Mus musculus

421 known processes

Stat5a

signal transducer and activator of transcription 5A

(Aliases: STAT5,AA959963)

Stat5a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
citrate metabolic process GO:0006101 3 1.000
creatine metabolic process GO:0006600 4 0.999
succinate metabolic process GO:0006105 4 0.998
taurine metabolic process GO:0019530 4 0.998
response to growth hormone GO:0060416 7 0.996
creatinine metabolic process GO:0046449 3 0.995
cd4 positive alpha beta t cell activation GO:0035710 45 0.991
Mouse
progesterone metabolic process GO:0042448 4 0.989
Mouse
regulation of jak stat cascade GO:0046425 34 0.989
Fly
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.986
Mouse
dicarboxylic acid metabolic process GO:0043648 18 0.985
allantoin metabolic process GO:0000255 3 0.985
positive regulation of mast cell differentiation GO:0060376 1 0.984
cellular lactam metabolic process GO:0072338 3 0.980
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.977
natural killer cell differentiation GO:0001779 21 0.976
jak stat cascade GO:0007259 42 0.973
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.972
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.971
isoleucine metabolic process GO:0006549 4 0.964
gamma delta t cell differentiation GO:0042492 11 0.961
phospholipid homeostasis GO:0055091 6 0.960
Mouse
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.960
Mouse
cellular response to x ray GO:0071481 2 0.959
Fly
regulation of b cell differentiation GO:0045577 23 0.958
peptidyl tyrosine phosphorylation GO:0018108 143 0.957
tricarboxylic acid metabolic process GO:0072350 5 0.956
cellular response to growth hormone stimulus GO:0071378 7 0.952
positive regulation of activated t cell proliferation GO:0042104 8 0.947
interleukin 2 biosynthetic process GO:0042094 15 0.945
cellular lipid metabolic process GO:0044255 323 0.940
t cell differentiation involved in immune response GO:0002292 30 0.931
Mouse
eye photoreceptor cell differentiation GO:0001754 41 0.931
Mouse
t helper 1 cell lineage commitment GO:0002296 2 0.930
Mouse
cellular response to peptide GO:1901653 92 0.925
carbohydrate metabolic process GO:0005975 230 0.924
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.924
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.922
Mouse
regulation of t cell activation GO:0050863 170 0.920
mammary gland lobule development GO:0061377 22 0.919
lactation GO:0007595 25 0.918
mast cell proliferation GO:0070662 4 0.918
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.917
Mouse
response to x ray GO:0010165 11 0.915
Fly
regulation of gamma delta t cell activation GO:0046643 9 0.914
regulation of interleukin 2 biosynthetic process GO:0045076 13 0.912
alpha beta t cell differentiation GO:0046632 69 0.910
Mouse
cellular ketone metabolic process GO:0042180 84 0.908
Mouse
regulation of natural killer cell activation GO:0032814 22 0.903
lymphocyte homeostasis GO:0002260 64 0.899
t cell lineage commitment GO:0002360 13 0.895
Mouse
positive regulation of natural killer cell activation GO:0032816 15 0.894
fatty acid metabolic process GO:0006631 121 0.892
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.892
Mouse
response to interleukin 4 GO:0070670 23 0.891
Mouse
regulation of antimicrobial humoral response GO:0002759 3 0.886
Fly
negative regulation of multi organism process GO:0043901 68 0.883
Fly
cellular amino acid metabolic process GO:0006520 103 0.883
activation of janus kinase activity GO:0042976 2 0.878
response to interferon gamma GO:0034341 34 0.877
Mouse
positive regulation of interleukin 2 biosynthetic process GO:0045086 8 0.877
macrophage fusion GO:0034238 3 0.872
Mouse
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.870
positive regulation of peptidase activity GO:0010952 49 0.868
Mouse
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.866
regulation of alpha beta t cell activation GO:0046634 53 0.860
mucosal associated lymphoid tissue development GO:0048537 12 0.855
regulation of leukocyte differentiation GO:1902105 159 0.852
positive regulation of gamma delta t cell activation GO:0046645 6 0.850
