Mus musculus

44 known processes

Adamts2

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2

(Aliases: mKIAA4060,A430089F14,ADAMTS-3,hPCPNI,4732482M10,KIAA4060,PCINP,ADAM-TS2)

Adamts2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular structure organization GO:0043062 148 0.933
extracellular matrix organization GO:0030198 147 0.911
collagen fibril organization GO:0030199 32 0.502
urogenital system development GO:0001655 261 0.485
Mouse
response to growth factor GO:0070848 198 0.458
regulation of cell adhesion GO:0030155 154 0.396
skeletal system development GO:0001501 356 0.226
cellular response to growth factor stimulus GO:0071363 197 0.223
endochondral bone morphogenesis GO:0060350 50 0.215
blood vessel morphogenesis GO:0048514 285 0.215
bone development GO:0060348 120 0.204
cellular response to amino acid stimulus GO:0071230 29 0.194
heart morphogenesis GO:0003007 178 0.176
cell adhesion GO:0007155 329 0.174
cellular response to organonitrogen compound GO:0071417 145 0.147
trabecula formation GO:0060343 24 0.142
embryonic skeletal system morphogenesis GO:0048704 91 0.142
protein heterooligomerization GO:0051291 14 0.130
sensory organ morphogenesis GO:0090596 242 0.125
small gtpase mediated signal transduction GO:0007264 97 0.123
cell substrate adhesion GO:0031589 130 0.121
protein heterotrimerization GO:0070208 8 0.120
physiological cardiac muscle hypertrophy GO:0003301 3 0.120
respiratory system development GO:0060541 190 0.120
ossification GO:0001503 216 0.119
renal system development GO:0072001 225 0.115
Mouse
regulation of cytokine production GO:0001817 266 0.111
regulation of cell motility GO:2000145 236 0.108
regulation of angiogenesis GO:0045765 81 0.099
oxidation reduction process GO:0055114 342 0.097
extrinsic apoptotic signaling pathway GO:0097191 126 0.096
protein trimerization GO:0070206 13 0.094
chondrocyte differentiation GO:0002062 72 0.092
palate development GO:0060021 76 0.090
response to amino acid GO:0043200 37 0.090
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.088
cardiac chamber development GO:0003205 108 0.087
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.087
connective tissue development GO:0061448 179 0.086
cell matrix adhesion GO:0007160 68 0.085
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.079
appendage morphogenesis GO:0035107 149 0.079
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.079
digestive system development GO:0055123 200 0.077
lung development GO:0030324 164 0.077
protein maturation GO:0051604 176 0.077
protein oligomerization GO:0051259 67 0.076
negative regulation of cell migration GO:0030336 59 0.076
positive regulation of nervous system development GO:0051962 221 0.075
embryonic skeletal system development GO:0048706 120 0.075
proteoglycan metabolic process GO:0006029 38 0.074
skin development GO:0043588 220 0.073
apoptotic signaling pathway GO:0097190 306 0.070
kidney development GO:0001822 213 0.067
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.067
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.066
nephron development GO:0072006 109 0.066
Mouse
response to organonitrogen compound GO:0010243 246 0.064
trabecula morphogenesis GO:0061383 40 0.063
respiratory tube development GO:0030323 167 0.063
regulation of cell migration GO:0030334 219 0.062
epithelial cell proliferation GO:0050673 174 0.061
regulation of apoptotic signaling pathway GO:2001233 197 0.060
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.058
forebrain development GO:0030900 302 0.057
cell recognition GO:0008037 83 0.057
fat cell differentiation GO:0045444 160 0.055
spermatogenesis GO:0007283 284 0.054
negative regulation of cell adhesion GO:0007162 45 0.053
defense response to bacterium GO:0042742 119 0.053
negative regulation of apoptotic signaling pathway GO:2001234 104 0.052
hexose metabolic process GO:0019318 98 0.052
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.051
limb development GO:0060173 166 0.051
camera type eye development GO:0043010 266 0.051
cardiac chamber morphogenesis GO:0003206 93 0.051
ureteric bud development GO:0001657 94 0.051
Mouse
ovulation GO:0030728 15 0.050
appendage development GO:0048736 166 0.048
regulation of cellular ketone metabolic process GO:0010565 66 0.048
anatomical structure homeostasis GO:0060249 145 0.047
