Mus musculus

67 known processes

Herc1

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1

(Aliases: MGC7618,2810449H11Rik,B230218H07,D130015N03Rik,tbl)

Herc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone methylation GO:0016571 71 0.157
protein modification by small protein conjugation or removal GO:0070647 207 0.099
negative regulation of intracellular signal transduction GO:1902532 167 0.091
protein alkylation GO:0008213 81 0.086
purine nucleotide metabolic process GO:0006163 302 0.076
histone modification GO:0016570 159 0.076
methylation GO:0032259 134 0.074
negative regulation of phosphorus metabolic process GO:0010563 184 0.072
nucleotide metabolic process GO:0009117 332 0.072
regulation of organelle organization GO:0033043 289 0.072
ribonucleotide metabolic process GO:0009259 291 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.070
protein ubiquitination GO:0016567 171 0.069
protein methylation GO:0006479 81 0.068
small gtpase mediated signal transduction GO:0007264 97 0.064
macromolecule methylation GO:0043414 120 0.064
rhythmic process GO:0048511 174 0.063
purine nucleoside metabolic process GO:0042278 241 0.062
purine containing compound catabolic process GO:0072523 213 0.060
glycosyl compound catabolic process GO:1901658 206 0.059
purine ribonucleoside metabolic process GO:0046128 241 0.057
purine containing compound metabolic process GO:0072521 311 0.057
histone lysine methylation GO:0034968 50 0.056
purine ribonucleoside catabolic process GO:0046130 205 0.055
ribonucleoside triphosphate metabolic process GO:0009199 220 0.055
regulation of cellular amino acid metabolic process GO:0006521 5 0.054
chromatin modification GO:0016568 187 0.054
regulation of cellular catabolic process GO:0031329 242 0.053
organonitrogen compound catabolic process GO:1901565 264 0.053
cation transport GO:0006812 399 0.052
covalent chromatin modification GO:0016569 163 0.051
purine ribonucleotide catabolic process GO:0009154 208 0.050
nucleoside phosphate metabolic process GO:0006753 338 0.050
nucleoside metabolic process GO:0009116 246 0.047
nucleoside phosphate catabolic process GO:1901292 222 0.047
regulation of mapk cascade GO:0043408 248 0.046
negative regulation of cellular protein metabolic process GO:0032269 247 0.045
purine nucleoside catabolic process GO:0006152 205 0.044
ribonucleoside metabolic process GO:0009119 245 0.044
amine metabolic process GO:0009308 45 0.044
cellular amino acid metabolic process GO:0006520 103 0.044
negative regulation of phosphate metabolic process GO:0045936 184 0.043
nucleoside triphosphate metabolic process GO:0009141 230 0.042
nucleobase containing small molecule metabolic process GO:0055086 352 0.042
myeloid cell differentiation GO:0030099 233 0.042
response to organonitrogen compound GO:0010243 246 0.041
peptidyl amino acid modification GO:0018193 336 0.041
gtp metabolic process GO:0046039 144 0.040
purine ribonucleotide metabolic process GO:0009150 290 0.040
aromatic compound catabolic process GO:0019439 286 0.040
regulation of nucleotide metabolic process GO:0006140 169 0.040
ribonucleoside catabolic process GO:0042454 206 0.039
cellular amine metabolic process GO:0044106 44 0.039
regulation of chromosome organization GO:0033044 83 0.039
striated muscle tissue development GO:0014706 293 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
regulation of gtp catabolic process GO:0033124 113 0.037
protein modification by small protein conjugation GO:0032446 187 0.037
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
gtp catabolic process GO:0006184 143 0.037
muscle tissue development GO:0060537 308 0.036
purine nucleotide catabolic process GO:0006195 211 0.036
glycosyl compound metabolic process GO:1901657 246 0.035
synaptic transmission GO:0007268 329 0.034
cellular nitrogen compound catabolic process GO:0044270 280 0.034
synapse organization GO:0050808 125 0.034
nucleoside triphosphate catabolic process GO:0009143 205 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.034
forebrain development GO:0030900 302 0.034
ribonucleoside triphosphate catabolic process GO:0009203 199 0.034
positive regulation of protein modification process GO:0031401 299 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
