Mus musculus

17 known processes

Ppm1m

protein phosphatase 1M

(Aliases: C77250,PP2Ceta,AW610647,2810423O19Rik)

Ppm1m biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleobase containing small molecule metabolic process GO:0055086 352 0.157
g protein coupled receptor signaling pathway GO:0007186 243 0.093
nucleoside phosphate metabolic process GO:0006753 338 0.087
cellular amino acid metabolic process GO:0006520 103 0.087
nucleotide metabolic process GO:0009117 332 0.086
nucleoside phosphate catabolic process GO:1901292 222 0.084
regulation of hydrolase activity GO:0051336 246 0.080
synaptic transmission GO:0007268 329 0.074
amine metabolic process GO:0009308 45 0.069
peptidyl amino acid modification GO:0018193 336 0.067
cellular homeostasis GO:0019725 240 0.063
nucleotide catabolic process GO:0009166 217 0.060
nucleoside catabolic process GO:0009164 206 0.059
histone modification GO:0016570 159 0.058
cellular ketone metabolic process GO:0042180 84 0.058
negative regulation of protein metabolic process GO:0051248 282 0.057
purine ribonucleotide metabolic process GO:0009150 290 0.055
regulation of cellular amino acid metabolic process GO:0006521 5 0.053
cellular amine metabolic process GO:0044106 44 0.052
cellular component assembly involved in morphogenesis GO:0010927 139 0.052
ribonucleoside metabolic process GO:0009119 245 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.049
organelle assembly GO:0070925 177 0.048
dna metabolic process GO:0006259 303 0.048
regulation of nucleotide metabolic process GO:0006140 169 0.048
oxidation reduction process GO:0055114 342 0.047
nuclear division GO:0000280 158 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
regulation of mapk cascade GO:0043408 248 0.046
fertilization GO:0009566 127 0.046
glycosyl compound metabolic process GO:1901657 246 0.046
organic cyclic compound catabolic process GO:1901361 295 0.046
nucleoside metabolic process GO:0009116 246 0.044
regulation of cell projection organization GO:0031344 206 0.043
regulation of cellular ketone metabolic process GO:0010565 66 0.043
heterocycle catabolic process GO:0046700 280 0.042
carbohydrate derivative catabolic process GO:1901136 231 0.041
nitrogen compound transport GO:0071705 271 0.041
negative regulation of cellular component organization GO:0051129 194 0.040
negative regulation of phosphorus metabolic process GO:0010563 184 0.040
purine nucleoside metabolic process GO:0042278 241 0.040
mapk cascade GO:0000165 281 0.040
muscle cell differentiation GO:0042692 261 0.039
chromatin modification GO:0016568 187 0.039
organonitrogen compound catabolic process GO:1901565 264 0.039
membrane organization GO:0061024 245 0.038
cellular protein complex assembly GO:0043623 116 0.038
ribonucleotide metabolic process GO:0009259 291 0.037
cellular nitrogen compound catabolic process GO:0044270 280 0.036
aromatic compound catabolic process GO:0019439 286 0.036
negative regulation of molecular function GO:0044092 258 0.036
regulation of defense response GO:0031347 233 0.036
positive regulation of protein modification process GO:0031401 299 0.036
positive regulation of cellular amine metabolic process GO:0033240 5 0.035
regulation of organelle organization GO:0033043 289 0.035
cell chemotaxis GO:0060326 81 0.035
purine nucleotide metabolic process GO:0006163 302 0.035
ribose phosphate metabolic process GO:0019693 291 0.035
negative regulation of hydrolase activity GO:0051346 71 0.035
organelle localization GO:0051640 179 0.034
cation transport GO:0006812 399 0.034
negative regulation of cytoskeleton organization GO:0051494 36 0.034
regulation of purine nucleotide metabolic process GO:1900542 169 0.034
heart process GO:0003015 94 0.033
cellular chemical homeostasis GO:0055082 215 0.033
ribonucleotide catabolic process GO:0009261 208 0.033
chromatin organization GO:0006325 206 0.032
organelle fission GO:0048285 170 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
purine ribonucleoside catabolic process GO:0046130 205 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.032
macromolecule catabolic process GO:0009057 281 0.031
carbohydrate metabolic process GO:0005975 230 0.031
cellular lipid metabolic process GO:0044255 323 0.030
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.030
transmembrane transport GO:0055085 412 0.030
immune response regulating signaling pathway GO:0002764 125 0.030
innate immune response GO:0045087 157 0.029
