Mus musculus

223 known processes

Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

(Aliases: Pgc-1alpha,Pgco1,Pgc1,PGC-1,Ppargc1,PGC-1v,A830037N07Rik)

Ppargc1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of fatty acid metabolic process GO:0019217 28 0.920
Rat
oxidation reduction process GO:0055114 342 0.905
circadian regulation of gene expression GO:0032922 48 0.901
regulation of fatty acid oxidation GO:0046320 10 0.899
Rat
negative regulation of cellular amine metabolic process GO:0033239 1 0.843
intracellular receptor signaling pathway GO:0030522 74 0.782
monocarboxylic acid metabolic process GO:0032787 191 0.733
Rat
dephosphorylation GO:0016311 129 0.730
Mouse
response to oxidative stress GO:0006979 123 0.686
cellular response to oxidative stress GO:0034599 76 0.671
fatty acid metabolic process GO:0006631 121 0.626
Rat
lipid catabolic process GO:0016042 69 0.622
regulation of cellular amine metabolic process GO:0033238 20 0.616
positive regulation of mitochondrion organization GO:0010822 17 0.612
striated muscle tissue development GO:0014706 293 0.581
negative regulation of fatty acid metabolic process GO:0045922 10 0.566
regulation of circadian rhythm GO:0042752 58 0.543
positive regulation of phosphatase activity GO:0010922 4 0.540
Mouse
energy derivation by oxidation of organic compounds GO:0015980 77 0.539
cellular metal ion homeostasis GO:0006875 151 0.536
cellular response to organonitrogen compound GO:0071417 145 0.532
lipid modification GO:0030258 65 0.532
Rat
circadian rhythm GO:0007623 114 0.520
regulation of mitochondrion organization GO:0010821 27 0.519
amine metabolic process GO:0009308 45 0.513
response to reactive oxygen species GO:0000302 56 0.505
Mouse
negative regulation of phosphorylation GO:0042326 166 0.504
inorganic cation transmembrane transport GO:0098662 207 0.502
nucleobase containing small molecule metabolic process GO:0055086 352 0.483
regulation of fatty acid beta oxidation GO:0031998 1 0.471
positive regulation of cellular respiration GO:1901857 3 0.464
acylglycerol metabolic process GO:0006639 55 0.460
lipid oxidation GO:0034440 29 0.459
Rat
cellular divalent inorganic cation homeostasis GO:0072503 127 0.458
white fat cell differentiation GO:0050872 15 0.457
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.446
myeloid cell differentiation GO:0030099 233 0.443
Mouse
lipid homeostasis GO:0055088 63 0.442
hexose metabolic process GO:0019318 98 0.440
Rat
skeletal system development GO:0001501 356 0.434
Mouse
muscle tissue development GO:0060537 308 0.423
carbohydrate metabolic process GO:0005975 230 0.417
Rat
cellular calcium ion homeostasis GO:0006874 119 0.415
monocarboxylic acid catabolic process GO:0072329 27 0.406
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.399
purine ribonucleoside metabolic process GO:0046128 241 0.382
purine nucleoside metabolic process GO:0042278 241 0.381
monosaccharide metabolic process GO:0005996 106 0.367
Rat
organ growth GO:0035265 117 0.366
cation transmembrane transport GO:0098655 266 0.354
regulation of myeloid cell differentiation GO:0045637 96 0.347
Mouse
response to organic cyclic compound GO:0014070 198 0.341
Rat
cation homeostasis GO:0055080 212 0.333
nucleoside monophosphate metabolic process GO:0009123 85 0.333
rhythmic process GO:0048511 174 0.328
regulation of ion homeostasis GO:2000021 64 0.322
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.321
cytosolic calcium ion homeostasis GO:0051480 70 0.320
cell proliferation in hindbrain GO:0021534 10 0.313
regulation of organ morphogenesis GO:2000027 144 0.312
regulation of cellular ketone metabolic process GO:0010565 66 0.310
Rat
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.307
cholesterol storage GO:0010878 4 0.305
cellular ketone metabolic process GO:0042180 84 0.304
Rat
cellular chemical homeostasis GO:0055082 215 0.304
dna metabolic process GO:0006259 303 0.298
regulation of blood pressure GO:0008217 93 0.296