cellular response to ionizing radiation GO:0071479 11 0.850
Fly
regulation of cellular amino acid metabolic process GO:0006521 5 0.845
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.844
Mouse
positive t cell selection GO:0043368 23 0.843
Mouse
natural killer cell activation GO:0030101 44 0.843
growth hormone receptor signaling pathway GO:0060396 7 0.841
regulation of macrophage fusion GO:0034239 3 0.831
Mouse
activation of cysteine type endopeptidase activity GO:0097202 27 0.827
Mouse
response to interleukin 2 GO:0070669 2 0.823
Mouse
regulation of defense response to virus by host GO:0050691 8 0.821
Fly
positive regulation of endopeptidase activity GO:0010950 43 0.821
Mouse
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.820
regulation of t cell differentiation GO:0045580 83 0.819
mammary gland epithelial cell proliferation GO:0033598 24 0.818
Mouse
negative regulation of type 2 immune response GO:0002829 8 0.817
Mouse
alpha amino acid metabolic process GO:1901605 59 0.817
hormone mediated signaling pathway GO:0009755 23 0.816
regulation of cytokine production GO:0001817 266 0.815
cellular response to radiation GO:0071478 28 0.813
Fly
regulation of lymphocyte differentiation GO:0045619 107 0.813
regulation of interleukin 2 production GO:0032663 28 0.812
cellular response to lipopolysaccharide GO:0071222 77 0.804
Mouse Fly
alpha beta t cell activation involved in immune response GO:0002287 31 0.803
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.802
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.799
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.799
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.796
Mouse
peptidyl tyrosine modification GO:0018212 145 0.795
negative regulation of erythrocyte differentiation GO:0045647 5 0.794
development of secondary male sexual characteristics GO:0046544 3 0.789
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.787
Mouse
regulation of alpha beta t cell differentiation GO:0046637 35 0.783
regulation of natural killer cell proliferation GO:0032817 2 0.781
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.781
regulation of erythrocyte differentiation GO:0045646 23 0.779
cytokine production GO:0001816 319 0.777
cellular modified amino acid metabolic process GO:0006575 63 0.775
type i interferon signaling pathway GO:0060337 10 0.773
Mouse
negative regulation of syncytium formation by plasma membrane fusion GO:0034242 5 0.768
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.765
regulation of mast cell proliferation GO:0070666 4 0.763
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.762
carbohydrate catabolic process GO:0016052 32 0.759
Mouse
dna recombination GO:0006310 92 0.758
Mouse
alpha beta t cell lineage commitment GO:0002363 7 0.758
Mouse
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.756
Mouse
positive regulation of lymphocyte differentiation GO:0045621 61 0.755
regulation of endopeptidase activity GO:0052548 89 0.752
Mouse
leukocyte differentiation GO:0002521 342 0.750
positive regulation of b cell differentiation GO:0045579 13 0.744
response to peptide hormone GO:0043434 127 0.743
regulation of cysteine type endopeptidase activity GO:2000116 65 0.737
Mouse
mast cell apoptotic process GO:0033024 5 0.737
protein processing GO:0016485 163 0.737
Mouse
neuron migration GO:0001764 122 0.736
Mouse
regulation of hydrolase activity GO:0051336 246 0.729
Mouse
peptidyl amino acid modification GO:0018193 336 0.727
erythrocyte differentiation GO:0030218 88 0.725
positive regulation of t cell proliferation GO:0042102 52 0.717
response to epidermal growth factor GO:0070849 4 0.714
mammary gland alveolus development GO:0060749 22 0.713
monosaccharide metabolic process GO:0005996 106 0.710
positive regulation of natural killer cell differentiation GO:0032825 7 0.706
urogenital system development GO:0001655 261 0.701
hexose metabolic process GO:0019318 98 0.699
regulation of lymphocyte activation GO:0051249 240 0.698
positive regulation of lymphocyte proliferation GO:0050671 70 0.696