apoptotic signaling pathway GO:0097190 306 0.032
posttranscriptional regulation of gene expression GO:0010608 155 0.032
ribonucleotide catabolic process GO:0009261 208 0.032
mapk cascade GO:0000165 281 0.032
endomembrane system organization GO:0010256 147 0.032
microtubule based process GO:0007017 236 0.032
regulation of purine nucleotide metabolic process GO:1900542 169 0.032
cytoplasmic transport GO:0016482 234 0.032
cellular response to organonitrogen compound GO:0071417 145 0.032
guanosine containing compound catabolic process GO:1901069 144 0.031
carbohydrate derivative catabolic process GO:1901136 231 0.031
heterocycle catabolic process GO:0046700 280 0.031
negative regulation of protein metabolic process GO:0051248 282 0.031
organic cyclic compound catabolic process GO:1901361 295 0.031
negative regulation of cellular component organization GO:0051129 194 0.031
protein localization to membrane GO:0072657 108 0.031
organophosphate catabolic process GO:0046434 232 0.031
cellular ketone metabolic process GO:0042180 84 0.030
leukocyte differentiation GO:0002521 342 0.030
chromatin organization GO:0006325 206 0.030
carbohydrate metabolic process GO:0005975 230 0.029
dna metabolic process GO:0006259 303 0.029
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.028
regulation of hydrolase activity GO:0051336 246 0.028
regulation of ion transmembrane transport GO:0034765 119 0.028
regulation of reactive oxygen species metabolic process GO:2000377 40 0.027
intracellular protein transport GO:0006886 204 0.027
regulation of nucleotide catabolic process GO:0030811 122 0.027
regulation of nucleoside metabolic process GO:0009118 130 0.027
male gamete generation GO:0048232 285 0.027
cell adhesion GO:0007155 329 0.026
wnt signaling pathway GO:0016055 188 0.026
regionalization GO:0003002 337 0.026
regulation of ras protein signal transduction GO:0046578 114 0.026
peptidyl serine modification GO:0018209 83 0.026
cellular response to hormone stimulus GO:0032870 150 0.026
actin filament based movement GO:0030048 23 0.026
organelle localization GO:0051640 179 0.026
positive regulation of cell development GO:0010720 237 0.025
response to acid chemical GO:0001101 111 0.025
purine nucleoside triphosphate catabolic process GO:0009146 203 0.025
spermatogenesis GO:0007283 284 0.025
response to peptide GO:1901652 136 0.025
germ cell development GO:0007281 185 0.025
compound eye development GO:0048749 1 0.025
guanosine containing compound metabolic process GO:1901068 144 0.025
regulation of membrane potential GO:0042391 192 0.025
muscle cell differentiation GO:0042692 261 0.025
regulation of purine nucleotide catabolic process GO:0033121 122 0.025
regulation of kinase activity GO:0043549 249 0.024
ras protein signal transduction GO:0007265 77 0.024
synapsis GO:0007129 34 0.024
regulation of cellular component biogenesis GO:0044087 181 0.024
transmembrane transport GO:0055085 412 0.024
regulation of cellular ketone metabolic process GO:0010565 66 0.024
ribose phosphate metabolic process GO:0019693 291 0.024
mrna metabolic process GO:0016071 84 0.024
regulation of histone methylation GO:0031060 30 0.024
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.023
cellular homeostasis GO:0019725 240 0.023
positive regulation of nervous system development GO:0051962 221 0.023
regulation of protein kinase activity GO:0045859 232 0.023
nucleotide catabolic process GO:0009166 217 0.023
nitrogen compound transport GO:0071705 271 0.022
peptidyl lysine methylation GO:0018022 29 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
reactive oxygen species metabolic process GO:0072593 84 0.022
rho protein signal transduction GO:0007266 32 0.022
positive regulation of gtpase activity GO:0043547 85 0.022
ion transmembrane transport GO:0034220 361 0.022
cellular chemical homeostasis GO:0055082 215 0.022
nucleoside catabolic process GO:0009164 206 0.021
divalent inorganic cation transport GO:0072511 178 0.021
oxidation reduction process GO:0055114 342 0.021
cell type specific apoptotic process GO:0097285 268 0.021
inorganic cation transmembrane transport GO:0098662 207 0.020
dna repair GO:0006281 107 0.020
