Mus musculus

0 known processes

Tmem66

transmembrane protein 66

(Aliases: 1810045K07Rik)

Tmem66 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein catabolic process GO:0030163 221 0.121
regulation of cellular amino acid metabolic process GO:0006521 5 0.111
cellular amino acid metabolic process GO:0006520 103 0.099
modification dependent macromolecule catabolic process GO:0043632 133 0.091
cellular ketone metabolic process GO:0042180 84 0.084
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.083
cellular amine metabolic process GO:0044106 44 0.083
amine metabolic process GO:0009308 45 0.082
macromolecule catabolic process GO:0009057 281 0.078
cellular protein catabolic process GO:0044257 155 0.072
cellular macromolecule catabolic process GO:0044265 206 0.065
protein modification by small protein conjugation or removal GO:0070647 207 0.061
apoptotic signaling pathway GO:0097190 306 0.061
regulation of cellular amine metabolic process GO:0033238 20 0.060
cation transport GO:0006812 399 0.053
ubiquitin dependent protein catabolic process GO:0006511 129 0.052
protein ubiquitination GO:0016567 171 0.051
modification dependent protein catabolic process GO:0019941 133 0.050
autophagy GO:0006914 45 0.050
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
regulation of cellular ketone metabolic process GO:0010565 66 0.047
protein modification by small protein conjugation GO:0032446 187 0.046
positive regulation of cellular amine metabolic process GO:0033240 5 0.045
regulation of cellular catabolic process GO:0031329 242 0.041
positive regulation of protein phosphorylation GO:0001934 242 0.041
regulation of cellular response to stress GO:0080135 159 0.038
metal ion homeostasis GO:0055065 189 0.037
oxidation reduction process GO:0055114 342 0.037
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.036
regulation of protein localization GO:0032880 231 0.036
cellular chemical homeostasis GO:0055082 215 0.035
cytoplasmic transport GO:0016482 234 0.035
peptidyl amino acid modification GO:0018193 336 0.035
negative regulation of protein metabolic process GO:0051248 282 0.035
regulation of transferase activity GO:0051338 263 0.035
mapk cascade GO:0000165 281 0.034
negative regulation of cellular protein metabolic process GO:0032269 247 0.034
spermatogenesis GO:0007283 284 0.034
positive regulation of protein modification process GO:0031401 299 0.033
reactive oxygen species metabolic process GO:0072593 84 0.033
negative regulation of cellular component organization GO:0051129 194 0.033
immune effector process GO:0002252 321 0.033
negative regulation of intracellular signal transduction GO:1902532 167 0.032
regulation of reactive oxygen species metabolic process GO:2000377 40 0.031
cation transmembrane transport GO:0098655 266 0.030
response to extracellular stimulus GO:0009991 127 0.030
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.030
positive regulation of programmed cell death GO:0043068 218 0.030
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.029
negative regulation of protein modification process GO:0031400 163 0.029
response to oxidative stress GO:0006979 123 0.029
regulation of intracellular transport GO:0032386 159 0.029
protein localization to organelle GO:0033365 185 0.028
regulation of mapk cascade GO:0043408 248 0.027
maintenance of location GO:0051235 89 0.027
intracellular protein transport GO:0006886 204 0.026
nitrogen compound transport GO:0071705 271 0.026
action potential GO:0001508 78 0.026
transmembrane transport GO:0055085 412 0.026
positive regulation of apoptotic process GO:0043065 217 0.026
cytokine production GO:0001816 319 0.026
cellular lipid metabolic process GO:0044255 323 0.026
male gamete generation GO:0048232 285 0.025
cellular homeostasis GO:0019725 240 0.025
response to endoplasmic reticulum stress GO:0034976 53 0.025
negative regulation of cell proliferation GO:0008285 296 0.025
regulation of kinase activity GO:0043549 249 0.025
organic hydroxy compound metabolic process GO:1901615 203 0.024
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.024
positive regulation of cell death GO:0010942 224 0.024
intrinsic apoptotic signaling pathway GO:0097193 132 0.024
cellular response to biotic stimulus GO:0071216 92 0.024
defense response to other organism GO:0098542 197 0.024
negative regulation of molecular function GO:0044092 258 0.023
alcohol metabolic process GO:0006066 116 0.023
organonitrogen compound catabolic process GO:1901565 264 0.023
small molecule catabolic process GO:0044282 71 0.023
