Mus musculus

17 known processes

Nek4

NIMA (never in mitosis gene a)-related expressed kinase 4

Nek4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cilium morphogenesis GO:0060271 102 0.318
cilium assembly GO:0042384 81 0.260
cellular component assembly involved in morphogenesis GO:0010927 139 0.116
cellular response to dna damage stimulus GO:0006974 207 0.080
Human
organelle assembly GO:0070925 177 0.080
dna repair GO:0006281 107 0.064
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.056
intraciliary transport GO:0042073 9 0.051
cellular amino acid metabolic process GO:0006520 103 0.047
microtubule based process GO:0007017 236 0.045
cellular ketone metabolic process GO:0042180 84 0.044
regulation of cellular amino acid metabolic process GO:0006521 5 0.044
cellular amine metabolic process GO:0044106 44 0.044
microtubule based movement GO:0007018 84 0.041
dna metabolic process GO:0006259 303 0.041
regulation of organelle organization GO:0033043 289 0.038
organelle fission GO:0048285 170 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.035
regulation of cellular amine metabolic process GO:0033238 20 0.035
ribose phosphate metabolic process GO:0019693 291 0.034
apoptotic signaling pathway GO:0097190 306 0.033
cellular nitrogen compound catabolic process GO:0044270 280 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.032
smoothened signaling pathway GO:0007224 105 0.032
organonitrogen compound catabolic process GO:1901565 264 0.032
nuclear division GO:0000280 158 0.031
ribonucleotide metabolic process GO:0009259 291 0.030
regulation of cellular component biogenesis GO:0044087 181 0.029
aromatic compound catabolic process GO:0019439 286 0.029
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
purine containing compound metabolic process GO:0072521 311 0.027
heterocycle catabolic process GO:0046700 280 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
small gtpase mediated signal transduction GO:0007264 97 0.027
camera type eye development GO:0043010 266 0.027
cytoskeleton dependent intracellular transport GO:0030705 50 0.027
ribonucleoside metabolic process GO:0009119 245 0.027
male gamete generation GO:0048232 285 0.027
amine metabolic process GO:0009308 45 0.027
membrane organization GO:0061024 245 0.026
nucleotide metabolic process GO:0009117 332 0.026
intraciliary retrograde transport GO:0035721 3 0.025
methylation GO:0032259 134 0.024
nucleoside phosphate metabolic process GO:0006753 338 0.024
chromatin organization GO:0006325 206 0.024
purine nucleoside metabolic process GO:0042278 241 0.023
intracellular protein transport GO:0006886 204 0.022
purine ribonucleotide catabolic process GO:0009154 208 0.022
meiotic nuclear division GO:0007126 115 0.022
sensory organ morphogenesis GO:0090596 242 0.022
neural tube development GO:0021915 160 0.021
nucleoside triphosphate catabolic process GO:0009143 205 0.021
ribonucleoside triphosphate catabolic process GO:0009203 199 0.021
organophosphate catabolic process GO:0046434 232 0.021
ribonucleoside catabolic process GO:0042454 206 0.021
glycosyl compound catabolic process GO:1901658 206 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
ras protein signal transduction GO:0007265 77 0.021
purine nucleoside triphosphate catabolic process GO:0009146 203 0.021
nucleoside catabolic process GO:0009164 206 0.021
glycosyl compound metabolic process GO:1901657 246 0.020
regulation of cilium assembly GO:1902017 7 0.020
positive regulation of protein modification process GO:0031401 299 0.020
fat cell differentiation GO:0045444 160 0.020
nucleoside metabolic process GO:0009116 246 0.020
purine containing compound catabolic process GO:0072523 213 0.020
macromolecule catabolic process GO:0009057 281 0.020
protein localization to organelle GO:0033365 185 0.020
negative regulation of cellular component organization GO:0051129 194 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
peptidyl amino acid modification GO:0018193 336 0.019
purine nucleotide catabolic process GO:0006195 211 0.019
skin development GO:0043588 220 0.019
limb development GO:0060173 166 0.019
skeletal system development GO:0001501 356 0.018
chromatin modification GO:0016568 187 0.018
protein maturation GO:0051604 176 0.018
anatomical structure homeostasis GO:0060249 145 0.018
regionalization GO:0003002 337 0.018
nucleotide catabolic process GO:0009166 217 0.018
