Mus musculus

198 known processes

Map3k1

mitogen-activated protein kinase kinase kinase 1

(Aliases: MEKK1,Mekk,MAPKKK1)

Map3k1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
endodermal cell fate specification GO:0001714 4 0.540
positive regulation of mapk cascade GO:0043410 170 0.531
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.516
Rat
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.501
digestive system development GO:0055123 200 0.396
macromolecule catabolic process GO:0009057 281 0.389
Rat
gene silencing GO:0016458 38 0.373
regulation of mapk cascade GO:0043408 248 0.360
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.312
respiratory tube development GO:0030323 167 0.294
modification dependent protein catabolic process GO:0019941 133 0.290
Rat
histone modification GO:0016570 159 0.287
covalent chromatin modification GO:0016569 163 0.276
cytokine biosynthetic process GO:0042089 68 0.272
positive regulation of protein modification process GO:0031401 299 0.260
cellular macromolecule catabolic process GO:0044265 206 0.258
Rat
negative regulation of cellular protein metabolic process GO:0032269 247 0.253
activation of mapkkk activity GO:0000185 1 0.216
positive regulation of protein kinase activity GO:0045860 144 0.206
regulation of cellular response to stress GO:0080135 159 0.199
protein catabolic process GO:0030163 221 0.192
Rat
myeloid cell differentiation GO:0030099 233 0.191
lung development GO:0030324 164 0.188
negative regulation of molecular function GO:0044092 258 0.187
digestive tract morphogenesis GO:0048546 147 0.184
modification dependent macromolecule catabolic process GO:0043632 133 0.180
Rat
proteasomal protein catabolic process GO:0010498 98 0.172
leukocyte differentiation GO:0002521 342 0.166
regulation of map kinase activity GO:0043405 120 0.166
regulation of cytokine production GO:0001817 266 0.156
positive regulation of kinase activity GO:0033674 155 0.154
apoptotic signaling pathway GO:0097190 306 0.148
positive regulation of jun kinase activity GO:0043507 30 0.146
regulation of protein serine threonine kinase activity GO:0071900 157 0.143
programmed necrotic cell death GO:0097300 28 0.137
digestive tract development GO:0048565 190 0.137
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.136
ossification GO:0001503 216 0.130
cardiac muscle contraction GO:0060048 32 0.128
protein polyubiquitination GO:0000209 33 0.126
Rat
negative regulation of phosphate metabolic process GO:0045936 184 0.120
activation of immune response GO:0002253 138 0.120
chromatin modification GO:0016568 187 0.120
chromatin organization GO:0006325 206 0.112
myeloid leukocyte differentiation GO:0002573 119 0.111
negative regulation of intracellular signal transduction GO:1902532 167 0.109
regulation of transferase activity GO:0051338 263 0.106
cellular protein catabolic process GO:0044257 155 0.106
Rat
posttranscriptional gene silencing GO:0016441 10 0.105
regulation of protein kinase activity GO:0045859 232 0.105
respiratory system development GO:0060541 190 0.102
muscle tissue development GO:0060537 308 0.101
cytokine production GO:0001816 319 0.098
positive regulation of transferase activity GO:0051347 167 0.098
regionalization GO:0003002 337 0.097
gland development GO:0048732 330 0.095
gene silencing by rna GO:0031047 19 0.093
blood circulation GO:0008015 195 0.092
negative regulation of phosphorus metabolic process GO:0010563 184 0.092
negative regulation of protein metabolic process GO:0051248 282 0.092
placenta development GO:0001890 140 0.091
cell fate commitment GO:0045165 210 0.090
activation of nf kappab inducing kinase activity GO:0007250 4 0.087
protein ubiquitination GO:0016567 171 0.087
Rat
skeletal system development GO:0001501 356 0.087
response to oxidative stress GO:0006979 123 0.085
dna metabolic process GO:0006259 303 0.084
morphogenesis of embryonic epithelium GO:0016331 159 0.082
rhythmic process GO:0048511 174 0.082
regulation of stress activated mapk cascade GO:0032872 69 0.082
heart contraction GO:0060047 93 0.081
mapk cascade GO:0000165 281 0.080
antigen receptor mediated signaling pathway GO:0050851 64 0.079
small gtpase mediated signal transduction GO:0007264 97 0.076
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.076
ubiquitin dependent protein catabolic process GO:0006511 129 0.075
Rat
positive regulation of map kinase activity GO:0043406 84 0.073
