Mus musculus

13 known processes

Sms

spermine synthase

(Aliases: AI427066,SpmST,gyro,Gy,SPMSY)

Sms biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 207 0.128
protein modification by small protein conjugation GO:0032446 187 0.087
transmembrane transport GO:0055085 412 0.079
synaptic transmission GO:0007268 329 0.074
regulation of cellular amino acid metabolic process GO:0006521 5 0.071
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.067
cellular amine metabolic process GO:0044106 44 0.065
cytoplasmic transport GO:0016482 234 0.063
organelle fission GO:0048285 170 0.057
protein ubiquitination GO:0016567 171 0.057
regulation of cellular amine metabolic process GO:0033238 20 0.052
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.052
apoptotic signaling pathway GO:0097190 306 0.051
regulation of apoptotic signaling pathway GO:2001233 197 0.050
regulation of cellular ketone metabolic process GO:0010565 66 0.049
amine metabolic process GO:0009308 45 0.048
cellular macromolecule catabolic process GO:0044265 206 0.048
cellular ketone metabolic process GO:0042180 84 0.046
glycosyl compound metabolic process GO:1901657 246 0.046
peptidyl amino acid modification GO:0018193 336 0.046
protein catabolic process GO:0030163 221 0.044
membrane organization GO:0061024 245 0.043
cellular amino acid metabolic process GO:0006520 103 0.042
cation transport GO:0006812 399 0.042
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
negative regulation of cellular protein metabolic process GO:0032269 247 0.042
cation transmembrane transport GO:0098655 266 0.041
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.039
regulation of cellular component biogenesis GO:0044087 181 0.038
ubiquitin dependent protein catabolic process GO:0006511 129 0.038
cellular response to arsenic containing substance GO:0071243 4 0.035
microtubule based process GO:0007017 236 0.035
regulation of cellular catabolic process GO:0031329 242 0.035
regulation of ion transmembrane transport GO:0034765 119 0.035
ion transmembrane transport GO:0034220 361 0.034
organelle localization GO:0051640 179 0.033
nucleobase containing small molecule metabolic process GO:0055086 352 0.033
positive regulation of apoptotic process GO:0043065 217 0.033
intracellular protein transport GO:0006886 204 0.032
nucleoside metabolic process GO:0009116 246 0.032
macromolecule catabolic process GO:0009057 281 0.031
spermatogenesis GO:0007283 284 0.031
cell type specific apoptotic process GO:0097285 268 0.031
negative regulation of cellular component organization GO:0051129 194 0.030
negative regulation of protein metabolic process GO:0051248 282 0.030
rna processing GO:0006396 105 0.030
modification dependent protein catabolic process GO:0019941 133 0.030
male gamete generation GO:0048232 285 0.029
olfactory learning GO:0008355 2 0.029
regulation of establishment of protein localization GO:0070201 181 0.029
regulation of protein catabolic process GO:0042176 108 0.028
cellular protein catabolic process GO:0044257 155 0.028
cellular response to organonitrogen compound GO:0071417 145 0.028
small gtpase mediated signal transduction GO:0007264 97 0.028
nitrogen compound transport GO:0071705 271 0.028
response to organonitrogen compound GO:0010243 246 0.028
positive regulation of programmed cell death GO:0043068 218 0.028
organelle assembly GO:0070925 177 0.028
proteasomal protein catabolic process GO:0010498 98 0.027
purine ribonucleoside metabolic process GO:0046128 241 0.027
microtubule cytoskeleton organization GO:0000226 157 0.026
ribonucleoside metabolic process GO:0009119 245 0.026
purine nucleoside metabolic process GO:0042278 241 0.026
oxidation reduction process GO:0055114 342 0.026
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.026
purine containing compound metabolic process GO:0072521 311 0.026
nucleoside phosphate metabolic process GO:0006753 338 0.025
regulation of cell cycle GO:0051726 281 0.025
purine nucleotide metabolic process GO:0006163 302 0.025
ras protein signal transduction GO:0007265 77 0.025
meiotic cell cycle GO:0051321 122 0.025
meiotic cell cycle process GO:1903046 77 0.024
regulation of proteolysis GO:0030162 164 0.024
positive regulation of cell development GO:0010720 237 0.024
regulation of mapk cascade GO:0043408 248 0.024
meiotic nuclear division GO:0007126 115 0.024
synapse organization GO:0050808 125 0.024
mitotic cell cycle process GO:1903047 159 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
histone modification GO:0016570 159 0.023
establishment of organelle localization GO:0051656 122 0.023
translation GO:0006412 93 0.023
positive regulation of cell death GO:0010942 224 0.023
mapk cascade GO:0000165 281 0.023
regulation of vesicle mediated transport GO:0060627 139 0.023
negative regulation of molecular function GO:0044092 258 0.023