ion transmembrane transport GO:0034220 361 0.293
Rat
response to alkaloid GO:0043279 34 0.292
ribonucleotide metabolic process GO:0009259 291 0.288
regulation of protein kinase activity GO:0045859 232 0.288
cation transport GO:0006812 399 0.284
forebrain development GO:0030900 302 0.281
cellular amine metabolic process GO:0044106 44 0.280
maintenance of location GO:0051235 89 0.280
tissue remodeling GO:0048771 102 0.278
Mouse
regulation of kinase activity GO:0043549 249 0.277
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.273
regulation of atp metabolic process GO:1903578 17 0.271
small molecule catabolic process GO:0044282 71 0.270
positive regulation of atp biosynthetic process GO:2001171 2 0.268
regulation of monooxygenase activity GO:0032768 7 0.268
negative regulation of protein modification process GO:0031400 163 0.267
metal ion homeostasis GO:0055065 189 0.267
positive regulation of fatty acid oxidation GO:0046321 4 0.267
Rat
lipid biosynthetic process GO:0008610 179 0.266
cellular ion homeostasis GO:0006873 165 0.262
calcium ion homeostasis GO:0055074 127 0.258
muscle contraction GO:0006936 101 0.258
ribose phosphate biosynthetic process GO:0046390 59 0.255
regulation of cellular amino acid metabolic process GO:0006521 5 0.254
cerebral cortex development GO:0021987 86 0.254
asymmetric stem cell division GO:0098722 3 0.250
lipid transport GO:0006869 98 0.247
purine ribonucleotide metabolic process GO:0009150 290 0.247
positive regulation of mapk cascade GO:0043410 170 0.242
positive regulation of kinase activity GO:0033674 155 0.242
cholesterol homeostasis GO:0042632 44 0.238
divalent inorganic cation transport GO:0072511 178 0.238
atp metabolic process GO:0046034 75 0.238
gland development GO:0048732 330 0.237
blood circulation GO:0008015 195 0.235
organophosphate biosynthetic process GO:0090407 122 0.232
regulation of glucose metabolic process GO:0010906 60 0.231
regulation of mapk cascade GO:0043408 248 0.230
purine containing compound biosynthetic process GO:0072522 70 0.230
positive regulation of tissue remodeling GO:0034105 19 0.229
Mouse
nucleotide metabolic process GO:0009117 332 0.228
negative regulation of phosphate metabolic process GO:0045936 184 0.227
actin cytoskeleton organization GO:0030036 220 0.227
Mouse
response to purine containing compound GO:0014074 28 0.225
neutral lipid metabolic process GO:0006638 57 0.224
generation of precursor metabolites and energy GO:0006091 103 0.224
asymmetric neuroblast division GO:0055059 1 0.222
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.220
male gamete generation GO:0048232 285 0.220
lipid localization GO:0010876 126 0.218
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.216
purine nucleotide biosynthetic process GO:0006164 65 0.215
regulation of fibroblast proliferation GO:0048145 34 0.215
glycerolipid metabolic process GO:0046486 122 0.213
peptidyl amino acid modification GO:0018193 336 0.206
negative regulation of blood pressure GO:0045776 22 0.206
anion transport GO:0006820 177 0.206
cellular lipid catabolic process GO:0044242 52 0.206
telomere maintenance via telomerase GO:0007004 1 0.204
response to organonitrogen compound GO:0010243 246 0.199
Rat
regulation of leukocyte differentiation GO:1902105 159 0.199
Mouse
cellular response to hormone stimulus GO:0032870 150 0.197
Rat
regulation of androgen receptor signaling pathway GO:0060765 3 0.193
placenta development GO:0001890 140 0.191
sensory organ morphogenesis GO:0090596 242 0.191
response to nutrient levels GO:0031667 109 0.188
Rat
cognition GO:0050890 149 0.188
regulation of neurotrophin trk receptor signaling pathway GO:0051386 4 0.188
positive regulation of cell development GO:0010720 237 0.186
ribonucleotide biosynthetic process GO:0009260 59 0.185
regulation of nitrogen cycle metabolic process GO:1903314 1 0.184
negative regulation of molecular function GO:0044092 258 0.184
Rat
bone resorption GO:0045453 38 0.182
