Mus musculus

41 known processes

Lgr5

leucine rich repeat containing G protein coupled receptor 5

(Aliases: Gpr49,FEX)

Lgr5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 329 0.827
Mouse Fly
regulation of cellular amine metabolic process GO:0033238 20 0.779
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.585
regulation of system process GO:0044057 200 0.497
regulation of membrane potential GO:0042391 192 0.416
locomotory behavior GO:0007626 195 0.416
Mouse
learning GO:0007612 98 0.367
associative learning GO:0008306 61 0.350
cellular amine metabolic process GO:0044106 44 0.337
Mouse
action potential GO:0001508 78 0.333
forebrain development GO:0030900 302 0.315
regulation of synaptic plasticity GO:0048167 87 0.314
cation transport GO:0006812 399 0.303
transmembrane transport GO:0055085 412 0.288
ion transmembrane transport GO:0034220 361 0.285
regionalization GO:0003002 337 0.285
cellular homeostasis GO:0019725 240 0.275
Mouse
metencephalon development GO:0022037 89 0.259
synapse organization GO:0050808 125 0.258
anion transport GO:0006820 177 0.253
developmental maturation GO:0021700 193 0.252
Fly
cellular ketone metabolic process GO:0042180 84 0.250
adult behavior GO:0030534 135 0.246
Mouse
regulation of ion transport GO:0043269 215 0.244
adult locomotory behavior GO:0008344 91 0.241
Mouse
regulation of cell motility GO:2000145 236 0.241
regulation of secretion by cell GO:1903530 249 0.240
Mouse
glial cell differentiation GO:0010001 131 0.225
regulation of protein localization GO:0032880 231 0.223
Mouse
membrane organization GO:0061024 245 0.223
epidermis development GO:0008544 187 0.220
circulatory system process GO:0003013 197 0.218
Mouse
sensory perception GO:0007600 245 0.217
positive regulation of cell development GO:0010720 237 0.214
regulation of cellular ketone metabolic process GO:0010565 66 0.211
spermatogenesis GO:0007283 284 0.210
Mouse
neuronal action potential GO:0019228 54 0.201
regulation of body fluid levels GO:0050878 162 0.194
gliogenesis GO:0042063 141 0.192
male gamete generation GO:0048232 285 0.191
Mouse
astrocyte differentiation GO:0048708 43 0.190
central nervous system neuron differentiation GO:0021953 162 0.187
digestive system development GO:0055123 200 0.184
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.182
organic anion transport GO:0015711 137 0.178
oxidation reduction process GO:0055114 342 0.176
cellular lipid metabolic process GO:0044255 323 0.172
regulation of cellular amino acid metabolic process GO:0006521 5 0.170
cellular chemical homeostasis GO:0055082 215 0.168
Mouse
sensory organ morphogenesis GO:0090596 242 0.168
Mouse
axonogenesis GO:0007409 274 0.165
amine metabolic process GO:0009308 45 0.165
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.165
mitochondrion distribution GO:0048311 4 0.163
morphogenesis of a polarized epithelium GO:0001738 37 0.163
skeletal system development GO:0001501 356 0.162
axon guidance GO:0007411 141 0.160
organelle localization GO:0051640 179 0.160
cell type specific apoptotic process GO:0097285 268 0.159
regulation of neuron death GO:1901214 134 0.159
cellular response to inorganic substance GO:0071241 37 0.157
regulation of organ morphogenesis GO:2000027 144 0.154
Mouse
neuron migration GO:0001764 122 0.152
cognition GO:0050890 149 0.148
response to drug GO:0042493 75 0.146
cerebellum development GO:0021549 77 0.146
regulation of organelle organization GO:0033043 289 0.146
Mouse
regulation of inflammatory response GO:0050727 147 0.146
wnt signaling pathway GO:0016055 188 0.143
nucleotide metabolic process GO:0009117 332 0.143
Mouse
renal system process GO:0003014 48 0.141
circadian rhythm GO:0007623 114 0.139
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.139
