Mus musculus

84 known processes

Plk5

polo-like kinase 5 (Drosophila)

(Aliases: MGC106082,6330514A18Rik)

Plk5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transmembrane transport GO:0034220 361 0.266
cation transport GO:0006812 399 0.227
cation transmembrane transport GO:0098655 266 0.107
inorganic ion transmembrane transport GO:0098660 234 0.091
organic anion transport GO:0015711 137 0.084
inorganic cation transmembrane transport GO:0098662 207 0.084
regulation of transmembrane transport GO:0034762 128 0.083
transmembrane transport GO:0055085 412 0.075
regulation of cellular amino acid metabolic process GO:0006521 5 0.073
regulation of ion transmembrane transport GO:0034765 119 0.071
synaptic transmission GO:0007268 329 0.070
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.056
divalent metal ion transport GO:0070838 172 0.056
cellular amino acid metabolic process GO:0006520 103 0.055
detection of stimulus GO:0051606 84 0.055
anion transport GO:0006820 177 0.054
divalent inorganic cation transport GO:0072511 178 0.047
phototransduction GO:0007602 17 0.044
cognition GO:0050890 149 0.038
Mouse
regulation of voltage gated calcium channel activity GO:1901385 4 0.037
nucleoside phosphate metabolic process GO:0006753 338 0.037
cellular chemical homeostasis GO:0055082 215 0.036
axonogenesis GO:0007409 274 0.036
cellular ketone metabolic process GO:0042180 84 0.035
nitrogen compound transport GO:0071705 271 0.035
regulation of ion transport GO:0043269 215 0.034
calcium ion transmembrane transport GO:0070588 85 0.034
neurotransmitter transport GO:0006836 76 0.034
regulation of cellular ketone metabolic process GO:0010565 66 0.034
peptidyl amino acid modification GO:0018193 336 0.034
microtubule based process GO:0007017 236 0.033
Yeast
amino acid transport GO:0006865 61 0.032
response to organic cyclic compound GO:0014070 198 0.031
organic acid transport GO:0015849 101 0.031
chemotaxis GO:0006935 247 0.029
calcium ion transport GO:0006816 159 0.029
regulation of neurotransmitter levels GO:0001505 87 0.029
cellular lipid metabolic process GO:0044255 323 0.028
establishment of organelle localization GO:0051656 122 0.028
positive regulation of protein phosphorylation GO:0001934 242 0.028
membrane organization GO:0061024 245 0.028
carboxylic acid transport GO:0046942 100 0.028
nucleotide metabolic process GO:0009117 332 0.027
positive regulation of cilium movement GO:0003353 1 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.026
nucleobase containing small molecule metabolic process GO:0055086 352 0.026
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.026
organelle localization GO:0051640 179 0.026
endomembrane system organization GO:0010256 147 0.026
neuron neuron synaptic transmission GO:0007270 69 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
learning GO:0007612 98 0.025
plasma membrane organization GO:0007009 90 0.024
nuclear division GO:0000280 158 0.024
Yeast
regulation of homeostatic process GO:0032844 182 0.024
establishment of vesicle localization GO:0051650 81 0.024
regulation of glutamate receptor signaling pathway GO:1900449 16 0.023
regulation of transporter activity GO:0032409 57 0.023
cation homeostasis GO:0055080 212 0.023
photoreceptor cell development GO:0042461 40 0.022
synaptic vesicle transport GO:0048489 57 0.022
negative regulation of molecular function GO:0044092 258 0.022
lateral inhibition GO:0046331 1 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
mitochondrion organization GO:0007005 134 0.022
neurotransmitter secretion GO:0007269 62 0.022
regulation of secretion GO:0051046 274 0.022
metal ion homeostasis GO:0055065 189 0.021
cellular amine metabolic process GO:0044106 44 0.021
negative regulation of cell proliferation GO:0008285 296 0.021
sodium ion transmembrane transport GO:0035725 49 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
positive regulation of nervous system development GO:0051962 221 0.021
organophosphate catabolic process GO:0046434 232 0.020
amine metabolic process GO:0009308 45 0.020
cellular homeostasis GO:0019725 240 0.020
regulation of kinase activity GO:0043549 249 0.020
sequestering of calcium ion GO:0051208 18 0.020
peptide secretion GO:0002790 114 0.020
sensory perception of light stimulus GO:0050953 54 0.020
peptidyl tyrosine modification GO:0018212 145 0.020
ribonucleotide metabolic process GO:0009259 291 0.020
regulation of transferase activity GO:0051338 263 0.020
regulation of organelle organization GO:0033043 289 0.019
Yeast
calcium ion homeostasis GO:0055074 127 0.019
activation of immune response GO:0002253 138 0.019
regulation of hormone levels GO:0010817 211 0.019
regulation of purine nucleotide metabolic process GO:1900542 169 0.019
multicellular organismal homeostasis GO:0048871 164 0.019
protein localization to organelle GO:0033365 185 0.019
regulation of nucleotide metabolic process GO:0006140 169 0.019
vesicle localization GO:0051648 86 0.019
regulation of protein kinase activity GO:0045859 232 0.018
spermatogenesis GO:0007283 284 0.018
cell recognition GO:0008037 83 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
synapse organization GO:0050808 125 0.018
glycoprotein metabolic process GO:0009100 116 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
synaptic vesicle localization GO:0097479 59 0.018
aromatic compound catabolic process GO:0019439 286 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
substantia nigra development GO:0021762 2 0.017
cell adhesion GO:0007155 329 0.017
regulation of ion transmembrane transporter activity GO:0032412 54 0.017
maintenance of location GO:0051235 89 0.017
peptide transport GO:0015833 133 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
hormone secretion GO:0046879 128 0.016