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.181
cerebellar granule cell precursor proliferation GO:0021930 10 0.180
negative regulation of protein metabolic process GO:0051248 282 0.178
regulation of transferase activity GO:0051338 263 0.177
regulation of vitamin d biosynthetic process GO:0060556 1 0.173
urogenital system development GO:0001655 261 0.172
inorganic ion transmembrane transport GO:0098660 234 0.169
mapk cascade GO:0000165 281 0.168
heterocycle catabolic process GO:0046700 280 0.162
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.159
female sex differentiation GO:0046660 84 0.158
inflammatory response GO:0006954 244 0.155
regulation of voltage gated calcium channel activity GO:1901385 4 0.153
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.152
glucose metabolic process GO:0006006 92 0.150
positive regulation of macroautophagy GO:0016239 3 0.147
regulation of feeding behavior GO:0060259 3 0.145
cholesterol transport GO:0030301 38 0.145
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.144
positive regulation of protein kinase activity GO:0045860 144 0.144
heart morphogenesis GO:0003007 178 0.142
cellular homeostasis GO:0019725 240 0.142
fatty acid biosynthetic process GO:0006633 41 0.140
triglyceride homeostasis GO:0070328 15 0.139
positive regulation of sodium ion transport GO:0010765 13 0.139
sterol homeostasis GO:0055092 45 0.139
positive regulation of dephosphorylation GO:0035306 6 0.138
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.138
fatty acid catabolic process GO:0009062 25 0.138
negative regulation of neuron death GO:1901215 98 0.136
cellular amino acid metabolic process GO:0006520 103 0.136
cytosolic calcium ion transport GO:0060401 48 0.136
single organism nuclear import GO:1902593 95 0.136
cellular protein catabolic process GO:0044257 155 0.135
cellular macromolecule catabolic process GO:0044265 206 0.135
multicellular organismal homeostasis GO:0048871 164 0.135
regulation of carbohydrate metabolic process GO:0006109 75 0.134
Rat
heart contraction GO:0060047 93 0.134
cellular nitrogen compound catabolic process GO:0044270 280 0.133
regulation of neuron differentiation GO:0045664 281 0.131
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.131
regulation of lipid metabolic process GO:0019216 118 0.129
Rat
regulation of cellular response to growth factor stimulus GO:0090287 82 0.129
purine containing compound metabolic process GO:0072521 311 0.128
negative regulation of cell proliferation GO:0008285 296 0.128
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.126
triglyceride metabolic process GO:0006641 51 0.126
regulation of apoptotic signaling pathway GO:2001233 197 0.126
steroid metabolic process GO:0008202 119 0.123
Rat
positive regulation of protein modification process GO:0031401 299 0.123
cardiocyte differentiation GO:0035051 87 0.123
regulation of lipid catabolic process GO:0050994 15 0.123
negative regulation of lipid metabolic process GO:0045833 30 0.121
negative regulation of phosphorus metabolic process GO:0010563 184 0.117
nucleoside phosphate biosynthetic process GO:1901293 79 0.116
fat cell differentiation GO:0045444 160 0.116
alpha amino acid metabolic process GO:1901605 59 0.116
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 4 0.116
nucleoside biosynthetic process GO:0009163 21 0.116
cellular lipid metabolic process GO:0044255 323 0.116
Rat
positive regulation of programmed cell death GO:0043068 218 0.116
transmembrane transport GO:0055085 412 0.115
Rat
protein localization to organelle GO:0033365 185 0.115
cell fate commitment GO:0045165 210 0.115
regulation of sterol transport GO:0032371 17 0.115
hexose biosynthetic process GO:0019319 39 0.115
positive regulation of cell death GO:0010942 224 0.114
ear development GO:0043583 200 0.114
regulation of peptide transport GO:0090087 91 0.113
amide transport GO:0042886 138 0.113
cytoplasmic transport GO:0016482 234 0.111