inflammatory response GO:0006954 244 0.693
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.691
regulation of cellular ketone metabolic process GO:0010565 66 0.688
response to lipopolysaccharide GO:0032496 128 0.687
Mouse Fly
leukocyte homeostasis GO:0001776 79 0.687
regulation of homeostatic process GO:0032844 182 0.686
regulation of kinase activity GO:0043549 249 0.680
leukocyte apoptotic process GO:0071887 71 0.679
response to ionizing radiation GO:0010212 42 0.678
Fly
multicellular organism growth GO:0035264 161 0.677
defense response to other organism GO:0098542 197 0.675
Fly
production of molecular mediator of immune response GO:0002440 103 0.666
Mouse
epithelial cell proliferation GO:0050673 174 0.664
Mouse
negative regulation of macrophage fusion GO:0034240 1 0.662
Mouse
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.657
positive regulation of defense response to virus by host GO:0002230 6 0.653
Fly
regulation of gamma delta t cell differentiation GO:0045586 9 0.650
response to peptide GO:1901652 136 0.650
t helper cell lineage commitment GO:0002295 6 0.649
Mouse
mammary gland epithelium development GO:0061180 65 0.648
body fluid secretion GO:0007589 53 0.647
regulation of t cell proliferation GO:0042129 92 0.646
somatic diversification of immune receptors GO:0002200 53 0.640
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.638
regulation of natural killer cell mediated immunity GO:0002715 19 0.627
t helper 1 cell differentiation GO:0045063 13 0.625
Mouse
cellular response to interleukin 4 GO:0071353 21 0.622
Mouse
regulation of adaptive immune response GO:0002819 90 0.619
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.613
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.607
positive regulation of adaptive immune response GO:0002821 61 0.607
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.603
alpha beta t cell activation GO:0046631 91 0.603
Mouse
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.603
adaptive immune response GO:0002250 155 0.601
Mouse
leukocyte proliferation GO:0070661 172 0.594
negative regulation of glycolytic process GO:0045820 4 0.589
Mouse
dna metabolic process GO:0006259 303 0.584
Mouse
positive regulation of t cell differentiation GO:0045582 52 0.577
regulation of activated t cell proliferation GO:0046006 16 0.576
regulation of type 2 immune response GO:0002828 18 0.563
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.559
sulfur compound metabolic process GO:0006790 100 0.558
cytokine biosynthetic process GO:0042089 68 0.549
positive regulation of proteolysis GO:0045862 85 0.549
Mouse
glucose metabolic process GO:0006006 92 0.548
cellular response to peptide hormone stimulus GO:0071375 92 0.546
regulation of peptidase activity GO:0052547 96 0.546
Mouse
lymphocyte differentiation GO:0030098 242 0.543
positive regulation of protein kinase activity GO:0045860 144 0.540
gland development GO:0048732 330 0.538
positive regulation of t cell activation GO:0050870 101 0.536
t helper cell differentiation GO:0042093 28 0.522
Mouse
somatic cell dna recombination GO:0016444 51 0.521
Mouse
pyruvate metabolic process GO:0006090 28 0.520
Mouse
mast cell differentiation GO:0060374 5 0.520
regulation of myeloid leukocyte differentiation GO:0002761 58 0.518
interleukin 4 mediated signaling pathway GO:0035771 2 0.516
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.514
defense response to virus GO:0051607 68 0.510
Fly
peyer s patch development GO:0048541 12 0.510
positive regulation of apoptotic process GO:0043065 217 0.509
Mouse
stem cell division GO:0017145 30 0.508
Fly
positive regulation of cell activation GO:0050867 158 0.500
lipid homeostasis GO:0055088 63 0.498
Mouse
positive regulation of cell killing GO:0031343 33 0.497
regulation of glucose metabolic process GO:0010906 60 0.491
valine metabolic process GO:0006573 4 0.490
photoreceptor cell differentiation GO:0046530 52 0.489
Mouse
t cell homeostasis GO:0043029 35 0.488
branched chain amino acid metabolic process GO:0009081 6 0.487
oxaloacetate metabolic process GO:0006107 5 0.482
regulation of cell activation GO:0050865 289 0.481