response to organic cyclic compound GO:0014070 198 0.023
regulation of secretion GO:0051046 274 0.022
regulation of protein transport GO:0051223 163 0.022
protein localization to nucleus GO:0034504 121 0.022
regulation of cell cycle GO:0051726 281 0.022
mitochondrion degradation GO:0000422 3 0.022
dna metabolic process GO:0006259 303 0.022
regulation of protein catabolic process GO:0042176 108 0.021
steroid metabolic process GO:0008202 119 0.021
organic cyclic compound catabolic process GO:1901361 295 0.021
inorganic ion transmembrane transport GO:0098660 234 0.021
myeloid cell differentiation GO:0030099 233 0.021
anion transport GO:0006820 177 0.021
leukocyte differentiation GO:0002521 342 0.021
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
membrane organization GO:0061024 245 0.020
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.020
fat cell differentiation GO:0045444 160 0.020
lipoprotein metabolic process GO:0042157 43 0.020
negative regulation of cellular amine metabolic process GO:0033239 1 0.020
endomembrane system organization GO:0010256 147 0.019
multicellular organismal signaling GO:0035637 91 0.019
cation homeostasis GO:0055080 212 0.019
regulation of vesicle mediated transport GO:0060627 139 0.019
positive regulation of kinase activity GO:0033674 155 0.019
cellular response to external stimulus GO:0071496 88 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.019
regulation of organelle organization GO:0033043 289 0.019
extracellular structure organization GO:0043062 148 0.018
microtubule cytoskeleton organization GO:0000226 157 0.018
regulation of body fluid levels GO:0050878 162 0.018
localization within membrane GO:0051668 4 0.018
microtubule based process GO:0007017 236 0.018
regulation of cytokine production GO:0001817 266 0.018
response to radiation GO:0009314 165 0.018
anatomical structure homeostasis GO:0060249 145 0.018
regulation of protein kinase activity GO:0045859 232 0.018
cellular response to molecule of bacterial origin GO:0071219 83 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.017
negative regulation of phosphorus metabolic process GO:0010563 184 0.017
organic hydroxy compound transport GO:0015850 93 0.017
homeostasis of number of cells GO:0048872 210 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
transmission of nerve impulse GO:0019226 76 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
cellular response to nutrient levels GO:0031669 64 0.017
positive regulation of transferase activity GO:0051347 167 0.017
response to organonitrogen compound GO:0010243 246 0.017
divalent metal ion transport GO:0070838 172 0.017
protein localization to vacuole GO:0072665 4 0.017
ossification GO:0001503 216 0.017
heterocycle catabolic process GO:0046700 280 0.017
i kappab kinase nf kappab signaling GO:0007249 85 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
myeloid leukocyte differentiation GO:0002573 119 0.016
positive regulation of cellular catabolic process GO:0031331 148 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
negative regulation of growth GO:0045926 99 0.016
regulation of binding GO:0051098 111 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.016
regulation of secretion by cell GO:1903530 249 0.016
divalent inorganic cation transport GO:0072511 178 0.016
t cell activation GO:0042110 289 0.016
glycerolipid metabolic process GO:0046486 122 0.016
response to peptide GO:1901652 136 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
inclusion body assembly GO:0070841 3 0.016
regulation of protein ubiquitination GO:0031396 52 0.016
muscle tissue development GO:0060537 308 0.016
protein import GO:0017038 101 0.016
peptidyl tyrosine phosphorylation GO:0018108 143 0.016
organic anion transport GO:0015711 137 0.016
interspecies interaction between organisms GO:0044419 83 0.016
nucleocytoplasmic transport GO:0006913 139 0.015
phospholipid metabolic process GO:0006644 87 0.015
nuclear transport GO:0051169 139 0.015
regulation of cell activation GO:0050865 289 0.015
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.015
cellular ion homeostasis GO:0006873 165 0.015
organophosphate catabolic process GO:0046434 232 0.015
striated muscle tissue development GO:0014706 293 0.015
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.015
sensory perception GO:0007600 245 0.015
regulation of cell cycle process GO:0010564 160 0.015
glycerophospholipid metabolic process GO:0006650 71 0.015
germ cell development GO:0007281 185 0.015
positive regulation of cholesterol storage GO:0010886 3 0.015
