Mus musculus

0 known processes

Ctsr

cathepsin R

(Aliases: AI428350)

Ctsr biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of microvillus organization GO:0032530 3 0.717
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.687
regulation of microvillus assembly GO:0032534 3 0.619
transforming growth factor beta secretion GO:0038044 1 0.580
negative regulation of endothelial cell migration GO:0010596 4 0.496
positive regulation of transforming growth factor beta secretion GO:2001203 1 0.464
regulation of transforming growth factor beta secretion GO:2001201 1 0.457
regulation of interleukin 10 secretion GO:2001179 4 0.204
interleukin 10 secretion GO:0072608 4 0.147
striated muscle tissue development GO:0014706 293 0.144
negative regulation of angiogenesis GO:0016525 25 0.143
myotube cell development GO:0014904 60 0.129
skeletal muscle fiber development GO:0048741 58 0.122
striated muscle cell development GO:0055002 125 0.119
muscle tissue development GO:0060537 308 0.115
muscle fiber development GO:0048747 76 0.107
camera type eye development GO:0043010 266 0.101
regulation of muscle tissue development GO:1901861 97 0.098
muscle cell development GO:0055001 133 0.094
skeletal muscle organ development GO:0060538 163 0.093
sensory perception GO:0007600 245 0.090
positive regulation of cell motility GO:2000147 116 0.089
angiogenesis GO:0001525 201 0.081
negative regulation of vasculature development GO:1901343 26 0.080
regulation of vasculature development GO:1901342 88 0.079
regulation of blood vessel endothelial cell migration GO:0043535 12 0.078
regulation of transferase activity GO:0051338 263 0.077
negative regulation of myoblast differentiation GO:0045662 18 0.077
action potential GO:0001508 78 0.076
regulation of myoblast differentiation GO:0045661 29 0.072
myotube differentiation GO:0014902 105 0.071
muscle cell differentiation GO:0042692 261 0.071
regulation of stem cell proliferation GO:0072091 78 0.068
positive regulation of neuroblast proliferation GO:0002052 19 0.067
cellular amino acid metabolic process GO:0006520 103 0.064
sprouting angiogenesis GO:0002040 26 0.062
regulation of cell motility GO:2000145 236 0.061
regulation of skeletal muscle fiber development GO:0048742 36 0.061
regulation of striated muscle cell differentiation GO:0051153 81 0.059
protein catabolic process GO:0030163 221 0.059
Mouse
negative regulation of blood vessel morphogenesis GO:2000181 25 0.059
transmission of nerve impulse GO:0019226 76 0.058
blood vessel endothelial cell migration GO:0043534 23 0.058
cation homeostasis GO:0055080 212 0.056
ear development GO:0043583 200 0.055
positive regulation of nervous system development GO:0051962 221 0.052
cellular homeostasis GO:0019725 240 0.051
regulation of neuroblast proliferation GO:1902692 27 0.051
positive regulation of cell migration GO:0030335 109 0.049
regulation of cellular amine metabolic process GO:0033238 20 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.048
detection of stimulus GO:0051606 84 0.047
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
ion transmembrane transport GO:0034220 361 0.046
stem cell proliferation GO:0072089 117 0.046
regulation of myotube differentiation GO:0010830 62 0.045
ameboidal type cell migration GO:0001667 128 0.045
blood vessel morphogenesis GO:0048514 285 0.045
leukocyte mediated immunity GO:0002443 174 0.044
myoblast differentiation GO:0045445 52 0.044
macromolecule catabolic process GO:0009057 281 0.044
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.043
neural precursor cell proliferation GO:0061351 121 0.042
positive regulation of endothelial cell migration GO:0010595 12 0.041
placenta development GO:0001890 140 0.041
Mouse
positive regulation of stem cell proliferation GO:2000648 59 0.041
positive regulation of angiogenesis GO:0045766 46 0.040
retina development in camera type eye GO:0060041 119 0.039
transmembrane transport GO:0055085 412 0.038
regulation of kinase activity GO:0043549 249 0.038
g protein coupled receptor signaling pathway GO:0007186 243 0.038
regulation of cellular component biogenesis GO:0044087 181 0.037
positive regulation of cellular amine metabolic process GO:0033240 5 0.037
nitrogen compound transport GO:0071705 271 0.036
cellular amine metabolic process GO:0044106 44 0.036
negative regulation of muscle cell differentiation GO:0051148 33 0.035
oxidation reduction process GO:0055114 342 0.035
defense response to bacterium GO:0042742 119 0.035