feeding behavior GO:0007631 62 0.481
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.479
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.479
Mouse
regulation of mast cell apoptotic process GO:0033025 5 0.479
g protein coupled receptor signaling pathway GO:0007186 243 0.478
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.469
syncytium formation by plasma membrane fusion GO:0000768 42 0.467
Mouse
generation of precursor metabolites and energy GO:0006091 103 0.458
Mouse
development of primary female sexual characteristics GO:0046545 73 0.457
leukocyte mediated cytotoxicity GO:0001909 62 0.457
type 2 immune response GO:0042092 23 0.456
Mouse
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.455
Mouse
t cell differentiation GO:0030217 174 0.455
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.450
Mouse
positive regulation of kinase activity GO:0033674 155 0.446
positive regulation of leukocyte proliferation GO:0070665 73 0.445
regulation of carbohydrate metabolic process GO:0006109 75 0.440
Mouse
syncytium formation GO:0006949 43 0.439
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.437
Mouse
maintenance of location GO:0051235 89 0.437
development of secondary female sexual characteristics GO:0046543 8 0.433
tyrosine phosphorylation of stat protein GO:0007260 23 0.433
monocarboxylic acid metabolic process GO:0032787 191 0.432
positive regulation of innate immune response GO:0045089 80 0.432
cellular carbohydrate metabolic process GO:0044262 119 0.431
Mouse
t cell selection GO:0045058 34 0.430
Mouse
embryonic placenta development GO:0001892 98 0.425
positive regulation of leukocyte mediated immunity GO:0002705 70 0.424
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.419
cellular response to epidermal growth factor stimulus GO:0071364 4 0.416
response to molecule of bacterial origin GO:0002237 143 0.413
Mouse Fly
regulation of protein kinase activity GO:0045859 232 0.411
negative regulation of nervous system development GO:0051961 156 0.410
Mouse
positive regulation of notch signaling pathway GO:0045747 18 0.409
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.409
immunoglobulin mediated immune response GO:0016064 69 0.405
Mouse
positive regulation of mast cell proliferation GO:0070668 3 0.404
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.403
oxidation reduction process GO:0055114 342 0.400
cellular amine metabolic process GO:0044106 44 0.395
regulation of lymphocyte proliferation GO:0050670 117 0.395
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.393
Mouse
response to organonitrogen compound GO:0010243 246 0.390
regulation of carbohydrate catabolic process GO:0043470 12 0.388
Mouse
segment specification GO:0007379 15 0.385
Fly
cell adhesion GO:0007155 329 0.377
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.374
Mouse
negative regulation of mast cell apoptotic process GO:0033026 4 0.372
regulation of activation of jak2 kinase activity GO:0010534 1 0.372
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.369
prolactin signaling pathway GO:0038161 5 0.368
post embryonic organ development GO:0048569 17 0.362
Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.362
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.361
carbohydrate biosynthetic process GO:0016051 74 0.359
mammary gland morphogenesis GO:0060443 54 0.356
Mouse Rat
regulation of cell adhesion GO:0030155 154 0.354
myeloid cell differentiation GO:0030099 233 0.351
negative regulation of neuron death GO:1901215 98 0.348
glycolytic process GO:0006096 20 0.348
Mouse
regulation of neuron death GO:1901214 134 0.345
cell activation involved in immune response GO:0002263 126 0.343
Mouse
somatic diversification of immunoglobulins GO:0016445 43 0.341
Mouse
response to type i interferon GO:0034340 12 0.340
Mouse
regulation of protein localization GO:0032880 231 0.340
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.338
Mouse
female sex differentiation GO:0046660 84 0.332
regulation of lymphocyte mediated immunity GO:0002706 84 0.331
negative regulation of myeloid cell differentiation GO:0045638 38 0.331