branching morphogenesis of an epithelial tube GO:0048754 159 0.047
Mouse
positive regulation of cell substrate adhesion GO:0010811 47 0.047
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.047
kidney epithelium development GO:0072073 121 0.047
Mouse
digestive tract development GO:0048565 190 0.046
cellular response to bmp stimulus GO:0071773 14 0.046
positive regulation of cell adhesion GO:0045785 80 0.045
positive regulation of cellular amine metabolic process GO:0033240 5 0.045
ear development GO:0043583 200 0.044
positive regulation of cytokine production GO:0001819 174 0.044
regulation of fat cell differentiation GO:0045598 81 0.044
regulation of response to wounding GO:1903034 189 0.043
cellular response to acid chemical GO:0071229 68 0.043
response to bmp GO:0071772 14 0.043
limb morphogenesis GO:0035108 149 0.043
glycoprotein metabolic process GO:0009100 116 0.043
cell growth involved in cardiac muscle cell development GO:0061049 3 0.043
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.043
mesenchyme development GO:0060485 152 0.042
carbohydrate metabolic process GO:0005975 230 0.042
muscle tissue development GO:0060537 308 0.041
male gamete generation GO:0048232 285 0.041
elastic fiber assembly GO:0048251 4 0.041
recognition of apoptotic cell GO:0043654 3 0.040
signal transduction in absence of ligand GO:0038034 55 0.040
mesonephros development GO:0001823 97 0.040
Mouse
regulation of system process GO:0044057 200 0.039
developmental maturation GO:0021700 193 0.039
telencephalon development GO:0021537 186 0.039
adiponectin secretion GO:0070162 2 0.039
angiogenesis GO:0001525 201 0.038
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 2 0.038
lateral line system development GO:0048925 1 0.037
organ growth GO:0035265 117 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
head morphogenesis GO:0060323 34 0.037
physiological muscle hypertrophy GO:0003298 3 0.037
positive regulation of adiponectin secretion GO:0070165 1 0.036
pallium development GO:0021543 120 0.036
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.036
odontogenesis GO:0042476 78 0.035
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.035
carbohydrate homeostasis GO:0033500 128 0.035
negative regulation of nervous system development GO:0051961 156 0.035
cytokine production GO:0001816 319 0.034
renal tubule morphogenesis GO:0061333 72 0.034
Mouse
fibril organization GO:0097435 2 0.033
cerebral cortex development GO:0021987 86 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
negative regulation of epithelial cell proliferation GO:0050680 64 0.032
cellular amino acid metabolic process GO:0006520 103 0.032
central nervous system vasculogenesis GO:0022009 3 0.031
striated muscle tissue development GO:0014706 293 0.030
heart trabecula formation GO:0060347 14 0.030
cardiac muscle tissue development GO:0048738 130 0.029
skeletal system morphogenesis GO:0048705 203 0.029
bone trabecula formation GO:0060346 9 0.028
bone trabecula morphogenesis GO:0061430 12 0.028
cellular lipid metabolic process GO:0044255 323 0.028
embryonic organ morphogenesis GO:0048562 276 0.028
regulation of vasculature development GO:1901342 88 0.028
prostate gland morphogenesis GO:0060512 32 0.028
kidney morphogenesis GO:0060993 83 0.027
Mouse
endoderm development GO:0007492 45 0.027
muscle tissue morphogenesis GO:0060415 53 0.027
negative regulation of cell development GO:0010721 169 0.027
lateral inhibition GO:0046331 1 0.027
rho protein signal transduction GO:0007266 32 0.027
monocarboxylic acid metabolic process GO:0032787 191 0.026
negative regulation of neuron migration GO:2001223 6 0.026
sensory system development GO:0048880 3 0.026
ear morphogenesis GO:0042471 118 0.026
hexose biosynthetic process GO:0019319 39 0.025
bone morphogenesis GO:0060349 78 0.025
cardiac ventricle morphogenesis GO:0003208 50 0.025
regulation of neuron migration GO:2001222 22 0.025
uterus morphogenesis GO:0061038 2 0.025
response to acid chemical GO:0001101 111 0.025
regulation of organ growth GO:0046620 61 0.025
stem cell differentiation GO:0048863 268 0.025
regulation of adiponectin secretion GO:0070163 2 0.025
negative regulation of neuron differentiation GO:0045665 101 0.025
axonogenesis GO:0007409 274 0.024
development of primary female sexual characteristics GO:0046545 73 0.024
negative regulation of cell motility GO:2000146 61 0.024