actin cytoskeleton organization GO:0030036 220 0.029
glycosyl compound catabolic process GO:1901658 206 0.029
regulation of membrane potential GO:0042391 192 0.029
purine nucleotide catabolic process GO:0006195 211 0.029
skeletal system development GO:0001501 356 0.029
cation transmembrane transport GO:0098655 266 0.029
cellular metal ion homeostasis GO:0006875 151 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
positive regulation of protein phosphorylation GO:0001934 242 0.028
peptidyl tyrosine phosphorylation GO:0018108 143 0.028
cation homeostasis GO:0055080 212 0.028
divalent inorganic cation transport GO:0072511 178 0.028
regulation of response to wounding GO:1903034 189 0.028
gtp catabolic process GO:0006184 143 0.028
regulation of anatomical structure size GO:0090066 178 0.028
peptidyl tyrosine modification GO:0018212 145 0.027
nucleoside triphosphate metabolic process GO:0009141 230 0.027
activation of immune response GO:0002253 138 0.027
cell division GO:0051301 120 0.027
divalent inorganic cation homeostasis GO:0072507 138 0.027
mitochondrion organization GO:0007005 134 0.027
regulation of intracellular transport GO:0032386 159 0.027
ribonucleoside triphosphate metabolic process GO:0009199 220 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
cytoplasmic transport GO:0016482 234 0.026
negative regulation of transferase activity GO:0051348 85 0.026
single fertilization GO:0007338 82 0.026
cellular ion homeostasis GO:0006873 165 0.026
activation of innate immune response GO:0002218 56 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
purine ribonucleoside metabolic process GO:0046128 241 0.026
regulation of protein complex assembly GO:0043254 83 0.026
intracellular protein transport GO:0006886 204 0.026
regulation of protein kinase activity GO:0045859 232 0.026
regulation of system process GO:0044057 200 0.025
cell adhesion GO:0007155 329 0.025
cofactor metabolic process GO:0051186 80 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.025
negative regulation of protein phosphorylation GO:0001933 126 0.025
cytokine production GO:0001816 319 0.025
organophosphate biosynthetic process GO:0090407 122 0.025
purine containing compound metabolic process GO:0072521 311 0.025
positive regulation of gtp catabolic process GO:0033126 85 0.025
ras protein signal transduction GO:0007265 77 0.025
regulation of kinase activity GO:0043549 249 0.024
purine containing compound catabolic process GO:0072523 213 0.024
striated muscle tissue development GO:0014706 293 0.024
heart contraction GO:0060047 93 0.024
organophosphate catabolic process GO:0046434 232 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.024
regulation of cell cycle GO:0051726 281 0.024
regulation of purine nucleotide catabolic process GO:0033121 122 0.023
muscle tissue development GO:0060537 308 0.023
endocytosis GO:0006897 168 0.023
cellular response to growth factor stimulus GO:0071363 197 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
positive regulation of transferase activity GO:0051347 167 0.023
regulation of peptidase activity GO:0052547 96 0.023
defense response to other organism GO:0098542 197 0.022
action potential GO:0001508 78 0.022
anatomical structure homeostasis GO:0060249 145 0.022
chemotaxis GO:0006935 247 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
regulation of cytokine production GO:0001817 266 0.022
negative regulation of immune system process GO:0002683 209 0.022
coenzyme metabolic process GO:0006732 52 0.022
multicellular organismal homeostasis GO:0048871 164 0.022
regulation of vesicle mediated transport GO:0060627 139 0.022
maintenance of location GO:0051235 89 0.021
peptide hormone secretion GO:0030072 109 0.021
regulation of hormone levels GO:0010817 211 0.021
sequestering of calcium ion GO:0051208 18 0.021
response to radiation GO:0009314 165 0.021
ribonucleoside triphosphate catabolic process GO:0009203 199 0.021
regulation of secretion by cell GO:1903530 249 0.021
guanosine containing compound metabolic process GO:1901068 144 0.021
calcium ion homeostasis GO:0055074 127 0.021
establishment of vesicle localization GO:0051650 81 0.021
regulation of cell motility GO:2000145 236 0.021
regulation of ras protein signal transduction GO:0046578 114 0.021
negative regulation of cell development GO:0010721 169 0.021
nucleoside triphosphate catabolic process GO:0009143 205 0.021
regulation of proteolysis GO:0030162 164 0.021