regulation of jun kinase activity GO:0043506 40 0.072
necrotic cell death GO:0070265 30 0.071
neural tube development GO:0021915 160 0.071
t cell proliferation GO:0042098 120 0.070
gastrulation GO:0007369 116 0.069
inflammatory response GO:0006954 244 0.068
immune response activating signal transduction GO:0002757 116 0.067
regulation of jnk cascade GO:0046328 62 0.065
negative regulation of necroptotic process GO:0060546 9 0.065
embryonic placenta development GO:0001892 98 0.065
epithelial tube formation GO:0072175 130 0.063
positive regulation of apoptotic process GO:0043065 217 0.063
Rat
negative regulation of phosphorylation GO:0042326 166 0.063
circulatory system process GO:0003013 197 0.062
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.061
regulation of cell cycle GO:0051726 281 0.061
immune effector process GO:0002252 321 0.059
protein modification by small protein conjugation GO:0032446 187 0.059
Rat
production of molecular mediator of immune response GO:0002440 103 0.058
cellular response to lipopolysaccharide GO:0071222 77 0.058
positive regulation of cytokine production GO:0001819 174 0.057
regulation of establishment of protein localization GO:0070201 181 0.057
cell type specific apoptotic process GO:0097285 268 0.056
cellular response to nitric oxide GO:0071732 4 0.056
embryonic organ morphogenesis GO:0048562 276 0.056
response to lipopolysaccharide GO:0032496 128 0.055
jnk cascade GO:0007254 72 0.054
rna interference GO:0016246 2 0.053
cytokine metabolic process GO:0042107 71 0.053
regulation of protein localization GO:0032880 231 0.053
t cell activation GO:0042110 289 0.052
physiological cardiac muscle hypertrophy GO:0003301 3 0.052
neuron apoptotic process GO:0051402 142 0.052
regulation of apoptotic signaling pathway GO:2001233 197 0.051
protein methylation GO:0006479 81 0.050
striated muscle contraction GO:0006941 45 0.049
translation GO:0006412 93 0.049
i kappab kinase nf kappab signaling GO:0007249 85 0.048
cellular response to abiotic stimulus GO:0071214 56 0.047
Human
negative regulation of protein modification process GO:0031400 163 0.047
regulation of proteolysis GO:0030162 164 0.047
regulation of ras protein signal transduction GO:0046578 114 0.047
defecation GO:0030421 1 0.047
tissue remodeling GO:0048771 102 0.046
positive regulation of programmed cell death GO:0043068 218 0.046
Rat
intrinsic apoptotic signaling pathway GO:0097193 132 0.046
protein modification by small protein conjugation or removal GO:0070647 207 0.046
Rat
regulation of hydrolase activity GO:0051336 246 0.045
heterocycle catabolic process GO:0046700 280 0.045
regulation of cytokine biosynthetic process GO:0042035 59 0.045
tube formation GO:0035148 140 0.044
cell growth GO:0016049 130 0.044
peptidyl amino acid modification GO:0018193 336 0.043
Rat
cellular response to molecule of bacterial origin GO:0071219 83 0.043
interleukin 1 mediated signaling pathway GO:0070498 4 0.043
myeloid leukocyte activation GO:0002274 83 0.043
cardiac muscle cell development GO:0055013 39 0.042
negative regulation of necrotic cell death GO:0060547 11 0.042
activation of mapk activity GO:0000187 59 0.042
cellular response to lipid GO:0071396 145 0.041
cell growth involved in cardiac muscle cell development GO:0061049 3 0.041
positive regulation of neuron apoptotic process GO:0043525 25 0.041
posttranscriptional gene silencing by rna GO:0035194 10 0.040
response to molecule of bacterial origin GO:0002237 143 0.040
epithelial tube morphogenesis GO:0060562 303 0.039
tube closure GO:0060606 91 0.039
primary neural tube formation GO:0014020 95 0.039
muscle cell differentiation GO:0042692 261 0.039
protein maturation GO:0051604 176 0.038
regulation of kinase activity GO:0043549 249 0.038
neuron death GO:0070997 154 0.038
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.038
immune response regulating signaling pathway GO:0002764 125 0.037
natural killer cell activation GO:0030101 44 0.037
negative regulation of proteolysis GO:0045861 74 0.037
endoderm formation GO:0001706 20 0.037
homeostasis of number of cells GO:0048872 210 0.035
cytokine mediated signaling pathway GO:0019221 115 0.035
innate immune response GO:0045087 157 0.035
embryonic epithelial tube formation GO:0001838 130 0.034
organic cyclic compound catabolic process GO:1901361 295 0.034
glycoprotein metabolic process GO:0009100 116 0.034
