Mus musculus

12 known processes

Adamts5

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

(Aliases: ADAMTS1,9530092O11Rik,AI481094,ADAMTS11,ADAM-TS5,ASMP-2)

Adamts5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular matrix organization GO:0030198 147 0.195
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.158
extracellular structure organization GO:0043062 148 0.137
Mouse
kidney development GO:0001822 213 0.112
Mouse
positive regulation of peptidase activity GO:0010952 49 0.104
bone development GO:0060348 120 0.099
renal system development GO:0072001 225 0.095
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.095
positive regulation of cellular amine metabolic process GO:0033240 5 0.091
camera type eye development GO:0043010 266 0.091
transmembrane transport GO:0055085 412 0.090
negative regulation of cell proliferation GO:0008285 296 0.090
skin development GO:0043588 220 0.085
reactive oxygen species metabolic process GO:0072593 84 0.076
respiratory system development GO:0060541 190 0.074
respiratory tube development GO:0030323 167 0.073
apoptotic signaling pathway GO:0097190 306 0.067
regulation of cellular amine metabolic process GO:0033238 20 0.064
cation transport GO:0006812 399 0.064
epithelial tube morphogenesis GO:0060562 303 0.062
positive regulation of proteolysis GO:0045862 85 0.054
response to radiation GO:0009314 165 0.053
stem cell differentiation GO:0048863 268 0.053
cell adhesion GO:0007155 329 0.053
connective tissue development GO:0061448 179 0.052
regulation of apoptotic signaling pathway GO:2001233 197 0.051
sensory organ morphogenesis GO:0090596 242 0.050
regulation of peptidase activity GO:0052547 96 0.048
positive regulation of nervous system development GO:0051962 221 0.047
generation of precursor metabolites and energy GO:0006091 103 0.045
anatomical structure homeostasis GO:0060249 145 0.044
collagen fibril organization GO:0030199 32 0.044
regulation of endopeptidase activity GO:0052548 89 0.043
regulation of hydrolase activity GO:0051336 246 0.043
regulation of neuron projection development GO:0010975 169 0.042
lung development GO:0030324 164 0.042
compound eye development GO:0048749 1 0.042
response to organic cyclic compound GO:0014070 198 0.041
single organismal cell cell adhesion GO:0016337 131 0.040
chondrocyte differentiation GO:0002062 72 0.038
endocytosis GO:0006897 168 0.038
heart morphogenesis GO:0003007 178 0.037
Mouse
regulation of proteolysis GO:0030162 164 0.037
nephron development GO:0072006 109 0.037
skeletal system development GO:0001501 356 0.037
response to amino acid GO:0043200 37 0.037
response to growth factor GO:0070848 198 0.036
cellular amine metabolic process GO:0044106 44 0.036
small gtpase mediated signal transduction GO:0007264 97 0.036
regulation of transmembrane transport GO:0034762 128 0.035
cellular response to growth factor stimulus GO:0071363 197 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
tube formation GO:0035148 140 0.034
regulation of system process GO:0044057 200 0.034
engulfment of apoptotic cell GO:0043652 3 0.033
ear morphogenesis GO:0042471 118 0.033
regulation of cellular amino acid metabolic process GO:0006521 5 0.033
negative regulation of protein metabolic process GO:0051248 282 0.033
striated muscle tissue development GO:0014706 293 0.033
cartilage development GO:0051216 140 0.033
morphogenesis of embryonic epithelium GO:0016331 159 0.033
urogenital system development GO:0001655 261 0.031
Mouse
oxidation reduction process GO:0055114 342 0.031
negative regulation of cellular component organization GO:0051129 194 0.031
forebrain development GO:0030900 302 0.031
negative regulation of cellular amine metabolic process GO:0033239 1 0.031
intrinsic apoptotic signaling pathway GO:0097193 132 0.031
muscle tissue development GO:0060537 308 0.031
positive regulation of endopeptidase activity GO:0010950 43 0.031
ear development GO:0043583 200 0.030
sensory system development GO:0048880 3 0.030
protein modification by small protein conjugation or removal GO:0070647 207 0.030
cellular amino acid metabolic process GO:0006520 103 0.029
muscle cell differentiation GO:0042692 261 0.029
amine metabolic process GO:0009308 45 0.029
cellular response to amino acid stimulus GO:0071230 29 0.029
