Mus musculus

14 known processes

Herc2

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

(Aliases: rjs,KIAA0393,jdf2,D7H15F32S1,D15F32S1h,mKIAA0393,D7H15F37S1)

Herc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
male gamete generation GO:0048232 285 0.072
cellular amino acid metabolic process GO:0006520 103 0.056
spermatogenesis GO:0007283 284 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.050
macromolecule catabolic process GO:0009057 281 0.049
purine nucleotide metabolic process GO:0006163 302 0.049
covalent chromatin modification GO:0016569 163 0.048
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
protein modification by small protein conjugation GO:0032446 187 0.046
Human
cation transmembrane transport GO:0098655 266 0.044
peptidyl amino acid modification GO:0018193 336 0.044
protein catabolic process GO:0030163 221 0.043
cellular protein catabolic process GO:0044257 155 0.042
ubiquitin dependent protein catabolic process GO:0006511 129 0.042
amine metabolic process GO:0009308 45 0.040
protein modification by small protein conjugation or removal GO:0070647 207 0.040
Human
endomembrane system organization GO:0010256 147 0.040
rhythmic process GO:0048511 174 0.039
sequestering of calcium ion GO:0051208 18 0.039
circadian rhythm GO:0007623 114 0.039
cellular amine metabolic process GO:0044106 44 0.039
nucleobase containing small molecule metabolic process GO:0055086 352 0.038
negative regulation of cellular protein metabolic process GO:0032269 247 0.037
cellular ketone metabolic process GO:0042180 84 0.037
nucleotide metabolic process GO:0009117 332 0.037
apoptotic signaling pathway GO:0097190 306 0.037
aromatic compound catabolic process GO:0019439 286 0.036
nucleoside phosphate catabolic process GO:1901292 222 0.035
cellular macromolecule catabolic process GO:0044265 206 0.034
regulation of organelle organization GO:0033043 289 0.034
positive regulation of protein modification process GO:0031401 299 0.034
positive regulation of cellular amine metabolic process GO:0033240 5 0.034
divalent inorganic cation transport GO:0072511 178 0.034
sequestering of metal ion GO:0051238 19 0.033
purine containing compound metabolic process GO:0072521 311 0.033
cognition GO:0050890 149 0.033
chromatin organization GO:0006325 206 0.033
dna metabolic process GO:0006259 303 0.032
Human
heterocycle catabolic process GO:0046700 280 0.032
regulation of cellular ketone metabolic process GO:0010565 66 0.032
ras protein signal transduction GO:0007265 77 0.032
glycosyl compound metabolic process GO:1901657 246 0.032
organic cyclic compound catabolic process GO:1901361 295 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
protein ubiquitination GO:0016567 171 0.031
Human
regulation of cell cycle GO:0051726 281 0.030
inorganic cation transmembrane transport GO:0098662 207 0.030
ribonucleoside catabolic process GO:0042454 206 0.030
cellular nitrogen compound catabolic process GO:0044270 280 0.029
actin cytoskeleton organization GO:0030036 220 0.029
negative regulation of protein metabolic process GO:0051248 282 0.029
nucleoside phosphate metabolic process GO:0006753 338 0.029
modification dependent protein catabolic process GO:0019941 133 0.029
axonogenesis GO:0007409 274 0.029
ribose phosphate metabolic process GO:0019693 291 0.029
response to organonitrogen compound GO:0010243 246 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.028
cation transport GO:0006812 399 0.027
ribonucleotide metabolic process GO:0009259 291 0.027
purine nucleotide catabolic process GO:0006195 211 0.027
purine ribonucleotide metabolic process GO:0009150 290 0.027
positive regulation of cellular catabolic process GO:0031331 148 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.027
memory GO:0007613 58 0.027
hematopoietic progenitor cell differentiation GO:0002244 143 0.027
transmembrane transport GO:0055085 412 0.026
regulation of cellular catabolic process GO:0031329 242 0.026
synaptic transmission GO:0007268 329 0.026
protein maturation GO:0051604 176 0.025
cellular response to dna damage stimulus GO:0006974 207 0.025
Human
histone modification GO:0016570 159 0.025
small gtpase mediated signal transduction GO:0007264 97 0.025
cellular ion homeostasis GO:0006873 165 0.025
immune effector process GO:0002252 321 0.025
learning or memory GO:0007611 148 0.025
dna repair GO:0006281 107 0.025
Human
metal ion homeostasis GO:0055065 189 0.024
ion transmembrane transport GO:0034220 361 0.024
regionalization GO:0003002 337 0.024
carbohydrate derivative catabolic process GO:1901136 231 0.024
regulation of system process GO:0044057 200 0.024
purine nucleoside metabolic process GO:0042278 241 0.023