positive regulation of transferase activity GO:0051347 167 0.330
immune effector process GO:0002252 321 0.328
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.328
response to oxygen levels GO:0070482 62 0.327
positive regulation of cell death GO:0010942 224 0.323
Mouse
prostate gland morphogenesis GO:0060512 32 0.323
regulation of t helper 1 cell differentiation GO:0045625 7 0.322
negative regulation of lymphocyte activation GO:0051250 91 0.321
neuropeptide signaling pathway GO:0007218 19 0.320
regulation of carbohydrate biosynthetic process GO:0043255 40 0.320
negative regulation of neuron migration GO:2001223 6 0.318
Mouse
b cell differentiation GO:0030183 78 0.312
t cell proliferation GO:0042098 120 0.312
positive regulation of hydrolase activity GO:0051345 148 0.310
Mouse
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.310
Mouse
negative regulation of t cell activation GO:0050868 65 0.308
interleukin 2 production GO:0032623 33 0.307
lymphocyte proliferation GO:0046651 164 0.305
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.303
Mouse
learning or memory GO:0007611 148 0.301
Fly
cellular carbohydrate catabolic process GO:0044275 15 0.300
Mouse
regulation of leukocyte apoptotic process GO:2000106 56 0.299
cellular response to hormone stimulus GO:0032870 150 0.298
regulation of immunoglobulin production GO:0002637 42 0.295
Mouse
female gonad development GO:0008585 71 0.295
regulation of myeloid cell apoptotic process GO:0033032 19 0.293
positive regulation of immune effector process GO:0002699 107 0.292
regulation of dna recombination GO:0000018 34 0.291
Mouse
cell killing GO:0001906 67 0.288
stem cell maintenance GO:0019827 130 0.287
Mouse Fly
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.287
positive regulation of lymphocyte activation GO:0051251 140 0.287
regulation of protein complex assembly GO:0043254 83 0.287
cellular response to cytokine stimulus GO:0071345 189 0.285
response to hypoxia GO:0001666 58 0.281
response to dsrna GO:0043331 30 0.276
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.276
Fly
isotype switching GO:0045190 36 0.276
Mouse
negative regulation of cell proliferation GO:0008285 296 0.274
Mouse
positive regulation of natural killer cell proliferation GO:0032819 2 0.273
Mouse
natural killer cell mediated cytotoxicity GO:0042267 29 0.270
regulation of b cell activation GO:0050864 81 0.270
temperature homeostasis GO:0001659 26 0.269
Mouse
regionalization GO:0003002 337 0.268
Fly
positive regulation of cytokine production GO:0001819 174 0.266
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.266
positive regulation of jak stat cascade GO:0046427 22 0.265
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.265
regulation of myeloid cell differentiation GO:0045637 96 0.264
regulation of body fluid levels GO:0050878 162 0.258
zymogen activation GO:0031638 41 0.257
Mouse
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.255
segmentation GO:0035282 93 0.255
Fly
t cell activation GO:0042110 289 0.254
regulation of production of molecular mediator of immune response GO:0002700 65 0.251
Mouse
prostate gland development GO:0030850 48 0.251
regulation of transferase activity GO:0051338 263 0.245
positive regulation of interleukin 2 production GO:0032743 19 0.243
natural killer cell mediated immunity GO:0002228 29 0.243
eating behavior GO:0042755 15 0.243
Mouse
neuron death GO:0070997 154 0.243
oogenesis GO:0048477 56 0.240
Fly
myotube differentiation GO:0014902 105 0.240
cellular response to interferon gamma GO:0071346 25 0.239
Mouse
response to estrogen GO:0043627 24 0.239
amine metabolic process GO:0009308 45 0.239
regulation of lipid metabolic process GO:0019216 118 0.238
acute inflammatory response GO:0002526 41 0.237
cell division GO:0051301 120 0.237
Fly
2 oxoglutarate metabolic process GO:0006103 7 0.237
t cell activation involved in immune response GO:0002286 43 0.234
Mouse
glucose homeostasis GO:0042593 128 0.234
Mouse
myeloid cell homeostasis GO:0002262 114 0.232
stem cell development GO:0048864 219 0.231
Mouse Fly