wound healing GO:0042060 157 0.138
neuromuscular process GO:0050905 99 0.137
regulation of epithelial cell proliferation GO:0050678 141 0.135
response to organic cyclic compound GO:0014070 198 0.133
regulation of cell projection organization GO:0031344 206 0.133
mechanoreceptor differentiation GO:0042490 67 0.132
Mouse
regulation of cell migration GO:0030334 219 0.129
cellular response to growth factor stimulus GO:0071363 197 0.126
epithelial cell development GO:0002064 159 0.125
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.124
skin development GO:0043588 220 0.123
blood circulation GO:0008015 195 0.120
Mouse
response to growth factor GO:0070848 198 0.120
hindbrain development GO:0030902 128 0.120
divalent inorganic cation homeostasis GO:0072507 138 0.119
gland development GO:0048732 330 0.118
response to metal ion GO:0010038 47 0.117
protein localization to organelle GO:0033365 185 0.113
blood vessel morphogenesis GO:0048514 285 0.112
organic hydroxy compound biosynthetic process GO:1901617 77 0.110
Mouse
organic acid biosynthetic process GO:0016053 86 0.110
anatomical structure homeostasis GO:0060249 145 0.109
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.108
Mouse
positive regulation of programmed cell death GO:0043068 218 0.108
cation homeostasis GO:0055080 212 0.107
mitochondrion organization GO:0007005 134 0.107
cell maturation GO:0048469 127 0.107
cellular ion homeostasis GO:0006873 165 0.106
response to organonitrogen compound GO:0010243 246 0.106
regulation of neuron differentiation GO:0045664 281 0.105
epithelial cell proliferation GO:0050673 174 0.104
Mouse
organic hydroxy compound metabolic process GO:1901615 203 0.104
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.104
embryonic organ morphogenesis GO:0048562 276 0.104
Mouse
multicellular organismal homeostasis GO:0048871 164 0.102
Mouse
catecholamine metabolic process GO:0006584 30 0.101
learning or memory GO:0007611 148 0.099
cellular amino acid metabolic process GO:0006520 103 0.099
tendon formation GO:0035992 4 0.098
central nervous system neuron development GO:0021954 67 0.098
inorganic ion transmembrane transport GO:0098660 234 0.097
negative regulation of protein metabolic process GO:0051248 282 0.096
calcium ion homeostasis GO:0055074 127 0.096
neuron projection guidance GO:0097485 141 0.095
camera type eye development GO:0043010 266 0.095
terpenoid metabolic process GO:0006721 25 0.095
negative regulation of immune system process GO:0002683 209 0.094
Mouse
neuron death GO:0070997 154 0.094
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.093
divalent inorganic cation transport GO:0072511 178 0.093
metal ion homeostasis GO:0055065 189 0.093
visual perception GO:0007601 52 0.093
establishment of organelle localization GO:0051656 122 0.093
macromolecule catabolic process GO:0009057 281 0.092
sensory perception of mechanical stimulus GO:0050954 107 0.092
intracellular protein transport GO:0006886 204 0.092
limb development GO:0060173 166 0.091
angiogenesis GO:0001525 201 0.091
negative regulation of neuron death GO:1901215 98 0.090
neuron projection extension GO:1990138 64 0.090
regulation of neuron projection development GO:0010975 169 0.090
response to inorganic substance GO:0010035 96 0.089
ensheathment of neurons GO:0007272 76 0.088
establishment of protein localization to organelle GO:0072594 118 0.088
phenol containing compound metabolic process GO:0018958 60 0.087
regulation of transferase activity GO:0051338 263 0.087
dendrite development GO:0016358 115 0.086
cellular response to calcium ion GO:0071277 14 0.086
negative regulation of cell proliferation GO:0008285 296 0.086
muscle cell differentiation GO:0042692 261 0.085
regulation of muscle tissue development GO:1901861 97 0.085
