Mus musculus

202 known processes

Irg1

immunoresponsive gene 1

(Aliases: AI323667)

Irg1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to lipopolysaccharide GO:0071222 77 0.913
positive regulation of defense response GO:0031349 124 0.811
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.791
neutrophil mediated killing of gram negative bacterium GO:0070945 4 0.751
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.689
positive regulation of neutrophil mediated killing of symbiont cell GO:0070961 1 0.678
response to molecule of bacterial origin GO:0002237 143 0.660
positive regulation of thymocyte migration GO:2000412 2 0.641
cellular response to molecule of bacterial origin GO:0071219 83 0.631
defense response to other organism GO:0098542 197 0.627
activation of innate immune response GO:0002218 56 0.620
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.617
positive regulation of cytokine production GO:0001819 174 0.605
response to lipopolysaccharide GO:0032496 128 0.603
interaction with symbiont GO:0051702 14 0.603
natural killer cell chemotaxis GO:0035747 1 0.584
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.583
cytokine production GO:0001816 319 0.565
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.559
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.553
leukocyte mediated immunity GO:0002443 174 0.539
regulation of defense response GO:0031347 233 0.533
leukocyte migration GO:0050900 124 0.530
production of molecular mediator of immune response GO:0002440 103 0.526
cytokine production involved in immune response GO:0002367 34 0.515
neutrophil chemotaxis GO:0030593 36 0.508
t helper 2 cell cytokine production GO:0035745 4 0.506
inflammatory response GO:0006954 244 0.505
neutrophil mediated cytotoxicity GO:0070942 8 0.472
regulation of leukocyte mediated immunity GO:0002703 104 0.455
mature dendritic cell differentiation GO:0097029 3 0.448
positive regulation of immune effector process GO:0002699 107 0.447
regulation of thymocyte migration GO:2000410 2 0.439
t helper 1 cell cytokine production GO:0035744 1 0.426
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.424
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.421
positive regulation of leukocyte mediated immunity GO:0002705 70 0.415
cellular response to cytokine stimulus GO:0071345 189 0.405
defense response to bacterium GO:0042742 119 0.402
b cell chemotaxis GO:0035754 3 0.399
neutrophil migration GO:1990266 37 0.394
granulocyte migration GO:0097530 43 0.393
cellular response to amino acid stimulus GO:0071230 29 0.389
myeloid cell differentiation GO:0030099 233 0.388
regulation of eosinophil migration GO:2000416 2 0.367
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.354
regulation of t helper 1 cell cytokine production GO:2000554 1 0.354
negative regulation of myoblast differentiation GO:0045662 18 0.348
regulation of chemokine production GO:0032642 30 0.341
positive regulation of b cell chemotaxis GO:2000538 2 0.341
regulation of innate immune response GO:0045088 91 0.340
dendritic cell dendrite assembly GO:0097026 2 0.336
regulation of natural killer cell chemotaxis GO:2000501 1 0.335
myeloid leukocyte differentiation GO:0002573 119 0.332
cdc42 protein signal transduction GO:0032488 0 0.327
cytokine secretion GO:0050663 72 0.320
disruption by host of symbiont cells GO:0051852 11 0.319
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.307
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.304
positive regulation of neutrophil chemotaxis GO:0090023 12 0.303
immunoglobulin production in mucosal tissue GO:0002426 3 0.302
thymocyte migration GO:0072679 2 0.300
chemotaxis GO:0006935 247 0.299
positive regulation of innate immune response GO:0045089 80 0.296
myeloid leukocyte mediated immunity GO:0002444 42 0.293
regulation of dendritic cell dendrite assembly GO:2000547 2 0.291
cell chemotaxis GO:0060326 81 0.288
regulation of protein transport GO:0051223 163 0.285
protein secretion GO:0009306 111 0.277
serotonin secretion by mast cell GO:0002552 1 0.273
regulation of cytokine production GO:0001817 266 0.272