telencephalon development GO:0021537 186 0.029
negative regulation of apoptotic signaling pathway GO:2001234 104 0.028
cardiac chamber development GO:0003205 108 0.028
Mouse
neural tube development GO:0021915 160 0.028
embryonic epithelial tube formation GO:0001838 130 0.028
regulation of cytokine production GO:0001817 266 0.028
dendrite development GO:0016358 115 0.028
nitrogen compound transport GO:0071705 271 0.027
ras protein signal transduction GO:0007265 77 0.027
neural tube formation GO:0001841 108 0.027
immune effector process GO:0002252 321 0.027
b cell activation GO:0042113 161 0.027
regulation of organ morphogenesis GO:2000027 144 0.027
response to oxidative stress GO:0006979 123 0.027
peptidyl amino acid modification GO:0018193 336 0.027
positive regulation of cell substrate adhesion GO:0010811 47 0.027
regulation of kinase activity GO:0043549 249 0.027
epidermis development GO:0008544 187 0.026
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.026
regulation of cell cycle GO:0051726 281 0.026
skeletal system morphogenesis GO:0048705 203 0.026
cell substrate adhesion GO:0031589 130 0.026
elastic fiber assembly GO:0048251 4 0.026
regulation of protein kinase activity GO:0045859 232 0.026
regulation of reactive oxygen species metabolic process GO:2000377 40 0.026
protein modification by small protein conjugation GO:0032446 187 0.026
protein processing GO:0016485 163 0.025
cytokine production GO:0001816 319 0.025
inter male aggressive behavior GO:0002121 3 0.025
physiological cardiac muscle hypertrophy GO:0003301 3 0.025
cellular ketone metabolic process GO:0042180 84 0.025
developmental maturation GO:0021700 193 0.025
appendage development GO:0048736 166 0.025
response to transforming growth factor beta GO:0071559 88 0.024
divalent metal ion transport GO:0070838 172 0.024
tissue homeostasis GO:0001894 115 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
cellular response to abiotic stimulus GO:0071214 56 0.024
protein maturation GO:0051604 176 0.024
positive regulation of cell death GO:0010942 224 0.023
organelle fission GO:0048285 170 0.023
palate development GO:0060021 76 0.023
response to endoplasmic reticulum stress GO:0034976 53 0.023
cellular response to organonitrogen compound GO:0071417 145 0.023
sensory perception GO:0007600 245 0.023
positive regulation of protein modification process GO:0031401 299 0.022
trunk segmentation GO:0035290 4 0.022
digestive system development GO:0055123 200 0.022
positive regulation of programmed cell death GO:0043068 218 0.022
extrinsic apoptotic signaling pathway GO:0097191 126 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.022
peptidyl tyrosine modification GO:0018212 145 0.022
regulation of ion transport GO:0043269 215 0.022
blood vessel morphogenesis GO:0048514 285 0.022
striated muscle cell development GO:0055002 125 0.022
epithelial cell proliferation GO:0050673 174 0.022
synapse organization GO:0050808 125 0.022
peptidyl tyrosine phosphorylation GO:0018108 143 0.021
acetylcholine secretion neurotransmission GO:0014055 2 0.021
phagocytosis GO:0006909 66 0.021
cellular response to acid chemical GO:0071229 68 0.021
regulation of cell motility GO:2000145 236 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.021
female gonad development GO:0008585 71 0.021
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.020
mitotic cell cycle GO:0000278 195 0.020
negative regulation of phosphorylation GO:0042326 166 0.020
negative regulation of phosphorus metabolic process GO:0010563 184 0.020
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.020
regulation of fibroblast proliferation GO:0048145 34 0.020
response to organonitrogen compound GO:0010243 246 0.020
negative regulation of catenin import into nucleus GO:0035414 2 0.020
energy derivation by oxidation of organic compounds GO:0015980 77 0.020
cellular lipid metabolic process GO:0044255 323 0.020
organelle localization GO:0051640 179 0.020
renal tubule morphogenesis GO:0061333 72 0.019
regulation of bmp signaling pathway GO:0030510 60 0.019
mitotic cell cycle process GO:1903047 159 0.019
organelle assembly GO:0070925 177 0.019
regulation of organelle organization GO:0033043 289 0.019