nerve development GO:0021675 67 0.084
positive regulation of protein kinase activity GO:0045860 144 0.084
regulation of astrocyte differentiation GO:0048710 20 0.083
regulation of mast cell differentiation GO:0060375 3 0.083
urogenital system development GO:0001655 261 0.083
Mouse
ear development GO:0043583 200 0.083
epithelial tube morphogenesis GO:0060562 303 0.082
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.082
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.082
fatty acid metabolic process GO:0006631 121 0.082
regulation of metal ion transport GO:0010959 106 0.082
transmission of nerve impulse GO:0019226 76 0.081
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.081
regulation of kinase activity GO:0043549 249 0.081
positive regulation of nervous system development GO:0051962 221 0.081
positive regulation of transferase activity GO:0051347 167 0.081
nucleobase containing small molecule metabolic process GO:0055086 352 0.080
Mouse
sensory perception of light stimulus GO:0050953 54 0.080
positive regulation of protein modification process GO:0031401 299 0.079
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.078
Mouse
cytoplasmic transport GO:0016482 234 0.078
canonical wnt signaling pathway GO:0060070 130 0.075
multi organism behavior GO:0051705 62 0.074
molting cycle GO:0042303 90 0.074
Fly
negative regulation of cellular amine metabolic process GO:0033239 1 0.073
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.073
carboxylic acid biosynthetic process GO:0046394 86 0.073
monocarboxylic acid biosynthetic process GO:0072330 61 0.072
intermediate filament cytoskeleton organization GO:0045104 26 0.072
regulation of anatomical structure size GO:0090066 178 0.072
stem cell development GO:0048864 219 0.072
Fly
calcium ion transport GO:0006816 159 0.071
chemotaxis GO:0006935 247 0.070
intermediate filament based process GO:0045103 27 0.070
multicellular organismal signaling GO:0035637 91 0.070
regulation of cell cycle GO:0051726 281 0.070
nitrogen compound transport GO:0071705 271 0.070
negative regulation of synapse maturation GO:2000297 2 0.069
regulation of smooth muscle contraction GO:0006940 22 0.069
phenol containing compound biosynthetic process GO:0046189 21 0.069
regulation of neurotransmitter levels GO:0001505 87 0.069
Mouse
placenta development GO:0001890 140 0.069
cellular response to organic cyclic compound GO:0071407 87 0.068
cell junction organization GO:0034330 77 0.068
cell fate commitment GO:0045165 210 0.068
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.067
myeloid cell differentiation GO:0030099 233 0.067
Mouse
lipid biosynthetic process GO:0008610 179 0.067
Mouse
divalent metal ion transport GO:0070838 172 0.067
anion transmembrane transport GO:0098656 71 0.066
cell differentiation involved in embryonic placenta development GO:0060706 26 0.066
cellular metal ion homeostasis GO:0006875 151 0.064
protein targeting GO:0006605 143 0.064
catecholamine biosynthetic process GO:0042423 11 0.064
multicellular organismal response to stress GO:0033555 62 0.064
cell chemotaxis GO:0060326 81 0.064
organelle fission GO:0048285 170 0.064
extracellular matrix organization GO:0030198 147 0.063
Mouse
organelle assembly GO:0070925 177 0.063
protein import GO:0017038 101 0.063
carboxylic acid transport GO:0046942 100 0.062
positive regulation of growth GO:0045927 104 0.062
Mouse
regulation of neuron apoptotic process GO:0043523 122 0.062
toxin transport GO:1901998 38 0.062
embryonic genitalia morphogenesis GO:0030538 4 0.062
intracellular receptor signaling pathway GO:0030522 74 0.062
Mouse
myelination GO:0042552 74 0.062
positive regulation of cell death GO:0010942 224 0.061
protein localization to nucleus GO:0034504 121 0.061
