|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.973
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.973
|
Mouse |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.954
|
Mouse |
|
|
alpha beta t cell activation involved in immune response
|
GO:0002287 |
31 |
0.910
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.895
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.894
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.889
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.874
|
|
|
|
negative regulation of t cell differentiation
|
GO:0045581 |
23 |
0.870
|
|
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
51 |
0.860
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.844
|
Mouse |
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.841
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.839
|
|
|
|
negative regulation of lymphocyte differentiation
|
GO:0045620 |
32 |
0.835
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.824
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.823
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.807
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.796
|
|
|
|
regulation of defense response to fungus
|
GO:1900150 |
1 |
0.793
|
Fly |
|
|
innate immune response
|
GO:0045087 |
157 |
0.787
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.780
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.766
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.763
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.757
|
Mouse |
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.753
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.750
|
|
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
16 |
0.746
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.744
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.739
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.735
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.729
|
|
|
|
dendritic cell differentiation
|
GO:0097028 |
26 |
0.727
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.723
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.719
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.707
|
Mouse |
|
|
t helper 1 type immune response
|
GO:0042088 |
25 |
0.690
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.687
|
Mouse |
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.676
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.664
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.659
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.653
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.649
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.649
|
Fly |
|
|
defense response to protozoan
|
GO:0042832 |
25 |
0.635
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.627
|
|
|
|
positive regulation of t helper 1 cell differentiation
|
GO:0045627 |
4 |
0.611
|
|
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
2 |
0.604
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.602
|
|
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.601
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.598
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.589
|
Mouse |
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.578
|
Mouse |
|
|
necroptotic process
|
GO:0070266 |
21 |
0.577
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.573
|
|
|
|
follicular dendritic cell differentiation
|
GO:0002268 |
2 |
0.572
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.568
|
Mouse |
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.555
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.553
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.551
|
|
|
|
positive regulation of interleukin 12 production
|
GO:0032735 |
21 |
0.549
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.539
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.535
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.533
|
Mouse |
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.529
|
|
|
|
marginal zone b cell differentiation
|
GO:0002315 |
2 |
0.529
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.527
|
Fly |
|
|
skin development
|
GO:0043588 |
220 |
0.510
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.503
|
Human |
|
|
t cell activation
|
GO:0042110 |
289 |
0.502
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
13 |
0.495
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.488
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.483
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.481
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
3 |
0.478
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.473
|
Mouse |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.469
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.463
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.462
|
Human |
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.452
|
|
|
|
t helper cell differentiation
|
GO:0042093 |
28 |
0.448
|
|
|
|
t cell differentiation involved in immune response
|
GO:0002292 |
30 |
0.447
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.444
|
|
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
2 |
0.442
|
Fly |
|
|
negative regulation of t helper 2 cell differentiation
|
GO:0045629 |
4 |
0.441
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.440
|
Mouse |
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.435
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.427
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.419
|
Mouse |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.418
|
Mouse |
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.416
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.402
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.393
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.392
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.390
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.390
|
|
|
|
positive regulation of fever generation by positive regulation of prostaglandin secretion
|
GO:0071812 |
2 |
0.389
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.381
|
|
|
|
interleukin 13 secretion
|
GO:0072611 |
2 |
0.376
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.366
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.362
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.362