regulation of cell projection organization GO:0031344 206 0.019
cellular response to oxidative stress GO:0034599 76 0.019
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.019
innate immune response GO:0045087 157 0.019
response to lipopolysaccharide GO:0032496 128 0.019
locomotory behavior GO:0007626 195 0.019
ion transmembrane transport GO:0034220 361 0.018
regulation of cell cycle process GO:0010564 160 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
branching morphogenesis of an epithelial tube GO:0048754 159 0.018
intracellular receptor signaling pathway GO:0030522 74 0.018
development of primary sexual characteristics GO:0045137 143 0.018
Mouse Worm
cytoplasmic transport GO:0016482 234 0.018
Worm
lateral line system development GO:0048925 1 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.018
kidney morphogenesis GO:0060993 83 0.018
negative regulation of protein modification process GO:0031400 163 0.018
retina development in camera type eye GO:0060041 119 0.018
negative regulation of growth GO:0045926 99 0.017
regulation of angiogenesis GO:0045765 81 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
establishment of organelle localization GO:0051656 122 0.017
organic hydroxy compound metabolic process GO:1901615 203 0.017
bone morphogenesis GO:0060349 78 0.017
protein ubiquitination GO:0016567 171 0.017
epithelium migration GO:0090132 63 0.017
mesoderm development GO:0007498 100 0.017
limb morphogenesis GO:0035108 149 0.017
nucleoside phosphate metabolic process GO:0006753 338 0.017
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.017
tissue remodeling GO:0048771 102 0.017
negative regulation of epithelial cell proliferation GO:0050680 64 0.017
hematopoietic progenitor cell differentiation GO:0002244 143 0.017
regulation of neuron differentiation GO:0045664 281 0.017
tube closure GO:0060606 91 0.017
regulation of endocytosis GO:0030100 69 0.017
regionalization GO:0003002 337 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
positive regulation of cell adhesion GO:0045785 80 0.017
regulation of cell migration GO:0030334 219 0.017
endomembrane system organization GO:0010256 147 0.017
regulation of hormone levels GO:0010817 211 0.017
embryonic organ morphogenesis GO:0048562 276 0.016
ceramide biosynthetic process GO:0046513 20 0.016
angiogenesis GO:0001525 201 0.016
protein oligomerization GO:0051259 67 0.016
regulation of cell activation GO:0050865 289 0.016
lateral inhibition GO:0046331 1 0.016
biomineral tissue development GO:0031214 64 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
smoothened signaling pathway GO:0007224 105 0.016
negative regulation of cell development GO:0010721 169 0.016
telencephalon cell migration GO:0022029 55 0.016
sequestering of calcium ion GO:0051208 18 0.016
rhythmic process GO:0048511 174 0.016
Mouse
regulation of cellular response to stress GO:0080135 159 0.016
adult behavior GO:0030534 135 0.016
regulation of wnt signaling pathway GO:0030111 123 0.016
divalent inorganic cation transport GO:0072511 178 0.016
membrane organization GO:0061024 245 0.016
regulation of membrane potential GO:0042391 192 0.016
nuclear division GO:0000280 158 0.015
negative regulation of ossification GO:0030279 49 0.015
microtubule based process GO:0007017 236 0.015
acetylcholine transport GO:0015870 2 0.015
myeloid cell differentiation GO:0030099 233 0.015
defense response to other organism GO:0098542 197 0.015
mitochondrion organization GO:0007005 134 0.015
pallium development GO:0021543 120 0.015
regulation of cysteine type endopeptidase activity GO:2000116 65 0.015
positive regulation of apoptotic signaling pathway GO:2001235 95 0.015
morphogenesis of a branching epithelium GO:0061138 193 0.015
cardiac muscle tissue development GO:0048738 130 0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.015
signal transduction in absence of ligand GO:0038034 55 0.015
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.015
positive regulation of kinase activity GO:0033674 155 0.015
acetate ester transport GO:1901374 2 0.015
cardiac ventricle development GO:0003231 83 0.014
regulation of organ growth GO:0046620 61 0.014
cellular response to lipid GO:0071396 145 0.014
regulation of cell adhesion GO:0030155 154 0.014