homeostasis of number of cells GO:0048872 210 0.228
regulation of glycolytic process GO:0006110 10 0.226
Mouse
protein maturation GO:0051604 176 0.225
Mouse
response to radiation GO:0009314 165 0.220
Fly
wnt signaling pathway GO:0016055 188 0.219
Fly
regulation of defense response GO:0031347 233 0.218
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.217
response to estradiol GO:0032355 12 0.216
regulation of natural killer cell differentiation GO:0032823 11 0.214
positive regulation of response to wounding GO:1903036 66 0.213
positive regulation of b cell mediated immunity GO:0002714 26 0.210
Mouse
regulation of androgen receptor signaling pathway GO:0060765 3 0.210
positive regulation of alpha beta t cell activation GO:0046635 39 0.208
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.207
cellular response to growth factor stimulus GO:0071363 197 0.206
Mouse
gluconeogenesis GO:0006094 39 0.206
regulation of isotype switching GO:0045191 22 0.205
Mouse
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.205
Mouse
single organism nuclear import GO:1902593 95 0.202
neuron apoptotic process GO:0051402 142 0.202
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.200
actin filament polymerization GO:0030041 44 0.198
cellular response to lipid GO:0071396 145 0.196
Mouse Fly
regulation of actin cytoskeleton organization GO:0032956 84 0.195
asymmetric stem cell division GO:0098722 3 0.187
myeloid cell apoptotic process GO:0033028 22 0.186
placenta development GO:0001890 140 0.185
positive regulation of defense response GO:0031349 124 0.185
regulation of organelle organization GO:0033043 289 0.185
positive regulation of cell cycle GO:0045787 92 0.182
positive regulation of immunoglobulin production GO:0002639 28 0.181
Mouse
regulation of defense response to virus GO:0050688 18 0.181
Fly
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.180
blastoderm segmentation GO:0007350 13 0.179
Fly
response to steroid hormone GO:0048545 56 0.177
cellular response to abiotic stimulus GO:0071214 56 0.175
Fly
negative regulation of cytokine production GO:0001818 84 0.174
immunoglobulin production GO:0002377 73 0.171
Mouse
innate immune response GO:0045087 157 0.171
response to alcohol GO:0097305 48 0.171
Rat
luteinization GO:0001553 8 0.169
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.169
lymphocyte mediated immunity GO:0002449 139 0.167
positive regulation of growth GO:0045927 104 0.167
cell fate commitment GO:0045165 210 0.166
Mouse
regulation of t helper cell differentiation GO:0045622 14 0.166
regulation of cell migration GO:0030334 219 0.166
Mouse
negative regulation of cell activation GO:0050866 111 0.166
digestive tract morphogenesis GO:0048546 147 0.160
Fly
cell type specific apoptotic process GO:0097285 268 0.157
prostate gland epithelium morphogenesis GO:0060740 31 0.157
negative regulation of protein metabolic process GO:0051248 282 0.155
b cell activation GO:0042113 161 0.155
lipid storage GO:0019915 36 0.153
regulation of cellular carbohydrate catabolic process GO:0043471 12 0.153
Mouse
response to insulin GO:0032868 100 0.153
negative regulation of leukocyte differentiation GO:1902106 51 0.153
positive regulation of inflammatory response GO:0050729 47 0.150
t helper 1 type immune response GO:0042088 25 0.150
Mouse
negative regulation of cell motility GO:2000146 61 0.149
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.144
apoptotic signaling pathway GO:0097190 306 0.143
regulation of leukocyte mediated immunity GO:0002703 104 0.141
digestive tract development GO:0048565 190 0.139
Fly
positive regulation of isotype switching GO:0045830 15 0.139
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.139
male gamete generation GO:0048232 285 0.135
regulation of cd8 positive alpha beta t cell activation GO:2001185 3 0.134
negative regulation of inflammatory response GO:0050728 61 0.133
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.133
lymphocyte activation involved in immune response GO:0002285 93 0.128
Mouse
c21 steroid hormone metabolic process GO:0008207 7 0.125
Mouse
