Mus musculus

14 known processes

Herc4

hect domain and RLD 4

(Aliases: mKIAA1593,4921531D01Rik,9530080M15Rik,1700056O17Rik)

Herc4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatogenesis GO:0007283 284 0.100
regulation of cell activation GO:0050865 289 0.096
protein modification by small protein conjugation GO:0032446 187 0.081
Mouse
male gamete generation GO:0048232 285 0.078
cellular protein catabolic process GO:0044257 155 0.067
Mouse
mapk cascade GO:0000165 281 0.067
regulation of cytokine production GO:0001817 266 0.064
regulation of t cell activation GO:0050863 170 0.062
regulation of cellular amino acid metabolic process GO:0006521 5 0.058
ribonucleotide catabolic process GO:0009261 208 0.058
regulation of lymphocyte activation GO:0051249 240 0.057
protein ubiquitination GO:0016567 171 0.057
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.053
cellular ketone metabolic process GO:0042180 84 0.053
dna metabolic process GO:0006259 303 0.051
cellular amino acid metabolic process GO:0006520 103 0.051
small gtpase mediated signal transduction GO:0007264 97 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.048
ubiquitin dependent protein catabolic process GO:0006511 129 0.046
Mouse
negative regulation of synapse assembly GO:0051964 3 0.046
regulation of cellular ketone metabolic process GO:0010565 66 0.046
positive regulation of mapk cascade GO:0043410 170 0.045
spermatid development GO:0007286 108 0.045
posttranscriptional regulation of gene expression GO:0010608 155 0.044
t cell proliferation GO:0042098 120 0.043
cytokine production GO:0001816 319 0.041
negative regulation of t cell activation GO:0050868 65 0.040
negative regulation of cellular protein metabolic process GO:0032269 247 0.039
protein modification by small protein conjugation or removal GO:0070647 207 0.039
Mouse
purine containing compound metabolic process GO:0072521 311 0.039
modification dependent protein catabolic process GO:0019941 133 0.038
Mouse
t cell activation GO:0042110 289 0.038
spermatid differentiation GO:0048515 115 0.038
negative regulation of protein metabolic process GO:0051248 282 0.037
lymphocyte proliferation GO:0046651 164 0.037
aromatic compound catabolic process GO:0019439 286 0.037
protein catabolic process GO:0030163 221 0.036
Mouse
negative regulation of cell activation GO:0050866 111 0.036
cation transport GO:0006812 399 0.036
positive regulation of cytokine production GO:0001819 174 0.036
peptidyl amino acid modification GO:0018193 336 0.036
regulation of organelle organization GO:0033043 289 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.034
Mouse
amine metabolic process GO:0009308 45 0.034
negative regulation of immune system process GO:0002683 209 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.032
cellular nitrogen compound catabolic process GO:0044270 280 0.031
purine containing compound catabolic process GO:0072523 213 0.031
negative regulation of molecular function GO:0044092 258 0.031
immune response activating signal transduction GO:0002757 116 0.031
negative regulation of cell proliferation GO:0008285 296 0.030
positive regulation of protein modification process GO:0031401 299 0.029
immune response regulating signaling pathway GO:0002764 125 0.029
carbohydrate derivative catabolic process GO:1901136 231 0.029
respiratory tube development GO:0030323 167 0.029
regulation of proteolysis GO:0030162 164 0.029
nucleoside catabolic process GO:0009164 206 0.028
nitrogen compound transport GO:0071705 271 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
fat cell differentiation GO:0045444 160 0.028
cellular response to dna damage stimulus GO:0006974 207 0.028
regulation of response to wounding GO:1903034 189 0.027
transmembrane transport GO:0055085 412 0.027
response to lipopolysaccharide GO:0032496 128 0.027
regulation of cytoskeleton organization GO:0051493 122 0.026
regulation of mapk cascade GO:0043408 248 0.026
ribonucleoside triphosphate catabolic process GO:0009203 199 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.025
regulation of defense response GO:0031347 233 0.025
nucleoside phosphate metabolic process GO:0006753 338 0.025
purine ribonucleotide catabolic process GO:0009154 208 0.025
heterocycle catabolic process GO:0046700 280 0.025
regulation of map kinase activity GO:0043405 120 0.025
activation of immune response GO:0002253 138 0.025
positive regulation of cell development GO:0010720 237 0.024
innate immune response GO:0045087 157 0.024
purine nucleotide catabolic process GO:0006195 211 0.023
cytoplasmic transport GO:0016482 234 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
lung development GO:0030324 164 0.023
negative regulation of lymphocyte activation GO:0051250 91 0.023
ribose phosphate metabolic process GO:0019693 291 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
limb development GO:0060173 166 0.023
negative regulation of growth GO:0045926 99 0.022
ribonucleoside metabolic process GO:0009119 245 0.022
interspecies interaction between organisms GO:0044419 83 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
regulation of hydrolase activity GO:0051336 246 0.022
dna repair GO:0006281 107 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
Mouse
organelle localization GO:0051640 179 0.022
regulation of apoptotic signaling pathway GO:2001233 197 0.021
regulation of inflammatory response GO:0050727 147 0.021
leukocyte proliferation GO:0070661 172 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
ras protein signal transduction GO:0007265 77 0.021
nucleoside triphosphate catabolic process GO:0009143 205 0.021