regulation of secretion GO:0051046 274 0.034
positive regulation of cell death GO:0010942 224 0.034
Rat
ras protein signal transduction GO:0007265 77 0.034
formation of primary germ layer GO:0001704 77 0.034
neural tube formation GO:0001841 108 0.034
regulation of chromatin modification GO:1903308 57 0.033
cardiac muscle tissue development GO:0048738 130 0.033
rho protein signal transduction GO:0007266 32 0.033
regulation of leukocyte proliferation GO:0070663 121 0.033
aromatic compound catabolic process GO:0019439 286 0.032
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 12 0.032
immunoglobulin production GO:0002377 73 0.032
leukocyte proliferation GO:0070661 172 0.032
regulation of defense response GO:0031347 233 0.032
heart morphogenesis GO:0003007 178 0.031
posttranscriptional regulation of gene expression GO:0010608 155 0.031
muscle system process GO:0003012 141 0.031
regulation of cell activation GO:0050865 289 0.031
regulation of leukocyte differentiation GO:1902105 159 0.031
protein deacetylation GO:0006476 32 0.031
protein processing GO:0016485 163 0.031
hematopoietic progenitor cell differentiation GO:0002244 143 0.030
histone acetylation GO:0016573 41 0.030
cell fate specification GO:0001708 72 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.030
regulation of secretion by cell GO:1903530 249 0.030
regulation of endopeptidase activity GO:0052548 89 0.030
regulation of response to biotic stimulus GO:0002831 38 0.030
lymphocyte proliferation GO:0046651 164 0.029
mrna catabolic process GO:0006402 22 0.029
cardiac muscle cell differentiation GO:0055007 69 0.029
peptidyl lysine modification GO:0018205 77 0.029
endodermal cell fate commitment GO:0001711 12 0.029
natural killer cell differentiation GO:0001779 21 0.029
endoderm development GO:0007492 45 0.029
protein alkylation GO:0008213 81 0.028
hepaticobiliary system development GO:0061008 67 0.028
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.028
histone methylation GO:0016571 71 0.028
carbohydrate derivative biosynthetic process GO:1901137 183 0.028
cellular response to cytokine stimulus GO:0071345 189 0.028
skeletal system morphogenesis GO:0048705 203 0.028
positive regulation of neuron death GO:1901216 28 0.028
appendage morphogenesis GO:0035107 149 0.027
multicellular organism growth GO:0035264 161 0.027
limb development GO:0060173 166 0.027
regulation of peptidase activity GO:0052547 96 0.027
striated muscle tissue development GO:0014706 293 0.027
regulation of lymphocyte activation GO:0051249 240 0.027
positive regulation of protein phosphorylation GO:0001934 242 0.027
erythrocyte differentiation GO:0030218 88 0.026
b cell activation GO:0042113 161 0.026
compound eye development GO:0048749 1 0.026
regulation of response to wounding GO:1903034 189 0.025
negative regulation of ras protein signal transduction GO:0046580 18 0.025
positive regulation of jnk cascade GO:0046330 46 0.025
regulation of chromatin silencing GO:0031935 2 0.025
lymphocyte differentiation GO:0030098 242 0.025
regulation of protein maturation GO:1903317 96 0.025
regulation of myeloid leukocyte differentiation GO:0002761 58 0.025
heart process GO:0003015 94 0.024
regulation of translation GO:0006417 71 0.024
muscle contraction GO:0006936 101 0.024
multicellular organismal homeostasis GO:0048871 164 0.024
purine nucleotide catabolic process GO:0006195 211 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
positive regulation of myeloid cell differentiation GO:0045639 43 0.024
regulation of wnt signaling pathway GO:0030111 123 0.024
cardiac muscle hypertrophy GO:0003300 23 0.024
rna catabolic process GO:0006401 29 0.024
cellular ketone metabolic process GO:0042180 84 0.024
regulation of neuron death GO:1901214 134 0.024
respiratory gaseous exchange GO:0007585 43 0.024
interspecies interaction between organisms GO:0044419 83 0.023
Rat
megakaryocyte differentiation GO:0030219 26 0.023
cellular amino acid metabolic process GO:0006520 103 0.023
tissue homeostasis GO:0001894 115 0.023
adaptive immune response GO:0002250 155 0.023
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.023
negative regulation of hydrolase activity GO:0051346 71 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.023
organonitrogen compound catabolic process GO:1901565 264 0.023
response to organic cyclic compound GO:0014070 198 0.023
