Mus musculus

62 known processes

Parl

presenilin associated, rhomboid-like

(Aliases: PRO2207,PSENIP2,Psarl,D16Ertd607e,PSARL1)

Parl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion organization GO:0007005 134 0.419
iron sulfur cluster assembly GO:0016226 3 0.327
mitochondrial fusion GO:0008053 9 0.192
Fly
purine ribonucleoside metabolic process GO:0046128 241 0.184
neural tube formation GO:0001841 108 0.181
nucleoside metabolic process GO:0009116 246 0.164
purine ribonucleotide metabolic process GO:0009150 290 0.162
embryonic epithelial tube formation GO:0001838 130 0.137
ribonucleotide metabolic process GO:0009259 291 0.133
nucleoside triphosphate metabolic process GO:0009141 230 0.128
ribose phosphate metabolic process GO:0019693 291 0.121
nucleobase containing small molecule metabolic process GO:0055086 352 0.118
organophosphate biosynthetic process GO:0090407 122 0.096
morphogenesis of embryonic epithelium GO:0016331 159 0.095
modification dependent macromolecule catabolic process GO:0043632 133 0.092
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.089
purine containing compound metabolic process GO:0072521 311 0.086
proteasomal ubiquitin independent protein catabolic process GO:0010499 1 0.083
neural tube development GO:0021915 160 0.080
positive regulation of membrane potential GO:0045838 15 0.077
nucleotide metabolic process GO:0009117 332 0.076
coenzyme biosynthetic process GO:0009108 23 0.075
cellular protein catabolic process GO:0044257 155 0.075
nucleoside phosphate metabolic process GO:0006753 338 0.075
mitochondrion morphogenesis GO:0070584 13 0.073
glycosyl compound metabolic process GO:1901657 246 0.069
metallo sulfur cluster assembly GO:0031163 3 0.067
proteasome assembly GO:0043248 1 0.064
stem cell differentiation GO:0048863 268 0.063
gonad development GO:0008406 141 0.062
purine nucleotide metabolic process GO:0006163 302 0.061
glycerophospholipid metabolic process GO:0006650 71 0.059
membrane organization GO:0061024 245 0.059
Fly
tube formation GO:0035148 140 0.057
cellular ketone metabolic process GO:0042180 84 0.051
methylation GO:0032259 134 0.050
transmembrane transport GO:0055085 412 0.049
protein catabolic process GO:0030163 221 0.048
ribonucleotide biosynthetic process GO:0009260 59 0.048
lipid biosynthetic process GO:0008610 179 0.048
cellular macromolecule catabolic process GO:0044265 206 0.047
neural tube closure GO:0001843 90 0.047
purine nucleotide biosynthetic process GO:0006164 65 0.047
ribose phosphate biosynthetic process GO:0046390 59 0.046
epithelial tube formation GO:0072175 130 0.046
ribonucleoside monophosphate metabolic process GO:0009161 80 0.045
cofactor metabolic process GO:0051186 80 0.044
purine ribonucleotide biosynthetic process GO:0009152 59 0.044
ribonucleotide catabolic process GO:0009261 208 0.043
proteasomal protein catabolic process GO:0010498 98 0.040
purine nucleoside metabolic process GO:0042278 241 0.040
trna wobble uridine modification GO:0002098 2 0.039
nucleoside phosphate biosynthetic process GO:1901293 79 0.039
purine nucleotide catabolic process GO:0006195 211 0.039
cellular lipid metabolic process GO:0044255 323 0.038
regulation of cellular amine metabolic process GO:0033238 20 0.038
epithelial tube morphogenesis GO:0060562 303 0.037
regulation of nucleotide metabolic process GO:0006140 169 0.037
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.037
sulfur compound metabolic process GO:0006790 100 0.037
aromatic compound catabolic process GO:0019439 286 0.036
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.036
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.034
ribonucleoside metabolic process GO:0009119 245 0.034
development of primary sexual characteristics GO:0045137 143 0.034
endocytosis GO:0006897 168 0.034
macromolecule catabolic process GO:0009057 281 0.033
ubiquitin dependent protein catabolic process GO:0006511 129 0.033
cation transmembrane transport GO:0098655 266 0.033
small molecule biosynthetic process GO:0044283 132 0.032
cellular amine metabolic process GO:0044106 44 0.032
inorganic ion transmembrane transport GO:0098660 234 0.031
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.030
organelle fusion GO:0048284 28 0.030
Fly
organonitrogen compound biosynthetic process GO:1901566 192 0.030