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.266
positive regulation of neutrophil mediated killing of fungus GO:0070965 1 0.262
cellular response to lipid GO:0071396 145 0.253
neutrophil mediated killing of bacterium GO:0070944 6 0.251
regulation of protein localization GO:0032880 231 0.248
regulation of mast cell activation GO:0033003 21 0.246
regulation of t helper 2 cell cytokine production GO:2000551 3 0.231
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.230
regulation of b cell chemotaxis GO:2000537 2 0.223
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.218
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.217
antibacterial peptide secretion GO:0002779 1 0.216
positive regulation of type 2 immune response GO:0002830 9 0.215
regulation of neutrophil mediated killing of bacterium GO:0070950 1 0.215
regulation of defense response to bacterium GO:1900424 3 0.214
regulation of multi organism process GO:0043900 111 0.213
positive regulation of monocyte chemotaxis GO:0090026 2 0.210
negative regulation of immune system process GO:0002683 209 0.208
regulation of response to wounding GO:1903034 189 0.208
regulation of skeletal muscle fiber development GO:0048742 36 0.208
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.208
regulation of neutrophil mediated killing of fungus GO:0070953 1 0.206
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.206
immune effector process GO:0002252 321 0.203
cation homeostasis GO:0055080 212 0.201
regulation of t cell proliferation GO:0042129 92 0.196
regulation of leukocyte proliferation GO:0070663 121 0.193
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.192
regulation of adiponectin secretion GO:0070163 2 0.192
calcium ion homeostasis GO:0055074 127 0.192
regulation of monocyte chemotaxis GO:0090025 3 0.190
leukocyte differentiation GO:0002521 342 0.190
mature natural killer cell chemotaxis GO:0035782 1 0.190
positive regulation of cytokine secretion GO:0050715 41 0.186
modification of morphology or physiology of other organism GO:0035821 18 0.185
adiponectin secretion GO:0070162 2 0.180
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.179
astrocyte cell migration GO:0043615 3 0.178
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.177
regulation of inflammatory response GO:0050727 147 0.174
positive regulation of leukocyte differentiation GO:1902107 86 0.173
cellular calcium ion homeostasis GO:0006874 119 0.173
positive regulation of eosinophil migration GO:2000418 2 0.172
regulation of cell migration GO:0030334 219 0.172
cytokine metabolic process GO:0042107 71 0.170
regulation of cell activation GO:0050865 289 0.170
regulation of protein serine threonine kinase activity GO:0071900 157 0.167
regulation of cellular response to stress GO:0080135 159 0.165
regulation of hematopoietic stem cell proliferation GO:1902033 3 0.162
interspecies interaction between organisms GO:0044419 83 0.162
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.161
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.160
positive regulation vascular endothelial growth factor production GO:0010575 10 0.159
jnk cascade GO:0007254 72 0.159
glucose transport GO:0015758 56 0.157
positive regulation of chemokine biosynthetic process GO:0045080 6 0.156
regulation of leukocyte differentiation GO:1902105 159 0.156
negative regulation of mast cell degranulation GO:0043305 4 0.154
response to organonitrogen compound GO:0010243 246 0.154
defense response to virus GO:0051607 68 0.152
cellular response to peptidoglycan GO:0071224 4 0.151
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.150
positive regulation of hematopoietic stem cell proliferation GO:1902035 2 0.149
response to peptidoglycan GO:0032494 9 0.148
antibacterial peptide biosynthetic process GO:0002780 2 0.146
response to interleukin 4 GO:0070670 23 0.145
homeostasis of number of cells GO:0048872 210 0.144
regulation of establishment of protein localization GO:0070201 181 0.143
inflammatory response to wounding GO:0090594 4 0.143
detection of fungus GO:0016046 2 0.143