formation of primary germ layer GO:0001704 77 0.024
tissue migration GO:0090130 68 0.024
regulation of hormone levels GO:0010817 211 0.024
notochord development GO:0030903 20 0.024
regulation of carbohydrate metabolic process GO:0006109 75 0.024
peptide transport GO:0015833 133 0.023
endochondral bone growth GO:0003416 19 0.023
regulation of ras protein signal transduction GO:0046578 114 0.023
cellular carbohydrate metabolic process GO:0044262 119 0.023
neuron projection guidance GO:0097485 141 0.023
metanephros development GO:0001656 79 0.023
glucose metabolic process GO:0006006 92 0.023
sensory perception GO:0007600 245 0.023
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.023
single organism cell adhesion GO:0098602 156 0.022
positive regulation of fatty acid oxidation GO:0046321 4 0.022
inner ear morphogenesis GO:0042472 101 0.022
interleukin 8 secretion GO:0072606 3 0.022
ras protein signal transduction GO:0007265 77 0.022
regulation of chondrocyte differentiation GO:0032330 33 0.022
cartilage development GO:0051216 140 0.022
negative regulation of phospholipase activity GO:0010519 4 0.022
pigmentation GO:0043473 71 0.022
nitrogen compound transport GO:0071705 271 0.021
response to oxidative stress GO:0006979 123 0.021
chondrocyte development GO:0002063 24 0.021
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.021
amine metabolic process GO:0009308 45 0.021
cell adhesion mediated by integrin GO:0033627 18 0.021
regulation of glucose metabolic process GO:0010906 60 0.021
positive regulation of protein modification process GO:0031401 299 0.021
female gonad development GO:0008585 71 0.021
regulation of cardiac muscle tissue growth GO:0055021 26 0.021
female sex differentiation GO:0046660 84 0.021
carbohydrate biosynthetic process GO:0016051 74 0.021
cellular amine metabolic process GO:0044106 44 0.021
aorta smooth muscle tissue morphogenesis GO:0060414 2 0.021
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
ameboidal type cell migration GO:0001667 128 0.020
myeloid leukocyte migration GO:0097529 57 0.020
positive regulation of neuron projection regeneration GO:0070572 2 0.020
chemotaxis GO:0006935 247 0.019
extracellular matrix assembly GO:0085029 12 0.019
replacement ossification GO:0036075 26 0.019
multicellular organism growth GO:0035264 161 0.019
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.019
monosaccharide metabolic process GO:0005996 106 0.019
nephron tubule development GO:0072080 84 0.019
Mouse
embryonic limb morphogenesis GO:0030326 126 0.019
dorsal ventral axon guidance GO:0033563 3 0.019
gliogenesis GO:0042063 141 0.019
regulation of rho protein signal transduction GO:0035023 71 0.018
face development GO:0060324 38 0.018
interleukin 8 production GO:0032637 4 0.018
response to reactive oxygen species GO:0000302 56 0.018
regulation of endothelial cell migration GO:0010594 22 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
cellular response to external stimulus GO:0071496 88 0.018
regulation of proteolysis GO:0030162 164 0.018
cellular response to oxidative stress GO:0034599 76 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
regulation of secretion GO:0051046 274 0.018
cellular macromolecule catabolic process GO:0044265 206 0.018
cellular response to cytokine stimulus GO:0071345 189 0.018
neuroepithelial cell differentiation GO:0060563 37 0.018
glucose homeostasis GO:0042593 128 0.017
female gamete generation GO:0007292 74 0.017
bmp signaling pathway GO:0030509 93 0.017
response to monosaccharide GO:0034284 67 0.017
regionalization GO:0003002 337 0.017
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.017
smoothened signaling pathway GO:0007224 105 0.017
mitotic cell cycle GO:0000278 195 0.017
cardiac ventricle development GO:0003231 83 0.017
mesenchymal cell differentiation GO:0048762 107 0.017
positive regulation of developmental pigmentation GO:0048087 6 0.017
growth plate cartilage development GO:0003417 14 0.017
negative regulation of macrophage chemotaxis GO:0010760 1 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
gonad development GO:0008406 141 0.017
regulation of mapk cascade GO:0043408 248 0.016
heart trabecula morphogenesis GO:0061384 26 0.016
stem cell development GO:0048864 219 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.016
antimicrobial peptide secretion GO:0002776 1 0.016