meiotic cell cycle GO:0051321 122 0.021
hormone secretion GO:0046879 128 0.021
regulation of cell migration GO:0030334 219 0.021
axonogenesis GO:0007409 274 0.021
positive regulation of cell death GO:0010942 224 0.020
negative regulation of kinase activity GO:0033673 81 0.020
protein ubiquitination GO:0016567 171 0.020
regulation of protein transport GO:0051223 163 0.020
microtubule based process GO:0007017 236 0.020
regulation of blood circulation GO:1903522 93 0.020
regulation of transferase activity GO:0051338 263 0.020
protein localization to organelle GO:0033365 185 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
positive regulation of apoptotic signaling pathway GO:2001235 95 0.020
positive regulation of gtpase activity GO:0043547 85 0.020
cellular divalent inorganic cation homeostasis GO:0072503 127 0.020
metal ion homeostasis GO:0055065 189 0.020
immune response activating signal transduction GO:0002757 116 0.020
ribonucleoside catabolic process GO:0042454 206 0.019
sensory perception GO:0007600 245 0.019
covalent chromatin modification GO:0016569 163 0.019
cellular response to cytokine stimulus GO:0071345 189 0.019
synaptic vesicle docking involved in exocytosis GO:0016081 4 0.019
male gamete generation GO:0048232 285 0.019
sequestering of metal ion GO:0051238 19 0.019
striated muscle cell development GO:0055002 125 0.019
cellular calcium ion homeostasis GO:0006874 119 0.019
cellular response to oxidative stress GO:0034599 76 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
cell type specific apoptotic process GO:0097285 268 0.018
protein polymerization GO:0051258 57 0.018
membrane fusion GO:0061025 38 0.018
leukocyte mediated immunity GO:0002443 174 0.018
regulation of binding GO:0051098 111 0.018
asymmetric stem cell division GO:0098722 3 0.018
regulation of secretion GO:0051046 274 0.018
t cell activation GO:0042110 289 0.017
response to organonitrogen compound GO:0010243 246 0.017
regulation of innate immune response GO:0045088 91 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
sulfur compound metabolic process GO:0006790 100 0.017
nuclear transport GO:0051169 139 0.017
vesicle organization GO:0016050 60 0.017
peptide transport GO:0015833 133 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
spermatogenesis GO:0007283 284 0.017
detection of stimulus GO:0051606 84 0.017
peptide secretion GO:0002790 114 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
amide transport GO:0042886 138 0.017
positive regulation of defense response GO:0031349 124 0.017
calcium ion transport GO:0006816 159 0.017
regulation of gtp catabolic process GO:0033124 113 0.017
ion transmembrane transport GO:0034220 361 0.017
response to oxidative stress GO:0006979 123 0.017
regulation of protein maturation GO:1903317 96 0.016
actin filament organization GO:0007015 113 0.016
cell substrate adhesion GO:0031589 130 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
regulation of neuron differentiation GO:0045664 281 0.016
positive regulation of nervous system development GO:0051962 221 0.016
protein catabolic process GO:0030163 221 0.016
establishment of organelle localization GO:0051656 122 0.016
regulation of clathrin mediated endocytosis GO:2000369 4 0.016
gtp metabolic process GO:0046039 144 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
regulation of protein localization GO:0032880 231 0.016
vesicle fusion GO:0006906 16 0.016
lipid biosynthetic process GO:0008610 179 0.016
immune effector process GO:0002252 321 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
mitotic cell cycle GO:0000278 195 0.016
regulation of cell activation GO:0050865 289 0.016
lipid localization GO:0010876 126 0.016
blood coagulation GO:0007596 76 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
regulation of peptide transport GO:0090087 91 0.016
muscle cell development GO:0055001 133 0.016
transmission of nerve impulse GO:0019226 76 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
regulation of chemotaxis GO:0050920 53 0.015
rho protein signal transduction GO:0007266 32 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
multicellular organism growth GO:0035264 161 0.015
regulation of cytoplasmic transport GO:1903649 112 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
regulation of protein binding GO:0043393 60 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
lymphocyte mediated immunity GO:0002449 139 0.015