myeloid leukocyte migration GO:0097529 57 0.142
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.142
cell activation involved in immune response GO:0002263 126 0.142
hormone secretion GO:0046879 128 0.139
positive regulation of jun kinase activity GO:0043507 30 0.139
keratinocyte migration GO:0051546 3 0.139
cellular metal ion homeostasis GO:0006875 151 0.139
regulation of secretion GO:0051046 274 0.138
regulation of map kinase activity GO:0043405 120 0.136
cellular response to organonitrogen compound GO:0071417 145 0.136
positive regulation of lymphocyte proliferation GO:0050671 70 0.136
t helper cell differentiation GO:0042093 28 0.136
regulation of cell motility GO:2000145 236 0.135
leukocyte apoptotic process GO:0071887 71 0.135
divalent inorganic cation homeostasis GO:0072507 138 0.134
regulation of myotube differentiation GO:0010830 62 0.132
cellular chemical homeostasis GO:0055082 215 0.131
ras protein signal transduction GO:0007265 77 0.131
positive regulation of muscle cell differentiation GO:0051149 39 0.129
t cell activation involved in immune response GO:0002286 43 0.129
positive regulation of cytokine production involved in immune response GO:0002720 19 0.129
t cell proliferation GO:0042098 120 0.127
detection of molecule of bacterial origin GO:0032490 2 0.126
positive regulation of inflammatory response GO:0050729 47 0.125
response to molecule of fungal origin GO:0002238 4 0.124
regulation of t helper 1 cell differentiation GO:0045625 7 0.123
killing of cells of other organism GO:0031640 13 0.123
regulation of stress activated mapk cascade GO:0032872 69 0.122
leukocyte activation involved in immune response GO:0002366 126 0.122
regulation of ion homeostasis GO:2000021 64 0.121
positive regulation of protein transport GO:0051222 93 0.121
nucleoside phosphate metabolic process GO:0006753 338 0.121
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.120
leukocyte chemotaxis GO:0030595 69 0.118
positive regulation of map kinase activity GO:0043406 84 0.117
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.117
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.117
regulation of jnk cascade GO:0046328 62 0.116
positive regulation of secretion GO:0051047 130 0.116
negative regulation of cellular protein metabolic process GO:0032269 247 0.116
cellular ion homeostasis GO:0006873 165 0.116
regulation of vesicle mediated transport GO:0060627 139 0.116
syncytium formation by plasma membrane fusion GO:0000768 42 0.115
activation of mapk activity GO:0000187 59 0.115
negative regulation of serotonin secretion GO:0014063 2 0.114
nitrogen compound transport GO:0071705 271 0.114
interleukin 12 secretion GO:0072610 3 0.112
regulation of chemotaxis GO:0050920 53 0.111
regulation of cytokine secretion GO:0050707 61 0.111
negative regulation of macrophage apoptotic process GO:2000110 3 0.110
peptide secretion GO:0002790 114 0.109
positive regulation of granulocyte chemotaxis GO:0071624 12 0.108
cytokine mediated signaling pathway GO:0019221 115 0.107
neutrophil mediated immunity GO:0002446 19 0.107
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.106
positive regulation of apoptotic process GO:0043065 217 0.106
macrophage chemotaxis GO:0048246 14 0.106
regulation of hormone levels GO:0010817 211 0.106
regulation of striated muscle cell differentiation GO:0051153 81 0.105
rho protein signal transduction GO:0007266 32 0.105
cellular amine metabolic process GO:0044106 44 0.105
interferon gamma production GO:0032609 67 0.105
regulation of defense response to fungus GO:1900150 1 0.104
regulation of cell projection assembly GO:0060491 38 0.103
small gtpase mediated signal transduction GO:0007264 97 0.102
antibacterial peptide production GO:0002778 2 0.102
positive regulation of chemokine production GO:0032722 22 0.102
positive regulation of killing of cells of other organism GO:0051712 3 0.102
cellular homeostasis GO:0019725 240 0.102
antimicrobial peptide production GO:0002775 2 0.101
defense response to gram positive bacterium GO:0050830 50 0.101
negative regulation of muscle cell differentiation GO:0051148 33 0.101