organelle localization GO:0051640 179 0.018
rna processing GO:0006396 105 0.018
mitotic cell cycle GO:0000278 195 0.017
Human
purine ribonucleoside metabolic process GO:0046128 241 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
limb morphogenesis GO:0035108 149 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
muscle tissue development GO:0060537 308 0.017
microtubule based transport GO:0010970 50 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
positive regulation of organelle organization GO:0010638 128 0.017
ribonucleotide catabolic process GO:0009261 208 0.017
regulation of cell activation GO:0050865 289 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
cell type specific apoptotic process GO:0097285 268 0.017
embryonic organ morphogenesis GO:0048562 276 0.017
regulation of protein localization GO:0032880 231 0.017
ear development GO:0043583 200 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
epithelial tube formation GO:0072175 130 0.016
microtubule cytoskeleton organization GO:0000226 157 0.016
appendage morphogenesis GO:0035107 149 0.016
cellular homeostasis GO:0019725 240 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
regulation of smoothened signaling pathway GO:0008589 58 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
retina development in camera type eye GO:0060041 119 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.015
spermatid differentiation GO:0048515 115 0.015
response to radiation GO:0009314 165 0.015
fertilization GO:0009566 127 0.015
cellular protein complex assembly GO:0043623 116 0.015
homeostasis of number of cells GO:0048872 210 0.015
spermatogenesis GO:0007283 284 0.015
protein localization to membrane GO:0072657 108 0.015
male meiosis GO:0007140 37 0.015
macromolecule methylation GO:0043414 120 0.015
embryonic appendage morphogenesis GO:0035113 126 0.015
leukocyte differentiation GO:0002521 342 0.015
regulation of cell cycle GO:0051726 281 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
regulation of cell motility GO:2000145 236 0.015
multicellular organismal homeostasis GO:0048871 164 0.014
myeloid cell differentiation GO:0030099 233 0.014
immune effector process GO:0002252 321 0.014
cellular lipid metabolic process GO:0044255 323 0.014
transmembrane transport GO:0055085 412 0.014
regulation of homeostatic process GO:0032844 182 0.014
histone modification GO:0016570 159 0.014
modification dependent protein catabolic process GO:0019941 133 0.014
appendage development GO:0048736 166 0.014
tube formation GO:0035148 140 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
meiotic cell cycle GO:0051321 122 0.014
maintenance of location GO:0051235 89 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
regulation of cellular catabolic process GO:0031329 242 0.014
photoreceptor cell differentiation GO:0046530 52 0.014
spermatid development GO:0007286 108 0.014
mitotic cell cycle process GO:1903047 159 0.014
epidermis development GO:0008544 187 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
skeletal muscle organ development GO:0060538 163 0.014
lymphocyte differentiation GO:0030098 242 0.014
protein ubiquitination GO:0016567 171 0.014
neural tube formation GO:0001841 108 0.014
germ cell development GO:0007281 185 0.014
dephosphorylation GO:0016311 129 0.013
epithelial cell proliferation GO:0050673 174 0.013
embryonic limb morphogenesis GO:0030326 126 0.013
regulation of cell cycle process GO:0010564 160 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
endomembrane system organization GO:0010256 147 0.013
regulation of intracellular transport GO:0032386 159 0.013
protein processing GO:0016485 163 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
response to organonitrogen compound GO:0010243 246 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
tube closure GO:0060606 91 0.013
cellular protein catabolic process GO:0044257 155 0.013
meiotic cell cycle process GO:1903046 77 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
lipid biosynthetic process GO:0008610 179 0.013
multicellular organism growth GO:0035264 161 0.013
meiosis i GO:0007127 60 0.012
skeletal system morphogenesis GO:0048705 203 0.012
covalent chromatin modification GO:0016569 163 0.012
striated muscle tissue development GO:0014706 293 0.012
negative regulation of molecular function GO:0044092 258 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