positive regulation of epithelial cell migration GO:0010634 19 0.035
response to organic cyclic compound GO:0014070 198 0.035
positive regulation of cell development GO:0010720 237 0.035
adaptive immune response GO:0002250 155 0.035
regulation of protein serine threonine kinase activity GO:0071900 157 0.035
cytokine production GO:0001816 319 0.035
amine metabolic process GO:0009308 45 0.035
regulation of cell projection assembly GO:0060491 38 0.034
response to radiation GO:0009314 165 0.034
positive regulation of cytokine production GO:0001819 174 0.033
negative regulation of epithelial cell migration GO:0010633 9 0.033
positive regulation of neural precursor cell proliferation GO:2000179 42 0.033
photoreceptor cell differentiation GO:0046530 52 0.032
skeletal system development GO:0001501 356 0.032
cation transmembrane transport GO:0098655 266 0.032
adult behavior GO:0030534 135 0.031
regulation of coagulation GO:0050818 31 0.030
aromatic compound catabolic process GO:0019439 286 0.030
response to light stimulus GO:0009416 135 0.030
cellular chemical homeostasis GO:0055082 215 0.030
cellular lipid metabolic process GO:0044255 323 0.029
metal ion homeostasis GO:0055065 189 0.029
sensory organ morphogenesis GO:0090596 242 0.029
immune effector process GO:0002252 321 0.029
connective tissue development GO:0061448 179 0.029
positive regulation of transferase activity GO:0051347 167 0.029
regulation of cell migration GO:0030334 219 0.029
regulation of endothelial cell migration GO:0010594 22 0.028
immune response activating signal transduction GO:0002757 116 0.028
cellular ketone metabolic process GO:0042180 84 0.028
cation transport GO:0006812 399 0.028
purine containing compound catabolic process GO:0072523 213 0.027
multicellular organismal signaling GO:0035637 91 0.027
retina morphogenesis in camera type eye GO:0060042 45 0.027
endothelial cell migration GO:0043542 44 0.027
monosaccharide metabolic process GO:0005996 106 0.027
leukocyte differentiation GO:0002521 342 0.026
associative learning GO:0008306 61 0.026
regulation of membrane potential GO:0042391 192 0.026
defense response to gram positive bacterium GO:0050830 50 0.026
regulation of hormone levels GO:0010817 211 0.026
synaptic transmission GO:0007268 329 0.026
regulation of lymphocyte proliferation GO:0050670 117 0.026
regulation of angiogenesis GO:0045765 81 0.026
inorganic ion transmembrane transport GO:0098660 234 0.025
carbohydrate metabolic process GO:0005975 230 0.025
purine nucleoside catabolic process GO:0006152 205 0.025
regulation of hydrolase activity GO:0051336 246 0.025
positive regulation of protein oligomerization GO:0032461 4 0.025
wound healing GO:0042060 157 0.025
negative regulation of cell motility GO:2000146 61 0.025
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.025
axonogenesis GO:0007409 274 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
positive regulation of response to wounding GO:1903036 66 0.024
multicellular organismal response to stress GO:0033555 62 0.024
negative regulation of growth GO:0045926 99 0.024
circulatory system process GO:0003013 197 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
trophoblast giant cell differentiation GO:0060707 15 0.024
Mouse
heterocycle catabolic process GO:0046700 280 0.024
positive regulation of protein modification process GO:0031401 299 0.024
conditioned taste aversion GO:0001661 4 0.023
positive regulation of cell projection organization GO:0031346 95 0.023
sensory perception of light stimulus GO:0050953 54 0.023
extracellular structure organization GO:0043062 148 0.023
regulation of cytokine production GO:0001817 266 0.023
response to amino acid GO:0043200 37 0.023
heart process GO:0003015 94 0.023
epithelium migration GO:0090132 63 0.023
extracellular matrix organization GO:0030198 147 0.022
cell type specific apoptotic process GO:0097285 268 0.022
regulation of neural precursor cell proliferation GO:2000177 70 0.022
learning or memory GO:0007611 148 0.022
regulation of leukocyte differentiation GO:1902105 159 0.022
response to inorganic substance GO:0010035 96 0.022
visual perception GO:0007601 52 0.022
epidermis development GO:0008544 187 0.022
negative regulation of protein metabolic process GO:0051248 282 0.021
regulation of blood coagulation GO:0030193 28 0.021
positive regulation of kinase activity GO:0033674 155 0.021
hematopoietic progenitor cell differentiation GO:0002244 143 0.021