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.100
regulation of cellular amine metabolic process GO:0033238 20 0.100
positive regulation of cell activation GO:0050867 158 0.099
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.099
tumor necrosis factor production GO:0032640 50 0.098
lymphocyte activation involved in immune response GO:0002285 93 0.098
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.098
chemokine production GO:0032602 34 0.098
modification by host of symbiont morphology or physiology GO:0051851 12 0.098
cellular ketone metabolic process GO:0042180 84 0.096
innate immune response GO:0045087 157 0.096
response to tumor necrosis factor GO:0034612 26 0.096
cellular divalent inorganic cation homeostasis GO:0072503 127 0.095
regulation of myoblast differentiation GO:0045661 29 0.094
anion transport GO:0006820 177 0.093
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.092
regulation of transferase activity GO:0051338 263 0.092
positive regulation of programmed cell death GO:0043068 218 0.092
positive regulation of chemotaxis GO:0050921 38 0.090
positive regulation of homeostatic process GO:0032846 64 0.090
regulation of protein kinase activity GO:0045859 232 0.090
regulation of neutrophil mediated cytotoxicity GO:0070948 2 0.089
prostaglandin transport GO:0015732 7 0.089
cellular response to biotic stimulus GO:0071216 92 0.088
negative regulation of secretion GO:0051048 61 0.088
positive regulation of cell killing GO:0031343 33 0.086
positive regulation of stress activated mapk cascade GO:0032874 48 0.086
positive regulation of lymphocyte migration GO:2000403 11 0.086
regulation of cellular amino acid metabolic process GO:0006521 5 0.085
positive regulation of myotube differentiation GO:0010831 24 0.084
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.084
granulocyte chemotaxis GO:0071621 39 0.084
lymphocyte proliferation GO:0046651 164 0.084
cellular amino acid metabolic process GO:0006520 103 0.083
activation of jun kinase activity GO:0007257 15 0.083
myotube cell development GO:0014904 60 0.083
second messenger mediated signaling GO:0019932 73 0.083
regulation of ion transport GO:0043269 215 0.082
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.082
neutrophil mediated killing of symbiont cell GO:0070943 8 0.081
positive regulation of acute inflammatory response GO:0002675 16 0.081
g protein coupled receptor signaling pathway GO:0007186 243 0.080
detection of yeast GO:0001879 2 0.080
angiogenesis GO:0001525 201 0.080
positive regulation of mapk cascade GO:0043410 170 0.080
killing by host of symbiont cells GO:0051873 11 0.080
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.079
disruption of cells of other organism GO:0044364 13 0.079
positive regulation of leukocyte proliferation GO:0070665 73 0.079
regulation of interferon gamma production GO:0032649 57 0.078
regulation of secretion by cell GO:1903530 249 0.078
regulation of alpha beta t cell proliferation GO:0046640 18 0.077
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.077
regulation of lymphocyte differentiation GO:0045619 107 0.077
regulation of body fluid levels GO:0050878 162 0.076
adaptive immune response GO:0002250 155 0.076
positive regulation of cell motility GO:2000147 116 0.076
sequestering of calcium ion GO:0051208 18 0.075
nucleobase containing small molecule metabolic process GO:0055086 352 0.075
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.074
protein kinase b signaling GO:0043491 74 0.074
peptide hormone secretion GO:0030072 109 0.074
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.074
regulation of interleukin 10 secretion GO:2001179 4 0.074
regulation of kinase activity GO:0043549 249 0.073
cellular response to acid chemical GO:0071229 68 0.073
hematopoietic stem cell proliferation GO:0071425 13 0.073
t cell differentiation involved in immune response GO:0002292 30 0.073
alpha beta t cell activation involved in immune response GO:0002287 31 0.073
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.073