positive regulation of cell motility GO:2000147 116 0.015
circadian rhythm GO:0007623 114 0.015
blood circulation GO:0008015 195 0.015
regulation of body fluid levels GO:0050878 162 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
striated muscle contraction GO:0006941 45 0.015
photoreceptor cell morphogenesis GO:0008594 3 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
mitotic cell cycle process GO:1903047 159 0.015
interleukin 8 production GO:0032637 4 0.014
regulation of feeding behavior GO:0060259 3 0.014
response to lipopolysaccharide GO:0032496 128 0.014
coagulation GO:0050817 78 0.014
establishment of protein localization to organelle GO:0072594 118 0.014
regulation of hormone secretion GO:0046883 88 0.014
regulation of peptide hormone secretion GO:0090276 75 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.014
negative regulation of organelle organization GO:0010639 90 0.014
positive regulation of kinase activity GO:0033674 155 0.014
negative regulation of cell activation GO:0050866 111 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
actin filament polymerization GO:0030041 44 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
cytosolic calcium ion homeostasis GO:0051480 70 0.014
skin development GO:0043588 220 0.014
regulation of actin nucleation GO:0051125 4 0.014
glycerolipid metabolic process GO:0046486 122 0.014
establishment of synaptic vesicle localization GO:0097480 57 0.014
asymmetric neuroblast division GO:0055059 1 0.014
protein targeting GO:0006605 143 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
glucose homeostasis GO:0042593 128 0.013
synaptic vesicle localization GO:0097479 59 0.013
regulation of neurotransmitter levels GO:0001505 87 0.013
neural precursor cell proliferation GO:0061351 121 0.013
monosaccharide metabolic process GO:0005996 106 0.013
regulation of protein processing GO:0070613 96 0.013
carbohydrate homeostasis GO:0033500 128 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
positive regulation of secretion GO:0051047 130 0.013
calcium ion dependent exocytosis GO:0017156 35 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.013
apoptotic signaling pathway GO:0097190 306 0.013
small molecule biosynthetic process GO:0044283 132 0.013
negative regulation of defense response GO:0031348 77 0.013
regulation of homeostatic process GO:0032844 182 0.013
positive regulation of cellular catabolic process GO:0031331 148 0.013
peptidyl serine phosphorylation GO:0018105 74 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
digestive tract development GO:0048565 190 0.013
axon ensheathment GO:0008366 76 0.013
multicellular organismal signaling GO:0035637 91 0.013
cytokine mediated signaling pathway GO:0019221 115 0.013
regulation of interleukin 8 production GO:0032677 3 0.013
regulation of postsynaptic membrane potential GO:0060078 48 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
regulation of ion transport GO:0043269 215 0.013
dephosphorylation GO:0016311 129 0.013
vesicle localization GO:0051648 86 0.013
positive regulation of nucleoside metabolic process GO:0045979 91 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
skeletal muscle organ development GO:0060538 163 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
protein processing GO:0016485 163 0.013
protein maturation GO:0051604 176 0.013
response to growth factor GO:0070848 198 0.013
lymphocyte differentiation GO:0030098 242 0.013
homeostasis of number of cells GO:0048872 210 0.012
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.012
skeletal system morphogenesis GO:0048705 203 0.012
negative regulation of lymphocyte activation GO:0051250 91 0.012
response to monosaccharide GO:0034284 67 0.012
cell growth GO:0016049 130 0.012
tissue homeostasis GO:0001894 115 0.012
negative regulation of cell cycle GO:0045786 123 0.012
leukocyte proliferation GO:0070661 172 0.012
g protein coupled receptor internalization GO:0002031 3 0.012
lymphocyte proliferation GO:0046651 164 0.012
interleukin 6 production GO:0032635 58 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.012
regulation of cellular response to stress GO:0080135 159 0.012
response to organic cyclic compound GO:0014070 198 0.012
positive regulation of actin nucleation GO:0051127 3 0.012
positive regulation of nucleotide catabolic process GO:0030813 88 0.012
positive regulation of cell development GO:0010720 237 0.012
wound healing GO:0042060 157 0.012