acute phase response GO:0006953 10 0.124
response to interleukin 15 GO:0070672 3 0.124
Mouse
cellular amide metabolic process GO:0043603 58 0.123
positive regulation of mitotic cell cycle GO:0045931 41 0.122
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.122
regulation of response to wounding GO:1903034 189 0.122
mast cell homeostasis GO:0033023 5 0.119
regulation of activation of janus kinase activity GO:0010533 1 0.116
negative regulation of cellular amine metabolic process GO:0033239 1 0.114
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.113
posttranscriptional regulation of gene expression GO:0010608 155 0.112
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.111
Mouse
regulation of humoral immune response GO:0002920 22 0.111
Fly
lipid localization GO:0010876 126 0.110
male sex differentiation GO:0046661 109 0.110
digestive system development GO:0055123 200 0.107
Fly
radial glial cell differentiation GO:0060019 6 0.107
Mouse
hindgut morphogenesis GO:0007442 7 0.105
Fly
response to decreased oxygen levels GO:0036293 59 0.105
b cell mediated immunity GO:0019724 71 0.102
Mouse
leukocyte mediated immunity GO:0002443 174 0.102
regulation of t helper 2 cell differentiation GO:0045628 8 0.101
cellular response to dna damage stimulus GO:0006974 207 0.100
sensory organ morphogenesis GO:0090596 242 0.100
Mouse
t helper 2 cell differentiation GO:0045064 12 0.099
regulation of steroid metabolic process GO:0019218 39 0.099
polysaccharide metabolic process GO:0005976 39 0.098
negative regulation of alpha beta t cell activation GO:0046636 18 0.098
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.098
rhythmic process GO:0048511 174 0.095
regulation of notch signaling pathway GO:0008593 35 0.095
Mouse
positive regulation of erythrocyte differentiation GO:0045648 11 0.095
ubiquitin dependent protein catabolic process GO:0006511 129 0.094
regulation of cell motility GO:2000145 236 0.093
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.092
negative regulation of t cell differentiation GO:0045581 23 0.091
regulation of immunoglobulin mediated immune response GO:0002889 37 0.090
Mouse
regulation of cytokine biosynthetic process GO:0042035 59 0.090
asymmetric neuroblast division GO:0055059 1 0.090
negative regulation of molecular function GO:0044092 258 0.089
negative regulation of cell development GO:0010721 169 0.089
Mouse
cellular ion homeostasis GO:0006873 165 0.088
gonad development GO:0008406 141 0.087
positive regulation of myeloid cell differentiation GO:0045639 43 0.087
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.087
humoral immune response GO:0006959 57 0.086
Fly
negative regulation of triglyceride metabolic process GO:0090209 4 0.086
cognition GO:0050890 149 0.086
Fly
negative regulation of cellular protein metabolic process GO:0032269 247 0.085
protein polymerization GO:0051258 57 0.085
regulation of neutrophil chemotaxis GO:0090022 14 0.084
somitogenesis GO:0001756 69 0.083
cytokine metabolic process GO:0042107 71 0.082
regulation of cytoskeleton organization GO:0051493 122 0.081
neural tube closure GO:0001843 90 0.080
negative regulation of alpha beta t cell differentiation GO:0046639 12 0.079
liver development GO:0001889 66 0.079
multicellular organismal response to stress GO:0033555 62 0.079
regulation of triglyceride metabolic process GO:0090207 17 0.079
regulation of inflammatory response GO:0050727 147 0.077
glial cell differentiation GO:0010001 131 0.076
Mouse
chromatin organization GO:0006325 206 0.075
organ growth GO:0035265 117 0.075
ribonucleotide metabolic process GO:0009259 291 0.073
negative regulation of interleukin 6 production GO:0032715 17 0.073
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.071
cytoplasmic transport GO:0016482 234 0.071
regulation of purine nucleotide metabolic process GO:1900542 169 0.071
apical constriction GO:0003383 4 0.070
regulation of t helper 1 type immune response GO:0002825 17 0.069
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.069

Stat5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.082
disease of anatomical entity DOID:7 0 0.082