interleukin 1 beta production GO:0032611 30 0.073
regulation of tumor necrosis factor production GO:0032680 49 0.073
nucleotide metabolic process GO:0009117 332 0.072
detection of biotic stimulus GO:0009595 10 0.072
cell recognition GO:0008037 83 0.072
purine nucleotide metabolic process GO:0006163 302 0.072
regulation of mapk cascade GO:0043408 248 0.071
positive regulation of cell migration GO:0030335 109 0.071
regulation of cell killing GO:0031341 40 0.071
regulation of cellular catabolic process GO:0031329 242 0.070
positive regulation of protein secretion GO:0050714 52 0.070
negative regulation of phosphorylation GO:0042326 166 0.070
regulation of jun kinase activity GO:0043506 40 0.069
regulation of response to biotic stimulus GO:0002831 38 0.069
dendritic cell differentiation GO:0097028 26 0.069
positive regulation of cell death GO:0010942 224 0.069
regulation of muscle tissue development GO:1901861 97 0.068
reactive nitrogen species metabolic process GO:2001057 0 0.068
positive regulation of protein kinase activity GO:0045860 144 0.067
leukocyte homeostasis GO:0001776 79 0.067
regulation of lymphocyte mediated immunity GO:0002706 84 0.067
positive regulation of prostaglandin secretion GO:0032308 5 0.067
antimicrobial peptide biosynthetic process GO:0002777 2 0.066
morphogenesis of a branching epithelium GO:0061138 193 0.066
organ or tissue specific immune response GO:0002251 13 0.066
negative regulation of protein modification process GO:0031400 163 0.066
regulation of t helper cell differentiation GO:0045622 14 0.065
growth of symbiont in host GO:0044117 23 0.065
negative regulation of protein metabolic process GO:0051248 282 0.064
wound healing involved in inflammatory response GO:0002246 4 0.064
positive regulation of interleukin 12 production GO:0032735 21 0.064
monosaccharide transport GO:0015749 58 0.063
t cell activation GO:0042110 289 0.063
sequestering of metal ion GO:0051238 19 0.063
endocytosis GO:0006897 168 0.063
regulation of protein secretion GO:0050708 82 0.063
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.063
regulation of membrane potential GO:0042391 192 0.063
regulation of immunoglobulin production GO:0002637 42 0.063
regulation of t cell differentiation GO:0045580 83 0.063
positive regulation of cytokine biosynthetic process GO:0042108 40 0.062
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.062
muscle fiber development GO:0048747 76 0.062
inflammatory cell apoptotic process GO:0006925 11 0.062
regulation of cytokine production involved in immune response GO:0002718 26 0.062
interleukin 12 production GO:0032615 32 0.061
regulation of fatty acid transport GO:2000191 10 0.061
myoblast differentiation GO:0045445 52 0.061
stress activated protein kinase signaling cascade GO:0031098 81 0.060
myeloid cell apoptotic process GO:0033028 22 0.060
positive regulation of jnk cascade GO:0046330 46 0.060
organic anion transport GO:0015711 137 0.059
cation transport GO:0006812 399 0.059
glycoprotein metabolic process GO:0009100 116 0.059
regulation of t cell activation GO:0050863 170 0.059
regulation of acute inflammatory response GO:0002673 27 0.059
fever generation GO:0001660 7 0.059
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.058
metal ion homeostasis GO:0055065 189 0.058
negative regulation of phosphorus metabolic process GO:0010563 184 0.058
negative regulation of cytokine production GO:0001818 84 0.057
response to amino acid GO:0043200 37 0.057
cytosolic calcium ion transport GO:0060401 48 0.057
muscle cell differentiation GO:0042692 261 0.057
positive regulation of adaptive immune response GO:0002821 61 0.057
regulation of growth of symbiont in host GO:0044126 19 0.057
regulation of cytokine biosynthetic process GO:0042035 59 0.057
purine containing compound metabolic process GO:0072521 311 0.057
regulation of acute inflammatory response to non antigenic stimulus GO:0002877 2 0.056
cytokine biosynthetic process GO:0042089 68 0.056
regulation of intracellular transport GO:0032386 159 0.056
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.056
t helper 1 cell differentiation GO:0045063 13 0.056