response to nitric oxide GO:0071731 4 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.022
positive regulation of defense response GO:0031349 124 0.022
blastocyst development GO:0001824 80 0.022
regulation of b cell activation GO:0050864 81 0.022
cellular response to biotic stimulus GO:0071216 92 0.022
wound healing GO:0042060 157 0.022
regulation of t cell activation GO:0050863 170 0.022
t cell differentiation GO:0030217 174 0.022
definitive hemopoiesis GO:0060216 20 0.022
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.022
pattern recognition receptor signaling pathway GO:0002221 47 0.022
negative regulation of cellular component organization GO:0051129 194 0.021
Rat
canonical wnt signaling pathway GO:0060070 130 0.021
negative regulation of osteoblast differentiation GO:0045668 30 0.021
regulation of system process GO:0044057 200 0.021
regulation of cellular amine metabolic process GO:0033238 20 0.021
regulation of cellular catabolic process GO:0031329 242 0.021
regulation of protein catabolic process GO:0042176 108 0.021
negative regulation of protein phosphorylation GO:0001933 126 0.021
extrinsic apoptotic signaling pathway GO:0097191 126 0.020
positive regulation of multi organism process GO:0043902 26 0.020
Rat
defense response to virus GO:0051607 68 0.020
renal system development GO:0072001 225 0.020
cell adhesion GO:0007155 329 0.020
single organism cell adhesion GO:0098602 156 0.020
regulation of inflammatory response GO:0050727 147 0.020
bone development GO:0060348 120 0.020
sensory organ morphogenesis GO:0090596 242 0.020
response to inorganic substance GO:0010035 96 0.020
negative regulation of peptidase activity GO:0010466 46 0.020
midgut development GO:0007494 4 0.020
regulation of protein transport GO:0051223 163 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
cellular metal ion homeostasis GO:0006875 151 0.020
protein secretion GO:0009306 111 0.020
pharynx development GO:0060465 1 0.020
fibroblast proliferation GO:0048144 35 0.019
regulation of nucleotide metabolic process GO:0006140 169 0.019
circadian rhythm GO:0007623 114 0.019
dna integrity checkpoint GO:0031570 28 0.019
regulation of chromatin organization GO:1902275 57 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
cardiocyte differentiation GO:0035051 87 0.019
kidney development GO:0001822 213 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
actin cytoskeleton organization GO:0030036 220 0.019
regulation of antibacterial peptide production GO:0002786 1 0.019
actin filament based movement GO:0030048 23 0.019
fat cell differentiation GO:0045444 160 0.018
positive regulation of stress activated mapk cascade GO:0032874 48 0.018
regulation of protein processing GO:0070613 96 0.018
myeloid cell homeostasis GO:0002262 114 0.018
histone deacetylation GO:0016575 26 0.018
cell activation involved in immune response GO:0002263 126 0.018
response to endoplasmic reticulum stress GO:0034976 53 0.018
positive regulation of cell activation GO:0050867 158 0.018
regulation of striated muscle cell differentiation GO:0051153 81 0.018
negative regulation of translation GO:0017148 22 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.018
metencephalon development GO:0022037 89 0.018
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.018
regulation of mrna stability GO:0043488 23 0.018
regulation of multi organism process GO:0043900 111 0.018
Rat
activation of jun kinase activity GO:0007257 15 0.018
regulation of t cell proliferation GO:0042129 92 0.018
regulation of interleukin 6 production GO:0032675 55 0.018
cytoplasmic mrna processing body assembly GO:0033962 6 0.018
cellular chemical homeostasis GO:0055082 215 0.018
response to topologically incorrect protein GO:0035966 25 0.017
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.017
macromolecule methylation GO:0043414 120 0.017
interferon beta production GO:0032608 16 0.017
defense response to other organism GO:0098542 197 0.017
positive regulation of t cell activation GO:0050870 101 0.017
connective tissue development GO:0061448 179 0.017
cellular response to external stimulus GO:0071496 88 0.017
Human
regulation of cell cycle process GO:0010564 160 0.017
positive regulation of lymphocyte proliferation GO:0050671 70 0.017
negative regulation of endopeptidase activity GO:0010951 44 0.017
anatomical structure homeostasis GO:0060249 145 0.017
stress activated mapk cascade GO:0051403 80 0.017
