Mus musculus

87 known processes

Skp2

S-phase kinase-associated protein 2 (p45)

(Aliases: FBXL1,MGC102075,MGC116668)

Skp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle GO:0051726 281 0.428
cellular response to dna damage stimulus GO:0006974 207 0.325
nuclear division GO:0000280 158 0.302
regulation of cell cycle process GO:0010564 160 0.238
dna metabolic process GO:0006259 303 0.197
organelle fission GO:0048285 170 0.185
response to radiation GO:0009314 165 0.176
regulation of mitotic cell cycle GO:0007346 126 0.148
mitotic cell cycle process GO:1903047 159 0.141
germ cell development GO:0007281 185 0.135
macromolecule catabolic process GO:0009057 281 0.126
cellular macromolecule catabolic process GO:0044265 206 0.118
positive regulation of programmed cell death GO:0043068 218 0.113
negative regulation of cell cycle GO:0045786 123 0.106
meiotic nuclear division GO:0007126 115 0.103
negative regulation of cell cycle phase transition GO:1901988 48 0.099
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.099
intrinsic apoptotic signaling pathway GO:0097193 132 0.099
meiotic cell cycle GO:0051321 122 0.095
regulation of mitotic cell cycle phase transition GO:1901990 73 0.090
positive regulation of apoptotic process GO:0043065 217 0.089
mitotic nuclear division GO:0007067 48 0.087
ubiquitin dependent protein catabolic process GO:0006511 129 0.085
cell cycle g1 s phase transition GO:0044843 57 0.079
positive regulation of cell death GO:0010942 224 0.065
nucleocytoplasmic transport GO:0006913 139 0.064
mitotic cell cycle GO:0000278 195 0.062
cellular response to organonitrogen compound GO:0071417 145 0.062
dna endoreduplication GO:0042023 4 0.061
negative regulation of cell cycle process GO:0010948 69 0.060
apoptotic signaling pathway GO:0097190 306 0.060
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.059
regulation of cell cycle phase transition GO:1901987 77 0.058
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.052
regulation of cytoplasmic transport GO:1903649 112 0.051
oxidation reduction process GO:0055114 342 0.050
protein localization to nucleus GO:0034504 121 0.050
dna repair GO:0006281 107 0.048
negative regulation of cellular protein metabolic process GO:0032269 247 0.047
b cell activation GO:0042113 161 0.046
regulation of cellular catabolic process GO:0031329 242 0.045
regulation of proteolysis GO:0030162 164 0.045
cytoplasmic transport GO:0016482 234 0.044
nuclear transport GO:0051169 139 0.043
regulation of transferase activity GO:0051338 263 0.043
cell fate commitment GO:0045165 210 0.042
membrane organization GO:0061024 245 0.041
dna dependent dna replication GO:0006261 24 0.040
chromatin modification GO:0016568 187 0.039
nucleoside metabolic process GO:0009116 246 0.038
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.038
response to light stimulus GO:0009416 135 0.038
regulation of intracellular transport GO:0032386 159 0.038
proteasomal protein catabolic process GO:0010498 98 0.038
regulation of cell cycle g1 s phase transition GO:1902806 35 0.037
cell cycle checkpoint GO:0000075 47 0.036
regulation of cell division GO:0051302 76 0.036
male gamete generation GO:0048232 285 0.036
nucleotide metabolic process GO:0009117 332 0.036
gonad development GO:0008406 141 0.035
cellular protein complex assembly GO:0043623 116 0.035
regulation of nucleocytoplasmic transport GO:0046822 73 0.035
intracellular protein transport GO:0006886 204 0.034
nucleobase containing small molecule metabolic process GO:0055086 352 0.034
posttranscriptional regulation of gene expression GO:0010608 155 0.034
female gamete generation GO:0007292 74 0.034
g1 s transition of mitotic cell cycle GO:0000082 57 0.034
methylation GO:0032259 134 0.033
production of molecular mediator of immune response GO:0002440 103 0.033
covalent chromatin modification GO:0016569 163 0.033
histone modification GO:0016570 159 0.032
response to organic cyclic compound GO:0014070 198 0.032
regulation of cellular protein catabolic process GO:1903362 61 0.032
protein ubiquitination GO:0016567 171 0.032
chromosome segregation GO:0007059 48 0.032
negative regulation of ligase activity GO:0051352 3 0.031
nitrogen compound transport GO:0071705 271 0.031
microtubule based process GO:0007017 236 0.031
protein methylation GO:0006479 81 0.030