purine containing compound catabolic process GO:0072523 213 0.023
nucleoside triphosphate catabolic process GO:0009143 205 0.023
nucleoside triphosphate metabolic process GO:0009141 230 0.023
cellular metal ion homeostasis GO:0006875 151 0.023
organelle localization GO:0051640 179 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
extracellular matrix organization GO:0030198 147 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
nucleoside catabolic process GO:0009164 206 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
cytoplasmic transport GO:0016482 234 0.022
sensory perception GO:0007600 245 0.021
regulation of chromatin modification GO:1903308 57 0.021
lateral inhibition GO:0046331 1 0.021
regulation of chromosome organization GO:0033044 83 0.021
compound eye development GO:0048749 1 0.021
nucleoside metabolic process GO:0009116 246 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.021
modification dependent macromolecule catabolic process GO:0043632 133 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
cell adhesion GO:0007155 329 0.021
cellular lipid metabolic process GO:0044255 323 0.020
response to growth factor GO:0070848 198 0.020
regulation of proteolysis GO:0030162 164 0.020
divalent metal ion transport GO:0070838 172 0.020
ribonucleotide catabolic process GO:0009261 208 0.020
inorganic ion transmembrane transport GO:0098660 234 0.020
actin filament polymerization GO:0030041 44 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
calcium ion transport into cytosol GO:0060402 48 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
learning GO:0007612 98 0.020
purine nucleoside catabolic process GO:0006152 205 0.020
cellular calcium ion homeostasis GO:0006874 119 0.020
purine ribonucleotide catabolic process GO:0009154 208 0.019
intracellular protein transport GO:0006886 204 0.019
negative regulation of cellular amine metabolic process GO:0033239 1 0.019
vesicle localization GO:0051648 86 0.019
cellular homeostasis GO:0019725 240 0.019
endocytosis GO:0006897 168 0.019
membrane organization GO:0061024 245 0.019
calcium ion transmembrane transport GO:0070588 85 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
rho protein signal transduction GO:0007266 32 0.018
regulation of intracellular transport GO:0032386 159 0.018
methylation GO:0032259 134 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
regulation of reactive oxygen species metabolic process GO:2000377 40 0.018
innate immune response GO:0045087 157 0.018
mitotic cytokinesis GO:0000281 4 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.018
cellular protein complex assembly GO:0043623 116 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
chromatin modification GO:0016568 187 0.018
regulation of cell cycle process GO:0010564 160 0.018
response to radiation GO:0009314 165 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
regulation of membrane potential GO:0042391 192 0.017
cellular chemical homeostasis GO:0055082 215 0.017
nuclear division GO:0000280 158 0.017
regulation of voltage gated calcium channel activity GO:1901385 4 0.017
positive regulation of cell development GO:0010720 237 0.017
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.017
divalent inorganic cation homeostasis GO:0072507 138 0.017
skeletal system development GO:0001501 356 0.017
macromolecule methylation GO:0043414 120 0.017
cation homeostasis GO:0055080 212 0.017
carbohydrate metabolic process GO:0005975 230 0.017
protein localization to membrane GO:0072657 108 0.017
regulation of protein catabolic process GO:0042176 108 0.017
microtubule cytoskeleton organization GO:0000226 157 0.017
microtubule based process GO:0007017 236 0.017
regulation of transferase activity GO:0051338 263 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
glycosyl compound catabolic process GO:1901658 206 0.016
cell growth GO:0016049 130 0.016
protein localization to organelle GO:0033365 185 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
protein processing GO:0016485 163 0.016
organophosphate catabolic process GO:0046434 232 0.016
positive regulation of organelle organization GO:0010638 128 0.016
olfactory learning GO:0008355 2 0.016
regulation of cell motility GO:2000145 236 0.016
mitotic cell cycle GO:0000278 195 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
cellular response to organonitrogen compound GO:0071417 145 0.016
locomotory behavior GO:0007626 195 0.016
regulation of cell migration GO:0030334 219 0.016
establishment of organelle localization GO:0051656 122 0.016
leukocyte differentiation GO:0002521 342 0.016
histone methylation GO:0016571 71 0.016
cellular component assembly involved in morphogenesis GO:0010927 139 0.015