nephron epithelium development GO:0072009 92 0.014
physiological muscle hypertrophy GO:0003298 3 0.014
neuron migration GO:0001764 122 0.014
ameboidal type cell migration GO:0001667 128 0.014
muscle cell development GO:0055001 133 0.014
cell growth GO:0016049 130 0.014
nephron tubule development GO:0072080 84 0.014
epithelial cell migration GO:0010631 63 0.014
cell growth involved in cardiac muscle cell development GO:0061049 3 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
macromolecule catabolic process GO:0009057 281 0.014
heart contraction GO:0060047 93 0.014
neuromuscular process GO:0050905 99 0.014
spinal cord development GO:0021510 81 0.014
inner ear morphogenesis GO:0042472 101 0.014
regulation of protein processing GO:0070613 96 0.014
regulation of ossification GO:0030278 112 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
cellular glucan metabolic process GO:0006073 32 0.014
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.014
sequestering of metal ion GO:0051238 19 0.014
cardiac chamber morphogenesis GO:0003206 93 0.014
Mouse
positive regulation of defense response GO:0031349 124 0.014
neurotransmitter transport GO:0006836 76 0.014
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
regulation of transferase activity GO:0051338 263 0.013
positive regulation of neuron differentiation GO:0045666 141 0.013
establishment of planar polarity GO:0001736 28 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
negative regulation of nervous system development GO:0051961 156 0.013
cellular response to inorganic substance GO:0071241 37 0.013
positive regulation of interleukin 8 production GO:0032757 2 0.013
single organism cell adhesion GO:0098602 156 0.013
sensory perception of light stimulus GO:0050953 54 0.013
multicellular organismal homeostasis GO:0048871 164 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
metal ion homeostasis GO:0055065 189 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
spermatogenesis GO:0007283 284 0.013
meiotic cell cycle GO:0051321 122 0.013
ureteric bud morphogenesis GO:0060675 62 0.013
morphogenesis of a branching structure GO:0001763 203 0.013
cell fate commitment GO:0045165 210 0.013
embryonic placenta development GO:0001892 98 0.013
neural tube closure GO:0001843 90 0.013
digestive tract development GO:0048565 190 0.013
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.013
establishment of tissue polarity GO:0007164 28 0.013
cellular protein complex assembly GO:0043623 116 0.013
positive regulation of phospholipase activity GO:0010518 3 0.013
mesonephros development GO:0001823 97 0.013
response to acid chemical GO:0001101 111 0.013
regulation of neurotransmitter levels GO:0001505 87 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
positive regulation of cytokine production GO:0001819 174 0.013
cellular response to lipopolysaccharide GO:0071222 77 0.013
response to inorganic substance GO:0010035 96 0.013
female gamete generation GO:0007292 74 0.013
Mouse
cell cell adhesion GO:0098609 41 0.013
mesonephric duct morphogenesis GO:0072180 4 0.013
ossification GO:0001503 216 0.013
hair follicle development GO:0001942 85 0.013
negative regulation of cell cycle GO:0045786 123 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
cell junction organization GO:0034330 77 0.012
sensory perception of sound GO:0007605 97 0.012
canonical wnt signaling pathway GO:0060070 130 0.012
ureteric bud development GO:0001657 94 0.012
lipid biosynthetic process GO:0008610 179 0.012
aromatic compound catabolic process GO:0019439 286 0.012
hormone secretion GO:0046879 128 0.012
fibroblast proliferation GO:0048144 35 0.012
covalent chromatin modification GO:0016569 163 0.012
cellular ion homeostasis GO:0006873 165 0.012
leukocyte proliferation GO:0070661 172 0.012
sphingolipid metabolic process GO:0006665 45 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.012
wnt signaling pathway GO:0016055 188 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
bmp signaling pathway GO:0030509 93 0.012
negative regulation of organelle organization GO:0010639 90 0.012
primary neural tube formation GO:0014020 95 0.012
positive regulation of homeostatic process GO:0032846 64 0.012
cognition GO:0050890 149 0.012
membrane lipid metabolic process GO:0006643 53 0.012