regulation of intracellular transport GO:0032386 159 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.023
inorganic cation transmembrane transport GO:0098662 207 0.023
divalent metal ion transport GO:0070838 172 0.023
regulation of protein kinase activity GO:0045859 232 0.022
regulation of ion transport GO:0043269 215 0.022
anatomical structure homeostasis GO:0060249 145 0.022
mrna splicing via spliceosome GO:0000398 43 0.022
mrna metabolic process GO:0016071 84 0.022
wnt signaling pathway GO:0016055 188 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
inorganic ion transmembrane transport GO:0098660 234 0.021
regulation of organelle organization GO:0033043 289 0.021
regulation of protein localization GO:0032880 231 0.021
ribonucleoside triphosphate metabolic process GO:0009199 220 0.021
ribonucleotide metabolic process GO:0009259 291 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.021
positive regulation of nervous system development GO:0051962 221 0.021
cellular lipid metabolic process GO:0044255 323 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
nucleoside phosphate catabolic process GO:1901292 222 0.021
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
response to organic cyclic compound GO:0014070 198 0.020
nucleotide metabolic process GO:0009117 332 0.020
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.020
cation homeostasis GO:0055080 212 0.020
mitotic cell cycle GO:0000278 195 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.020
regulation of kinase activity GO:0043549 249 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
nucleoside catabolic process GO:0009164 206 0.020
cellular homeostasis GO:0019725 240 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
dna metabolic process GO:0006259 303 0.019
learning or memory GO:0007611 148 0.019
protein polymerization GO:0051258 57 0.019
regulation of cellular protein catabolic process GO:1903362 61 0.019
cellular protein complex assembly GO:0043623 116 0.019
carbohydrate derivative biosynthetic process GO:1901137 183 0.019
protein localization to organelle GO:0033365 185 0.019
organic anion transport GO:0015711 137 0.019
aromatic compound catabolic process GO:0019439 286 0.019
regulation of protein transport GO:0051223 163 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.019
modification dependent macromolecule catabolic process GO:0043632 133 0.019
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.019
positive regulation of protein modification process GO:0031401 299 0.019
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.018
axonogenesis GO:0007409 274 0.018
regulation of transmembrane transport GO:0034762 128 0.018
covalent chromatin modification GO:0016569 163 0.018
regulation of membrane potential GO:0042391 192 0.018
heterocycle catabolic process GO:0046700 280 0.018
fertilization GO:0009566 127 0.018
rna splicing GO:0008380 54 0.018
regulation of cellular response to stress GO:0080135 159 0.018
anion transport GO:0006820 177 0.018
rna splicing via transesterification reactions GO:0000375 43 0.017
regulation of neuron apoptotic process GO:0043523 122 0.017
maintenance of location GO:0051235 89 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
nucleotide catabolic process GO:0009166 217 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
response to radiation GO:0009314 165 0.017
dendrite development GO:0016358 115 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
sensory perception GO:0007600 245 0.017
regulation of peptidase activity GO:0052547 96 0.017
muscle cell differentiation GO:0042692 261 0.017
organic hydroxy compound metabolic process GO:1901615 203 0.017
locomotory behavior GO:0007626 195 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
nuclear division GO:0000280 158 0.017
establishment of protein localization to organelle GO:0072594 118 0.017
purine containing compound catabolic process GO:0072523 213 0.016
organophosphate biosynthetic process GO:0090407 122 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
Rat
stem cell differentiation GO:0048863 268 0.016
response to molecule of bacterial origin GO:0002237 143 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
regulation of hormone levels GO:0010817 211 0.016
cellularization GO:0007349 1 0.016
chromatin modification GO:0016568 187 0.016
carboxylic acid transport GO:0046942 100 0.016
chromatin organization GO:0006325 206 0.016
cognition GO:0050890 149 0.016
response to oxidative stress GO:0006979 123 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
positive regulation of apoptotic signaling pathway GO:2001235 95 0.016
nuclear transport GO:0051169 139 0.016
neuron death GO:0070997 154 0.015
glycosyl compound catabolic process GO:1901658 206 0.015
spermatid development GO:0007286 108 0.015
ribonucleoprotein complex subunit organization GO:0071826 28 0.015