positive regulation of protein phosphorylation GO:0001934 242 0.020
negative regulation of phosphorylation GO:0042326 166 0.020
circadian rhythm GO:0007623 114 0.020
anion transport GO:0006820 177 0.020
regulation of protein localization GO:0032880 231 0.019
microtubule cytoskeleton organization GO:0000226 157 0.019
cognition GO:0050890 149 0.019
skeletal system development GO:0001501 356 0.019
digestive system development GO:0055123 200 0.019
embryonic organ morphogenesis GO:0048562 276 0.019
organelle fission GO:0048285 170 0.019
regulation of ion transport GO:0043269 215 0.019
immune effector process GO:0002252 321 0.019
response to oxidative stress GO:0006979 123 0.019
regulation of neuron differentiation GO:0045664 281 0.019
positive regulation of ras gtpase activity GO:0032320 65 0.019
response to extracellular stimulus GO:0009991 127 0.019
microtubule polymerization or depolymerization GO:0031109 26 0.019
multicellular organismal signaling GO:0035637 91 0.019
positive regulation of organelle organization GO:0010638 128 0.018
organophosphate biosynthetic process GO:0090407 122 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
regulation of transferase activity GO:0051338 263 0.018
glucose homeostasis GO:0042593 128 0.018
nuclear division GO:0000280 158 0.018
microtubule nucleation GO:0007020 2 0.018
cellular protein complex assembly GO:0043623 116 0.018
response to insulin GO:0032868 100 0.018
fat cell differentiation GO:0045444 160 0.018
protein localization to plasma membrane GO:0072659 57 0.018
regulation of cell motility GO:2000145 236 0.018
cellular response to insulin stimulus GO:0032869 78 0.018
positive regulation of gtp catabolic process GO:0033126 85 0.018
morphogenesis of embryonic epithelium GO:0016331 159 0.018
heart morphogenesis GO:0003007 178 0.018
maintenance of location GO:0051235 89 0.018
calcium ion transport GO:0006816 159 0.018
olfactory learning GO:0008355 2 0.017
negative regulation of mapk cascade GO:0043409 65 0.017
lipid localization GO:0010876 126 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
gene silencing GO:0016458 38 0.017
learning or memory GO:0007611 148 0.017
regulation of cell projection organization GO:0031344 206 0.017
regulation of cell size GO:0008361 72 0.017
cellular response to dna damage stimulus GO:0006974 207 0.017
camera type eye development GO:0043010 266 0.017
regulation of chromatin organization GO:1902275 57 0.017
cellular lipid metabolic process GO:0044255 323 0.017
regulation of cell migration GO:0030334 219 0.017
divalent metal ion transport GO:0070838 172 0.017
digestive tract development GO:0048565 190 0.016
regulation of histone modification GO:0031056 56 0.016
negative regulation of molecular function GO:0044092 258 0.016
positive regulation of cell death GO:0010942 224 0.016
response to nutrient levels GO:0031667 109 0.016
neuromuscular process GO:0050905 99 0.016
positive regulation of histone modification GO:0031058 28 0.016
membrane organization GO:0061024 245 0.016
dna recombination GO:0006310 92 0.016
leukocyte mediated immunity GO:0002443 174 0.016
cellular response to peptide GO:1901653 92 0.016
inflammatory response GO:0006954 244 0.016
protein targeting to membrane GO:0006612 20 0.016
glycerolipid metabolic process GO:0046486 122 0.016
protein maturation GO:0051604 176 0.016
regulation of system process GO:0044057 200 0.016
positive regulation of nucleoside metabolic process GO:0045979 91 0.016
macromolecule catabolic process GO:0009057 281 0.016
autophagy GO:0006914 45 0.016
cellular calcium ion homeostasis GO:0006874 119 0.016
histone h3 k4 methylation GO:0051568 23 0.016
organelle assembly GO:0070925 177 0.016
cation transmembrane transport GO:0098655 266 0.015
homeostasis of number of cells GO:0048872 210 0.015
axonogenesis GO:0007409 274 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
regulation of transmembrane transport GO:0034762 128 0.015
protein catabolic process GO:0030163 221 0.015
phospholipid metabolic process GO:0006644 87 0.015
regulation of cell cycle GO:0051726 281 0.015
neuronal action potential GO:0019228 54 0.015
cellular response to lipid GO:0071396 145 0.015
negative regulation of protein modification process GO:0031400 163 0.015