cellular glucan metabolic process GO:0006073 32 0.016
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.016
morphogenesis of an endothelium GO:0003159 2 0.016
negative regulation of proteolysis GO:0045861 74 0.016
positive regulation of melanocyte differentiation GO:0045636 5 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
positive regulation of apoptotic process GO:0043065 217 0.015
positive regulation of cell projection organization GO:0031346 95 0.015
anatomical structure maturation GO:0071695 49 0.015
activation of immune response GO:0002253 138 0.015
positive regulation of pigment cell differentiation GO:0050942 5 0.015
prostate gland epithelium morphogenesis GO:0060740 31 0.015
cellular response to inorganic substance GO:0071241 37 0.015
regulation of protein maturation GO:1903317 96 0.015
cardiac muscle tissue growth GO:0055017 37 0.015
positive regulation of cell development GO:0010720 237 0.015
midgut development GO:0007494 4 0.015
cardiac muscle hypertrophy GO:0003300 23 0.015
nucleobase containing small molecule metabolic process GO:0055086 352 0.015
negative regulation of blood vessel morphogenesis GO:2000181 25 0.015
mucopolysaccharide metabolic process GO:1903510 25 0.015
ventricular cardiac muscle tissue development GO:0003229 38 0.015
regulation of organelle organization GO:0033043 289 0.015
regulation of protein secretion GO:0050708 82 0.015
regulation of chemotaxis GO:0050920 53 0.015
neuron migration GO:0001764 122 0.015
ovulation from ovarian follicle GO:0001542 9 0.015
regulation of bmp signaling pathway GO:0030510 60 0.015
negative regulation of immune system process GO:0002683 209 0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.015
positive regulation of cell migration GO:0030335 109 0.015
response to transforming growth factor beta GO:0071559 88 0.014
positive regulation of cell death GO:0010942 224 0.014
transmembrane transport GO:0055085 412 0.014
regulation of peptidase activity GO:0052547 96 0.014
regulation of developmental pigmentation GO:0048070 14 0.014
cellular response to nitric oxide GO:0071732 4 0.014
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.014
segmentation GO:0035282 93 0.014
leukocyte chemotaxis GO:0030595 69 0.014
positive regulation of apoptotic signaling pathway GO:2001235 95 0.014
melanocyte differentiation GO:0030318 25 0.014
glucose transport GO:0015758 56 0.014
heart growth GO:0060419 45 0.014
positive regulation of hormone secretion GO:0046887 38 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
hormone secretion GO:0046879 128 0.014
regulation of testosterone biosynthetic process GO:2000224 2 0.014
ovulation cycle GO:0042698 59 0.014
neuromuscular process GO:0050905 99 0.014
nephron tubule morphogenesis GO:0072078 68 0.014
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
defense response to other organism GO:0098542 197 0.013
cellular ketone metabolic process GO:0042180 84 0.013
positive regulation vascular endothelial growth factor production GO:0010575 10 0.013
response to inorganic substance GO:0010035 96 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.013
glial cell migration GO:0008347 7 0.013
sperm egg recognition GO:0035036 37 0.013
development of primary sexual characteristics GO:0045137 143 0.013
innate immune response GO:0045087 157 0.013
negative regulation of growth GO:0045926 99 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
protein hydroxylation GO:0018126 4 0.013
glucan metabolic process GO:0044042 32 0.013
regulation of defense response GO:0031347 233 0.013
regulation of epithelial cell migration GO:0010632 35 0.013
synapse organization GO:0050808 125 0.013
sulfur compound metabolic process GO:0006790 100 0.013
single fertilization GO:0007338 82 0.013
endothelial cell migration GO:0043542 44 0.013
odontogenesis of dentin containing tooth GO:0042475 66 0.013
mesenchymal cell development GO:0014031 93 0.013
renal tubule development GO:0061326 87 0.012
Mouse
regulation of carbohydrate biosynthetic process GO:0043255 40 0.012
cell chemotaxis GO:0060326 81 0.012
metanephric loop of henle development GO:0072236 4 0.012
insulin processing GO:0030070 2 0.012
transmission of nerve impulse GO:0019226 76 0.012
generation of precursor metabolites and energy GO:0006091 103 0.012
gland development GO:0048732 330 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