|
|
|
|
positive regulation of antimicrobial peptide biosynthetic process
|
GO:0002807 |
1 |
0.359
|
Fly |
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.351
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.349
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.348
|
|
|
|
b cell activation involved in immune response
|
GO:0002312 |
50 |
0.347
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.344
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.343
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.341
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.340
|
Mouse |
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.335
|
Mouse |
|
|
activation of immune response
|
GO:0002253 |
138 |
0.333
|
Mouse |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.333
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.328
|
|
|
|
regulation of cd8 positive alpha beta t cell activation
|
GO:2001185 |
3 |
0.326
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.319
|
|
|
|
regulation of myd88 independent toll like receptor signaling pathway
|
GO:0034127 |
1 |
0.318
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.315
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.313
|
|
|
|
regulation of t helper 1 cell differentiation
|
GO:0045625 |
7 |
0.311
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.310
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.308
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.304
|
|
|
|
germinal center formation
|
GO:0002467 |
16 |
0.301
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.298
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.297
|
|
|
|
interleukin 12 biosynthetic process
|
GO:0042090 |
8 |
0.292
|
|
|
|
positive regulation of type i interferon mediated signaling pathway
|
GO:0060340 |
4 |
0.284
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.280
|
|
|
|
regulation of cd4 positive alpha beta t cell activation
|
GO:2000514 |
24 |
0.279
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.273
|
Mouse |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.272
|
|
|
|
negative regulation of tumor necrosis factor biosynthetic process
|
GO:0042536 |
1 |
0.271
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.269
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.266
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.265
|
|
|
|
interleukin 12 production
|
GO:0032615 |
32 |
0.265
|
|
|
|
spleen development
|
GO:0048536 |
39 |
0.262
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.258
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.257
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.256
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.255
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.246
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.245
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.244
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.244
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.241
|
|
|
|
t helper 2 cell differentiation
|
GO:0045064 |
12 |
0.237
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.236
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.233
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.231
|
Mouse Fly |
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.229
|
|
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
0.229
|
|
|
|
t helper 2 cell cytokine production
|
GO:0035745 |
4 |
0.226
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
42 |
0.225
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
91 |
0.223
|
Human |
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.220
|
|
|
|
negative regulation of t helper 1 cell differentiation
|
GO:0045626 |
3 |
0.219
|
|
|
|
negative regulation of interleukin 5 secretion
|
GO:2000663 |
1 |
0.215
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.213
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.205
|
Fly |
|
|
follicular dendritic cell activation
|
GO:0002266 |
2 |
0.202
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.200
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.198
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.197
|
Human |
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.193
|
Fly |
|
|
cd4 positive or cd8 positive alpha beta t cell lineage commitment
|
GO:0043369 |
8 |
0.191
|
|
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
39 |
0.189
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.187
|
Mouse Fly |
|
|
response to type i interferon
|
GO:0034340 |
12 |
0.186
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.186
|
Human |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.185
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.184
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.182
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.182
|
Human |
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.181
|
|
|
|
antimicrobial peptide biosynthetic process
|
GO:0002777 |
2 |
0.180
|
Fly |
|
|
myd88 independent toll like receptor signaling pathway
|
GO:0002756 |
3 |
0.179
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.177
|
Human |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.177
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
2 |
0.173
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
68 |
0.171
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.170
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.169
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.169
|
Human |
|
|
mapk cascade
|
GO:0000165 |
281 |
0.161
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.160
|
Human Mouse |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.160
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.158
|
Human Mouse |
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.156
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.155
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.154
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.153
|
|
|
|
negative regulation of interferon beta production
|
GO:0032688 |
3 |
0.152
|
|
|
|
negative regulation of cytokine biosynthetic process
|
GO:0042036 |
13 |
0.151
|
|
|
|
antibacterial peptide biosynthetic process
|
GO:0002780 |
2 |
0.151
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.151
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.150