regulation of homeostatic process GO:0032844 182 0.015
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.015
peptidyl lysine modification GO:0018205 77 0.015
stress activated mapk cascade GO:0051403 80 0.015
extrinsic apoptotic signaling pathway GO:0097191 126 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.015
locomotory behavior GO:0007626 195 0.015
response to oxygen levels GO:0070482 62 0.015
regulation of defense response GO:0031347 233 0.015
action potential GO:0001508 78 0.015
regulation of cell cycle process GO:0010564 160 0.015
positive regulation of growth GO:0045927 104 0.015
response to inorganic substance GO:0010035 96 0.015
negative regulation of synapse assembly GO:0051964 3 0.015
sequestering of calcium ion GO:0051208 18 0.015
regulation of chromatin modification GO:1903308 57 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.014
regulation of intracellular transport GO:0032386 159 0.014
protein targeting GO:0006605 143 0.014
sequestering of metal ion GO:0051238 19 0.014
multicellular organism growth GO:0035264 161 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
positive regulation of chromatin modification GO:1903310 28 0.014
skeletal muscle organ development GO:0060538 163 0.014
neural tube closure GO:0001843 90 0.014
rac protein signal transduction GO:0016601 13 0.014
regulation of secretion GO:0051046 274 0.014
calcium ion transmembrane transport GO:0070588 85 0.014
multi multicellular organism process GO:0044706 109 0.014
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.014
carbohydrate homeostasis GO:0033500 128 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
response to peptide hormone GO:0043434 127 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
positive regulation of nucleotide catabolic process GO:0030813 88 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.014
regulation of rho protein signal transduction GO:0035023 71 0.014
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.014
regulation of cellular component size GO:0032535 121 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of anatomical structure size GO:0090066 178 0.013
negative regulation of cell development GO:0010721 169 0.013
protein processing GO:0016485 163 0.013
positive regulation of nucleotide metabolic process GO:0045981 114 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
histone h4 k16 acetylation GO:0043984 3 0.013
protein localization to organelle GO:0033365 185 0.013
engulfment of apoptotic cell GO:0043652 3 0.013
regulation of myeloid cell differentiation GO:0045637 96 0.013
neural precursor cell proliferation GO:0061351 121 0.013
cytokine production GO:0001816 319 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
plasma membrane organization GO:0007009 90 0.013
regulation of protein processing GO:0070613 96 0.013
response to growth factor GO:0070848 198 0.013
male meiosis GO:0007140 37 0.013
regulation of cell substrate adhesion GO:0010810 73 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
telencephalon development GO:0021537 186 0.013
response to starvation GO:0042594 65 0.013
positive regulation of chromosome organization GO:2001252 33 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
fertilization GO:0009566 127 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
dendrite development GO:0016358 115 0.013
cytoskeleton dependent intracellular transport GO:0030705 50 0.012
meiotic nuclear division GO:0007126 115 0.012
transmission of nerve impulse GO:0019226 76 0.012
translation GO:0006412 93 0.012
meiosis i GO:0007127 60 0.012
b cell activation GO:0042113 161 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
lipid biosynthetic process GO:0008610 179 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
regulation of response to wounding GO:1903034 189 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
cell recognition GO:0008037 83 0.012
dephosphorylation GO:0016311 129 0.012
midgut development GO:0007494 4 0.012
regulation of protein complex assembly GO:0043254 83 0.012
positive regulation of neuron projection development GO:0010976 79 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
response to lipopolysaccharide GO:0032496 128 0.012
