Mus musculus

83 known processes

Pde4a

phosphodiesterase 4A, cAMP specific

(Aliases: Dpde2,D9Ertd60e)

Pde4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.218
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.198
Mouse
organophosphate catabolic process GO:0046434 232 0.165
nucleobase containing small molecule metabolic process GO:0055086 352 0.125
cation transport GO:0006812 399 0.118
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.097
inorganic ion transmembrane transport GO:0098660 234 0.093
Mouse
membrane organization GO:0061024 245 0.089
ion transmembrane transport GO:0034220 361 0.084
Mouse
synaptic transmission GO:0007268 329 0.083
Mouse Fly
regulation of cellular amino acid metabolic process GO:0006521 5 0.081
regulation of transmembrane transport GO:0034762 128 0.071
Mouse
purine nucleoside catabolic process GO:0006152 205 0.070
organic anion transport GO:0015711 137 0.066
glycosyl compound catabolic process GO:1901658 206 0.062
organic cyclic compound catabolic process GO:1901361 295 0.060
rho protein signal transduction GO:0007266 32 0.059
nucleoside phosphate metabolic process GO:0006753 338 0.059
positive regulation of cellular catabolic process GO:0031331 148 0.057
regulation of cellular amine metabolic process GO:0033238 20 0.055
Mouse
cation transmembrane transport GO:0098655 266 0.055
Mouse
cellular ketone metabolic process GO:0042180 84 0.051
purine ribonucleotide metabolic process GO:0009150 290 0.051
dorsal ventral axon guidance GO:0033563 3 0.051
aromatic compound catabolic process GO:0019439 286 0.051
positive regulation of cellular amine metabolic process GO:0033240 5 0.050
purine nucleoside metabolic process GO:0042278 241 0.049
ribose phosphate metabolic process GO:0019693 291 0.049
plasma membrane organization GO:0007009 90 0.049
synaptic transmission glutamatergic GO:0035249 36 0.047
homeostasis of number of cells GO:0048872 210 0.047
Mouse
ribonucleoside metabolic process GO:0009119 245 0.047
multicellular organismal signaling GO:0035637 91 0.046
regulation of purine nucleotide catabolic process GO:0033121 122 0.044
oxidation reduction process GO:0055114 342 0.044
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.043
regulation of cell migration GO:0030334 219 0.042
nucleoside triphosphate metabolic process GO:0009141 230 0.041
ras protein signal transduction GO:0007265 77 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.041
endomembrane system organization GO:0010256 147 0.040
g protein coupled receptor signaling pathway GO:0007186 243 0.040
ribonucleoside triphosphate metabolic process GO:0009199 220 0.040
apoptotic signaling pathway GO:0097190 306 0.039
purine ribonucleoside metabolic process GO:0046128 241 0.038
ribonucleotide catabolic process GO:0009261 208 0.038
small gtpase mediated signal transduction GO:0007264 97 0.038
purine nucleotide metabolic process GO:0006163 302 0.038
actin cytoskeleton organization GO:0030036 220 0.038
nucleotide catabolic process GO:0009166 217 0.037
nuclear division GO:0000280 158 0.037
regulation of inward rectifier potassium channel activity GO:1901979 1 0.037
regulation of membrane potential GO:0042391 192 0.037
regulation of metal ion transport GO:0010959 106 0.036
Mouse
myeloid cell differentiation GO:0030099 233 0.036
regulation of cellular catabolic process GO:0031329 242 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
cellular lipid metabolic process GO:0044255 323 0.035
cellular component assembly involved in morphogenesis GO:0010927 139 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
nucleoside triphosphate catabolic process GO:0009143 205 0.035
renal sodium ion transport GO:0003096 2 0.034
protein localization to membrane GO:0072657 108 0.033
purine containing compound metabolic process GO:0072521 311 0.033
purine ribonucleotide catabolic process GO:0009154 208 0.033
nucleoside metabolic process GO:0009116 246 0.033
divalent metal ion transport GO:0070838 172 0.033
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.033
regulation of cell activation GO:0050865 289 0.033
regulation of ion transport GO:0043269 215 0.033
Mouse
organelle fission GO:0048285 170 0.031
regulation of engulfment of apoptotic cell GO:1901074 2 0.031
hematopoietic progenitor cell differentiation GO:0002244 143 0.031