neural tube closure GO:0001843 90 0.017
cellular response to inorganic substance GO:0071241 37 0.017
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.016
amine metabolic process GO:0009308 45 0.016
negative regulation of ossification GO:0030279 49 0.016
cellular response to topologically incorrect protein GO:0035967 25 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
cellular divalent inorganic cation homeostasis GO:0072503 127 0.016
negative regulation of kinase activity GO:0033673 81 0.016
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.016
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.016
regulation of production of molecular mediator of immune response GO:0002700 65 0.016
histone lysine methylation GO:0034968 50 0.016
cellular lipid metabolic process GO:0044255 323 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.016
negative regulation of immune system process GO:0002683 209 0.016
cellular response to steroid hormone stimulus GO:0071383 33 0.016
intermediate filament based process GO:0045103 27 0.016
regulation of adaptive immune response GO:0002819 90 0.016
positive regulation of proteolysis GO:0045862 85 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
cellular amine metabolic process GO:0044106 44 0.016
appendage development GO:0048736 166 0.016
glycosyl compound metabolic process GO:1901657 246 0.015
calcium ion homeostasis GO:0055074 127 0.015
regulation of blood circulation GO:1903522 93 0.015
sensory system development GO:0048880 3 0.015
interleukin 12 production GO:0032615 32 0.015
leukocyte activation involved in immune response GO:0002366 126 0.015
methylation GO:0032259 134 0.015
viral transcription GO:0019083 3 0.015
Rat
response to growth factor GO:0070848 198 0.015
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.015
cellular response to x ray GO:0071481 2 0.015
protein import into nucleus GO:0006606 95 0.015
regulation of innate immune response GO:0045088 91 0.015
regulation of viral transcription GO:0046782 3 0.015
Rat
peptidyl lysine acetylation GO:0018394 45 0.015
wnt signaling pathway GO:0016055 188 0.015
regulation of body fluid levels GO:0050878 162 0.015
extracellular structure organization GO:0043062 148 0.015
camera type eye development GO:0043010 266 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
metal ion homeostasis GO:0055065 189 0.015
labyrinthine layer development GO:0060711 49 0.015
odontogenesis of dentin containing tooth GO:0042475 66 0.015
reactive oxygen species metabolic process GO:0072593 84 0.015
cell division GO:0051301 120 0.015
regulation of protein secretion GO:0050708 82 0.015
negative regulation of protein processing GO:0010955 79 0.015
negative regulation of protein maturation GO:1903318 79 0.015
positive regulation of immune effector process GO:0002699 107 0.015
myeloid dendritic cell activation GO:0001773 25 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.014
mammary gland morphogenesis GO:0060443 54 0.014
cellular response to oxidative stress GO:0034599 76 0.014
skeletal muscle cell differentiation GO:0035914 66 0.014
positive regulation of dna templated transcription elongation GO:0032786 2 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
embryonic appendage morphogenesis GO:0035113 126 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
positive regulation of organelle organization GO:0010638 128 0.014
positive regulation of apoptotic signaling pathway GO:2001235 95 0.014
negative regulation of mapk cascade GO:0043409 65 0.014
chemotaxis GO:0006935 247 0.014
positive regulation of interleukin 12 production GO:0032735 21 0.014
regulation of osteoblast differentiation GO:0045667 67 0.014
bone morphogenesis GO:0060349 78 0.014
embryonic skeletal system development GO:0048706 120 0.014
skeletal muscle organ development GO:0060538 163 0.014
chondrocyte differentiation GO:0002062 72 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
syncytium formation by plasma membrane fusion GO:0000768 42 0.014
intermediate filament cytoskeleton organization GO:0045104 26 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.014
neuronal action potential GO:0019228 54 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.014
ear morphogenesis GO:0042471 118 0.014
mammary gland epithelium development GO:0061180 65 0.014
histone h3 k9 dimethylation GO:0036123 4 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