response to molecule of bacterial origin GO:0002237 143 0.015
regulation of hydrolase activity GO:0051336 246 0.015
nucleotide metabolic process GO:0009117 332 0.015
cellular response to extracellular stimulus GO:0031668 81 0.015
regulation of multi organism process GO:0043900 111 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
ion transmembrane transport GO:0034220 361 0.015
mitotic cell cycle GO:0000278 195 0.015
protein acylation GO:0043543 64 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
dna recombination GO:0006310 92 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
lysosomal transport GO:0007041 10 0.014
endocytosis GO:0006897 168 0.014
cellular response to lipid GO:0071396 145 0.014
protein lipidation GO:0006497 28 0.014
substantia nigra development GO:0021762 2 0.014
negative regulation of defense response GO:0031348 77 0.014
protein import into nucleus GO:0006606 95 0.014
retrograde transport endosome to golgi GO:0042147 2 0.014
cell adhesion GO:0007155 329 0.014
organelle fission GO:0048285 170 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
regulation of cell motility GO:2000145 236 0.014
protein targeting to vacuole GO:0006623 3 0.014
negative regulation of multi organism process GO:0043901 68 0.014
protein refolding GO:0042026 1 0.014
regionalization GO:0003002 337 0.014
single organism nuclear import GO:1902593 95 0.014
lipid localization GO:0010876 126 0.014
peptidyl tyrosine modification GO:0018212 145 0.014
negative regulation of protein transport GO:0051224 46 0.014
negative regulation of cell development GO:0010721 169 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
cellular response to oxidative stress GO:0034599 76 0.014
sequestering of calcium ion GO:0051208 18 0.014
regulation of intracellular protein transport GO:0033157 82 0.014
response to oxygen levels GO:0070482 62 0.014
nucleoside triphosphate metabolic process GO:0009141 230 0.014
purine nucleotide metabolic process GO:0006163 302 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
sterol transmembrane transport GO:0035382 2 0.014
positive regulation of secretion by cell GO:1903532 114 0.014
calcium ion homeostasis GO:0055074 127 0.014
response to starvation GO:0042594 65 0.014
regulation of homeostatic process GO:0032844 182 0.014
lipid biosynthetic process GO:0008610 179 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
regulation of cytoplasmic transport GO:1903649 112 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
negative regulation of nervous system development GO:0051961 156 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
growth of symbiont in host GO:0044117 23 0.013
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.013
misfolded protein transport GO:0070843 1 0.013
nuclear division GO:0000280 158 0.013
negative regulation of cell cycle GO:0045786 123 0.013
response to nutrient levels GO:0031667 109 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
aromatic compound catabolic process GO:0019439 286 0.013
mitotic cell cycle process GO:1903047 159 0.013
wnt signaling pathway GO:0016055 188 0.013
canonical wnt signaling pathway GO:0060070 130 0.013
g protein coupled receptor signaling pathway GO:0007186 243 0.013
meiotic cell cycle GO:0051321 122 0.013
regulation of membrane potential GO:0042391 192 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
regulation of defense response to bacterium GO:1900424 3 0.013
regulation of protein binding GO:0043393 60 0.013
cellular response to topologically incorrect protein GO:0035967 25 0.013
regulation of removal of superoxide radicals GO:2000121 4 0.013
calcium ion transport GO:0006816 159 0.013
phagocytosis GO:0006909 66 0.013
lipoprotein biosynthetic process GO:0042158 33 0.012
regulation of cell migration GO:0030334 219 0.012
neuronal action potential GO:0019228 54 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
sterol metabolic process GO:0016125 58 0.012
negative regulation of cytokine production GO:0001818 84 0.012
regulation of inclusion body assembly GO:0090083 1 0.012
positive regulation of cell development GO:0010720 237 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
ensheathment of neurons GO:0007272 76 0.012
er nucleus signaling pathway GO:0006984 27 0.012
locomotory behavior GO:0007626 195 0.012
gonad development GO:0008406 141 0.012
protein maturation GO:0051604 176 0.012
cholesterol transport GO:0030301 38 0.012
lipid transport GO:0006869 98 0.012
nuclear import GO:0051170 95 0.012