muscle cell differentiation GO:0042692 261 0.012
Mouse
regulation of proteolysis GO:0030162 164 0.012
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
t cell activation GO:0042110 289 0.012
intracellular mrna localization GO:0008298 4 0.012
male genitalia morphogenesis GO:0048808 4 0.012
embryonic digit morphogenesis GO:0042733 56 0.012
chromosome organization involved in meiosis GO:0070192 39 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
cellular response to cytokine stimulus GO:0071345 189 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
renal system development GO:0072001 225 0.012
negative regulation of immune system process GO:0002683 209 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
rho protein signal transduction GO:0007266 32 0.012
regulation of anatomical structure size GO:0090066 178 0.012
primary neural tube formation GO:0014020 95 0.012
regulation of protein processing GO:0070613 96 0.012
digestive system development GO:0055123 200 0.012
sensory perception GO:0007600 245 0.011
wnt signaling pathway GO:0016055 188 0.011
adult behavior GO:0030534 135 0.011
negative regulation of nervous system development GO:0051961 156 0.011
regulation of cell adhesion GO:0030155 154 0.011
regulation of chromosome organization GO:0033044 83 0.011
forebrain development GO:0030900 302 0.011
cell division GO:0051301 120 0.011
blastocyst development GO:0001824 80 0.011
lateral inhibition GO:0046331 1 0.011
positive regulation of cell activation GO:0050867 158 0.011
axonogenesis GO:0007409 274 0.011
negative regulation of cell development GO:0010721 169 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
glycerolipid metabolic process GO:0046486 122 0.011
peptidyl lysine modification GO:0018205 77 0.011
regulation of protein maturation GO:1903317 96 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
regulation of protein complex assembly GO:0043254 83 0.011
transmission of nerve impulse GO:0019226 76 0.011
telencephalon development GO:0021537 186 0.011
urogenital system development GO:0001655 261 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
eye photoreceptor cell differentiation GO:0001754 41 0.011
neuronal action potential GO:0019228 54 0.011
bone development GO:0060348 120 0.011
protein catabolic process GO:0030163 221 0.011
mrna metabolic process GO:0016071 84 0.011
dna recombination GO:0006310 92 0.011
regulation of defense response GO:0031347 233 0.011
male anatomical structure morphogenesis GO:0090598 4 0.011
response to growth factor GO:0070848 198 0.011
regulation of protein transport GO:0051223 163 0.011
protein polymerization GO:0051258 57 0.011
carbohydrate metabolic process GO:0005975 230 0.011
multicellular organismal signaling GO:0035637 91 0.011
response to acid chemical GO:0001101 111 0.011
chromosome segregation GO:0007059 48 0.011
protein localization to nucleus GO:0034504 121 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
nucleus organization GO:0006997 45 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
inflammatory response GO:0006954 244 0.011
hindbrain development GO:0030902 128 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
regulation of cell projection organization GO:0031344 206 0.010
regulation of membrane potential GO:0042391 192 0.010
tissue homeostasis GO:0001894 115 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
nitrogen compound transport GO:0071705 271 0.010
negative regulation of organelle organization GO:0010639 90 0.010
spindle assembly involved in mitosis GO:0090307 4 0.010
rac protein signal transduction GO:0016601 13 0.010
sequestering of calcium ion GO:0051208 18 0.010
developmental maturation GO:0021700 193 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.010
regulation of cell migration GO:0030334 219 0.010
regulation of transferase activity GO:0051338 263 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
actin filament organization GO:0007015 113 0.010
cation transport GO:0006812 399 0.010
regulation of hydrolase activity GO:0051336 246 0.010
Mouse
photoreceptor cell development GO:0042461 40 0.010

Nek4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.024
immune system disease DOID:2914 0 0.023
retinal disease DOID:5679 0 0.022
sensory system disease DOID:0050155 0 0.022
eye and adnexa disease DOID:1492 0 0.022
eye disease DOID:5614 0 0.022
hematopoietic system disease DOID:74 0 0.020
retinal degeneration DOID:8466 0 0.016