myeloid leukocyte differentiation GO:0002573 119 0.061
Mouse
small molecule biosynthetic process GO:0044283 132 0.061
Mouse
retinoid metabolic process GO:0001523 24 0.060
establishment of vesicle localization GO:0051650 81 0.060
positive regulation of protein phosphorylation GO:0001934 242 0.060
skeletal system morphogenesis GO:0048705 203 0.060
sensory perception of sound GO:0007605 97 0.060
organophosphate biosynthetic process GO:0090407 122 0.060
Mouse
purine nucleotide biosynthetic process GO:0006164 65 0.059
Mouse
homeostasis of number of cells GO:0048872 210 0.059
cation transmembrane transport GO:0098655 266 0.058
auditory receptor cell fate determination GO:0042668 3 0.058
engulfment of apoptotic cell GO:0043652 3 0.058
cellular response to hormone stimulus GO:0032870 150 0.058
Mouse
peptidyl amino acid modification GO:0018193 336 0.058
vesicle localization GO:0051648 86 0.058
regulation of wnt signaling pathway GO:0030111 123 0.058
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.057
nucleoside phosphate metabolic process GO:0006753 338 0.057
Mouse
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.057
neuron maturation GO:0042551 29 0.057
morphogenesis of a branching epithelium GO:0061138 193 0.057
Mouse
apoptotic signaling pathway GO:0097190 306 0.057
feeding behavior GO:0007631 62 0.057
diterpenoid metabolic process GO:0016101 24 0.057
neurotransmitter transport GO:0006836 76 0.056
negative regulation of nervous system development GO:0051961 156 0.056
negative regulation of cell cycle GO:0045786 123 0.056
regulation of proteolysis GO:0030162 164 0.056
cellular response to metal ion GO:0071248 31 0.056
glial cell development GO:0021782 54 0.055
ear morphogenesis GO:0042471 118 0.055
Mouse
second messenger mediated signaling GO:0019932 73 0.055
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.055
stem cell maintenance GO:0019827 130 0.055
potassium ion transport GO:0006813 52 0.055
cellular component assembly involved in morphogenesis GO:0010927 139 0.054
intermediate filament organization GO:0045109 15 0.054
mitral valve development GO:0003174 4 0.054
regulation of homeostatic process GO:0032844 182 0.054
Mouse
steroid biosynthetic process GO:0006694 47 0.053
Mouse
purine containing compound metabolic process GO:0072521 311 0.053
Mouse
response to radiation GO:0009314 165 0.053
neuron neuron synaptic transmission GO:0007270 69 0.053
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.053
fertilization GO:0009566 127 0.053
organic acid transport GO:0015849 101 0.053
respiratory tube development GO:0030323 167 0.053
optic nerve structural organization GO:0021633 2 0.053
inorganic cation transmembrane transport GO:0098662 207 0.052
mitotic cell cycle process GO:1903047 159 0.052
multi multicellular organism process GO:0044706 109 0.052
mitral valve morphogenesis GO:0003183 4 0.052
establishment of synaptic vesicle localization GO:0097480 57 0.052
behavioral fear response GO:0001662 28 0.052
cerebellar cortex development GO:0021695 48 0.052
cytokine production GO:0001816 319 0.052
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.052
Mouse Fly
asymmetric neuroblast division GO:0055059 1 0.052
tendon cell differentiation GO:0035990 4 0.051
germ cell development GO:0007281 185 0.051
Mouse
sensory system development GO:0048880 3 0.051
mapk cascade GO:0000165 281 0.051
Mouse
renal system development GO:0072001 225 0.051
Mouse
tissue homeostasis GO:0001894 115 0.051
Mouse
actin cytoskeleton organization GO:0030036 220 0.051
bmp signaling pathway GO:0030509 93 0.050
negative regulation of molecular function GO:0044092 258 0.050
negative regulation of intracellular signal transduction GO:1902532 167 0.050
regulation of hormone levels GO:0010817 211 0.050