amide transport GO:0042886 138 0.015
response to lipopolysaccharide GO:0032496 128 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
forebrain development GO:0030900 302 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
epithelial cell development GO:0002064 159 0.015
negative regulation of synapse assembly GO:0051964 3 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
cellular chemical homeostasis GO:0055082 215 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
regionalization GO:0003002 337 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
multicellular organismal signaling GO:0035637 91 0.015
multicellular organism growth GO:0035264 161 0.015
mrna processing GO:0006397 63 0.015
inflammatory response GO:0006954 244 0.015
response to light stimulus GO:0009416 135 0.015
organophosphate catabolic process GO:0046434 232 0.015
male courtship behavior GO:0008049 2 0.015
regulation of body fluid levels GO:0050878 162 0.015
endomembrane system organization GO:0010256 147 0.015
male anatomical structure morphogenesis GO:0090598 4 0.015
carbohydrate metabolic process GO:0005975 230 0.014
divalent inorganic cation transport GO:0072511 178 0.014
calcium ion transport GO:0006816 159 0.014
regulation of hydrolase activity GO:0051336 246 0.014
negative regulation of protein modification process GO:0031400 163 0.014
epithelial cell proliferation GO:0050673 174 0.014
spermatid differentiation GO:0048515 115 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
germ cell development GO:0007281 185 0.014
regulation of transferase activity GO:0051338 263 0.014
multi multicellular organism process GO:0044706 109 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
respiratory system development GO:0060541 190 0.014
gland development GO:0048732 330 0.014
protein polyubiquitination GO:0000209 33 0.014
mitochondrion distribution GO:0048311 4 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
telencephalon development GO:0021537 186 0.014
negative regulation of nervous system development GO:0051961 156 0.014
cytokine production GO:0001816 319 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
adult walking behavior GO:0007628 41 0.014
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
organic acid transport GO:0015849 101 0.014
development of primary sexual characteristics GO:0045137 143 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
male genitalia morphogenesis GO:0048808 4 0.013
blood vessel morphogenesis GO:0048514 285 0.013
regulation of secretion GO:0051046 274 0.013
anion transmembrane transport GO:0098656 71 0.013
protein maturation GO:0051604 176 0.013
learning GO:0007612 98 0.013
metal ion homeostasis GO:0055065 189 0.013
lymphocyte proliferation GO:0046651 164 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
regulation of protein processing GO:0070613 96 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
action potential GO:0001508 78 0.013
cellular ion homeostasis GO:0006873 165 0.013
protein localization to nucleus GO:0034504 121 0.013
regulation of neuron differentiation GO:0045664 281 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
cellular component assembly involved in morphogenesis GO:0010927 139 0.013
carboxylic acid biosynthetic process GO:0046394 86 0.013
spindle assembly involved in mitosis GO:0090307 4 0.013
cell division GO:0051301 120 0.013
neuron apoptotic process GO:0051402 142 0.013
transmission of nerve impulse GO:0019226 76 0.013
oocyte axis specification GO:0007309 2 0.013
establishment or maintenance of cell polarity GO:0007163 86 0.013
macromolecule methylation GO:0043414 120 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of neuron projection development GO:0010975 169 0.013
negative regulation of cell development GO:0010721 169 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
nucleotide biosynthetic process GO:0009165 78 0.013
rac protein signal transduction GO:0016601 13 0.012
cofactor metabolic process GO:0051186 80 0.012
positive regulation of organelle organization GO:0010638 128 0.012
myosin filament organization GO:0031033 3 0.012
developmental maturation GO:0021700 193 0.012
carbohydrate homeostasis GO:0033500 128 0.012
regulation of nucleocytoplasmic transport GO:0046822 73 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
compound eye development GO:0048749 1 0.012
microtubule nucleation GO:0007020 2 0.012
methylation GO:0032259 134 0.012
calcium ion transmembrane transport GO:0070588 85 0.012
immune effector process GO:0002252 321 0.012
endocytosis GO:0006897 168 0.012
development of primary male sexual characteristics GO:0046546 88 0.012
skeletal muscle organ development GO:0060538 163 0.012
regulation of canonical wnt signaling pathway GO:0060828 82 0.012
tissue homeostasis GO:0001894 115 0.012