dendrite development GO:0016358 115 0.015
regulation of defense response GO:0031347 233 0.015
protein methylation GO:0006479 81 0.015
fertilization GO:0009566 127 0.015
inflammatory response GO:0006954 244 0.015
spermatid differentiation GO:0048515 115 0.015
organelle assembly GO:0070925 177 0.015
negative regulation of synapse assembly GO:0051964 3 0.015
nitrogen compound transport GO:0071705 271 0.015
regulation of hydrolase activity GO:0051336 246 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
purine ribonucleoside metabolic process GO:0046128 241 0.015
myeloid cell differentiation GO:0030099 233 0.015
regulation of purine nucleotide catabolic process GO:0033121 122 0.015
neuromuscular process GO:0050905 99 0.015
fat cell differentiation GO:0045444 160 0.015
regulation of hormone levels GO:0010817 211 0.015
positive regulation of proteolysis GO:0045862 85 0.015
nucleotide catabolic process GO:0009166 217 0.015
multicellular organism growth GO:0035264 161 0.015
translation GO:0006412 93 0.015
calcium ion homeostasis GO:0055074 127 0.015
mitotic cell cycle process GO:1903047 159 0.015
action potential GO:0001508 78 0.015
oocyte axis specification GO:0007309 2 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
regulation of protein maturation GO:1903317 96 0.014
wnt signaling pathway GO:0016055 188 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.014
actin polymerization or depolymerization GO:0008154 54 0.014
regulation of ion homeostasis GO:2000021 64 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
peptidyl serine modification GO:0018209 83 0.014
protein polymerization GO:0051258 57 0.014
response to endoplasmic reticulum stress GO:0034976 53 0.014
cell type specific apoptotic process GO:0097285 268 0.014
cell activation involved in immune response GO:0002263 126 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
glycoprotein metabolic process GO:0009100 116 0.014
establishment of vesicle localization GO:0051650 81 0.014
organic anion transport GO:0015711 137 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
release of sequestered calcium ion into cytosol GO:0051209 42 0.013
regulation of cell adhesion GO:0030155 154 0.013
striated muscle myosin thick filament assembly GO:0071688 1 0.013
g protein coupled receptor signaling pathway GO:0007186 243 0.013
adult locomotory behavior GO:0008344 91 0.013
second messenger mediated signaling GO:0019932 73 0.013
terminal button organization GO:0072553 3 0.013
response to light stimulus GO:0009416 135 0.013
ossification GO:0001503 216 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
positive regulation of nervous system development GO:0051962 221 0.013
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
response to inorganic substance GO:0010035 96 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
myeloid leukocyte activation GO:0002274 83 0.013
maintenance of location GO:0051235 89 0.013
regulation of protein kinase activity GO:0045859 232 0.013
microtubule based movement GO:0007018 84 0.013
defecation GO:0030421 1 0.013
small molecule biosynthetic process GO:0044283 132 0.013
negative regulation of protein modification process GO:0031400 163 0.013
cell recognition GO:0008037 83 0.013
axon guidance GO:0007411 141 0.013
rna interference GO:0016246 2 0.013
germ cell development GO:0007281 185 0.013
positive regulation of cell death GO:0010942 224 0.013
actin filament organization GO:0007015 113 0.013
regulation of protein processing GO:0070613 96 0.013
cytosolic calcium ion transport GO:0060401 48 0.013
cytosolic calcium ion homeostasis GO:0051480 70 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
cellularization GO:0007349 1 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
regulation of inflammatory response GO:0050727 147 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
regulation of feeding behavior GO:0060259 3 0.012
respiratory system development GO:0060541 190 0.012
cytokinetic process GO:0032506 2 0.012
cytokine mediated signaling pathway GO:0019221 115 0.012
atp metabolic process GO:0046034 75 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
protein polyubiquitination GO:0000209 33 0.012
nuclear transport GO:0051169 139 0.012
spermatid development GO:0007286 108 0.012
actin filament based movement GO:0030048 23 0.012
regulation of translation GO:0006417 71 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
negative regulation of proteolysis GO:0045861 74 0.012
adult behavior GO:0030534 135 0.012
leukocyte activation involved in immune response GO:0002366 126 0.012
development of primary sexual characteristics GO:0045137 143 0.012
histone lysine methylation GO:0034968 50 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