nucleoside metabolic process GO:0009116 246 0.021
modification dependent macromolecule catabolic process GO:0043632 133 0.021
Mouse
substrate adhesion dependent cell spreading GO:0034446 30 0.021
organic cyclic compound catabolic process GO:1901361 295 0.021
regulation of transferase activity GO:0051338 263 0.021
regulation of cell cycle process GO:0010564 160 0.021
regulation of cellular catabolic process GO:0031329 242 0.021
apoptotic signaling pathway GO:0097190 306 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.021
cell type specific apoptotic process GO:0097285 268 0.021
cellular protein complex assembly GO:0043623 116 0.020
regulation of t cell proliferation GO:0042129 92 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
cellular response to lipid GO:0071396 145 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.020
macromolecule catabolic process GO:0009057 281 0.020
Mouse
regulation of cell cycle GO:0051726 281 0.020
cellular amine metabolic process GO:0044106 44 0.020
regulation of ras protein signal transduction GO:0046578 114 0.020
skeletal muscle organ development GO:0060538 163 0.020
digestive system development GO:0055123 200 0.020
compound eye development GO:0048749 1 0.020
protein localization to organelle GO:0033365 185 0.019
nucleotide metabolic process GO:0009117 332 0.019
positive regulation of nervous system development GO:0051962 221 0.019
regulation of nucleotide metabolic process GO:0006140 169 0.019
cellular response to molecule of bacterial origin GO:0071219 83 0.019
rho protein signal transduction GO:0007266 32 0.019
positive regulation of map kinase activity GO:0043406 84 0.019
histone modification GO:0016570 159 0.018
response to organonitrogen compound GO:0010243 246 0.018
nucleotide catabolic process GO:0009166 217 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.018
regulation of lymphocyte proliferation GO:0050670 117 0.018
regulation of purine nucleotide catabolic process GO:0033121 122 0.018
multi multicellular organism process GO:0044706 109 0.018
positive regulation of hydrolase activity GO:0051345 148 0.018
germ cell development GO:0007281 185 0.018
negative regulation of phosphorylation GO:0042326 166 0.017
positive regulation of transferase activity GO:0051347 167 0.017
positive regulation of organelle organization GO:0010638 128 0.017
homeostasis of number of cells GO:0048872 210 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
lateral inhibition GO:0046331 1 0.017
regulation of protein kinase activity GO:0045859 232 0.017
sensory perception GO:0007600 245 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.017
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.016
regulation of cellular response to stress GO:0080135 159 0.016
cell substrate adhesion GO:0031589 130 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.016
multicellular organism growth GO:0035264 161 0.016
positive regulation of lymphocyte activation GO:0051251 140 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
positive regulation of defense response GO:0031349 124 0.016
response to molecule of bacterial origin GO:0002237 143 0.016
organophosphate catabolic process GO:0046434 232 0.016
chemotaxis GO:0006935 247 0.016
purine ribonucleoside metabolic process GO:0046128 241 0.016
protein maturation GO:0051604 176 0.016
regulation of nucleotide catabolic process GO:0030811 122 0.016
neuron death GO:0070997 154 0.016
positive regulation of kinase activity GO:0033674 155 0.016
cell fate commitment GO:0045165 210 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.016
gland development GO:0048732 330 0.015
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.015
peptidyl tyrosine modification GO:0018212 145 0.015
regulation of cellular component size GO:0032535 121 0.015
cellular homeostasis GO:0019725 240 0.015
appendage development GO:0048736 166 0.015
protein processing GO:0016485 163 0.015
leukocyte mediated immunity GO:0002443 174 0.015
dna recombination GO:0006310 92 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.015
regulation of anatomical structure size GO:0090066 178 0.015
negative regulation of neuron apoptotic process GO:0043524 92 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
i kappab kinase nf kappab signaling GO:0007249 85 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
response to peptide GO:1901652 136 0.015
response to acid chemical GO:0001101 111 0.015
regulation of protein catabolic process GO:0042176 108 0.015
carbohydrate metabolic process GO:0005975 230 0.015
myeloid cell homeostasis GO:0002262 114 0.015
regulation of protein localization GO:0032880 231 0.015
regulation of homeostatic process GO:0032844 182 0.015
sensory organ morphogenesis GO:0090596 242 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
dephosphorylation GO:0016311 129 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
meiosis i GO:0007127 60 0.014
immune effector process GO:0002252 321 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
anatomical structure homeostasis GO:0060249 145 0.014
positive regulation of cell activation GO:0050867 158 0.014
regulation of leukocyte proliferation GO:0070663 121 0.014
negative regulation of t cell proliferation GO:0042130 38 0.014
endocytosis GO:0006897 168 0.014
Mouse
cellular response to hormone stimulus GO:0032870 150 0.014
regulation of protein processing GO:0070613 96 0.014
wnt signaling pathway GO:0016055 188 0.014
hepaticobiliary system development GO:0061008 67 0.014
peptidyl serine modification GO:0018209 83 0.014
