Mus musculus

0 known processes

Hecw1

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

(Aliases: Nedl1,9330116H24Rik,E130207I19Rik,AV273951)

Hecw1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transmembrane transport GO:0034220 361 0.247
synaptic transmission GO:0007268 329 0.152
transmembrane transport GO:0055085 412 0.137
locomotory behavior GO:0007626 195 0.135
g protein coupled glutamate receptor signaling pathway GO:0007216 3 0.086
sensory perception GO:0007600 245 0.080
regulation of neuron differentiation GO:0045664 281 0.076
regulation of membrane potential GO:0042391 192 0.066
cognition GO:0050890 149 0.064
regulation of cellular ketone metabolic process GO:0010565 66 0.063
skeletal system development GO:0001501 356 0.057
cell adhesion GO:0007155 329 0.056
regulation of system process GO:0044057 200 0.054
inorganic ion transmembrane transport GO:0098660 234 0.052
inorganic cation transmembrane transport GO:0098662 207 0.051
ribonucleotide metabolic process GO:0009259 291 0.050
regulation of cell projection organization GO:0031344 206 0.050
neuron neuron synaptic transmission GO:0007270 69 0.049
peptidyl amino acid modification GO:0018193 336 0.047
g protein coupled receptor signaling pathway GO:0007186 243 0.047
sensory organ morphogenesis GO:0090596 242 0.047
cellular ketone metabolic process GO:0042180 84 0.046
retina development in camera type eye GO:0060041 119 0.045
long term synaptic potentiation GO:0060291 25 0.042
cellular homeostasis GO:0019725 240 0.042
regulation of neuron projection development GO:0010975 169 0.041
camera type eye development GO:0043010 266 0.041
conditioned taste aversion GO:0001661 4 0.040
adult behavior GO:0030534 135 0.040
cellular amino acid metabolic process GO:0006520 103 0.039
positive regulation of hydrolase activity GO:0051345 148 0.039
positive regulation of cell development GO:0010720 237 0.037
synapse organization GO:0050808 125 0.037
regulation of cellular amino acid metabolic process GO:0006521 5 0.037
nucleotide metabolic process GO:0009117 332 0.037
nitrogen compound transport GO:0071705 271 0.037
learning or memory GO:0007611 148 0.035
cation transmembrane transport GO:0098655 266 0.033
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.032
skin development GO:0043588 220 0.031
negative regulation of cell proliferation GO:0008285 296 0.031
negative regulation of bone trabecula formation GO:1900155 1 0.031
nucleoside metabolic process GO:0009116 246 0.031
regulation of ion transmembrane transport GO:0034765 119 0.030
stem cell differentiation GO:0048863 268 0.029
heterocycle catabolic process GO:0046700 280 0.029
regulation of organelle organization GO:0033043 289 0.029
cellular chemical homeostasis GO:0055082 215 0.029
calcium ion homeostasis GO:0055074 127 0.029
nucleobase containing small molecule metabolic process GO:0055086 352 0.029
regulation of secretion GO:0051046 274 0.029
gland development GO:0048732 330 0.028
regulation of synaptic plasticity GO:0048167 87 0.028
divalent inorganic cation transport GO:0072511 178 0.028
regulation of feeding behavior GO:0060259 3 0.028
axonogenesis GO:0007409 274 0.028
ribonucleoside metabolic process GO:0009119 245 0.027
metal ion homeostasis GO:0055065 189 0.027
regulation of transmembrane transport GO:0034762 128 0.027
cellular nitrogen compound catabolic process GO:0044270 280 0.027
adult walking behavior GO:0007628 41 0.026
amine metabolic process GO:0009308 45 0.026
exocytosis GO:0006887 121 0.026
adult locomotory behavior GO:0008344 91 0.026
multicellular organism growth GO:0035264 161 0.025
organic anion transport GO:0015711 137 0.025
divalent inorganic cation homeostasis GO:0072507 138 0.025
negative regulation of cell development GO:0010721 169 0.025
ribonucleoside triphosphate catabolic process GO:0009203 199 0.025
endomembrane system organization GO:0010256 147 0.025
retina morphogenesis in camera type eye GO:0060042 45 0.025
negative regulation of cellular component organization GO:0051129 194 0.024
positive regulation of nervous system development GO:0051962 221 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
calcium ion transport GO:0006816 159 0.024
ras protein signal transduction GO:0007265 77 0.024
learning GO:0007612 98 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
ear development GO:0043583 200 0.024
mechanoreceptor differentiation GO:0042490 67 0.024
positive regulation of neuron differentiation GO:0045666 141 0.023
cellular amine metabolic process GO:0044106 44 0.023
ribose phosphate metabolic process GO:0019693 291 0.023
negative regulation of nervous system development GO:0051961 156 0.023