nuclear transcribed mrna catabolic process GO:0000956 16 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.014
male gamete generation GO:0048232 285 0.013
cellular homeostasis GO:0019725 240 0.013
cation transmembrane transport GO:0098655 266 0.013
granulocyte differentiation GO:0030851 17 0.013
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.013
regulation of binding GO:0051098 111 0.013
peptidyl lysine methylation GO:0018022 29 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.013
lateral inhibition GO:0046331 1 0.013
myotube differentiation GO:0014902 105 0.013
purine ribonucleoside metabolic process GO:0046128 241 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.013
angiogenesis GO:0001525 201 0.013
regulation of leukocyte mediated immunity GO:0002703 104 0.013
positive regulation of t cell mediated immunity GO:0002711 24 0.013
spermatogenesis GO:0007283 284 0.013
sensory perception of mechanical stimulus GO:0050954 107 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.013
divalent metal ion transport GO:0070838 172 0.013
organelle localization GO:0051640 179 0.013
regulation of lymphocyte mediated immunity GO:0002706 84 0.013
regulation of protein deacetylation GO:0090311 17 0.013
circadian regulation of gene expression GO:0032922 48 0.013
negative regulation of chromatin silencing GO:0031936 1 0.013
gene silencing by mirna GO:0035195 10 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.013
monocyte differentiation GO:0030224 9 0.013
purine containing compound catabolic process GO:0072523 213 0.013
nucleotide metabolic process GO:0009117 332 0.013
regulation of neuron apoptotic process GO:0043523 122 0.012
cellular ion homeostasis GO:0006873 165 0.012
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.012
negative regulation of wnt signaling pathway GO:0030178 73 0.012
development of primary sexual characteristics GO:0045137 143 0.012
negative regulation of cell activation GO:0050866 111 0.012
leukocyte mediated immunity GO:0002443 174 0.012
epithelial cell proliferation GO:0050673 174 0.012
negative regulation of transferase activity GO:0051348 85 0.012
dna recombination GO:0006310 92 0.012
extracellular matrix organization GO:0030198 147 0.012
internal protein amino acid acetylation GO:0006475 42 0.012
regulation of rho protein signal transduction GO:0035023 71 0.012
establishment of organelle localization GO:0051656 122 0.012
cation homeostasis GO:0055080 212 0.012
microtubule based process GO:0007017 236 0.012
endodermal cell differentiation GO:0035987 14 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.012
ion transmembrane transport GO:0034220 361 0.012
response to transforming growth factor beta GO:0071559 88 0.012
multi multicellular organism process GO:0044706 109 0.012
response to steroid hormone GO:0048545 56 0.012
cellular response to dna damage stimulus GO:0006974 207 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
limb morphogenesis GO:0035108 149 0.012
osteoclast differentiation GO:0030316 62 0.012
intracellular protein transport GO:0006886 204 0.012
female sex differentiation GO:0046660 84 0.012
clathrin coat assembly GO:0048268 2 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
regulation of defense response to bacterium GO:1900424 3 0.012
regulation of interferon beta production GO:0032648 13 0.011
detection of stimulus GO:0051606 84 0.011
response to temperature stimulus GO:0009266 55 0.011
cell recognition GO:0008037 83 0.011
activation of innate immune response GO:0002218 56 0.011
olfactory learning GO:0008355 2 0.011
negative regulation of phospholipase activity GO:0010519 4 0.011
regulation of myeloid cell differentiation GO:0045637 96 0.011
protein targeting GO:0006605 143 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
response to acid chemical GO:0001101 111 0.011
natural killer cell proliferation GO:0001787 3 0.011
positive regulation of t cell proliferation GO:0042102 52 0.011
regulation of organ morphogenesis GO:2000027 144 0.011
oxidation reduction process GO:0055114 342 0.011
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.011
striated muscle hypertrophy GO:0014897 24 0.011
protein deacylation GO:0035601 36 0.011
response to estrogen GO:0043627 24 0.011
regulation of protein complex assembly GO:0043254 83 0.011

Map3k1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.014