spermatogenesis GO:0007283 284 0.030
amine metabolic process GO:0009308 45 0.030
ion transmembrane transport GO:0034220 361 0.030
cellular homeostasis GO:0019725 240 0.030
regulation of phospholipid biosynthetic process GO:0071071 3 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.029
nucleoside triphosphate catabolic process GO:0009143 205 0.029
heterocycle catabolic process GO:0046700 280 0.029
nucleoside monophosphate metabolic process GO:0009123 85 0.029
organic cyclic compound catabolic process GO:1901361 295 0.029
cellular amino acid metabolic process GO:0006520 103 0.028
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.028
cofactor biosynthetic process GO:0051188 41 0.028
rna processing GO:0006396 105 0.028
ribonucleoside triphosphate metabolic process GO:0009199 220 0.028
cellular response to dna damage stimulus GO:0006974 207 0.027
skeletal system development GO:0001501 356 0.027
regulation of nucleoside metabolic process GO:0009118 130 0.027
negative regulation of intracellular signal transduction GO:1902532 167 0.027
ossification GO:0001503 216 0.027
purine nucleoside monophosphate metabolic process GO:0009126 81 0.027
purine containing compound biosynthetic process GO:0072522 70 0.027
regulation of purine nucleotide catabolic process GO:0033121 122 0.026
macromolecule methylation GO:0043414 120 0.026
mitotic cytokinesis GO:0000281 4 0.026
phospholipid metabolic process GO:0006644 87 0.026
coenzyme metabolic process GO:0006732 52 0.025
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.025
regulation of hydrolase activity GO:0051336 246 0.025
carbohydrate derivative catabolic process GO:1901136 231 0.025
t cell activation GO:0042110 289 0.025
cristae formation GO:0042407 3 0.025
modification dependent protein catabolic process GO:0019941 133 0.025
nucleoside monophosphate biosynthetic process GO:0009124 12 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.024
regulation of purine nucleotide metabolic process GO:1900542 169 0.023
organophosphate catabolic process GO:0046434 232 0.023
guanosine containing compound metabolic process GO:1901068 144 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
negative regulation of mitochondrion organization GO:0010823 9 0.022
membrane fusion GO:0061025 38 0.021
Fly
regulation of cellular component biogenesis GO:0044087 181 0.021
negative regulation of cellular amine metabolic process GO:0033239 1 0.021
inner mitochondrial membrane organization GO:0007007 5 0.021
cation homeostasis GO:0055080 212 0.021
cellularization GO:0007349 1 0.021
positive regulation of protein modification process GO:0031401 299 0.020
regulation of cell cycle process GO:0010564 160 0.020
calcium ion homeostasis GO:0055074 127 0.020
primary neural tube formation GO:0014020 95 0.020
germ cell development GO:0007281 185 0.019
regulation of cellular amino acid metabolic process GO:0006521 5 0.019
divalent metal ion transport GO:0070838 172 0.019
nucleotide catabolic process GO:0009166 217 0.019
regulation of transmembrane transport GO:0034762 128 0.019
epithelial cell proliferation GO:0050673 174 0.018
positive regulation of nucleoside metabolic process GO:0045979 91 0.018
gtp catabolic process GO:0006184 143 0.018
nitrogen compound transport GO:0071705 271 0.018
apoptotic mitochondrial changes GO:0008637 48 0.017
cardiolipin metabolic process GO:0032048 3 0.017
alcohol metabolic process GO:0006066 116 0.017
positive regulation of hydrolase activity GO:0051345 148 0.017
divalent inorganic cation transport GO:0072511 178 0.017
mitochondrial genome maintenance GO:0000002 15 0.017
purine containing compound catabolic process GO:0072523 213 0.017
inorganic cation transmembrane transport GO:0098662 207 0.017
response to inorganic substance GO:0010035 96 0.017
response to oxidative stress GO:0006979 123 0.016
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.016
endomembrane system organization GO:0010256 147 0.016
glycerolipid metabolic process GO:0046486 122 0.016
antigen receptor mediated signaling pathway GO:0050851 64 0.016
cellular protein complex assembly GO:0043623 116 0.016
synaptic transmission GO:0007268 329 0.016
gland development GO:0048732 330 0.016
positive regulation of cellular amine metabolic process GO:0033240 5 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
cation transport GO:0006812 399 0.016
