Mus musculus

18 known processes

Eif4e

eukaryotic translation initiation factor 4E

(Aliases: EG668879,Eif4e-ps,If4e,MGC103177,eIF-4E)

Eif4e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
translational initiation GO:0006413 24 0.424
regulation of translational initiation GO:0006446 15 0.158
regulation of translation GO:0006417 71 0.145
Human Worm
dna metabolic process GO:0006259 303 0.106
Fly
posttranscriptional regulation of gene expression GO:0010608 155 0.100
Human Worm
translation GO:0006412 93 0.095
cellular amine metabolic process GO:0044106 44 0.094
male gamete generation GO:0048232 285 0.089
Worm
spermatogenesis GO:0007283 284 0.082
Worm
stem cell differentiation GO:0048863 268 0.072
stem cell development GO:0048864 219 0.069
amine metabolic process GO:0009308 45 0.068
synaptic transmission GO:0007268 329 0.061
transmembrane transport GO:0055085 412 0.059
cellular amino acid metabolic process GO:0006520 103 0.052
negative regulation of synapse assembly GO:0051964 3 0.046
regulation of cell cycle GO:0051726 281 0.046
Human
response to organonitrogen compound GO:0010243 246 0.045
chromatin organization GO:0006325 206 0.041
Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.037
protein ubiquitination GO:0016567 171 0.037
regulation of synapse structural plasticity GO:0051823 4 0.035
mesenchyme development GO:0060485 152 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.032
oocyte axis specification GO:0007309 2 0.031
detection of stimulus GO:0051606 84 0.031
cilium morphogenesis GO:0060271 102 0.031
macromolecule catabolic process GO:0009057 281 0.030
cellular response to organonitrogen compound GO:0071417 145 0.030
mesenchymal cell differentiation GO:0048762 107 0.030
developmental maturation GO:0021700 193 0.030
Worm
muscle cell differentiation GO:0042692 261 0.029
mitochondrion organization GO:0007005 134 0.028
oocyte construction GO:0007308 2 0.028
olfactory learning GO:0008355 2 0.027
cellular homeostasis GO:0019725 240 0.026
regulation of cellular component biogenesis GO:0044087 181 0.026
cation transport GO:0006812 399 0.026
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.026
microtubule based process GO:0007017 236 0.026
Fly
mesenchymal cell development GO:0014031 93 0.025
protein catabolic process GO:0030163 221 0.025
response to peptide hormone GO:0043434 127 0.024
regulation of organelle organization GO:0033043 289 0.024
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.024
lipid storage GO:0019915 36 0.023
Worm
regulation of system process GO:0044057 200 0.023
regulation of body fluid levels GO:0050878 162 0.023
negative regulation of cell development GO:0010721 169 0.023
cellular ketone metabolic process GO:0042180 84 0.023
positive regulation of cell development GO:0010720 237 0.022
cellular protein complex assembly GO:0043623 116 0.022
proteasomal protein catabolic process GO:0010498 98 0.022
nitrogen compound transport GO:0071705 271 0.022
synapse organization GO:0050808 125 0.022
development of primary sexual characteristics GO:0045137 143 0.022
dna packaging GO:0006323 30 0.021
Fly
spermine metabolic process GO:0008215 3 0.021
regulation of homeostatic process GO:0032844 182 0.020
ras protein signal transduction GO:0007265 77 0.020
cellularization GO:0007349 1 0.020
regulation of protein catabolic process GO:0042176 108 0.020
intracellular receptor signaling pathway GO:0030522 74 0.020
sensory perception GO:0007600 245 0.020
mitotic cell cycle process GO:1903047 159 0.020
Human Fly
maintenance of location GO:0051235 89 0.020
Worm
regulation of kinase activity GO:0043549 249 0.020
habituation GO:0046959 3 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
mitotic cell cycle GO:0000278 195 0.019
Human Fly
positive regulation of organelle organization GO:0010638 128 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
establishment of protein localization to organelle GO:0072594 118 0.019
protein polymerization GO:0051258 57 0.018
cation transmembrane transport GO:0098655 266 0.018
regulation of neuron differentiation GO:0045664 281 0.018
cognition GO:0050890 149 0.018
methylation GO:0032259 134 0.018
spermatid differentiation GO:0048515 115 0.018
Worm
cell adhesion GO:0007155 329 0.018
metal ion homeostasis GO:0055065 189 0.018
divalent metal ion transport GO:0070838 172 0.018
negative regulation of protein metabolic process GO:0051248 282 0.018
microtubule cytoskeleton organization GO:0000226 157 0.017
Fly
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.017
regulation of cellular amino acid metabolic process GO:0006521 5 0.017
organonitrogen compound biosynthetic process GO:1901566 192 0.017
positive regulation of nervous system development GO:0051962 221 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
cation homeostasis GO:0055080 212 0.017
heterochromatin organization GO:0070828 4 0.017
regulation of intracellular transport GO:0032386 159 0.017
respiratory system development GO:0060541 190 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
rna interference GO:0016246 2 0.016
organelle assembly GO:0070925 177 0.016
regulation of binding GO:0051098 111 0.016