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.150
|
Mouse |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.149
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.149
|
Human |
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.149
|
|
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
0.148
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.146
|
Human Mouse |
|
|
regulation of interleukin 5 secretion
|
GO:2000662 |
2 |
0.146
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.145
|
Mouse |
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.143
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.143
|
|
|
|
regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043370 |
21 |
0.142
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.141
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
2 |
0.140
|
|
|
|
regulation of cytokine secretion
|
GO:0050707 |
61 |
0.139
|
|
|
|
regulation of type 2 immune response
|
GO:0002828 |
18 |
0.138
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.138
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.138
|
Mouse |
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.137
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.137
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.137
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.136
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
89 |
0.135
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.135
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.135
|
|
|
|
keratinocyte differentiation
|
GO:0030216 |
48 |
0.132
|
|
|
|
positive regulation of antibacterial peptide biosynthetic process
|
GO:0006963 |
1 |
0.130
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.130
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.130
|
|
|
|
regulation of vitamin d biosynthetic process
|
GO:0060556 |
1 |
0.129
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.129
|
|
|
|
positive regulation of leukocyte apoptotic process
|
GO:2000108 |
21 |
0.127
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.127
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.126
|
|
|
|
response to muramyl dipeptide
|
GO:0032495 |
9 |
0.125
|
Mouse |
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.125
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.125
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.125
|
Human Mouse |
|
|
lateral line system development
|
GO:0048925 |
1 |
0.124
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.123
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.122
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.122
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.121
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.120
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
116 |
0.120
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.119
|
Fly |
|
|
molting cycle
|
GO:0042303 |
90 |
0.118
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.118
|
Human Mouse |
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.117
|
Mouse |
|
|
negative regulation of cd4 positive alpha beta t cell activation
|
GO:2000515 |
10 |
0.117
|
|
|
|
positive regulation of neutrophil mediated killing of symbiont cell
|
GO:0070961 |
1 |
0.117
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.117
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
18 |
0.117
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.117
|
|
|
|
circadian regulation of gene expression
|
GO:0032922 |
48 |
0.116
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.116
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.115
|
Human Mouse |
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.114
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.114
|
Human Mouse |
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.113
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.109
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.108
|
|
|
|
action potential
|
GO:0001508 |
78 |
0.107
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.106
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.106
|
|
|
|
positive regulation of syncytium formation by plasma membrane fusion
|
GO:0060143 |
17 |
0.106
|
|
|
|
interferon gamma production
|
GO:0032609 |
67 |
0.105
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
10 |
0.105
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.104
|
Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.102
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
38 |
0.102
|
Mouse |
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.102
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.101
|
|
|
|
regulation of vitamin metabolic process
|
GO:0030656 |
3 |
0.101
|
|
|
|
toll like receptor 4 signaling pathway
|
GO:0034142 |
9 |
0.100
|
Mouse |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.100
|
|
|
|
regulation of calcidiol 1 monooxygenase activity
|
GO:0060558 |
1 |
0.100
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.100
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.099
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.097
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
0.097
|
|
|
|
t helper 17 cell lineage commitment
|
GO:0072540 |
4 |
0.095
|
|
|
|
regulation of immunoglobulin mediated immune response
|
GO:0002889 |
37 |
0.094
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.094
|
|
|
|
interleukin 10 production
|
GO:0032613 |
23 |
0.094
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.094
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.092
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.092
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.092
|
Human Mouse |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.091
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.091
|
|
|
|
regulation of interleukin 10 production
|
GO:0032653 |
21 |
0.091
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.091
|
Human |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.090
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.089
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.089
|
|
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
7 |
0.089
|
|
|
|
negative regulation of interleukin 13 production
|
GO:0032696 |
2 |
0.088
|
|
|
|
negative regulation of intracellular protein transport
|
GO:0090317 |