amine metabolic process GO:0009308 45 0.030
Mouse
nucleotide metabolic process GO:0009117 332 0.030
ribonucleoside triphosphate catabolic process GO:0009203 199 0.030
regulation of neurotransmitter levels GO:0001505 87 0.030
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.030
peptidyl amino acid modification GO:0018193 336 0.029
Mouse
purine ribonucleoside catabolic process GO:0046130 205 0.029
regulation of g protein activated inward rectifier potassium channel activity GO:1900128 1 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
macromolecule catabolic process GO:0009057 281 0.028
regulation of cellular ketone metabolic process GO:0010565 66 0.028
glycerolipid metabolic process GO:0046486 122 0.028
regulation of nucleoside metabolic process GO:0009118 130 0.028
neuron death GO:0070997 154 0.028
immune response regulating signaling pathway GO:0002764 125 0.027
peptidyl serine phosphorylation GO:0018105 74 0.027
Mouse
dephosphorylation GO:0016311 129 0.027
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.027
gtp metabolic process GO:0046039 144 0.027
cellular amine metabolic process GO:0044106 44 0.027
Mouse
protein catabolic process GO:0030163 221 0.027
circulatory system process GO:0003013 197 0.027
Mouse
synaptic vesicle localization GO:0097479 59 0.027
transmission of nerve impulse GO:0019226 76 0.026
actin filament organization GO:0007015 113 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
regulation of nucleotide catabolic process GO:0030811 122 0.026
negative regulation of immune system process GO:0002683 209 0.026
cellular protein complex assembly GO:0043623 116 0.026
potassium ion transport GO:0006813 52 0.026
regulation of defense response GO:0031347 233 0.025
action potential GO:0001508 78 0.025
intracellular protein transport GO:0006886 204 0.025
gtp catabolic process GO:0006184 143 0.025
glycerophospholipid metabolic process GO:0006650 71 0.025
neuron neuron synaptic transmission GO:0007270 69 0.024
regulation of cell motility GO:2000145 236 0.024
regulation of ion transmembrane transporter activity GO:0032412 54 0.024
Mouse
anion transport GO:0006820 177 0.024
fat cell differentiation GO:0045444 160 0.024
meiotic cell cycle GO:0051321 122 0.024
positive regulation of nucleoside metabolic process GO:0045979 91 0.024
regulation of cellular component biogenesis GO:0044087 181 0.023
sensory perception GO:0007600 245 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.023
memory GO:0007613 58 0.023
Fly
regulation of ion transmembrane transport GO:0034765 119 0.023
Mouse
regulation of cell cycle GO:0051726 281 0.023
positive regulation of organelle organization GO:0010638 128 0.023
rac protein signal transduction GO:0016601 13 0.023
leukocyte differentiation GO:0002521 342 0.022
negative regulation of protein modification process GO:0031400 163 0.022
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
positive regulation of protein modification process GO:0031401 299 0.022
positive regulation of nucleotide metabolic process GO:0045981 114 0.022
regulation of organelle organization GO:0033043 289 0.022
single organism cell adhesion GO:0098602 156 0.022
adult behavior GO:0030534 135 0.022
neuron apoptotic process GO:0051402 142 0.022
wnt signaling pathway GO:0016055 188 0.021
muscle contraction GO:0006936 101 0.021
Mouse
establishment of vesicle localization GO:0051650 81 0.021
regulation of voltage gated calcium channel activity GO:1901385 4 0.021
Mouse
t cell activation GO:0042110 289 0.021
regulation of gtp catabolic process GO:0033124 113 0.021
peptidyl tyrosine phosphorylation GO:0018108 143 0.021
positive regulation of cell development GO:0010720 237 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
protein targeting GO:0006605 143 0.021
response to molecule of bacterial origin GO:0002237 143 0.021
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.021
peptidyl tyrosine modification GO:0018212 145 0.021
positive regulation of homeostatic process GO:0032846 64 0.021
activation of immune response GO:0002253 138 0.020
cardiac muscle cell contraction GO:0086003 7 0.020
Mouse
organelle localization GO:0051640 179 0.020
negative regulation of cell activation GO:0050866 111 0.020
engulfment of apoptotic cell GO:0043652 3 0.020
inflammatory response GO:0006954 244 0.020