humoral immune response GO:0006959 57 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
Mouse
endomembrane system organization GO:0010256 147 0.012
regulation of cell projection organization GO:0031344 206 0.012
developmental pigmentation GO:0048066 40 0.012
regulation of cell substrate adhesion GO:0010810 73 0.012
germ cell development GO:0007281 185 0.012
immune effector process GO:0002252 321 0.012
compound eye development GO:0048749 1 0.012
retina development in camera type eye GO:0060041 119 0.012
regulation of smoothened signaling pathway GO:0008589 58 0.012
extracellular fibril organization GO:0043206 2 0.012
regulation of protein processing GO:0070613 96 0.012
negative regulation of protein maturation GO:1903318 79 0.012
mesonephric duct morphogenesis GO:0072180 4 0.012
oviduct development GO:0060066 3 0.012
mesonephric epithelium development GO:0072163 94 0.012
Mouse
cellular modified amino acid metabolic process GO:0006575 63 0.011
negative regulation of fat cell differentiation GO:0045599 36 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
negative regulation of angiogenesis GO:0016525 25 0.011
rhythmic process GO:0048511 174 0.011
protein processing GO:0016485 163 0.011
gastrulation GO:0007369 116 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.011
fatty acid metabolic process GO:0006631 121 0.011
face morphogenesis GO:0060325 29 0.011
epithelial cell development GO:0002064 159 0.011
neuromuscular process controlling balance GO:0050885 59 0.011
phagosome maturation GO:0090382 4 0.011
regulation of secretion by cell GO:1903530 249 0.011
negative regulation of bmp signaling pathway GO:0030514 35 0.011
regulation of cardiac muscle hypertrophy GO:0010611 13 0.011
tissue remodeling GO:0048771 102 0.011
negative regulation of lipoprotein lipase activity GO:0051005 1 0.011
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.011
regulation of anatomical structure size GO:0090066 178 0.011
fertilization GO:0009566 127 0.011
tendon development GO:0035989 6 0.011
lipid modification GO:0030258 65 0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.011
epidermis morphogenesis GO:0048730 33 0.011
cellular response to mechanical stimulus GO:0071260 7 0.011
sprouting angiogenesis GO:0002040 26 0.011
positive regulation of bmp signaling pathway GO:0030513 23 0.011
positive regulation of glucose import GO:0046326 14 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
adult behavior GO:0030534 135 0.011
positive regulation of anagen GO:0051885 1 0.011
ubiquitin dependent smad protein catabolic process GO:0030579 2 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
positive regulation of proteolysis GO:0045862 85 0.010
cellular polysaccharide metabolic process GO:0044264 38 0.010
positive regulation of behavior GO:0048520 40 0.010
positive regulation of glucose transport GO:0010828 16 0.010
cardiac cell development GO:0055006 41 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
inflammatory response GO:0006954 244 0.010
positive regulation of transferase activity GO:0051347 167 0.010
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.010
glucose import GO:0046323 32 0.010
negative regulation of neuron projection regeneration GO:0070571 3 0.010
peptide secretion GO:0002790 114 0.010
monosaccharide transport GO:0015749 58 0.010
aorta development GO:0035904 23 0.010
aorta morphogenesis GO:0035909 22 0.010
cellular response to abiotic stimulus GO:0071214 56 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
protein catabolic process GO:0030163 221 0.010
mesonephric tubule development GO:0072164 94 0.010
Mouse

Adamts2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.583
disease of anatomical entity DOID:7 0 0.583
nervous system disease DOID:863 0 0.583
musculoskeletal system disease DOID:17 0 0.436
muscular disease DOID:0080000 0 0.263
myopathy DOID:423 0 0.238
muscle tissue disease DOID:66 0 0.238
eye and adnexa disease DOID:1492 0 0.120
eye disease DOID:5614 0 0.120
connective tissue disease DOID:65 0 0.098
muscular dystrophy DOID:9884 0 0.086
retinal disease DOID:5679 0 0.072
congenital muscular dystrophy DOID:0050557 0 0.052
bone development disease DOID:0080006 0 0.049
bone disease DOID:0080001 0 0.049
osteochondrodysplasia DOID:2256 0 0.023
retinal degeneration DOID:8466 0 0.019
osteogenesis imperfecta DOID:12347 0 0.010