plasma cell differentiation GO:0002317 3 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
establishment of protein localization to vacuole GO:0072666 4 0.012
ras protein signal transduction GO:0007265 77 0.012
actin cytoskeleton organization GO:0030036 220 0.012
dephosphorylation GO:0016311 129 0.012
cellular protein complex assembly GO:0043623 116 0.012
nucleoside metabolic process GO:0009116 246 0.012
regulation of map kinase activity GO:0043405 120 0.012
lymphocyte proliferation GO:0046651 164 0.012
positive regulation of organelle organization GO:0010638 128 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.012
lymphocyte differentiation GO:0030098 242 0.012
regulation of cellular protein catabolic process GO:1903362 61 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
sterol transport GO:0015918 38 0.012
positive regulation of protein catabolic process GO:0045732 60 0.012
cell growth GO:0016049 130 0.011
response to light stimulus GO:0009416 135 0.011
circulatory system process GO:0003013 197 0.011
production of molecular mediator of immune response GO:0002440 103 0.011
exocytosis GO:0006887 121 0.011
sequestering of metal ion GO:0051238 19 0.011
leukocyte proliferation GO:0070661 172 0.011
lipid catabolic process GO:0016042 69 0.011
response to lipopolysaccharide GO:0032496 128 0.011
ribonucleoside metabolic process GO:0009119 245 0.011
purine containing compound metabolic process GO:0072521 311 0.011
response to bacterial lipoprotein GO:0032493 4 0.011
regulation of proteolysis GO:0030162 164 0.011
compound eye development GO:0048749 1 0.011
camera type eye development GO:0043010 266 0.011
rho protein signal transduction GO:0007266 32 0.011
single organism cell adhesion GO:0098602 156 0.011
epithelial cell proliferation GO:0050673 174 0.011
meiotic nuclear division GO:0007126 115 0.011
gliogenesis GO:0042063 141 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
organic acid biosynthetic process GO:0016053 86 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.011
response to topologically incorrect protein GO:0035966 25 0.011
regulation of t cell activation GO:0050863 170 0.011
l amino acid transport GO:0015807 32 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
inflammatory response GO:0006954 244 0.011
response to growth factor GO:0070848 198 0.011
histone modification GO:0016570 159 0.011
positive regulation of proteolysis GO:0045862 85 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
small molecule biosynthetic process GO:0044283 132 0.011
nucleoside catabolic process GO:0009164 206 0.011
water soluble vitamin biosynthetic process GO:0042364 3 0.011
second messenger mediated signaling GO:0019932 73 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
positive regulation of cell activation GO:0050867 158 0.011
regulation of response to wounding GO:1903034 189 0.011
skin development GO:0043588 220 0.011
ribonucleotide metabolic process GO:0009259 291 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
epidermis development GO:0008544 187 0.011
cell activation involved in immune response GO:0002263 126 0.011
progesterone metabolic process GO:0042448 4 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
regulation of defense response GO:0031347 233 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
leukocyte migration GO:0050900 124 0.010
glial cell differentiation GO:0010001 131 0.010
positive regulation of cytokine production GO:0001819 174 0.010
pharynx development GO:0060465 1 0.010
b cell activation GO:0042113 161 0.010
positive regulation of macroautophagy GO:0016239 3 0.010
muscle contraction GO:0006936 101 0.010
cellular response to starvation GO:0009267 57 0.010
nucleoside phosphate catabolic process GO:1901292 222 0.010
regulation of anatomical structure size GO:0090066 178 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
cell type specific apoptotic process GO:0097285 268 0.010

Tmem66 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
musculoskeletal system disease DOID:17 0 0.065
connective tissue disease DOID:65 0 0.065
nervous system disease DOID:863 0 0.041
bone disease DOID:0080001 0 0.027
disease of metabolism DOID:0014667 0 0.027
central nervous system disease DOID:331 0 0.020
brain disease DOID:936 0 0.020
immune system disease DOID:2914 0 0.015
acquired metabolic disease DOID:0060158 0 0.014
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.012
hematopoietic system disease DOID:74 0 0.011
bone remodeling disease DOID:0080005 0 0.010
inherited metabolic disorder DOID:655 0 0.010