cellular metal ion homeostasis GO:0006875 151 0.021
regulation of epithelial cell migration GO:0010632 35 0.021
epithelial cell migration GO:0010631 63 0.021
mitotic cell cycle GO:0000278 195 0.021
Mouse
regulation of t cell proliferation GO:0042129 92 0.021
regulation of protein kinase activity GO:0045859 232 0.021
t cell activation GO:0042110 289 0.021
cell adhesion GO:0007155 329 0.020
learning GO:0007612 98 0.020
regulation of ion transport GO:0043269 215 0.020
neuronal action potential GO:0019228 54 0.020
cellular divalent inorganic cation homeostasis GO:0072503 127 0.020
skin development GO:0043588 220 0.020
regulation of hemostasis GO:1900046 28 0.020
positive regulation of protein kinase activity GO:0045860 144 0.020
hemostasis GO:0007599 78 0.020
myeloid leukocyte differentiation GO:0002573 119 0.020
tumor necrosis factor production GO:0032640 50 0.020
tissue homeostasis GO:0001894 115 0.020
nucleoside metabolic process GO:0009116 246 0.020
regulation of neuron differentiation GO:0045664 281 0.019
organic anion transport GO:0015711 137 0.019
chromatin organization GO:0006325 206 0.019
anatomical structure homeostasis GO:0060249 145 0.019
peptidyl amino acid modification GO:0018193 336 0.019
regulation of system process GO:0044057 200 0.019
tissue migration GO:0090130 68 0.019
positive regulation of secretion by cell GO:1903532 114 0.019
cellular response to organic cyclic compound GO:0071407 87 0.019
positive regulation of mapk cascade GO:0043410 170 0.018
regulation of protein transport GO:0051223 163 0.018
regulation of proteolysis GO:0030162 164 0.018
multi multicellular organism process GO:0044706 109 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
cellular nitrogen compound catabolic process GO:0044270 280 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
bone resorption GO:0045453 38 0.018
embryonic placenta development GO:0001892 98 0.018
Mouse
regulation of lymphocyte activation GO:0051249 240 0.018
glucose homeostasis GO:0042593 128 0.018
cognition GO:0050890 149 0.018
fear response GO:0042596 33 0.018
protein maturation GO:0051604 176 0.018
photoreceptor cell morphogenesis GO:0008594 3 0.017
rhythmic process GO:0048511 174 0.017
neuron projection guidance GO:0097485 141 0.017
photoreceptor cell development GO:0042461 40 0.017
defense response to other organism GO:0098542 197 0.017
regulation of wound healing GO:0061041 40 0.017
gamma aminobutyric acid signaling pathway GO:0007214 8 0.017
calcium ion transport GO:0006816 159 0.017
axon ensheathment GO:0008366 76 0.017
purine ribonucleotide catabolic process GO:0009154 208 0.017
regulation of protein catabolic process GO:0042176 108 0.017
sa node cell action potential GO:0086015 4 0.017
response to oxygen levels GO:0070482 62 0.017
regulation of protein oligomerization GO:0032459 4 0.017
t cell proliferation GO:0042098 120 0.016
myeloid cell differentiation GO:0030099 233 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
mapk cascade GO:0000165 281 0.016
glycosyl compound catabolic process GO:1901658 206 0.016
response to growth factor GO:0070848 198 0.016
cell growth involved in cardiac muscle cell development GO:0061049 3 0.016
sensory perception of sound GO:0007605 97 0.016
negative regulation of cell migration GO:0030336 59 0.016
regulation of action potential GO:0098900 4 0.016
visual learning GO:0008542 44 0.016
fat cell differentiation GO:0045444 160 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
detection of abiotic stimulus GO:0009582 60 0.016
positive regulation of immune effector process GO:0002699 107 0.016
neuron death GO:0070997 154 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
nucleotide metabolic process GO:0009117 332 0.016
neuroblast proliferation GO:0007405 49 0.016
regulation of leukocyte proliferation GO:0070663 121 0.016
regulation of response to wounding GO:1903034 189 0.016
regulation of cell projection organization GO:0031344 206 0.015
tissue remodeling GO:0048771 102 0.015
Mouse
regulation of secretion by cell GO:1903530 249 0.015
positive regulation of eosinophil migration GO:2000418 2 0.015
development of primary sexual characteristics GO:0045137 143 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
positive regulation of blood vessel endothelial cell migration GO:0043536 5 0.015
response to acid chemical GO:0001101 111 0.015
axon target recognition GO:0007412 4 0.015
exocytosis GO:0006887 121 0.015