positive regulation of protein modification process GO:0031401 299 0.023
positive regulation of long term neuronal synaptic plasticity GO:0048170 3 0.023
divalent metal ion transport GO:0070838 172 0.023
purine nucleoside metabolic process GO:0042278 241 0.022
regulation of ion transport GO:0043269 215 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
glucose homeostasis GO:0042593 128 0.022
amide transport GO:0042886 138 0.022
cellular calcium ion homeostasis GO:0006874 119 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
ribonucleoside catabolic process GO:0042454 206 0.021
organelle localization GO:0051640 179 0.021
telencephalon development GO:0021537 186 0.021
endocytosis GO:0006897 168 0.021
response to organic cyclic compound GO:0014070 198 0.021
embryonic organ morphogenesis GO:0048562 276 0.021
striated muscle tissue development GO:0014706 293 0.021
regulation of hormone levels GO:0010817 211 0.021
aromatic compound catabolic process GO:0019439 286 0.021
neurotransmitter transport GO:0006836 76 0.021
purine nucleotide metabolic process GO:0006163 302 0.020
regulation of kinase activity GO:0043549 249 0.020
carbohydrate homeostasis GO:0033500 128 0.020
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway GO:0007196 3 0.020
regulation of homeostatic process GO:0032844 182 0.020
dendrite development GO:0016358 115 0.020
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
vesicle localization GO:0051648 86 0.020
fat cell differentiation GO:0045444 160 0.020
regulation of purine nucleotide catabolic process GO:0033121 122 0.020
cation transport GO:0006812 399 0.020
peptide secretion GO:0002790 114 0.020
purine nucleotide catabolic process GO:0006195 211 0.019
regulation of neurotransmitter levels GO:0001505 87 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
regulation of secretion by cell GO:1903530 249 0.019
regulation of purine nucleotide metabolic process GO:1900542 169 0.019
visual perception GO:0007601 52 0.019
positive regulation of protein kinase activity GO:0045860 144 0.019
cell type specific apoptotic process GO:0097285 268 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
regulation of hydrolase activity GO:0051336 246 0.019
regulation of ion transmembrane transporter activity GO:0032412 54 0.019
regulation of nucleoside metabolic process GO:0009118 130 0.019
central nervous system neuron differentiation GO:0021953 162 0.018
stem cell development GO:0048864 219 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
positive regulation of transferase activity GO:0051347 167 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
developmental cell growth GO:0048588 84 0.018
regulation of transporter activity GO:0032409 57 0.018
muscle tissue development GO:0060537 308 0.018
anion transport GO:0006820 177 0.018
response to organonitrogen compound GO:0010243 246 0.018
cellular ion homeostasis GO:0006873 165 0.018
cellular lipid metabolic process GO:0044255 323 0.018
small gtpase mediated signal transduction GO:0007264 97 0.018
transmission of nerve impulse GO:0019226 76 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
apoptotic signaling pathway GO:0097190 306 0.017
mapk cascade GO:0000165 281 0.017
epithelial cell development GO:0002064 159 0.017
microtubule based process GO:0007017 236 0.017
regulation of postsynaptic membrane potential GO:0060078 48 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
covalent chromatin modification GO:0016569 163 0.017
cation homeostasis GO:0055080 212 0.017
positive regulation of kinase activity GO:0033674 155 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
multicellular organismal response to stress GO:0033555 62 0.017
positive regulation of organelle organization GO:0010638 128 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.016
nuclear division GO:0000280 158 0.016
mitochondrion distribution GO:0048311 4 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
cell substrate adhesion GO:0031589 130 0.016
cellular divalent inorganic cation homeostasis GO:0072503 127 0.016
positive regulation of gtpase activity GO:0043547 85 0.016
regulation of cell adhesion GO:0030155 154 0.016
ossification GO:0001503 216 0.016
cell maturation GO:0048469 127 0.016
nucleoside catabolic process GO:0009164 206 0.016
positive regulation of secretion by cell GO:1903532 114 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.016
regulation of neuronal synaptic plasticity GO:0048168 30 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
fear response GO:0042596 33 0.016
positive regulation of cell projection organization GO:0031346 95 0.016
male gamete generation GO:0048232 285 0.016
