maturation GO:0051604 176 0.015
negative regulation of cellular protein metabolic process GO:0032269 247 0.015
positive regulation of protein modification process GO:0031401 299 0.015
neural tube closure GO:0001843 90 0.015
regulation of secretion by cell GO:1903530 249 0.015
regulation of protein catabolic process GO:0042176 108 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
immune effector process GO:0002252 321 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
ear morphogenesis GO:0042471 118 0.014
cellular chemical homeostasis GO:0055082 215 0.014
limb morphogenesis GO:0035108 149 0.014
asymmetric stem cell division GO:0098722 3 0.014
sensory perception of mechanical stimulus GO:0050954 107 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
positive regulation of cell development GO:0010720 237 0.014
protein localization to membrane GO:0072657 108 0.014
regulation of blood vessel size GO:0050880 56 0.014
maintenance of location GO:0051235 89 0.014
neural precursor cell proliferation GO:0061351 121 0.014
peptidyl amino acid modification GO:0018193 336 0.014
response to growth factor GO:0070848 198 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
carbohydrate homeostasis GO:0033500 128 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
guanosine containing compound metabolic process GO:1901068 144 0.014
intracellular protein transport GO:0006886 204 0.014
cation transmembrane transport GO:0098655 266 0.014
compound eye development GO:0048749 1 0.013
muscle cell differentiation GO:0042692 261 0.013
regulation of protein localization GO:0032880 231 0.013
regulation of protein processing GO:0070613 96 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
peptide transport GO:0015833 133 0.013
renal tubule development GO:0061326 87 0.013
myeloid cell differentiation GO:0030099 233 0.013
regulation of homeostatic process GO:0032844 182 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
bone development GO:0060348 120 0.013
sensory perception of chemical stimulus GO:0007606 51 0.013
regulation of gtp catabolic process GO:0033124 113 0.013
insulin secretion GO:0030073 89 0.012
hormone secretion GO:0046879 128 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
positive regulation of nucleoside metabolic process GO:0045979 91 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
morphogenesis of embryonic epithelium GO:0016331 159 0.012
regulation of protein maturation GO:1903317 96 0.012
oxidation reduction process GO:0055114 342 0.012
oocyte axis specification GO:0007309 2 0.012
vascular process in circulatory system GO:0003018 62 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
response to transforming growth factor beta GO:0071559 88 0.012
positive regulation of cell projection organization GO:0031346 95 0.012
cell type specific apoptotic process GO:0097285 268 0.012
glycoprotein metabolic process GO:0009100 116 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.012
macromolecule catabolic process GO:0009057 281 0.012
positive regulation of growth GO:0045927 104 0.012
establishment or maintenance of cell polarity GO:0007163 86 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
asymmetric neuroblast division GO:0055059 1 0.012
regulation of cytokine production GO:0001817 266 0.012
vascular smooth muscle contraction GO:0014829 5 0.012
regulation of tube size GO:0035150 57 0.011
regulation of intracellular transport GO:0032386 159 0.011
regulation of proteolysis GO:0030162 164 0.011
modification dependent protein catabolic process GO:0019941 133 0.011
neural tube formation GO:0001841 108 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
positive regulation of nervous system development GO:0051962 221 0.011
learning or memory GO:0007611 148 0.011
Worm
endomembrane system organization GO:0010256 147 0.011
negative regulation of appetite GO:0032099 7 0.011
lymphocyte differentiation GO:0030098 242 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
action potential GO:0001508 78 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
olfactory learning GO:0008355 2 0.011
Worm
skeletal muscle organ development GO:0060538 163 0.011
developmental maturation GO:0021700 193 0.011
cytokine production GO:0001816 319 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
ossification GO:0001503 216 0.011
oocyte anterior posterior axis specification GO:0007314 2 0.011
carbohydrate metabolic process GO:0005975 230 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
sensory perception of sound GO:0007605 97 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
peptide secretion GO:0002790 114 0.011
response to monosaccharide GO:0034284 67 0.011
regulation of microtubule based process GO:0032886 52 0.011
regulation of multi organism process GO:0043900 111 0.011
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.011
cell fate commitment GO:0045165 210 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
regulation of protein transport GO:0051223 163 0.011
neuronal action potential GO:0019228 54 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
male courtship behavior GO:0008049 2 0.011
rhythmic process GO:0048511 174 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.011
cartilage development GO:0051216 140 0.011
smooth muscle contraction GO:0006939 44 0.011
regulation of cell activation GO:0050865 289 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.010
small molecule biosynthetic process GO:0044283 132 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
kidney epithelium development GO:0072073 121 0.010
reactive nitrogen species metabolic process GO:2001057 0 0.010
chemotaxis GO:0006935 247 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
transmission of nerve impulse GO:0019226 76 0.010
brain morphogenesis GO:0048854 32 0.010
regulation of lipid metabolic process GO:0019216 118 0.010
striatum development GO:0021756 14 0.010
exocytosis GO:0006887 121 0.010
vasoconstriction GO:0042310 27 0.010

Ttc8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.095
retinal disease DOID:5679 0 0.095
eye and adnexa disease DOID:1492 0 0.095
sensory system disease DOID:0050155 0 0.095
disease of anatomical entity DOID:7 0 0.095
eye disease DOID:5614 0 0.095
retinal degeneration DOID:8466 0 0.035
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.016
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.013
central nervous system disease DOID:331 0 0.013