regulation of killing of cells of other organism GO:0051709 4 0.056
positive regulation of kinase activity GO:0033674 155 0.055
t cell mediated immunity GO:0002456 50 0.055
immune response regulating signaling pathway GO:0002764 125 0.055
epithelial cell proliferation GO:0050673 174 0.055
gland development GO:0048732 330 0.054
regulation of vascular endothelial growth factor production GO:0010574 13 0.054
leukocyte mediated cytotoxicity GO:0001909 62 0.054
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.053
alpha beta t cell proliferation GO:0046633 21 0.053
cytosolic calcium ion homeostasis GO:0051480 70 0.053
positive regulation of macrophage chemotaxis GO:0010759 5 0.053
immunoglobulin mediated immune response GO:0016064 69 0.052
calcium ion transport GO:0006816 159 0.052
detection of peptidoglycan GO:0032499 1 0.052
heterocycle catabolic process GO:0046700 280 0.052
regulation of neutrophil chemotaxis GO:0090022 14 0.051
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.051
regulation of reactive oxygen species metabolic process GO:2000377 40 0.051
positive regulation of lymphocyte differentiation GO:0045621 61 0.051
positive regulation of striated muscle cell differentiation GO:0051155 35 0.051
cell killing GO:0001906 67 0.051
aromatic compound catabolic process GO:0019439 286 0.051
pattern recognition receptor signaling pathway GO:0002221 47 0.051
mammary gland epithelium development GO:0061180 65 0.050
interleukin 18 production GO:0032621 4 0.050
peptide transport GO:0015833 133 0.050
chemokine metabolic process GO:0050755 10 0.050
negative regulation of mast cell activation involved in immune response GO:0033007 5 0.049
positive regulation of transferase activity GO:0051347 167 0.049
mast cell activation involved in immune response GO:0002279 20 0.049
b cell mediated immunity GO:0019724 71 0.049
interleukin 1 production GO:0032612 31 0.048
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.048
regulation of adaptive immune response GO:0002819 90 0.048
organonitrogen compound biosynthetic process GO:1901566 192 0.047
peptide metabolic process GO:0006518 46 0.047
myeloid cell activation involved in immune response GO:0002275 34 0.047
lymphocyte chemotaxis GO:0048247 10 0.047
regulation of interleukin 12 production GO:0032655 30 0.047
cell cell recognition GO:0009988 44 0.047
carbohydrate transport GO:0008643 62 0.047
dendritic cell chemotaxis GO:0002407 7 0.047
cellular amide metabolic process GO:0043603 58 0.047
mast cell activation GO:0045576 27 0.046
negative regulation of syncytium formation by plasma membrane fusion GO:0034242 5 0.046
defense response to gram negative bacterium GO:0050829 28 0.046
amide transport GO:0042886 138 0.046
carboxylic acid transport GO:0046942 100 0.045
peptidyl amino acid modification GO:0018193 336 0.045
protein catabolic process GO:0030163 221 0.045
positive regulation of t cell cytokine production GO:0002726 5 0.045
alpha beta t cell activation GO:0046631 91 0.044
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.044
fatty acid derivative transport GO:1901571 14 0.044
positive regulation of t cell migration GO:2000406 10 0.044
positive regulation of cellular catabolic process GO:0031331 148 0.044
positive regulation of myoblast differentiation GO:0045663 8 0.044
neutrophil mediated killing of fungus GO:0070947 3 0.044
response to protozoan GO:0001562 28 0.044
organic acid transport GO:0015849 101 0.043
toll like receptor signaling pathway GO:0002224 38 0.043
positive regulation of neuron death GO:1901216 28 0.043
positive regulation of lymphocyte activation GO:0051251 140 0.043
positive regulation of cell projection organization GO:0031346 95 0.043
wound healing GO:0042060 157 0.043
negative regulation of mast cell activation GO:0033004 6 0.042
calcium mediated signaling GO:0019722 46 0.042
positive regulation of t cell differentiation GO:0045582 52 0.042
acute inflammatory response GO:0002526 41 0.042
regulation of neutrophil migration GO:1902622 14 0.042
positive regulation of protein phosphorylation GO:0001934 242 0.042