action potential GO:0001508 78 0.015
developmental maturation GO:0021700 193 0.015
engulfment of apoptotic cell GO:0043652 3 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.015
single organism cell adhesion GO:0098602 156 0.015
mitotic cell cycle process GO:1903047 159 0.015
regulation of transferase activity GO:0051338 263 0.015
behavioral fear response GO:0001662 28 0.015
hormone secretion GO:0046879 128 0.015
inter male aggressive behavior GO:0002121 3 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
behavioral defense response GO:0002209 28 0.015
regulation of mapk cascade GO:0043408 248 0.015
germ cell development GO:0007281 185 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
rap protein signal transduction GO:0032486 3 0.015
peptide transport GO:0015833 133 0.015
organophosphate catabolic process GO:0046434 232 0.015
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.015
digestive tract development GO:0048565 190 0.015
ribonucleotide catabolic process GO:0009261 208 0.014
palate development GO:0060021 76 0.014
multicellular organismal signaling GO:0035637 91 0.014
purine containing compound metabolic process GO:0072521 311 0.014
organelle fission GO:0048285 170 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
regulation of stem cell differentiation GO:2000736 50 0.014
cerebellum development GO:0021549 77 0.014
synaptic vesicle transport GO:0048489 57 0.014
cell growth GO:0016049 130 0.014
establishment of vesicle localization GO:0051650 81 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
neuron migration GO:0001764 122 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.014
histone modification GO:0016570 159 0.014
organic cyclic compound catabolic process GO:1901361 295 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
synaptic vesicle localization GO:0097479 59 0.014
insulin secretion GO:0030073 89 0.014
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
microtubule cytoskeleton organization GO:0000226 157 0.013
cardiac chamber development GO:0003205 108 0.013
positive regulation of phospholipase activity GO:0010518 3 0.013
sodium ion transport GO:0006814 73 0.013
positive regulation of keratinocyte proliferation GO:0010838 4 0.013
lipid transport GO:0006869 98 0.013
regulation of protein kinase activity GO:0045859 232 0.013
intracellular distribution of mitochondria GO:0048312 1 0.013
purine containing compound catabolic process GO:0072523 213 0.013
calcium ion transmembrane transport GO:0070588 85 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
carbohydrate metabolic process GO:0005975 230 0.013
erk1 and erk2 cascade GO:0070371 77 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
response to radiation GO:0009314 165 0.013
oxidation reduction process GO:0055114 342 0.013
cellular response to abiotic stimulus GO:0071214 56 0.013
memory GO:0007613 58 0.013
establishment of synaptic vesicle localization GO:0097480 57 0.013
rna splicing GO:0008380 54 0.013
compound eye development GO:0048749 1 0.013
inner ear receptor cell development GO:0060119 39 0.013
positive regulation of cell death GO:0010942 224 0.013
peptidyl serine phosphorylation GO:0018105 74 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
negative regulation of organelle organization GO:0010639 90 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
regulation of proteolysis GO:0030162 164 0.013
chromatin modification GO:0016568 187 0.013
negative regulation of neuron apoptotic process GO:0043524 92 0.013
positive regulation of cellular catabolic process GO:0031331 148 0.013
positive regulation of neuron projection development GO:0010976 79 0.013
sensory perception of light stimulus GO:0050953 54 0.013
single fertilization GO:0007338 82 0.013
neural retina development GO:0003407 41 0.013
chemotaxis GO:0006935 247 0.012
mrna metabolic process GO:0016071 84 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
protein secretion GO:0009306 111 0.012
regulation of map kinase activity GO:0043405 120 0.012
regulation of neuron death GO:1901214 134 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
maintenance of location GO:0051235 89 0.012
inner ear receptor cell differentiation GO:0060113 61 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
sodium ion transmembrane transport GO:0035725 49 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
regulation of cellular response to stress GO:0080135 159 0.012
anatomical structure homeostasis GO:0060249 145 0.012
central nervous system neuron development GO:0021954 67 0.012
cilium morphogenesis GO:0060271 102 0.012