establishment of protein localization to membrane GO:0090150 54 0.020
energy derivation by oxidation of organic compounds GO:0015980 77 0.020
positive regulation of leukocyte differentiation GO:1902107 86 0.020
negative regulation of cell motility GO:2000146 61 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
protein localization to plasma membrane GO:0072659 57 0.019
regulation of cardiac muscle contraction GO:0055117 21 0.019
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.019
adult locomotory behavior GO:0008344 91 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
cytoplasmic transport GO:0016482 234 0.019
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.019
compound eye development GO:0048749 1 0.019
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.019
Mouse
regulation of body fluid levels GO:0050878 162 0.018
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.018
positive regulation of gtp catabolic process GO:0033126 85 0.018
rna interference GO:0016246 2 0.018
guanosine containing compound metabolic process GO:1901068 144 0.018
regulation of vesicle mediated transport GO:0060627 139 0.018
spermatogenesis GO:0007283 284 0.018
regulation of actin filament based process GO:0032970 99 0.018
Mouse
mapk cascade GO:0000165 281 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
tissue homeostasis GO:0001894 115 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
stem cell differentiation GO:0048863 268 0.017
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
microtubule based process GO:0007017 236 0.017
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.017
lymphocyte differentiation GO:0030098 242 0.017
nucleoside catabolic process GO:0009164 206 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
male gamete generation GO:0048232 285 0.017
cellular response to biotic stimulus GO:0071216 92 0.017
Mouse
mitotic cell cycle process GO:1903047 159 0.017
regulation of transporter activity GO:0032409 57 0.016
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.016
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.016
ribonucleoside monophosphate metabolic process GO:0009161 80 0.016
heterocycle catabolic process GO:0046700 280 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
calcium ion transmembrane transport GO:0070588 85 0.016
Mouse
amino acid transport GO:0006865 61 0.016
locomotory behavior GO:0007626 195 0.016
Mouse
l glutamate import into cell GO:1990123 3 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
neuronal action potential GO:0019228 54 0.016
cation homeostasis GO:0055080 212 0.016
Mouse
lipid modification GO:0030258 65 0.016
ensheathment of neurons GO:0007272 76 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
calcium ion transport GO:0006816 159 0.016
Mouse
regulation of glutamate receptor signaling pathway GO:1900449 16 0.015
regulation of myeloid cell differentiation GO:0045637 96 0.015
potassium ion homeostasis GO:0055075 4 0.015
synaptic vesicle transport GO:0048489 57 0.015
regulation of nucleotide metabolic process GO:0006140 169 0.015
organic acid transport GO:0015849 101 0.015
guanosine containing compound catabolic process GO:1901069 144 0.015
male meiosis GO:0007140 37 0.015
cellular protein catabolic process GO:0044257 155 0.015
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.015
potassium ion import GO:0010107 1 0.015
sodium ion transport GO:0006814 73 0.015
cellular response to acid chemical GO:0071229 68 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
Mouse
response to acid chemical GO:0001101 111 0.015
positive regulation of nervous system development GO:0051962 221 0.015
regulation of system process GO:0044057 200 0.015
Mouse
regulation of cell projection organization GO:0031344 206 0.015
purine containing compound catabolic process GO:0072523 213 0.015
amino acid import into cell GO:1902837 4 0.014
regulation of inflammatory response GO:0050727 147 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
Mouse
regulation of neuron death GO:1901214 134 0.014
male anatomical structure morphogenesis GO:0090598 4 0.014
defecation GO:0030421 1 0.014
skeletal system development GO:0001501 356 0.014
cell growth GO:0016049 130 0.014
Fly
spermatid differentiation GO:0048515 115 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