negative regulation of nervous system development GO:0051961 156 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
regulation of cell projection organization GO:0031344 206 0.014
fertilization GO:0009566 127 0.014
Mouse
regulation of cell migration GO:0030334 219 0.014
multi organism behavior GO:0051705 62 0.014
rna processing GO:0006396 105 0.014
inflammatory response GO:0006954 244 0.014
cation transmembrane transport GO:0098655 266 0.014
erk1 and erk2 cascade GO:0070371 77 0.014
nuclear division GO:0000280 158 0.014
cellular chemical homeostasis GO:0055082 215 0.014
regulation of kinase activity GO:0043549 249 0.014
meiotic cell cycle process GO:1903046 77 0.013
antigen receptor mediated signaling pathway GO:0050851 64 0.013
regulation of innate immune response GO:0045088 91 0.013
terminal button organization GO:0072553 3 0.013
maintenance of location GO:0051235 89 0.013
Worm
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.013
b cell differentiation GO:0030183 78 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
mitochondrion organization GO:0007005 134 0.013
cellular response to lipopolysaccharide GO:0071222 77 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
actin cytoskeleton organization GO:0030036 220 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
establishment of organelle localization GO:0051656 122 0.013
positive regulation of nucleotide metabolic process GO:0045981 114 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.013
response to oxidative stress GO:0006979 123 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
regulation of translation GO:0006417 71 0.013
organelle fission GO:0048285 170 0.013
ion transmembrane transport GO:0034220 361 0.013
cellular response to peptide GO:1901653 92 0.012
lymphocyte differentiation GO:0030098 242 0.012
translation GO:0006412 93 0.012
regulation of neural precursor cell proliferation GO:2000177 70 0.012
lipid localization GO:0010876 126 0.012
Worm
response to organic cyclic compound GO:0014070 198 0.012
divalent inorganic cation transport GO:0072511 178 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
respiratory system development GO:0060541 190 0.012
covalent chromatin modification GO:0016569 163 0.012
pharynx development GO:0060465 1 0.012
regulation of ion transport GO:0043269 215 0.012
regulation of ossification GO:0030278 112 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
regulation of multi organism process GO:0043900 111 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
ribonucleotide metabolic process GO:0009259 291 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
neuron apoptotic process GO:0051402 142 0.012
transmission of nerve impulse GO:0019226 76 0.012
positive regulation of gtpase activity GO:0043547 85 0.012
canonical wnt signaling pathway GO:0060070 130 0.012
regulation of neuron projection development GO:0010975 169 0.012
chromosome organization involved in meiosis GO:0070192 39 0.012
negative regulation of lymphocyte proliferation GO:0050672 45 0.012
response to growth factor GO:0070848 198 0.012
multicellular organismal signaling GO:0035637 91 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
actin polymerization or depolymerization GO:0008154 54 0.011
response to light stimulus GO:0009416 135 0.011
regulation of body fluid levels GO:0050878 162 0.011
positive regulation of cellular amine metabolic process GO:0033240 5 0.011
b cell activation GO:0042113 161 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
protein acylation GO:0043543 64 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
skin development GO:0043588 220 0.011
regulation of gtp catabolic process GO:0033124 113 0.011
cellular ion homeostasis GO:0006873 165 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
tissue homeostasis GO:0001894 115 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
digestive tract morphogenesis GO:0048546 147 0.011
metal ion homeostasis GO:0055065 189 0.011
glucose homeostasis GO:0042593 128 0.011
anion transport GO:0006820 177 0.011
response to peptide hormone GO:0043434 127 0.011
response to topologically incorrect protein GO:0035966 25 0.011
regulation of neuron differentiation GO:0045664 281 0.011
positive regulation of cell death GO:0010942 224 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
double strand break repair GO:0006302 48 0.011
response to insulin GO:0032868 100 0.011
ossification GO:0001503 216 0.011
synaptic transmission GO:0007268 329 0.011
regulation of b cell activation GO:0050864 81 0.011
chromatin modification GO:0016568 187 0.011
oocyte axis specification GO:0007309 2 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
labyrinthine layer development GO:0060711 49 0.011
development of primary sexual characteristics GO:0045137 143 0.010
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.010
tissue remodeling GO:0048771 102 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
regulation of endocytosis GO:0030100 69 0.010
glycerolipid metabolic process GO:0046486 122 0.010
muscle tissue development GO:0060537 308 0.010
cell division GO:0051301 120 0.010
divalent metal ion transport GO:0070838 172 0.010
camera type eye development GO:0043010 266 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
appendage morphogenesis GO:0035107 149 0.010
negative regulation of transferase activity GO:0051348 85 0.010
regulation of neuron death GO:1901214 134 0.010

Herc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
cancer DOID:162 0 0.015
nervous system disease DOID:863 0 0.015
disease of anatomical entity DOID:7 0 0.015
disease of metabolism DOID:0014667 0 0.012