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
regulation of feeding behavior GO:0060259 3 0.015
female sex differentiation GO:0046660 84 0.015
coagulation GO:0050817 78 0.015
positive regulation of phospholipase activity GO:0010518 3 0.015
carbohydrate derivative catabolic process GO:1901136 231 0.015
regulation of protein maturation GO:1903317 96 0.015
regulation of phospholipase a2 activity GO:0032429 3 0.015
stem cell differentiation GO:0048863 268 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
positive regulation of defense response GO:0031349 124 0.015
inflammatory response GO:0006954 244 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
morphogenesis of a branching structure GO:0001763 203 0.015
regulation of phospholipase c activity GO:1900274 3 0.015
carboxylic acid transport GO:0046942 100 0.015
regulation of protein processing GO:0070613 96 0.015
detection of stimulus involved in sensory perception GO:0050906 44 0.014
regulation of anatomical structure size GO:0090066 178 0.014
activation of immune response GO:0002253 138 0.014
adult locomotory behavior GO:0008344 91 0.014
regulation of secretion GO:0051046 274 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
neuromuscular process GO:0050905 99 0.014
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
regulation of organelle organization GO:0033043 289 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.014
retinal cone cell development GO:0046549 8 0.014
cell recognition GO:0008037 83 0.014
palate development GO:0060021 76 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
calcium ion homeostasis GO:0055074 127 0.014
monosaccharide transport GO:0015749 58 0.014
blood coagulation GO:0007596 76 0.014
muscle system process GO:0003012 141 0.014
regulation of transcription by glucose GO:0046015 3 0.014
mesenchymal cell development GO:0014031 93 0.013
nucleoside catabolic process GO:0009164 206 0.013
ensheathment of neurons GO:0007272 76 0.013
divalent metal ion transport GO:0070838 172 0.013
glomerular endothelium development GO:0072011 2 0.013
stem cell development GO:0048864 219 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
detection of external stimulus GO:0009581 61 0.013
regulation of t cell activation GO:0050863 170 0.013
regulation of cellular catabolic process GO:0031329 242 0.013
regulation of cell activation GO:0050865 289 0.013
ossification GO:0001503 216 0.013
response to organonitrogen compound GO:0010243 246 0.013
phospholipid metabolic process GO:0006644 87 0.013
female gonad development GO:0008585 71 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
homeostasis of number of cells GO:0048872 210 0.013
chromatin modification GO:0016568 187 0.013
cellular ion homeostasis GO:0006873 165 0.013
apoptotic signaling pathway GO:0097190 306 0.013
cytoplasmic transport GO:0016482 234 0.013
covalent chromatin modification GO:0016569 163 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
ribonucleoside metabolic process GO:0009119 245 0.013
branching morphogenesis of an epithelial tube GO:0048754 159 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
respiratory tube development GO:0030323 167 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
protein ubiquitination GO:0016567 171 0.013
t cell differentiation GO:0030217 174 0.013
cell differentiation involved in embryonic placenta development GO:0060706 26 0.013
Mouse
negative regulation of protein maturation GO:1903318 79 0.013
regulation of organ morphogenesis GO:2000027 144 0.012
maintenance of location GO:0051235 89 0.012
regulation of metal ion transport GO:0010959 106 0.012
glucose metabolic process GO:0006006 92 0.012
amide transport GO:0042886 138 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
fertilization GO:0009566 127 0.012
positive regulation of keratinocyte proliferation GO:0010838 4 0.012
organophosphate catabolic process GO:0046434 232 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
innate immune response GO:0045087 157 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
cellular response to external stimulus GO:0071496 88 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
regulation of defense response GO:0031347 233 0.012
ras protein signal transduction GO:0007265 77 0.012
gland development GO:0048732 330 0.012
positive regulation of protein complex assembly GO:0031334 45 0.012
hormone metabolic process GO:0042445 86 0.012
response to extracellular stimulus GO:0009991 127 0.012