27 |
0.088
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.088
|
|
|
|
negative regulation of interleukin 5 production
|
GO:0032714 |
4 |
0.087
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.087
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.086
|
|
|
|
negative regulation of interleukin 12 biosynthetic process
|
GO:0045083 |
1 |
0.086
|
|
|
|
negative regulation of interleukin 13 secretion
|
GO:2000666 |
1 |
0.086
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.086
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.086
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.086
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.085
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.085
|
|
|
|
regulation of myd88 dependent toll like receptor signaling pathway
|
GO:0034124 |
2 |
0.084
|
|
|
|
cd4 positive alpha beta t cell cytokine production
|
GO:0035743 |
4 |
0.084
|
|
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
4 |
0.084
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
127 |
0.084
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
130 |
0.083
|
|
|
|
immunoglobulin production involved in immunoglobulin mediated immune response
|
GO:0002381 |
43 |
0.083
|
|
|
|
response to dsrna
|
GO:0043331 |
30 |
0.083
|
Mouse |
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.082
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.082
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
30 |
0.082
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.082
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
83 |
0.081
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.081
|
|
|
|
regulation of neutrophil mediated killing of gram negative bacterium
|
GO:0070951 |
1 |
0.080
|
|
|
|
hair cycle
|
GO:0042633 |
90 |
0.080
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
11 |
0.080
|
|
|
|
cellular response to type i interferon
|
GO:0071357 |
10 |
0.080
|
|
|
|
lymph node development
|
GO:0048535 |
18 |
0.080
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.080
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.079
|
Human |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.079
|
Mouse |
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.078
|
|
|
|
t cell extravasation
|
GO:0072683 |
4 |
0.078
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.078
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.077
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.077
|
Human |
|
|
positive regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060261 |
5 |
0.077
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.076
|
|
|
|
negative regulation of alpha beta t cell differentiation
|
GO:0046639 |
12 |
0.076
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.076
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.076
|
Fly |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.076
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.076
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.074
|
|
|
|
regulation of t helper 1 type immune response
|
GO:0002825 |
17 |
0.073
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
36 |
0.073
|
|
|
|
regulation of fever generation by regulation of prostaglandin secretion
|
GO:0071810 |
2 |
0.073
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.072
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.072
|
|
|
|
negative regulation of b cell proliferation
|
GO:0030889 |
13 |
0.072
|
|
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
39 |
0.070
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
83 |
0.070
|
|
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.070
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.070
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.070
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.069
|
|
|
|
somatic recombination of immunoglobulin genes involved in immune response
|
GO:0002204 |
36 |
0.069
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.069
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.068
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.068
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.068
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.068
|
|
|
|
syncytium formation
|
GO:0006949 |
43 |
0.068
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.067
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.067
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
65 |
0.067
|
|
|
|
thymocyte migration
|
GO:0072679 |
2 |
0.067
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.067
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.066
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.066
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
119 |
0.065
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.065
|
|
|
|
response to hypoxia
|
GO:0001666 |
58 |
0.065
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
24 |
0.065
|
Human |
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.065
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.065
|
|
|
|
regulation of interleukin 12 biosynthetic process
|
GO:0045075 |
8 |
0.065
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.064
|
|
|
|
polysaccharide metabolic process
|
GO:0005976 |
39 |
0.064
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.064
|
|
|
|
regulation of glucose transport
|
GO:0010827 |
32 |
0.064
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.063
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.063
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.063
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.063
|
|
|
|
response to protozoan
|
GO:0001562 |
28 |
0.062
|
|
|
|
antibacterial humoral response
|
GO:0019731 |
8 |
0.062
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.062
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.062
|
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.062
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
17 |
0.062
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.061
|
|
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.061
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
3 |
0.061
|
|
|
|
regulation of interleukin 13 secretion
|
GO:2000665 |
2 |
0.061
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.061
|
Mouse |
|
|
regulation of odontogenesis
|
GO:0042481 |
18 |
0.061