rho protein signal transduction GO:0007266 32 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
macromolecule catabolic process GO:0009057 281 0.012
positive regulation of secretion GO:0051047 130 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
regulation of fat cell differentiation GO:0045598 81 0.012
hindbrain development GO:0030902 128 0.012
axon guidance GO:0007411 141 0.012
protein localization to organelle GO:0033365 185 0.012
immune effector process GO:0002252 321 0.012
forebrain development GO:0030900 302 0.012
fertilization GO:0009566 127 0.012
homeostasis of number of cells GO:0048872 210 0.012
sensory perception of mechanical stimulus GO:0050954 107 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.012
membrane hyperpolarization GO:0060081 21 0.012
response to acid chemical GO:0001101 111 0.012
positive regulation of nucleotide catabolic process GO:0030813 88 0.012
spermatogenesis GO:0007283 284 0.012
connective tissue development GO:0061448 179 0.012
response to retinoic acid GO:0032526 56 0.012
positive regulation of map kinase activity GO:0043406 84 0.011
regulation of cellular component size GO:0032535 121 0.011
response to peptide hormone GO:0043434 127 0.011
synaptic transmission glutamatergic GO:0035249 36 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
neuron apoptotic process GO:0051402 142 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
regulation of retina development in camera type eye GO:1902866 3 0.011
cell cell adhesion GO:0098609 41 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
sensory perception of pain GO:0019233 47 0.011
response to oxygen levels GO:0070482 62 0.011
regulation of anatomical structure size GO:0090066 178 0.011
membrane organization GO:0061024 245 0.011
bone development GO:0060348 120 0.011
epidermis development GO:0008544 187 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
skeletal muscle organ development GO:0060538 163 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
lipid localization GO:0010876 126 0.011
organelle assembly GO:0070925 177 0.011
nucleotide catabolic process GO:0009166 217 0.011
peptidyl lysine modification GO:0018205 77 0.011
chromatin organization GO:0006325 206 0.011
lateral line system development GO:0048925 1 0.011
blood vessel morphogenesis GO:0048514 285 0.011
placenta development GO:0001890 140 0.011
cellular protein complex assembly GO:0043623 116 0.011
b cell differentiation GO:0030183 78 0.011
establishment or maintenance of cell polarity GO:0007163 86 0.011
tissue homeostasis GO:0001894 115 0.011
positive regulation of nucleoside metabolic process GO:0045979 91 0.011
activation of mapkkk activity GO:0000185 1 0.011
metencephalon development GO:0022037 89 0.011
gtp catabolic process GO:0006184 143 0.011
organonitrogen compound catabolic process GO:1901565 264 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
defecation GO:0030421 1 0.011
vesicle organization GO:0016050 60 0.011
neurotransmitter secretion GO:0007269 62 0.011
feeding behavior GO:0007631 62 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
neuromuscular process GO:0050905 99 0.011
regulation of protein transport GO:0051223 163 0.010
bmp signaling pathway GO:0030509 93 0.010
cell division GO:0051301 120 0.010
rna processing GO:0006396 105 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.010
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.010
cardiac muscle contraction GO:0060048 32 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
positive regulation of fatty acid oxidation GO:0046321 4 0.010
protein acylation GO:0043543 64 0.010
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.010
neuron projection extension GO:1990138 64 0.010
associative learning GO:0008306 61 0.010
positive regulation of growth GO:0045927 104 0.010
response to growth factor GO:0070848 198 0.010
mitotic cell cycle GO:0000278 195 0.010
regulation of axon extension GO:0030516 43 0.010
regulation of neural retina development GO:0061074 3 0.010
negative regulation of cell cycle GO:0045786 123 0.010
regulation of peptide secretion GO:0002791 77 0.010
neuron death GO:0070997 154 0.010
sensory perception of sound GO:0007605 97 0.010
pancreatic a cell fate commitment GO:0003326 2 0.010

Hecw1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
nervous system disease DOID:863 0 0.074
sensory system disease DOID:0050155 0 0.024
gastrointestinal system cancer DOID:3119 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
central nervous system disease DOID:331 0 0.015
eye and adnexa disease DOID:1492 0 0.013
retinal disease DOID:5679 0 0.012
eye disease DOID:5614 0 0.012
retinal degeneration DOID:8466 0 0.011