protein polymerization GO:0051258 57 0.012
jnk cascade GO:0007254 72 0.012
regulation of ras gtpase activity GO:0032318 88 0.012
adult locomotory behavior GO:0008344 91 0.012
cation homeostasis GO:0055080 212 0.012
regulation of cellular response to stress GO:0080135 159 0.012
cell fate commitment GO:0045165 210 0.012
interleukin 6 production GO:0032635 58 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
microtubule based movement GO:0007018 84 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
establishment of organelle localization GO:0051656 122 0.012
exocytosis GO:0006887 121 0.012
negative regulation of organelle organization GO:0010639 90 0.012
cell substrate adhesion GO:0031589 130 0.012
establishment or maintenance of cell polarity GO:0007163 86 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
gastrulation GO:0007369 116 0.012
glycerophospholipid metabolic process GO:0006650 71 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
actin cytoskeleton organization GO:0030036 220 0.011
appendage development GO:0048736 166 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
digestive tract morphogenesis GO:0048546 147 0.011
asymmetric stem cell division GO:0098722 3 0.011
blood vessel morphogenesis GO:0048514 285 0.011
regulation of neuron projection development GO:0010975 169 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
microtubule based transport GO:0010970 50 0.011
muscle system process GO:0003012 141 0.011
oocyte construction GO:0007308 2 0.011
t cell activation GO:0042110 289 0.011
positive regulation of kinase activity GO:0033674 155 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
regulation of protein maturation GO:1903317 96 0.011
body morphogenesis GO:0010171 45 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
protein depolymerization GO:0051261 34 0.011
response to decreased oxygen levels GO:0036293 59 0.011
response to transforming growth factor beta GO:0071559 88 0.011
circulatory system process GO:0003013 197 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
male sex differentiation GO:0046661 109 0.011
rna processing GO:0006396 105 0.011
metal ion homeostasis GO:0055065 189 0.011
mitotic cell cycle GO:0000278 195 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
i kappab kinase nf kappab signaling GO:0007249 85 0.011
tube formation GO:0035148 140 0.011
cell activation involved in immune response GO:0002263 126 0.011
amide transport GO:0042886 138 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
kidney development GO:0001822 213 0.011
skeletal system morphogenesis GO:0048705 203 0.011
peptide hormone secretion GO:0030072 109 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
rna interference GO:0016246 2 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
primary neural tube formation GO:0014020 95 0.011
cardiac muscle cell differentiation GO:0055007 69 0.011
chemotaxis GO:0006935 247 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.010
peptide transport GO:0015833 133 0.010
regulation of lymphocyte activation GO:0051249 240 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
cellular response to decreased oxygen levels GO:0036294 18 0.010
positive regulation of histone methylation GO:0031062 16 0.010
regulation of microtubule based process GO:0032886 52 0.010
neural tube formation GO:0001841 108 0.010
immune response regulating signaling pathway GO:0002764 125 0.010
male genitalia morphogenesis GO:0048808 4 0.010
positive regulation of dna templated transcription elongation GO:0032786 2 0.010
second messenger mediated signaling GO:0019932 73 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010
glucose metabolic process GO:0006006 92 0.010
adult behavior GO:0030534 135 0.010
sensory perception of sound GO:0007605 97 0.010
mitochondrion distribution GO:0048311 4 0.010
peptide secretion GO:0002790 114 0.010
cardiac muscle tissue development GO:0048738 130 0.010

Herc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
nervous system disease DOID:863 0 0.048
neuropathy DOID:870 0 0.015
musculoskeletal system disease DOID:17 0 0.012
immune system disease DOID:2914 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
central nervous system disease DOID:331 0 0.011