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
64 |
0.061
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.061
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.061
|
|
|
|
regulation of b cell mediated immunity
|
GO:0002712 |
37 |
0.060
|
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.060
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.059
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.059
|
|
|
|
positive regulation of cd4 positive alpha beta t cell activation
|
GO:2000516 |
16 |
0.059
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.059
|
Human Mouse |
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.059
|
|
|
|
regulation of cd8 positive alpha beta t cell proliferation
|
GO:2000564 |
1 |
0.059
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.059
|
|
|
|
negative regulation of interferon beta biosynthetic process
|
GO:0045358 |
1 |
0.059
|
|
|
|
positive regulation of interleukin 12 biosynthetic process
|
GO:0045084 |
6 |
0.058
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.058
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.058
|
|
|
|
mature dendritic cell differentiation
|
GO:0097029 |
3 |
0.058
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.058
|
|
|
|
somatic diversification of immunoglobulins involved in immune response
|
GO:0002208 |
36 |
0.057
|
|
|
|
cerebral cortex cell migration
|
GO:0021795 |
44 |
0.057
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.057
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.057
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.057
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.057
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.057
|
Fly |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.056
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.056
|
|
|
|
somatic recombination of immunoglobulin gene segments
|
GO:0016447 |
42 |
0.056
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.056
|
|
|
|
response to amino acid
|
GO:0043200 |
37 |
0.055
|
|
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.055
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.055
|
|
|
|
regulation of syncytium formation by plasma membrane fusion
|
GO:0060142 |
23 |
0.055
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.055
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.055
|
|
|
|
protein deubiquitination
|
GO:0016579 |
19 |
0.055
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.054
|
|
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.054
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.054
|
Human |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.053
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
28 |
0.053
|
|
|
|
protein complex localization
|
GO:0031503 |
19 |
0.053
|
Human |
|
|
response to acid chemical
|
GO:0001101 |
111 |
0.053
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.053
|
|
|
|
growth involved in symbiotic interaction
|
GO:0044110 |
23 |
0.053
|
|
|
|
mammary gland alveolus development
|
GO:0060749 |
22 |
0.053
|
|
|
|
fat soluble vitamin biosynthetic process
|
GO:0042362 |
4 |
0.053
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.053
|
|
|
|
negative regulation of transcription factor import into nucleus
|
GO:0042992 |
13 |
0.053
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
116 |
0.052
|
|
|
|
t cell chemotaxis
|
GO:0010818 |
6 |
0.052
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.052
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
2 |
0.051
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.051
|
|
|
|
protein kinase c activating g protein coupled receptor signaling pathway
|
GO:0007205 |
4 |
0.051
|
|
|
|
positive regulation of cytokine secretion involved in immune response
|
GO:0002741 |
2 |
0.051
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
81 |
0.051
|
|
|
|
positive regulation of type 2 immune response
|
GO:0002830 |
9 |
0.050
|
|
|
|
myd88 dependent toll like receptor signaling pathway
|
GO:0002755 |
7 |
0.050
|
|
|
|
protein acylation
|
GO:0043543 |
64 |
0.050
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.050
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.049
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
119 |
0.049
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.049
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.049
|
Fly |
|
|
t cell apoptotic process
|
GO:0070231 |
39 |
0.049
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.048
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.048
|
|
|
|
positive regulation of acute inflammatory response
|
GO:0002675 |
16 |
0.048
|
|
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.048
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
94 |
0.048
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.047
|
|
|
|
notch signaling pathway
|
GO:0007219 |
71 |
0.047
|
Mouse |
|
|
regulation of myoblast differentiation
|
GO:0045661 |
29 |
0.047
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.047
|
Human |
|
|
positive regulation of growth hormone receptor signaling pathway
|
GO:0060399 |
3 |
0.047
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.047
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.047
|
|
|
|
circadian temperature homeostasis
|
GO:0060086 |
2 |
0.047
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.046
|
|
|
|
mucopolysaccharide metabolic process
|
GO:1903510 |
25 |
0.046
|
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.046
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.046
|
|
|
|
hair follicle development
|
GO:0001942 |
85 |
0.046
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.046
|
|
|
|
striated muscle cell development
|
GO:0055002 |
125 |
0.046
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.046
|
|
|
|
histone modification
|
GO:0016570 |
159 |
0.045
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.045
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.045
|
Fly |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.045
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.044
|
|
|
|
t cell migration
|
GO:0072678 |
19 |
0.044
|
|
|
|
response to alcohol
|
GO:0097305 |
48 |
0.044
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.044
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.044
|
Fly |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.044
|
|