glial cell differentiation GO:0010001 131 0.012
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
labyrinthine layer development GO:0060711 49 0.012
glycogen metabolic process GO:0005977 32 0.012
gland development GO:0048732 330 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
regulation of ion homeostasis GO:2000021 64 0.012
embryonic skeletal system development GO:0048706 120 0.012
regulation of actin filament based process GO:0032970 99 0.012
polysaccharide metabolic process GO:0005976 39 0.012
cellular response to superoxide GO:0071451 14 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
cation homeostasis GO:0055080 212 0.012
lung alveolus development GO:0048286 45 0.012
regulation of intracellular transport GO:0032386 159 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
membrane lipid biosynthetic process GO:0046467 32 0.012
heterocycle catabolic process GO:0046700 280 0.011
cellular polysaccharide metabolic process GO:0044264 38 0.011
cation transmembrane transport GO:0098655 266 0.011
protein localization to organelle GO:0033365 185 0.011
regulation of osteoblast differentiation GO:0045667 67 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.011
somite development GO:0061053 81 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
negative regulation of bmp signaling pathway GO:0030514 35 0.011
meiotic cell cycle process GO:1903046 77 0.011
development of primary female sexual characteristics GO:0046545 73 0.011
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.011
regulation of testosterone biosynthetic process GO:2000224 2 0.011
negative regulation of molecular function GO:0044092 258 0.011
forebrain cell migration GO:0021885 58 0.011
regulation of cell substrate adhesion GO:0010810 73 0.011
endothelial cell migration GO:0043542 44 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
positive regulation of transferase activity GO:0051347 167 0.011
kidney epithelium development GO:0072073 121 0.011
neurotransmitter secretion GO:0007269 62 0.011
regulation of removal of superoxide radicals GO:2000121 4 0.011
regulation of muscle tissue development GO:1901861 97 0.011
regulation of mapk cascade GO:0043408 248 0.011
organ growth GO:0035265 117 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
rho protein signal transduction GO:0007266 32 0.011
male gamete generation GO:0048232 285 0.011
regulation of translation GO:0006417 71 0.011
regulation of sphingolipid biosynthetic process GO:0090153 1 0.011
translation GO:0006412 93 0.011
regulation of homeostatic process GO:0032844 182 0.011
regulation of b cell activation GO:0050864 81 0.011
cerebral cortex development GO:0021987 86 0.011
blood circulation GO:0008015 195 0.010
midgut development GO:0007494 4 0.010
response to reactive oxygen species GO:0000302 56 0.010
epithelial tube formation GO:0072175 130 0.010
sphingolipid biosynthetic process GO:0030148 26 0.010
reactive nitrogen species metabolic process GO:2001057 0 0.010
limb development GO:0060173 166 0.010
regulation of stem cell proliferation GO:0072091 78 0.010
epithelial cell development GO:0002064 159 0.010
response to oxygen radical GO:0000305 16 0.010
developmental programmed cell death GO:0010623 41 0.010
wound healing GO:0042060 157 0.010
cellular response to biotic stimulus GO:0071216 92 0.010
response to decreased oxygen levels GO:0036293 59 0.010
meiotic nuclear division GO:0007126 115 0.010
spermatid development GO:0007286 108 0.010
intracellular protein transport GO:0006886 204 0.010

Adamts5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.083
musculoskeletal system disease DOID:17 0 0.083
myopathy DOID:423 0 0.076
muscular disease DOID:0080000 0 0.076
muscle tissue disease DOID:66 0 0.076
nervous system disease DOID:863 0 0.048
sensory system disease DOID:0050155 0 0.021
eye and adnexa disease DOID:1492 0 0.021
retinal disease DOID:5679 0 0.018
retinal degeneration DOID:8466 0 0.018
eye disease DOID:5614 0 0.018
heart disease DOID:114 0 0.017
cardiovascular system disease DOID:1287 0 0.017
cardiomyopathy DOID:0050700 0 0.017
intrinsic cardiomyopathy DOID:0060036 0 0.015
central nervous system disease DOID:331 0 0.013
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010