response to organic cyclic compound GO:0014070 198 0.014
Mouse
axonogenesis GO:0007409 274 0.014
Fly
phosphatidylinositol metabolic process GO:0046488 45 0.014
regulation of receptor activity GO:0010469 41 0.014
regulation of canonical wnt signaling pathway GO:0060828 82 0.014
maintenance of location GO:0051235 89 0.014
intracellular mrna localization GO:0008298 4 0.014
regulation of cation channel activity GO:2001257 22 0.014
Mouse
regulation of protein transport GO:0051223 163 0.014
synapse assembly GO:0007416 56 0.014
regulation of epithelial cell proliferation GO:0050678 141 0.014
regulation of response to wounding GO:1903034 189 0.014
positive regulation of renal sodium excretion GO:0035815 2 0.014
epithelial cell proliferation GO:0050673 174 0.014
organelle assembly GO:0070925 177 0.014
osteoclast differentiation GO:0030316 62 0.014
regulation of resting membrane potential GO:0060075 3 0.014
blood circulation GO:0008015 195 0.014
Mouse
regulation of fat cell differentiation GO:0045598 81 0.014
actomyosin structure organization GO:0031032 56 0.014
prevention of polyspermy GO:0060468 4 0.014
single fertilization GO:0007338 82 0.013
immune response activating signal transduction GO:0002757 116 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
Mouse
cellular potassium ion transport GO:0071804 43 0.013
glycoprotein biosynthetic process GO:0009101 89 0.013
response to lipopolysaccharide GO:0032496 128 0.013
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.013
Mouse
establishment of endothelial blood brain barrier GO:0014045 3 0.013
regulation of long term synaptic depression GO:1900452 3 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
positive regulation of cytoskeleton organization GO:0051495 49 0.013
leukocyte migration GO:0050900 124 0.013
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.013
embryonic genitalia morphogenesis GO:0030538 4 0.013
lipid biosynthetic process GO:0008610 179 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
protein autophosphorylation GO:0046777 61 0.013
organophosphate ester transport GO:0015748 28 0.013
positive regulation of neuron projection development GO:0010976 79 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.013
divalent inorganic cation transport GO:0072511 178 0.013
Mouse
positive regulation of phagocytosis engulfment GO:0060100 3 0.013
positive regulation of cell projection organization GO:0031346 95 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
glycoprotein metabolic process GO:0009100 116 0.013
regulation of homeostatic process GO:0032844 182 0.013
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
regulation of hydrolase activity GO:0051336 246 0.013
regulation of leukocyte proliferation GO:0070663 121 0.013
regulation of cell substrate adhesion GO:0010810 73 0.013
developmental maturation GO:0021700 193 0.013
leukocyte homeostasis GO:0001776 79 0.013
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
regulation of t cell activation GO:0050863 170 0.013
positive regulation of nucleotide catabolic process GO:0030813 88 0.013
carboxylic acid transport GO:0046942 100 0.013
establishment of organelle localization GO:0051656 122 0.013
regulation of protein secretion GO:0050708 82 0.012
cell adhesion GO:0007155 329 0.012
exocytosis GO:0006887 121 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
glutamate receptor signaling pathway GO:0007215 35 0.012
actin filament based movement GO:0030048 23 0.012
Mouse
vesicle organization GO:0016050 60 0.012
substantia nigra development GO:0021762 2 0.012
actin mediated cell contraction GO:0070252 15 0.012
Mouse
protein modification by small protein conjugation GO:0032446 187 0.012
negative regulation of neuron apoptotic process GO:0043524 92 0.012
amino acid uptake involved in synaptic transmission GO:0051933 3 0.012
l glutamate uptake involved in synaptic transmission GO:0051935 3 0.012
positive regulation of rho gtpase activity GO:0032321 41 0.012
cell type specific apoptotic process GO:0097285 268 0.012
carbohydrate metabolic process GO:0005975 230 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
response to inorganic substance GO:0010035 96 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
establishment of synaptic vesicle localization GO:0097480 57 0.012