negative regulation of protein metabolic process GO:0051248 282 0.030
organophosphate biosynthetic process GO:0090407 122 0.030
neuroblast differentiation GO:0014016 2 0.030
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.030
nucleoside phosphate metabolic process GO:0006753 338 0.029
heterocycle catabolic process GO:0046700 280 0.029
peptidyl amino acid modification GO:0018193 336 0.029
regulation of mrna stability GO:0043488 23 0.029
cell type specific apoptotic process GO:0097285 268 0.029
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.028
cellular amine metabolic process GO:0044106 44 0.028
response to organonitrogen compound GO:0010243 246 0.028
purine nucleoside metabolic process GO:0042278 241 0.027
protein targeting GO:0006605 143 0.027
protein catabolic process GO:0030163 221 0.027
positive regulation of cellular catabolic process GO:0031331 148 0.027
negative regulation of cell proliferation GO:0008285 296 0.027
hematopoietic progenitor cell differentiation GO:0002244 143 0.027
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.026
negative regulation of mitotic cell cycle GO:0045930 58 0.026
macromolecule methylation GO:0043414 120 0.026
regulation of protein catabolic process GO:0042176 108 0.025
purine nucleoside triphosphate metabolic process GO:0009144 226 0.025
cell division GO:0051301 120 0.025
cellular protein catabolic process GO:0044257 155 0.024
recombinational repair GO:0000725 21 0.024
aromatic compound catabolic process GO:0019439 286 0.024
spermatid development GO:0007286 108 0.024
regulation of anatomical structure size GO:0090066 178 0.024
regulation of establishment of protein localization GO:0070201 181 0.024
circulatory system process GO:0003013 197 0.024
ribonucleoside triphosphate catabolic process GO:0009203 199 0.023
regulation of lymphocyte activation GO:0051249 240 0.023
mitotic sister chromatid segregation GO:0000070 14 0.023
spermatogenesis GO:0007283 284 0.023
nucleoside catabolic process GO:0009164 206 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.023
protein modification by small protein conjugation or removal GO:0070647 207 0.023
dna replication GO:0006260 52 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
protein maturation GO:0051604 176 0.022
response to inorganic substance GO:0010035 96 0.022
nucleoside phosphate biosynthetic process GO:1901293 79 0.022
protein import GO:0017038 101 0.022
regulation of cellular amino acid metabolic process GO:0006521 5 0.022
positive regulation of mitotic cell cycle GO:0045931 41 0.022
cellular amino acid metabolic process GO:0006520 103 0.022
sister chromatid segregation GO:0000819 20 0.021
modification dependent macromolecule catabolic process GO:0043632 133 0.021
leukocyte activation involved in immune response GO:0002366 126 0.021
blood circulation GO:0008015 195 0.021
mitochondrial genome maintenance GO:0000002 15 0.021
dna recombination GO:0006310 92 0.021
regulation of organelle organization GO:0033043 289 0.021
regulation of transcription by chromatin organization GO:0034401 0 0.021
positive regulation of cell cycle phase transition GO:1901989 17 0.020
purine nucleoside triphosphate catabolic process GO:0009146 203 0.020
engulfment of apoptotic cell GO:0043652 3 0.020
regulation of cellular amine metabolic process GO:0033238 20 0.020
regulation of intracellular protein transport GO:0033157 82 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
regulation of protein transport GO:0051223 163 0.019
regulation of cellular response to stress GO:0080135 159 0.019
response to acid chemical GO:0001101 111 0.019
cellular response to hormone stimulus GO:0032870 150 0.019
carbohydrate derivative biosynthetic process GO:1901137 183 0.019
regulation of protein kinase activity GO:0045859 232 0.019
protein oligomerization GO:0051259 67 0.019
negative regulation of cellular component organization GO:0051129 194 0.019
regulation of chromosome segregation GO:0051983 21 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
regulation of nuclear division GO:0051783 56 0.019
somatic cell dna recombination GO:0016444 51 0.019
somatic diversification of immunoglobulins GO:0016445 43 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.019
somatic diversification of immune receptors GO:0002200 53 0.019
myeloid cell differentiation GO:0030099 233 0.019