double strand break repair via homologous recombination GO:0000724 21 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
protein processing GO:0016485 163 0.012
mitotic nuclear division GO:0007067 48 0.012
protein alkylation GO:0008213 81 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
protein localization to membrane GO:0072657 108 0.012
defense response to other organism GO:0098542 197 0.012
lateral inhibition GO:0046331 1 0.012
urogenital system development GO:0001655 261 0.012
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
camera type eye development GO:0043010 266 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
positive regulation of protein transport GO:0051222 93 0.012
negative regulation of proteolysis GO:0045861 74 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
muscle tissue development GO:0060537 308 0.012
rna interference GO:0016246 2 0.012
regulation of cell projection organization GO:0031344 206 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
regulation of mrna processing GO:0050684 41 0.012
leukocyte differentiation GO:0002521 342 0.012
plasma membrane organization GO:0007009 90 0.012
sequestering of calcium ion GO:0051208 18 0.011
protein methylation GO:0006479 81 0.011
female gamete generation GO:0007292 74 0.011
mitochondrion organization GO:0007005 134 0.011
protein targeting GO:0006605 143 0.011
oocyte construction GO:0007308 2 0.011
regulation of cell motility GO:2000145 236 0.011
cell fate commitment GO:0045165 210 0.011
cellular response to oxidative stress GO:0034599 76 0.011
canonical wnt signaling pathway GO:0060070 130 0.011
actin cytoskeleton organization GO:0030036 220 0.011
male sex differentiation GO:0046661 109 0.011
regulation of secretion by cell GO:1903530 249 0.011
negative regulation of organelle organization GO:0010639 90 0.011
glycerolipid metabolic process GO:0046486 122 0.011
male gonad development GO:0008584 88 0.011
nuclear import GO:0051170 95 0.011
chromosome segregation GO:0007059 48 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
lipid localization GO:0010876 126 0.011
signal transduction by p53 class mediator GO:0072331 51 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
sodium ion transport GO:0006814 73 0.011
regulation of cell migration GO:0030334 219 0.011
blood circulation GO:0008015 195 0.011
lipid biosynthetic process GO:0008610 179 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
regulation of protein maturation GO:1903317 96 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
organ regeneration GO:0031100 2 0.011
negative regulation of protein maturation GO:1903318 79 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
adult behavior GO:0030534 135 0.011
striated muscle tissue development GO:0014706 293 0.011
notch signaling pathway GO:0007219 71 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
regulation of cell activation GO:0050865 289 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
cell growth GO:0016049 130 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
small molecule biosynthetic process GO:0044283 132 0.011
regulation of homeostatic process GO:0032844 182 0.011
myosin filament assembly GO:0031034 2 0.011
establishment of vesicle localization GO:0051650 81 0.011
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
localization within membrane GO:0051668 4 0.010
regulation of ion transmembrane transporter activity GO:0032412 54 0.010
regulation of neuron death GO:1901214 134 0.010
defense response to bacterium GO:0042742 119 0.010
positive regulation of transferase activity GO:0051347 167 0.010
innate immune response GO:0045087 157 0.010
adaptive immune response GO:0002250 155 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
b cell activation GO:0042113 161 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
cellular response to lipid GO:0071396 145 0.010
lipid transport GO:0006869 98 0.010
regulation of mitotic cell cycle GO:0007346 126 0.010
response to uv GO:0009411 44 0.010
regulation of multi organism process GO:0043900 111 0.010
morphogenesis of a branching epithelium GO:0061138 193 0.010
meiosis i GO:0007127 60 0.010
circulatory system process GO:0003013 197 0.010
neuronal action potential GO:0019228 54 0.010
regulation of cell cycle process GO:0010564 160 0.010
regulation of binding GO:0051098 111 0.010
pole plasm assembly GO:0007315 2 0.010
g protein coupled receptor signaling pathway GO:0007186 243 0.010
t cell activation GO:0042110 289 0.010
smoothened signaling pathway GO:0007224 105 0.010

Sms disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
musculoskeletal system disease DOID:17 0 0.026
central nervous system disease DOID:331 0 0.021
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.021
neurodegenerative disease DOID:1289 0 0.019
myopathy DOID:423 0 0.018
muscular disease DOID:0080000 0 0.018
muscle tissue disease DOID:66 0 0.018