receptor mediated endocytosis GO:0006898 51 0.015
protein localization to organelle GO:0033365 185 0.015
intracellular protein transport GO:0006886 204 0.015
atp metabolic process GO:0046034 75 0.015
cd4 positive alpha beta t cell activation GO:0035710 45 0.015
extracellular structure organization GO:0043062 148 0.015
phosphatidylglycerol metabolic process GO:0046471 3 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
oogenesis GO:0048477 56 0.015
ncrna processing GO:0034470 26 0.015
regulation of nucleotide catabolic process GO:0030811 122 0.015
regulation of feeding behavior GO:0060259 3 0.015
tube closure GO:0060606 91 0.015
small gtpase mediated signal transduction GO:0007264 97 0.014
protein import GO:0017038 101 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
regulation of phosphatidylcholine biosynthetic process GO:2001245 2 0.014
action potential GO:0001508 78 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
regulation of organelle organization GO:0033043 289 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
regulation of gtp catabolic process GO:0033124 113 0.014
maternal determination of anterior posterior axis embryo GO:0008358 2 0.013
divalent inorganic cation homeostasis GO:0072507 138 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
regulation of membrane potential GO:0042391 192 0.013
energy derivation by oxidation of organic compounds GO:0015980 77 0.013
negative regulation of alcohol biosynthetic process GO:1902931 4 0.013
regulation of lipid metabolic process GO:0019216 118 0.013
mrna metabolic process GO:0016071 84 0.013
t cell proliferation GO:0042098 120 0.013
hematopoietic stem cell differentiation GO:0060218 8 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
small molecule catabolic process GO:0044282 71 0.013
digestive system development GO:0055123 200 0.012
trna processing GO:0008033 11 0.012
purine nucleoside biosynthetic process GO:0042451 19 0.012
cytoplasmic transport GO:0016482 234 0.012
organic acid biosynthetic process GO:0016053 86 0.012
cellular chemical homeostasis GO:0055082 215 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
corticotropin releasing hormone secretion GO:0043396 2 0.012
connective tissue development GO:0061448 179 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
protein targeting GO:0006605 143 0.012
organic acid catabolic process GO:0016054 51 0.012
trna metabolic process GO:0006399 11 0.012
synapse organization GO:0050808 125 0.012
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
immune effector process GO:0002252 321 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
organonitrogen compound catabolic process GO:1901565 264 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
cartilage development GO:0051216 140 0.011
leukocyte migration GO:0050900 124 0.011
mitochondrial dna replication GO:0006264 7 0.011
peptidyl amino acid modification GO:0018193 336 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
response to transforming growth factor beta GO:0071559 88 0.011
nucleoside catabolic process GO:0009164 206 0.011
metal ion homeostasis GO:0055065 189 0.011
calcium ion transport GO:0006816 159 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
protein methylation GO:0006479 81 0.011
nucleoside biosynthetic process GO:0009163 21 0.011
response to oxygen levels GO:0070482 62 0.011
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.011
male gamete generation GO:0048232 285 0.011
rna splicing via transesterification reactions GO:0000375 43 0.011
nucleobase containing compound transport GO:0015931 27 0.010
camera type eye development GO:0043010 266 0.010
positive regulation of protein complex assembly GO:0031334 45 0.010
regulation of mrna processing GO:0050684 41 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
neuronal action potential GO:0019228 54 0.010
blood vessel morphogenesis GO:0048514 285 0.010
t cell differentiation GO:0030217 174 0.010
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.010
gtp metabolic process GO:0046039 144 0.010

Parl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.023
disease of metabolism DOID:0014667 0 0.016
inherited metabolic disorder DOID:655 0 0.016
sensory system disease DOID:0050155 0 0.015
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015