regulation of circadian rhythm GO:0042752 58 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
purine nucleotide catabolic process GO:0006195 211 0.018
muscle system process GO:0003012 141 0.018
cell maturation GO:0048469 127 0.018
cell activation involved in immune response GO:0002263 126 0.018
chromosome separation GO:0051304 14 0.018
organonitrogen compound biosynthetic process GO:1901566 192 0.018
negative regulation of protein modification process GO:0031400 163 0.018
regionalization GO:0003002 337 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
regulation of membrane potential GO:0042391 192 0.018
regulation of proteasomal protein catabolic process GO:0061136 46 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.017
regulation of protein processing GO:0070613 96 0.017
cellular component assembly involved in morphogenesis GO:0010927 139 0.017
skeletal system development GO:0001501 356 0.017
dna hypermethylation GO:0044026 3 0.017
rhythmic process GO:0048511 174 0.017
ribose phosphate metabolic process GO:0019693 291 0.017
intracellular mrna localization GO:0008298 4 0.017
lymphocyte mediated immunity GO:0002449 139 0.017
histone lysine methylation GO:0034968 50 0.017
histone methylation GO:0016571 71 0.017
rna processing GO:0006396 105 0.017
isotype switching GO:0045190 36 0.017
male meiosis i GO:0007141 16 0.016
glycosyl compound metabolic process GO:1901657 246 0.016
multicellular organismal signaling GO:0035637 91 0.016
protein polymerization GO:0051258 57 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.016
dna modification GO:0006304 50 0.016
positive regulation of proteolysis GO:0045862 85 0.016
chromatin organization GO:0006325 206 0.016
cellular nitrogen compound catabolic process GO:0044270 280 0.016
nuclear dna replication GO:0033260 3 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
organophosphate catabolic process GO:0046434 232 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
regulation of meiotic cell cycle GO:0051445 34 0.015
regulation of rna stability GO:0043487 26 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
protein heterotetramerization GO:0051290 4 0.015
negative regulation of protein dephosphorylation GO:0035308 2 0.015
mrna splicing via spliceosome GO:0000398 43 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
mrna metabolic process GO:0016071 84 0.015
meiotic cell cycle process GO:1903046 77 0.015
regulation of cell activation GO:0050865 289 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
b cell mediated immunity GO:0019724 71 0.015
amine metabolic process GO:0009308 45 0.015
positive regulation of cell cycle GO:0045787 92 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.014
nucleotide catabolic process GO:0009166 217 0.014
regulation of hydrolase activity GO:0051336 246 0.014
positive regulation of protein modification process GO:0031401 299 0.014
cellular response to radiation GO:0071478 28 0.014
regulation of protein localization GO:0032880 231 0.014
positive regulation of hydrolase activity GO:0051345 148 0.014
spermatid differentiation GO:0048515 115 0.014
rna splicing via transesterification reactions GO:0000375 43 0.014
cellular ketone metabolic process GO:0042180 84 0.014
regulation of chromatin silencing GO:0031935 2 0.014
microtubule cytoskeleton organization GO:0000226 157 0.014
single organism nuclear import GO:1902593 95 0.014
protein localization to organelle GO:0033365 185 0.014
protein import into nucleus GO:0006606 95 0.014
small molecule biosynthetic process GO:0044283 132 0.014
mitochondrion organization GO:0007005 134 0.014
cellularization GO:0007349 1 0.014
transmission of nerve impulse GO:0019226 76 0.014
maintenance of location GO:0051235 89 0.014
purine containing compound catabolic process GO:0072523 213 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
cellular response to organic cyclic compound GO:0071407 87 0.013
negative regulation of cell division GO:0051782 24 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
regulation of cellular ketone metabolic process GO:0010565 66 0.013
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.013
negative regulation of molecular function GO:0044092 258 0.013
compound eye development GO:0048749 1 0.013
immune effector process GO:0002252 321 0.013
deoxyribonucleotide metabolic process GO:0009262 14 0.013
regulation of cell cycle checkpoint GO:1901976 9 0.013