bone remodeling GO:0046849 53 0.111
Mouse
striated muscle contraction GO:0006941 45 0.111
regulation of ion transmembrane transporter activity GO:0032412 54 0.110
Rat
cellular carbohydrate metabolic process GO:0044262 119 0.110
Rat
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.110
glycosyl compound metabolic process GO:1901657 246 0.109
cardiac muscle tissue development GO:0048738 130 0.109
lipoprotein transport GO:0042953 7 0.109
organic acid transport GO:0015849 101 0.108
organic hydroxy compound transport GO:0015850 93 0.108
small molecule biosynthetic process GO:0044283 132 0.108
g protein coupled receptor signaling pathway GO:0007186 243 0.107
response to camp GO:0051591 14 0.107
negative regulation of growth GO:0045926 99 0.107
purine ribonucleotide biosynthetic process GO:0009152 59 0.106
prostate gland development GO:0030850 48 0.106
organonitrogen compound biosynthetic process GO:1901566 192 0.106
carboxylic acid biosynthetic process GO:0046394 86 0.105
sodium ion transmembrane transport GO:0035725 49 0.105
sodium ion transport GO:0006814 73 0.105
sodium ion import GO:0097369 1 0.103
skeletal system morphogenesis GO:0048705 203 0.103
Mouse
regulation of bone remodeling GO:0046850 28 0.102
Mouse
tissue homeostasis GO:0001894 115 0.102
Mouse
regulation of homeostatic process GO:0032844 182 0.102
purine ribonucleoside biosynthetic process GO:0046129 19 0.101
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.100
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.100
positive regulation of gluconeogenesis GO:0045722 11 0.100
purine nucleoside biosynthetic process GO:0042451 19 0.099
branching morphogenesis of an epithelial tube GO:0048754 159 0.098
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.097
sterol transport GO:0015918 38 0.097
epithelial tube morphogenesis GO:0060562 303 0.096
reactive nitrogen species metabolic process GO:2001057 0 0.095
membrane biogenesis GO:0044091 12 0.094
ribonucleoside biosynthetic process GO:0042455 21 0.094
regulation of osteoclast differentiation GO:0045670 36 0.094
Mouse
carboxylic acid catabolic process GO:0046395 51 0.094
regulation of relaxation of muscle GO:1901077 8 0.093
negative regulation of hormone secretion GO:0046888 20 0.092
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.092
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.092
multicellular organismal signaling GO:0035637 91 0.091
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.091
regulation of dephosphorylation GO:0035303 18 0.091
Mouse
rna dependent dna replication GO:0006278 3 0.090
regulation of secretion by cell GO:1903530 249 0.090
muscle system process GO:0003012 141 0.090
negative regulation of fat cell differentiation GO:0045599 36 0.090
organonitrogen compound catabolic process GO:1901565 264 0.089
regulation of renal output by angiotensin GO:0002019 2 0.087
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.087
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.087
positive regulation of lipid metabolic process GO:0045834 40 0.086
Rat
telencephalon development GO:0021537 186 0.086
regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902253 13 0.085
regulation of secretion GO:0051046 274 0.084
negative regulation of systemic arterial blood pressure GO:0003085 15 0.084
organic anion transport GO:0015711 137 0.084
regulation of muscle system process GO:0090257 80 0.084
regulation of ion transport GO:0043269 215 0.084
Rat
muscle cell differentiation GO:0042692 261 0.083
purine ribonucleotide catabolic process GO:0009154 208 0.083
ubiquitin dependent protein catabolic process GO:0006511 129 0.083
nucleoside metabolic process GO:0009116 246 0.083
organic acid catabolic process GO:0016054 51 0.082
ribose phosphate metabolic process GO:0019693 291 0.082
regulation of protein serine threonine kinase activity GO:0071900 157 0.081
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902238 1 0.081
neuron migration GO:0001764 122 0.080