Mouse
positive regulation of keratinocyte proliferation GO:0010838 4 0.050
lens development in camera type eye GO:0002088 62 0.050
camp biosynthetic process GO:0006171 31 0.050
Mouse
regulation of binding GO:0051098 111 0.050
regulation of transmembrane transport GO:0034762 128 0.050
potassium ion transmembrane transport GO:0071805 43 0.050
negative regulation of epithelial cell proliferation GO:0050680 64 0.049
inorganic anion transport GO:0015698 43 0.049
myeloid cell homeostasis GO:0002262 114 0.049
positive regulation of cell motility GO:2000147 116 0.049
keratinocyte differentiation GO:0030216 48 0.049
striated muscle tissue development GO:0014706 293 0.049
regulation of gliogenesis GO:0014013 50 0.049
microtubule based process GO:0007017 236 0.048
positive regulation of apoptotic process GO:0043065 217 0.048
amino acid transport GO:0006865 61 0.048
establishment of tissue polarity GO:0007164 28 0.048
negative regulation of neuron apoptotic process GO:0043524 92 0.048
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.048
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.048
regulation of feeding behavior GO:0060259 3 0.048
positive regulation of kinase activity GO:0033674 155 0.048
response to oxygen levels GO:0070482 62 0.047
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.047
developmental growth involved in morphogenesis GO:0060560 138 0.047
embryonic placenta development GO:0001892 98 0.047
regulation of stem cell differentiation GO:2000736 50 0.047
rhodopsin mediated signaling pathway GO:0016056 4 0.047
endomembrane system organization GO:0010256 147 0.047
multi organism reproductive behavior GO:0044705 29 0.046
cerebellar granule cell precursor proliferation GO:0021930 10 0.046
cartilage development GO:0051216 140 0.046
ameboidal type cell migration GO:0001667 128 0.046
ribose phosphate metabolic process GO:0019693 291 0.046
Mouse
telencephalon development GO:0021537 186 0.046
exocytosis GO:0006887 121 0.046
leukocyte differentiation GO:0002521 342 0.046
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.046
cytokine mediated signaling pathway GO:0019221 115 0.045
cellular nitrogen compound catabolic process GO:0044270 280 0.045
peripheral nervous system development GO:0007422 53 0.045
sodium ion transport GO:0006814 73 0.045
digestive tract development GO:0048565 190 0.045
peptide secretion GO:0002790 114 0.045
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.045
response to light stimulus GO:0009416 135 0.045
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.045
positive regulation of stem cell differentiation GO:2000738 23 0.044
phospholipid metabolic process GO:0006644 87 0.044
cell division GO:0051301 120 0.044
photoreceptor cell development GO:0042461 40 0.043
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.043
Mouse
inner ear morphogenesis GO:0042472 101 0.043
Mouse
nuclear transport GO:0051169 139 0.043
endocrine system development GO:0035270 98 0.043
microtubule cytoskeleton organization GO:0000226 157 0.043
organic cyclic compound catabolic process GO:1901361 295 0.043
hippocampus development GO:0021766 52 0.043
intestinal epithelial structure maintenance GO:0060729 4 0.043
single fertilization GO:0007338 82 0.042
corticotropin hormone secreting cell differentiation GO:0060128 3 0.042
inflammatory response GO:0006954 244 0.042
rhythmic process GO:0048511 174 0.042
Mouse
regulation of circadian rhythm GO:0042752 58 0.042
response to acid chemical GO:0001101 111 0.042
purine ribonucleotide biosynthetic process GO:0009152 59 0.042
Mouse
hair follicle development GO:0001942 85 0.042
isoprenoid metabolic process GO:0006720 29 0.042
cardiac muscle tissue development GO:0048738 130 0.042