cilium morphogenesis GO:0060271 102 0.012
circadian regulation of gene expression GO:0032922 48 0.012
gonad development GO:0008406 141 0.012
ribonucleoside monophosphate catabolic process GO:0009158 57 0.012
regulation of cellular component size GO:0032535 121 0.012
protein autophosphorylation GO:0046777 61 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
response to oxygen levels GO:0070482 62 0.012
regulation of circadian rhythm GO:0042752 58 0.012
negative regulation of nervous system development GO:0051961 156 0.012
single fertilization GO:0007338 82 0.012
organ growth GO:0035265 117 0.012
mapk cascade GO:0000165 281 0.012
response to transforming growth factor beta GO:0071559 88 0.012
cellular response to lipopolysaccharide GO:0071222 77 0.012
protein alkylation GO:0008213 81 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
glycerophospholipid metabolic process GO:0006650 71 0.012
positive regulation of cell adhesion GO:0045785 80 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
myosin filament organization GO:0031033 3 0.012
regulation of kinase activity GO:0043549 249 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
male courtship behavior GO:0008049 2 0.011
regulation of protein complex assembly GO:0043254 83 0.011
extracellular structure organization GO:0043062 148 0.011
meiotic cell cycle GO:0051321 122 0.011
anion transport GO:0006820 177 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
negative regulation of cell migration GO:0030336 59 0.011
muscle system process GO:0003012 141 0.011
regulation of cell substrate adhesion GO:0010810 73 0.011
blood vessel morphogenesis GO:0048514 285 0.011
regulation of histone modification GO:0031056 56 0.011
cytokine production GO:0001816 319 0.011
exocytosis GO:0006887 121 0.011
negative regulation of molecular function GO:0044092 258 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
oocyte anterior posterior axis specification GO:0007314 2 0.011
epithelial cell development GO:0002064 159 0.011
muscle cell differentiation GO:0042692 261 0.011
regulation of response to wounding GO:1903034 189 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
regulation of protein localization GO:0032880 231 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
plasma membrane organization GO:0007009 90 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of anatomical structure size GO:0090066 178 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
positive regulation of transferase activity GO:0051347 167 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
macromolecule glycosylation GO:0043413 55 0.011
cell substrate adhesion GO:0031589 130 0.011
regulation of mapk cascade GO:0043408 248 0.011
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.010
organelle fission GO:0048285 170 0.010
regulation of ion transport GO:0043269 215 0.010
phospholipid metabolic process GO:0006644 87 0.010
synaptic vesicle localization GO:0097479 59 0.010
establishment of mitochondrion localization GO:0051654 4 0.010
negative regulation of cell development GO:0010721 169 0.010
calcium ion transport GO:0006816 159 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
glycoprotein biosynthetic process GO:0009101 89 0.010
cell division GO:0051301 120 0.010
negative regulation of endothelial cell migration GO:0010596 4 0.010
establishment of blood nerve barrier GO:0008065 3 0.010
regulation of cytokine production GO:0001817 266 0.010
positive regulation of cell cycle GO:0045787 92 0.010
mrna metabolic process GO:0016071 84 0.010
guanosine containing compound catabolic process GO:1901069 144 0.010
synaptic vesicle transport GO:0048489 57 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010
positive regulation of cell cycle process GO:0090068 61 0.010
synapse organization GO:0050808 125 0.010
regulation of homeostatic process GO:0032844 182 0.010
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.010
protein oligomerization GO:0051259 67 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.010
peptide hormone secretion GO:0030072 109 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010

Herc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.045
nervous system disease DOID:863 0 0.045
central nervous system disease DOID:331 0 0.025
musculoskeletal system disease DOID:17 0 0.025
immune system disease DOID:2914 0 0.017
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
muscle tissue disease DOID:66 0 0.014
muscular disease DOID:0080000 0 0.014
connective tissue disease DOID:65 0 0.014
neurodegenerative disease DOID:1289 0 0.013
hematopoietic system disease DOID:74 0 0.011
disease of mental health DOID:150 0 0.010