striated muscle myosin thick filament assembly GO:0071688 1 0.013
endocytosis GO:0006897 168 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
negative regulation of protein processing GO:0010955 79 0.013
urogenital system development GO:0001655 261 0.013
positive regulation of cytoplasmic transport GO:1903651 40 0.013
regulation of system process GO:0044057 200 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
positive regulation of cell cycle process GO:0090068 61 0.013
gene silencing GO:0016458 38 0.013
positive regulation of intracellular transport GO:0032388 70 0.012
alpha amino acid metabolic process GO:1901605 59 0.012
nucleotide biosynthetic process GO:0009165 78 0.012
cell adhesion GO:0007155 329 0.012
nucleus organization GO:0006997 45 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
establishment of protein localization to organelle GO:0072594 118 0.012
regulation of kinase activity GO:0043549 249 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
response to uv GO:0009411 44 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
action potential GO:0001508 78 0.012
ribonucleotide metabolic process GO:0009259 291 0.012
innate immune response GO:0045087 157 0.012
ras protein signal transduction GO:0007265 77 0.012
positive regulation of cell development GO:0010720 237 0.012
antimicrobial peptide biosynthetic process GO:0002777 2 0.012
nuclear import GO:0051170 95 0.012
immunoglobulin production GO:0002377 73 0.012
double strand break repair GO:0006302 48 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
response to growth factor GO:0070848 198 0.012
protein processing GO:0016485 163 0.012
connective tissue development GO:0061448 179 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
cellular response to acid chemical GO:0071229 68 0.011
adaptive immune response GO:0002250 155 0.011
heterochromatin organization GO:0070828 4 0.011
immunoglobulin mediated immune response GO:0016064 69 0.011
leukocyte proliferation GO:0070661 172 0.011
lipid biosynthetic process GO:0008610 179 0.011
regulation of cell shape GO:0008360 39 0.011
lymphocyte proliferation GO:0046651 164 0.011
fatty acid metabolic process GO:0006631 121 0.011
cellular lipid metabolic process GO:0044255 323 0.011
neuroblast fate determination GO:0007400 1 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
purine containing compound metabolic process GO:0072521 311 0.011
dna catabolic process endonucleolytic GO:0000737 15 0.011
cellular response to lipid GO:0071396 145 0.011
development of primary sexual characteristics GO:0045137 143 0.011
oogenesis GO:0048477 56 0.011
regulation of multi organism process GO:0043900 111 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
regulation of b cell activation GO:0050864 81 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
sensory perception GO:0007600 245 0.011
angiogenesis GO:0001525 201 0.011
organism emergence from protective structure GO:0071684 4 0.011
peptidyl lysine modification GO:0018205 77 0.011
regulation of rna splicing GO:0043484 37 0.011
mitotic cell cycle checkpoint GO:0007093 31 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
positive regulation of organelle organization GO:0010638 128 0.011
protein alkylation GO:0008213 81 0.011
attachment of spindle microtubules to kinetochore GO:0008608 4 0.011
regulation of protein targeting GO:1903533 61 0.011
negative regulation of transferase activity GO:0051348 85 0.011
neuroblast fate commitment GO:0014017 1 0.011
lymphocyte differentiation GO:0030098 242 0.011
mrna processing GO:0006397 63 0.011
cation transport GO:0006812 399 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
nucleoside phosphate catabolic process GO:1901292 222 0.010
wnt signaling pathway GO:0016055 188 0.010
purine nucleoside catabolic process GO:0006152 205 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
lateral inhibition GO:0046331 1 0.010
respiratory system development GO:0060541 190 0.010
regulation of exit from mitosis GO:0007096 1 0.010
regulation of actin filament based process GO:0032970 99 0.010
regulation of protein complex assembly GO:0043254 83 0.010

Skp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.084
cancer DOID:162 0 0.051
organ system cancer DOID:0050686 0 0.036
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018