camera type eye development GO:0043010 266 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
heterocycle catabolic process GO:0046700 280 0.016
mammary gland bud formation GO:0060615 2 0.016
actin cytoskeleton organization GO:0030036 220 0.016
purine containing compound metabolic process GO:0072521 311 0.015
sodium ion transport GO:0006814 73 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
response to light stimulus GO:0009416 135 0.015
alpha amino acid metabolic process GO:1901605 59 0.015
regulation of membrane potential GO:0042391 192 0.015
cellular nitrogen compound catabolic process GO:0044270 280 0.015
learning or memory GO:0007611 148 0.015
Mouse
sulfur compound metabolic process GO:0006790 100 0.015
amide transport GO:0042886 138 0.015
regulation of system process GO:0044057 200 0.015
regulation of neuronal synaptic plasticity GO:0048168 30 0.015
intracellular protein transport GO:0006886 204 0.015
ribonucleoside metabolic process GO:0009119 245 0.014
inorganic anion transport GO:0015698 43 0.014
regulation of hormone secretion GO:0046883 88 0.014
establishment of synaptic vesicle localization GO:0097480 57 0.014
mapk cascade GO:0000165 281 0.014
regulation of synaptic plasticity GO:0048167 87 0.014
Mouse
cellular calcium ion homeostasis GO:0006874 119 0.014
positive regulation of protein modification process GO:0031401 299 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
fat soluble vitamin biosynthetic process GO:0042362 4 0.014
cytoplasmic transport GO:0016482 234 0.014
glutamate receptor signaling pathway GO:0007215 35 0.014
response to radiation GO:0009314 165 0.014
regulation of metal ion transport GO:0010959 106 0.014
oxidation reduction process GO:0055114 342 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
photoreceptor cell differentiation GO:0046530 52 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
cellular response to abiotic stimulus GO:0071214 56 0.013
retina development in camera type eye GO:0060041 119 0.013
locomotory behavior GO:0007626 195 0.013
potassium ion transmembrane transport GO:0071805 43 0.013
positive regulation of kinase activity GO:0033674 155 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.013
regulation of neuron projection development GO:0010975 169 0.013
male gamete generation GO:0048232 285 0.013
lipid transport GO:0006869 98 0.013
peptide hormone secretion GO:0030072 109 0.013
lipid localization GO:0010876 126 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
positive regulation of secretion GO:0051047 130 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
sensory organ morphogenesis GO:0090596 242 0.012
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
one carbon metabolic process GO:0006730 1 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
cellular ion homeostasis GO:0006873 165 0.012
eye photoreceptor cell differentiation GO:0001754 41 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
kidney development GO:0001822 213 0.012
organelle fission GO:0048285 170 0.012
Yeast
renal system development GO:0072001 225 0.012
meiotic nuclear division GO:0007126 115 0.012
Yeast
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
regulation of cell cycle process GO:0010564 160 0.012
carbohydrate metabolic process GO:0005975 230 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of proteolysis GO:0030162 164 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
nuclear transport GO:0051169 139 0.011
regulation of calcium ion transport GO:0051924 69 0.011
anatomical structure homeostasis GO:0060249 145 0.011
glucose homeostasis GO:0042593 128 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
Yeast
nucleoside metabolic process GO:0009116 246 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
positive regulation of long term neuronal synaptic plasticity GO:0048170 3 0.011
regulation of gamma aminobutyric acid secretion GO:0014052 2 0.011
transmission of nerve impulse GO:0019226 76 0.011
regulation of receptor activity GO:0010469 41 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
regulation of peptide secretion GO:0002791 77 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
protein autophosphorylation GO:0046777 61 0.011
regulation of cell motility GO:2000145 236 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
phosphatidylinositol metabolic process GO:0046488 45 0.011
adult behavior GO:0030534 135 0.011
regulation of high voltage gated calcium channel activity GO:1901841 2 0.011
protein palmitoylation GO:0018345 14 0.011
regulation of cell cycle GO:0051726 281 0.011
cellular response to acid chemical GO:0071229 68 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.010
protein oligomerization GO:0051259 67 0.010
cilium morphogenesis GO:0060271 102 0.010
regulation of anion transport GO:0044070 27 0.010
regulation of neurotransmitter transport GO:0051588 35 0.010
wnt signaling pathway GO:0016055 188 0.010
exocytosis GO:0006887 121 0.010
tube formation GO:0035148 140 0.010
rap protein signal transduction GO:0032486 3 0.010
glycosyl compound metabolic process GO:1901657 246 0.010
regulation of body fluid levels GO:0050878 162 0.010
cellular potassium ion transport GO:0071804 43 0.010
protein targeting GO:0006605 143 0.010
response to organonitrogen compound GO:0010243 246 0.010
spermatid differentiation GO:0048515 115 0.010

Plk5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.078
sensory system disease DOID:0050155 0 0.078
disease of anatomical entity DOID:7 0 0.078
eye and adnexa disease DOID:1492 0 0.044
eye disease DOID:5614 0 0.044
retinal degeneration DOID:8466 0 0.018
retinal disease DOID:5679 0 0.018
retinitis pigmentosa DOID:10584 0 0.014
central nervous system disease DOID:331 0 0.012
cardiovascular system disease DOID:1287 0 0.011