positive regulation of interferon gamma production GO:0032729 39 0.042
negative regulation of cellular component organization GO:0051129 194 0.041
regulation of antimicrobial humoral response GO:0002759 3 0.041
regulation of mast cell degranulation GO:0043304 16 0.041
t cell costimulation GO:0031295 14 0.040
positive regulation of interleukin 1 beta production GO:0032731 16 0.040
stress activated mapk cascade GO:0051403 80 0.040
negative regulation of protein phosphorylation GO:0001933 126 0.040
positive regulation of t cell mediated immunity GO:0002711 24 0.040
regulation of fever generation GO:0031620 6 0.040
positive regulation of response to wounding GO:1903036 66 0.040
response to drug GO:0042493 75 0.040
phagocytosis GO:0006909 66 0.040
mucosal immune response GO:0002385 13 0.039
neuron death GO:0070997 154 0.039
maintenance of location GO:0051235 89 0.039
regulation of production of molecular mediator of immune response GO:0002700 65 0.039
regulation of glucose transport GO:0010827 32 0.039
positive regulation of behavior GO:0048520 40 0.039
regulation of lymphocyte activation GO:0051249 240 0.039
positive regulation of cellular amine metabolic process GO:0033240 5 0.039
ribonucleotide metabolic process GO:0009259 291 0.038
regulation of leukocyte apoptotic process GO:2000106 56 0.038
regulation of protein kinase b signaling GO:0051896 56 0.038
regulation of cellular ketone metabolic process GO:0010565 66 0.038
positive regulation of mast cell degranulation GO:0043306 10 0.038
positive regulation of secretion by cell GO:1903532 114 0.038
phosphatidylinositol mediated signaling GO:0048015 41 0.038
positive regulation of hydrolase activity GO:0051345 148 0.038
amine metabolic process GO:0009308 45 0.038
reactive oxygen species metabolic process GO:0072593 84 0.038
release of sequestered calcium ion into cytosol GO:0051209 42 0.038
cellular response to hormone stimulus GO:0032870 150 0.038
chronic inflammatory response GO:0002544 9 0.037
positive regulation of regulated secretory pathway GO:1903307 10 0.037
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.037
alpha beta t cell differentiation GO:0046632 69 0.037
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.037
antimicrobial peptide secretion GO:0002776 1 0.037
response to arsenic containing substance GO:0046685 5 0.037
carbohydrate derivative catabolic process GO:1901136 231 0.037
response to interleukin 1 GO:0070555 11 0.036
regulation of homeostatic process GO:0032844 182 0.036
regulation of neuron apoptotic process GO:0043523 122 0.036
purine nucleotide catabolic process GO:0006195 211 0.036
response to acid chemical GO:0001101 111 0.036
regulation of hydrolase activity GO:0051336 246 0.036
skeletal muscle organ development GO:0060538 163 0.035
interleukin 1 secretion GO:0050701 16 0.035
t helper 1 type immune response GO:0042088 25 0.035
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.035
negative regulation of kinase activity GO:0033673 81 0.035
skeletal muscle fiber development GO:0048741 58 0.035
positive regulation of neutrophil migration GO:1902624 12 0.035
muscle tissue development GO:0060537 308 0.035
histamine production involved in inflammatory response GO:0002349 1 0.035
regulation of cell adhesion GO:0030155 154 0.035
icosanoid transport GO:0071715 14 0.035
positive regulation of nucleotide metabolic process GO:0045981 114 0.035
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.034
t helper 17 cell lineage commitment GO:0072540 4 0.034
purine containing compound catabolic process GO:0072523 213 0.034
regulation of vasculature development GO:1901342 88 0.034
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.034
multicellular organismal homeostasis GO:0048871 164 0.034
mammary gland duct morphogenesis GO:0060603 38 0.034
activation of mapk activity involved in innate immune response GO:0035419 2 0.034

Irg1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.159
disease of cellular proliferation DOID:14566 0 0.159
organ system cancer DOID:0050686 0 0.074
gastrointestinal system cancer DOID:3119 0 0.048