protein processing GO:0016485 163 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
myelination GO:0042552 74 0.012
cellular response to acid chemical GO:0071229 68 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
nuclear division GO:0000280 158 0.012
response to vitamin d GO:0033280 3 0.012
single fertilization GO:0007338 82 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
lateral inhibition GO:0046331 1 0.011
negative regulation of cell cycle GO:0045786 123 0.011
Mouse
glycosyl compound metabolic process GO:1901657 246 0.011
oocyte construction GO:0007308 2 0.011
cell maturation GO:0048469 127 0.011
purine containing compound metabolic process GO:0072521 311 0.011
negative regulation of cell development GO:0010721 169 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
positive regulation of phospholipase c activity GO:0010863 2 0.011
sensory perception of pain GO:0019233 47 0.011
regulation of apoptotic signaling pathway GO:2001233 197 0.011
negative regulation of molecular function GO:0044092 258 0.011
epithelial cell proliferation GO:0050673 174 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
negative regulation of immune system process GO:0002683 209 0.011
negative regulation of protein processing GO:0010955 79 0.011
regulation of monocyte chemotaxis GO:0090025 3 0.011
endocytosis GO:0006897 168 0.011
blood circulation GO:0008015 195 0.011
digestive tract morphogenesis GO:0048546 147 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
ovulation cycle GO:0042698 59 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
regulation of protein localization GO:0032880 231 0.011
cellular response to lipid GO:0071396 145 0.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.011
protein localization to organelle GO:0033365 185 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
neuron apoptotic process GO:0051402 142 0.011
response to monosaccharide GO:0034284 67 0.011
regulation of response to drug GO:2001023 2 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
histone modification GO:0016570 159 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
forebrain cell migration GO:0021885 58 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
regulation of postsynaptic membrane potential GO:0060078 48 0.011
development of primary female sexual characteristics GO:0046545 73 0.011
cytosolic calcium ion homeostasis GO:0051480 70 0.011
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.010
cellular response to monosaccharide stimulus GO:0071326 47 0.010
carbohydrate transport GO:0008643 62 0.010
peptide secretion GO:0002790 114 0.010
monocarboxylic acid transport GO:0015718 44 0.010
nucleoside triphosphate catabolic process GO:0009143 205 0.010
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.010
regulation of reactive oxygen species metabolic process GO:2000377 40 0.010
multicellular organism growth GO:0035264 161 0.010
neuron migration GO:0001764 122 0.010
protein localization to nucleus GO:0034504 121 0.010
epithelial cell development GO:0002064 159 0.010
pattern specification involved in metanephros development GO:0072268 4 0.010
activation of phospholipase c activity GO:0007202 2 0.010
protein secretion GO:0009306 111 0.010
regulation of inflammatory response GO:0050727 147 0.010
physiological cardiac muscle hypertrophy GO:0003301 3 0.010
nuclear transport GO:0051169 139 0.010
organelle fission GO:0048285 170 0.010
lymphocyte proliferation GO:0046651 164 0.010
cellular response to abiotic stimulus GO:0071214 56 0.010
regulation of peptidase activity GO:0052547 96 0.010
negative regulation of protein modification process GO:0031400 163 0.010
blood vessel remodeling GO:0001974 33 0.010
Mouse
positive regulation of cell activation GO:0050867 158 0.010
generation of precursor metabolites and energy GO:0006091 103 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
heart contraction GO:0060047 93 0.010
muscle contraction GO:0006936 101 0.010
single organism nuclear import GO:1902593 95 0.010
anion transport GO:0006820 177 0.010
behavioral defense response GO:0002209 28 0.010
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.010

Ctsr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.053
disease of anatomical entity DOID:7 0 0.053
sensory system disease DOID:0050155 0 0.037
eye disease DOID:5614 0 0.037
eye and adnexa disease DOID:1492 0 0.037
retinal disease DOID:5679 0 0.026
retinal degeneration DOID:8466 0 0.015