calcium ion transport GO:0006816 159 0.080
cellular response to nutrient levels GO:0031669 64 0.080
regulation of endothelial cell proliferation GO:0001936 23 0.080
peptide secretion GO:0002790 114 0.080
regulation of heart contraction GO:0008016 77 0.079
fibroblast proliferation GO:0048144 35 0.079
mammary gland lobule development GO:0061377 22 0.079
feeding behavior GO:0007631 62 0.078
positive regulation of apoptotic signaling pathway GO:2001235 95 0.077
response to organophosphorus GO:0046683 22 0.077
response to steroid hormone GO:0048545 56 0.077
actin filament organization GO:0007015 113 0.076
Mouse
negative regulation of neurotrophin trk receptor signaling pathway GO:0051387 2 0.076
mitochondrial dna metabolic process GO:0032042 13 0.076
response to extracellular stimulus GO:0009991 127 0.076
Rat
ammonia assimilation cycle GO:0019676 2 0.076
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.075
response to radiation GO:0009314 165 0.074
negative regulation of apoptotic signaling pathway GO:2001234 104 0.074
response to light stimulus GO:0009416 135 0.074
morphogenesis of a branching structure GO:0001763 203 0.074
cellular response to starvation GO:0009267 57 0.074
negative regulation of fatty acid oxidation GO:0046322 5 0.073
regulation of epithelial cell proliferation GO:0050678 141 0.073
cellular response to organic cyclic compound GO:0071407 87 0.073
regulation of atp biosynthetic process GO:2001169 3 0.073
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.072
glycosyl compound biosynthetic process GO:1901659 21 0.072
positive regulation of transferase activity GO:0051347 167 0.072
regulation of response to wounding GO:1903034 189 0.072
apoptotic process involved in morphogenesis GO:0060561 25 0.071
carbohydrate biosynthetic process GO:0016051 74 0.071
fatty acid beta oxidation GO:0006635 16 0.071
purine nucleotide catabolic process GO:0006195 211 0.071
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.071
chromatin organization GO:0006325 206 0.071
positive regulation of sodium ion transmembrane transport GO:1902307 4 0.070
positive regulation of ion transport GO:0043270 65 0.070
regulation of tissue remodeling GO:0034103 38 0.070
Mouse
reactive oxygen species biosynthetic process GO:1903409 8 0.070
organic acid biosynthetic process GO:0016053 86 0.069
trophectodermal cellular morphogenesis GO:0001831 3 0.068
lipid storage GO:0019915 36 0.068
cellular response to prostaglandin stimulus GO:0071379 2 0.068
nucleocytoplasmic transport GO:0006913 139 0.067
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1990127 1 0.067
regulation of hormone secretion GO:0046883 88 0.067
intracellular protein transport GO:0006886 204 0.067
positive regulation of protein phosphorylation GO:0001934 242 0.066
nitrogen compound transport GO:0071705 271 0.066
sequestering of triglyceride GO:0030730 6 0.066
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.066
cellular response to lipid GO:0071396 145 0.066
Rat
nucleoside triphosphate metabolic process GO:0009141 230 0.066
muscle cell proliferation GO:0033002 52 0.065
Rat
ossification GO:0001503 216 0.065
Mouse
peptidyl serine modification GO:0018209 83 0.065
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.065
regulation of protein localization GO:0032880 231 0.064
male sex differentiation GO:0046661 109 0.064
monocarboxylic acid biosynthetic process GO:0072330 61 0.063
calcium ion transmembrane transport GO:0070588 85 0.063
directional locomotion GO:0033058 3 0.063
cerebellum development GO:0021549 77 0.063
macromolecule catabolic process GO:0009057 281 0.063
negative regulation of ion transport GO:0043271 28 0.063
positive regulation of cholesterol transport GO:0032376 9 0.063
cellular response to peptide hormone stimulus GO:0071375 92 0.063
peptide hormone secretion GO:0030072 109 0.063
regulation of vitamin metabolic process GO:0030656 3 0.063
hippocampus development GO:0021766 52 0.063