mitotic cell cycle GO:0000278 195 0.012
cell activation involved in immune response GO:0002263 126 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
protein kinase b signaling GO:0043491 74 0.012
molting cycle GO:0042303 90 0.012
neuromuscular process GO:0050905 99 0.012
peptidyl serine modification GO:0018209 83 0.012
Mouse
cellular response to dna damage stimulus GO:0006974 207 0.012
positive regulation of ion transport GO:0043270 65 0.012
mesodermal cell migration GO:0008078 4 0.012
positive regulation of cellular component biogenesis GO:0044089 94 0.012
asymmetric neuroblast division GO:0055059 1 0.012
regulation of protein kinase activity GO:0045859 232 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.011
Mouse
response to radiation GO:0009314 165 0.011
Mouse
monovalent inorganic cation homeostasis GO:0055067 33 0.011
single organismal cell cell adhesion GO:0016337 131 0.011
cardiac muscle cell action potential GO:0086001 11 0.011
wound healing GO:0042060 157 0.011
response to pain GO:0048265 26 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
regulation of secretion by cell GO:1903530 249 0.011
mitotic cytokinesis GO:0000281 4 0.011
regulation of proteolysis GO:0030162 164 0.011
axon ensheathment GO:0008366 76 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.011
cognition GO:0050890 149 0.011
Mouse Fly
regulation of intracellular transport GO:0032386 159 0.011
Mouse
nitrogen compound transport GO:0071705 271 0.011
neurotransmitter secretion GO:0007269 62 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
Mouse
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.011
regulation of mitotic cell cycle phase transition GO:1901990 73 0.011
arp2 3 complex mediated actin nucleation GO:0034314 3 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
cell junction organization GO:0034330 77 0.011
positive regulation of apoptotic cell clearance GO:2000427 3 0.011
telencephalon development GO:0021537 186 0.011
regulation of calcium ion transmembrane transport GO:1903169 20 0.011
Mouse
regulation of cell cycle process GO:0010564 160 0.011
cellular homeostasis GO:0019725 240 0.011
Mouse
nuclear transport GO:0051169 139 0.011
positive regulation of defense response GO:0031349 124 0.011
phosphatidylethanolamine metabolic process GO:0046337 2 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
macromolecule methylation GO:0043414 120 0.011
anatomical structure maturation GO:0071695 49 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.011
blood vessel morphogenesis GO:0048514 285 0.011
immune effector process GO:0002252 321 0.011
regulation of anatomical structure size GO:0090066 178 0.011
dicarboxylic acid transport GO:0006835 29 0.010
fatty acid metabolic process GO:0006631 121 0.010
regulation of cell growth GO:0001558 91 0.010
sequestering of metal ion GO:0051238 19 0.010
response to light stimulus GO:0009416 135 0.010
Mouse
acid secretion GO:0046717 33 0.010
camp metabolic process GO:0046058 40 0.010
behavioral response to nutrient GO:0051780 1 0.010
regulation of cell size GO:0008361 72 0.010
positive regulation of gtpase activity GO:0043547 85 0.010
negative regulation of molecular function GO:0044092 258 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.010
directional locomotion GO:0033058 3 0.010
vesicle localization GO:0051648 86 0.010
cellular polysaccharide metabolic process GO:0044264 38 0.010
actin filament bundle assembly GO:0051017 40 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
protein polymerization GO:0051258 57 0.010
cell cell junction organization GO:0045216 72 0.010
cellular response to insulin stimulus GO:0032869 78 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.010

Pde4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.039
disease of anatomical entity DOID:7 0 0.039
musculoskeletal system disease DOID:17 0 0.039
muscle tissue disease DOID:66 0 0.039
nervous system disease DOID:863 0 0.037
central nervous system disease DOID:331 0 0.031
epilepsy syndrome DOID:1826 0 0.026
brain disease DOID:936 0 0.026
electroclinical syndrome DOID:0050701 0 0.026
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.015
cardiovascular system disease DOID:1287 0 0.011
connective tissue disease DOID:65 0 0.011
bone disease DOID:0080001 0 0.011