protein complex disassembly GO:0043241 40 0.012
vesicle docking involved in exocytosis GO:0006904 7 0.012
detection of external stimulus GO:0009581 61 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
forebrain development GO:0030900 302 0.012
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.012
membrane depolarization GO:0051899 64 0.012
cytokinetic process GO:0032506 2 0.012
positive regulation of peptide hormone secretion GO:0090277 31 0.012
regulation of neuron death GO:1901214 134 0.012
muscle contraction GO:0006936 101 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
camera type eye development GO:0043010 266 0.012
mitotic nuclear division GO:0007067 48 0.012
t cell proliferation GO:0042098 120 0.012
lamellipodium organization GO:0097581 29 0.012
response to light stimulus GO:0009416 135 0.012
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.012
hemostasis GO:0007599 78 0.012
regulation of t cell activation GO:0050863 170 0.011
lysosome organization GO:0007040 21 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
actin polymerization or depolymerization GO:0008154 54 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
respiratory system development GO:0060541 190 0.011
synaptic vesicle transport GO:0048489 57 0.011
neuronal action potential GO:0019228 54 0.011
post embryonic retina morphogenesis in camera type eye GO:0060060 3 0.011
gliogenesis GO:0042063 141 0.011
lytic vacuole organization GO:0080171 21 0.011
regulation of synaptic vesicle priming GO:0010807 4 0.011
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
energy derivation by oxidation of organic compounds GO:0015980 77 0.011
anion transport GO:0006820 177 0.011
protein deacylation GO:0035601 36 0.011
lung development GO:0030324 164 0.011
bone development GO:0060348 120 0.011
divalent metal ion transport GO:0070838 172 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
cellular response to acid chemical GO:0071229 68 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
retina development in camera type eye GO:0060041 119 0.011
regulation of inflammatory response GO:0050727 147 0.011
cardiac muscle contraction GO:0060048 32 0.011
regulation of cellular component size GO:0032535 121 0.011
actomyosin structure organization GO:0031032 56 0.011
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
positive regulation of cardiac muscle contraction GO:0060452 2 0.011
negative regulation of protein modification process GO:0031400 163 0.011
inflammatory response GO:0006954 244 0.011
endomembrane system organization GO:0010256 147 0.011
adult locomotory behavior GO:0008344 91 0.011
detection of abiotic stimulus GO:0009582 60 0.011
positive regulation of growth GO:0045927 104 0.011
regulation of ossification GO:0030278 112 0.011
regulation of t cell proliferation GO:0042129 92 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
peptidyl serine modification GO:0018209 83 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
response to inorganic substance GO:0010035 96 0.011
negative regulation of protein maturation GO:1903318 79 0.010
cellular response to lipid GO:0071396 145 0.010
negative regulation of nervous system development GO:0051961 156 0.010
inorganic ion transmembrane transport GO:0098660 234 0.010
positive regulation of creb transcription factor activity GO:0032793 4 0.010
regionalization GO:0003002 337 0.010
positive regulation of interleukin 8 production GO:0032757 2 0.010
reactive oxygen species metabolic process GO:0072593 84 0.010
neuron apoptotic process GO:0051402 142 0.010
locomotory behavior GO:0007626 195 0.010
glycerophospholipid metabolic process GO:0006650 71 0.010
hexose metabolic process GO:0019318 98 0.010
regulation of protein targeting GO:1903533 61 0.010
regulation of leukocyte mediated immunity GO:0002703 104 0.010
regulation of actin polymerization or depolymerization GO:0008064 45 0.010
cell killing GO:0001906 67 0.010
membrane lipid metabolic process GO:0006643 53 0.010
modification dependent protein catabolic process GO:0019941 133 0.010
regulation of intracellular protein transport GO:0033157 82 0.010

Ppm1m disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
eye disease DOID:5614 0 0.017
sensory system disease DOID:0050155 0 0.017
eye and adnexa disease DOID:1492 0 0.017
disease of metabolism DOID:0014667 0 0.017
central nervous system disease DOID:331 0 0.014
immune system disease DOID:2914 0 0.013
retinal disease DOID:5679 0 0.011