regionalization GO:0003002 337 0.063
embryonic placenta development GO:0001892 98 0.062
regulation of organelle organization GO:0033043 289 0.062
regulation of blood circulation GO:1903522 93 0.062
regulation of protein transport GO:0051223 163 0.062
protein targeting GO:0006605 143 0.062
response to oxygen levels GO:0070482 62 0.061
Rat
glutamate metabolic process GO:0006536 9 0.060
male genitalia morphogenesis GO:0048808 4 0.060
neuron apoptotic process GO:0051402 142 0.060
regulation of peptide secretion GO:0002791 77 0.060
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.060
sa node cell action potential GO:0086015 4 0.059
cellular potassium ion transport GO:0071804 43 0.059
regulation of carbohydrate biosynthetic process GO:0043255 40 0.058
positive regulation of ion transmembrane transport GO:0034767 24 0.058
glutamine family amino acid metabolic process GO:0009064 15 0.057
positive regulation of nervous system development GO:0051962 221 0.057
mammary gland morphogenesis GO:0060443 54 0.057
carboxylic acid transport GO:0046942 100 0.057
male anatomical structure morphogenesis GO:0090598 4 0.057
acylglycerol homeostasis GO:0055090 16 0.057
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.056
negative regulation of epithelial cell proliferation GO:0050680 64 0.056
maternal process involved in female pregnancy GO:0060135 32 0.056
positive regulation of calcium ion transport GO:0051928 27 0.056
regulation of ion transmembrane transport GO:0034765 119 0.056
Rat
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.056
Mouse
receptor biosynthetic process GO:0032800 3 0.055
positive regulation of hydrolase activity GO:0051345 148 0.055
Mouse
aromatic compound catabolic process GO:0019439 286 0.055
protein localization to nucleus GO:0034504 121 0.055
regulation of muscle tissue development GO:1901861 97 0.054
renal system development GO:0072001 225 0.054
glucose homeostasis GO:0042593 128 0.054
spermatogenesis GO:0007283 284 0.054
leukocyte differentiation GO:0002521 342 0.054
Mouse
cell proliferation in external granule layer GO:0021924 10 0.053
positive regulation of neuron differentiation GO:0045666 141 0.053
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.053
regulation of erk1 and erk2 cascade GO:0070372 71 0.053
regulation of gluconeogenesis GO:0006111 30 0.053
apoptotic signaling pathway GO:0097190 306 0.053
regulation of morphogenesis of a branching structure GO:0060688 53 0.053
peptidyl serine phosphorylation GO:0018105 74 0.052
negative regulation of intracellular signal transduction GO:1902532 167 0.052
divalent metal ion transport GO:0070838 172 0.052
potassium ion transmembrane transport GO:0071805 43 0.052
negative regulation of cell growth GO:0030308 44 0.051
positive regulation of fatty acid metabolic process GO:0045923 8 0.051
Rat
cellular response to acid chemical GO:0071229 68 0.051
Rat
apoptotic process involved in mammary gland involution GO:0060057 4 0.051
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902218 1 0.050
relaxation of muscle GO:0090075 18 0.050
brown fat cell differentiation GO:0050873 36 0.050
regulation of long term synaptic potentiation GO:1900271 4 0.050
positive regulation of myeloid cell differentiation GO:0045639 43 0.050
Mouse
positive regulation of homeostatic process GO:0032846 64 0.050
regulation of map kinase activity GO:0043405 120 0.050
organophosphate catabolic process GO:0046434 232 0.050
synaptic transmission GO:0007268 329 0.050
action potential GO:0001508 78 0.049
membrane organization GO:0061024 245 0.049
response to glycoside GO:1903416 2 0.049
gliogenesis GO:0042063 141 0.049
notochord cell development GO:0060035 1 0.049
positive regulation of bone remodeling GO:0046852 13 0.049
Mouse
signal transduction by p53 class mediator GO:0072331 51 0.049
regulation of metal ion transport GO:0010959 106 0.048
cellular response to extracellular stimulus GO:0031668 81 0.048
carbohydrate homeostasis GO:0033500 128 0.048