keratinocyte proliferation GO:0043616 21 0.042
carbohydrate homeostasis GO:0033500 128 0.041
alcohol metabolic process GO:0006066 116 0.041
Mouse
regulation of ossification GO:0030278 112 0.041
cellular calcium ion homeostasis GO:0006874 119 0.041
positive regulation of cell migration GO:0030335 109 0.041
regulation of intracellular transport GO:0032386 159 0.041
regulation of defense response GO:0031347 233 0.041
Mouse
positive regulation of wnt signaling pathway GO:0030177 45 0.041
maintenance of location GO:0051235 89 0.041
leukocyte homeostasis GO:0001776 79 0.040
positive regulation of secretion by cell GO:1903532 114 0.040
regulation of establishment of protein localization GO:0070201 181 0.040
Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.040
cell substrate adhesion GO:0031589 130 0.040
blood coagulation GO:0007596 76 0.040
reproductive behavior GO:0019098 32 0.040
mammary gland morphogenesis GO:0060443 54 0.040
cellular response to cytokine stimulus GO:0071345 189 0.039
aromatic compound catabolic process GO:0019439 286 0.039
cell growth GO:0016049 130 0.039
muscle tissue development GO:0060537 308 0.039
endocytosis GO:0006897 168 0.038
positive regulation of mapk cascade GO:0043410 170 0.038
mating GO:0007618 27 0.038
meiotic cell cycle GO:0051321 122 0.038
protein oligomerization GO:0051259 67 0.038
regulation of cytokine production GO:0001817 266 0.038
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.038
cellular macromolecule catabolic process GO:0044265 206 0.038
regulation of purine nucleotide metabolic process GO:1900542 169 0.038
Mouse
dopamine metabolic process GO:0042417 23 0.038
response to glucocorticoid GO:0051384 20 0.038
mesenchyme development GO:0060485 152 0.038
Fly
regulation of chromosome organization GO:0033044 83 0.038
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.037
nucleoside phosphate biosynthetic process GO:1901293 79 0.037
Mouse
regulation of axon diameter GO:0031133 6 0.037
glucose homeostasis GO:0042593 128 0.037
cellular response to lipid GO:0071396 145 0.037
b cell activation GO:0042113 161 0.037
Mouse
smooth muscle contraction GO:0006939 44 0.036
respiratory system development GO:0060541 190 0.036
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.036
auditory receptor cell fate specification GO:0042667 1 0.036
spermatid development GO:0007286 108 0.036
Mouse
heart contraction GO:0060047 93 0.036
body morphogenesis GO:0010171 45 0.036
protein maturation GO:0051604 176 0.036
regulation of mitosis GO:0007088 29 0.036
negative regulation of oxidative phosphorylation uncoupler activity GO:2000276 2 0.035
cell adhesion GO:0007155 329 0.035
regulation of epidermis development GO:0045682 33 0.035
ribonucleotide metabolic process GO:0009259 291 0.035
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.035
cellular response to acid chemical GO:0071229 68 0.035
nucleocytoplasmic transport GO:0006913 139 0.035
protein modification by small protein conjugation GO:0032446 187 0.035
cell cell signaling involved in lung development GO:0060495 1 0.035
negative regulation of phosphorus metabolic process GO:0010563 184 0.035
regulation of cellular catabolic process GO:0031329 242 0.035
muscle contraction GO:0006936 101 0.034
response to extracellular stimulus GO:0009991 127 0.034
protein catabolic process GO:0030163 221 0.034
intermediate filament bundle assembly GO:0045110 3 0.034
cyclic purine nucleotide metabolic process GO:0052652 43 0.034
Mouse
axon ensheathment GO:0008366 76 0.034
response to hypoxia GO:0001666 58 0.034
negative regulation of cellular component organization GO:0051129 194 0.034
organophosphate catabolic process GO:0046434 232 0.034
substrate adhesion dependent cell spreading GO:0034446 30 0.034