negative regulation of cellular protein metabolic process GO:0032269 247 0.016
ubiquitin dependent protein catabolic process GO:0006511 129 0.016
regulation of protein localization GO:0032880 231 0.016
multi multicellular organism process GO:0044706 109 0.016
protein processing GO:0016485 163 0.015
regulation of neuron projection development GO:0010975 169 0.015
heterochromatin assembly GO:0031507 2 0.015
negative regulation of translational initiation GO:0045947 4 0.015
ion transmembrane transport GO:0034220 361 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
inflammatory response GO:0006954 244 0.015
chemotaxis GO:0006935 247 0.015
mitotic chromosome condensation GO:0007076 1 0.015
Fly
cytoplasmic transport GO:0016482 234 0.015
divalent inorganic cation homeostasis GO:0072507 138 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.014
glucose homeostasis GO:0042593 128 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
protein methylation GO:0006479 81 0.014
negative regulation of molecular function GO:0044092 258 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
male courtship behavior GO:0008049 2 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
regulation of cell projection organization GO:0031344 206 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
locomotory behavior GO:0007626 195 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
cellular chemical homeostasis GO:0055082 215 0.014
polyamine biosynthetic process GO:0006596 2 0.014
chromatin modification GO:0016568 187 0.014
regulation of transferase activity GO:0051338 263 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
carbohydrate homeostasis GO:0033500 128 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
sensory perception of touch GO:0050975 2 0.013
cell maturation GO:0048469 127 0.013
Worm
cellular response to organic cyclic compound GO:0071407 87 0.013
muscle tissue development GO:0060537 308 0.013
regulation of proteolysis GO:0030162 164 0.013
positive regulation of protein modification process GO:0031401 299 0.013
response to light stimulus GO:0009416 135 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
protein maturation GO:0051604 176 0.013
learning GO:0007612 98 0.013
regulation of cellular response to stress GO:0080135 159 0.013
rac protein signal transduction GO:0016601 13 0.012
negative regulation of neuron differentiation GO:0045665 101 0.012
cellular lipid metabolic process GO:0044255 323 0.012
response to insulin GO:0032868 100 0.012
regulation of cellular ketone metabolic process GO:0010565 66 0.012
striated muscle tissue development GO:0014706 293 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
wnt signaling pathway GO:0016055 188 0.012
fertilization GO:0009566 127 0.012
rna localization GO:0006403 23 0.012
small molecule biosynthetic process GO:0044283 132 0.012
regulation of metal ion transport GO:0010959 106 0.012
regulation of cell motility GO:2000145 236 0.012
intracellular protein transport GO:0006886 204 0.012
inorganic cation transmembrane transport GO:0098662 207 0.012
microtubule organizing center organization GO:0031023 28 0.012
response to inorganic substance GO:0010035 96 0.012
male sex differentiation GO:0046661 109 0.012
mapk cascade GO:0000165 281 0.012
rna splicing GO:0008380 54 0.012
placenta development GO:0001890 140 0.012
cellular response to hormone stimulus GO:0032870 150 0.011
oogenesis GO:0048477 56 0.011
Worm
dendrite development GO:0016358 115 0.011
immune effector process GO:0002252 321 0.011
homeostasis of number of cells GO:0048872 210 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
regulation of anatomical structure size GO:0090066 178 0.011
synapse assembly GO:0007416 56 0.011
positive regulation of cell death GO:0010942 224 0.011
sequestering of calcium ion GO:0051208 18 0.011
ossification GO:0001503 216 0.011
peptidyl amino acid modification GO:0018193 336 0.011
detection of external stimulus GO:0009581 61 0.011
nucleobase containing small molecule metabolic process GO:0055086 352 0.011
female gamete generation GO:0007292 74 0.011
Worm
negative regulation of intracellular signal transduction GO:1902532 167 0.011
regulation of protein maturation GO:1903317 96 0.011
development of primary male sexual characteristics GO:0046546 88 0.011
membrane organization GO:0061024 245 0.011
cellular biogenic amine metabolic process GO:0006576 28 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.011
negative regulation of neuron projection development GO:0010977 50 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
cellular component assembly involved in morphogenesis GO:0010927 139 0.010
skeletal muscle organ development GO:0060538 163 0.010
cellular protein catabolic process GO:0044257 155 0.010
negative regulation of nervous system development GO:0051961 156 0.010
regulation of cell division GO:0051302 76 0.010
alpha amino acid metabolic process GO:1901605 59 0.010

Eif4e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.102
disease of anatomical entity DOID:7 0 0.102
neurodegenerative disease DOID:1289 0 0.102
nervous system disease DOID:863 0 0.102
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018