nucleoside phosphate catabolic process GO:1901292 222 0.048
positive regulation of apoptotic process GO:0043065 217 0.048
vasodilation GO:0042311 28 0.048
negative regulation of membrane potential GO:0045837 4 0.047
establishment of protein localization to organelle GO:0072594 118 0.047
protein catabolic process GO:0030163 221 0.047
response to ammonium ion GO:0060359 21 0.047
neuron death GO:0070997 154 0.047
i kappab kinase nf kappab signaling GO:0007249 85 0.047
phospholipase c activating angiotensin activated signaling pathway GO:0086097 1 0.046
regulation of cation channel activity GO:2001257 22 0.046
cellular response to growth factor stimulus GO:0071363 197 0.046
regulation of establishment of protein localization GO:0070201 181 0.046
response to bile acid GO:1903412 1 0.046
regulation of hormone levels GO:0010817 211 0.046
Rat
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.046
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.046
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.045
development of primary female sexual characteristics GO:0046545 73 0.045
telencephalon cell migration GO:0022029 55 0.045
gluconeogenesis GO:0006094 39 0.045
substantia nigra development GO:0021762 2 0.044
heart growth GO:0060419 45 0.044
regulation of response to oxidative stress GO:1902882 19 0.044
regulation of reproductive process GO:2000241 66 0.044
regulation of nucleotide biosynthetic process GO:0030808 34 0.044
angiogenesis GO:0001525 201 0.044
mitochondrion organization GO:0007005 134 0.044
leukocyte migration GO:0050900 124 0.044
hormone secretion GO:0046879 128 0.044
cardiac muscle tissue morphogenesis GO:0055008 44 0.044
response to starvation GO:0042594 65 0.044
Rat
mammary gland duct morphogenesis GO:0060603 38 0.044
epithelial cell development GO:0002064 159 0.043
response to osmotic stress GO:0006970 21 0.043
trabecula formation GO:0060343 24 0.043
Mouse
regulation of cellular respiration GO:0043457 10 0.043
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.043
sequestering of calcium ion GO:0051208 18 0.043
modification dependent protein catabolic process GO:0019941 133 0.043
ribonucleotide catabolic process GO:0009261 208 0.043
establishment or maintenance of neuroblast polarity GO:0045196 1 0.043
epidermis development GO:0008544 187 0.043
positive regulation of behavior GO:0048520 40 0.043
regulation of peptide hormone secretion GO:0090276 75 0.043
cellular response to hypoxia GO:0071456 17 0.042
Rat
regulation of protein stability GO:0031647 52 0.042
cellular response to radiation GO:0071478 28 0.042
regulation of nucleocytoplasmic transport GO:0046822 73 0.042
camera type eye development GO:0043010 266 0.042
peptidyl lysine deacetylation GO:0034983 1 0.042
gonad development GO:0008406 141 0.042
mammary gland epithelium development GO:0061180 65 0.042
positive regulation of glucose metabolic process GO:0010907 21 0.041
sodium ion export GO:0071436 2 0.041
glycerolipid biosynthetic process GO:0045017 50 0.041
keratinocyte migration GO:0051546 3 0.041
regulation of urea metabolic process GO:0034255 1 0.041
intrinsic apoptotic signaling pathway GO:0097193 132 0.040
cell cell signaling involved in lung development GO:0060495 1 0.040
multicellular organism growth GO:0035264 161 0.040
cardiac muscle cell differentiation GO:0055007 69 0.040
intestinal absorption GO:0050892 13 0.040
regulation of the force of heart contraction GO:0002026 17 0.040
regulation of mesenchymal cell proliferation GO:0010464 37 0.040
regulation of fat cell differentiation GO:0045598 81 0.040

Ppargc1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.890
acquired metabolic disease DOID:0060158 0 0.854
obesity DOID:9970 0 0.459
nutrition disease DOID:374 0 0.459
overnutrition DOID:654 0 0.459
diabetes mellitus DOID:9351 0 0.172
type 2 diabetes mellitus DOID:9352 0 0.172
carbohydrate metabolism disease DOID:0050013 0 0.172
glucose metabolism disease DOID:4194 0 0.172