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.034
regulation of protein secretion GO:0050708 82 0.033
Mouse
forebrain generation of neurons GO:0021872 63 0.033
regulation of protein kinase activity GO:0045859 232 0.033
regulation of protein transport GO:0051223 163 0.033
Mouse
mesodermal cell migration GO:0008078 4 0.033
response to decreased oxygen levels GO:0036293 59 0.033
connective tissue development GO:0061448 179 0.033
oocyte axis specification GO:0007309 2 0.033
mitotic cell cycle GO:0000278 195 0.033
positive regulation of cell cycle GO:0045787 92 0.033
ribose phosphate biosynthetic process GO:0046390 59 0.033
Mouse
ribonucleotide biosynthetic process GO:0009260 59 0.032
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.032
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
cellular response to external stimulus GO:0071496 88 0.032
nucleotide catabolic process GO:0009166 217 0.032
innate immune response GO:0045087 157 0.032
response to amino acid GO:0043200 37 0.032
cytosolic calcium ion homeostasis GO:0051480 70 0.032
mesenchymal cell differentiation GO:0048762 107 0.032
Fly
organic acid catabolic process GO:0016054 51 0.031
positive regulation of organelle organization GO:0010638 128 0.031
regulation of tube size GO:0035150 57 0.031
protein processing GO:0016485 163 0.031
positive regulation of innate immune response GO:0045089 80 0.031
Mouse
cell cell junction organization GO:0045216 72 0.031
morphogenesis of embryonic epithelium GO:0016331 159 0.031
establishment or maintenance of neuroblast polarity GO:0045196 1 0.031
amide transport GO:0042886 138 0.031
regulation of epidermal cell differentiation GO:0045604 21 0.031
regulation of nucleotide biosynthetic process GO:0030808 34 0.031
Mouse
neuron apoptotic process GO:0051402 142 0.031
response to temperature stimulus GO:0009266 55 0.031
intracellular distribution of mitochondria GO:0048312 1 0.031
hair follicle morphogenesis GO:0031069 29 0.030
morphogenesis of a branching structure GO:0001763 203 0.030
Mouse
purine ribonucleotide catabolic process GO:0009154 208 0.030
nuclear division GO:0000280 158 0.030
regulation of neuronal synaptic plasticity GO:0048168 30 0.030
cyclic nucleotide biosynthetic process GO:0009190 44 0.030
Mouse
bone development GO:0060348 120 0.030
establishment of neuroblast polarity GO:0045200 1 0.030
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.030
Mouse
carbohydrate transport GO:0008643 62 0.030
oligodendrocyte differentiation GO:0048709 53 0.030
lateral line system development GO:0048925 1 0.029
brown fat cell differentiation GO:0050873 36 0.029
vascular process in circulatory system GO:0003018 62 0.029
reflex GO:0060004 22 0.029
i kappab kinase nf kappab signaling GO:0007249 85 0.029
fear response GO:0042596 33 0.029
regulation of ph GO:0006885 26 0.029
regulation of cell cycle process GO:0010564 160 0.029
ribonucleotide catabolic process GO:0009261 208 0.029
regulation of retina development in camera type eye GO:1902866 3 0.029
protein import into nucleus GO:0006606 95 0.029
erythrocyte differentiation GO:0030218 88 0.029
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.029
white fat cell proliferation GO:0070343 2 0.029
regulation of hydrolase activity GO:0051336 246 0.029
bone remodeling GO:0046849 53 0.028
Mouse
mesenchymal cell development GO:0014031 93 0.028
Fly
activation of immune response GO:0002253 138 0.028
Mouse
skeletal muscle organ development GO:0060538 163 0.028
long term synaptic potentiation GO:0060291 25 0.028
regulation of vesicle mediated transport GO:0060627 139 0.028

Lgr5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.104
cardiovascular system disease DOID:1287 0 0.104
nervous system disease DOID:863 0 0.066
heart disease DOID:114 0 0.038