Mus musculus

15 known processes

Sp4

trans-acting transcription factor 4

(Aliases: HF-1b,HF1-b,5730497N03Rik)

Sp4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cilium morphogenesis GO:0060271 102 0.172
gene silencing GO:0016458 38 0.167
Fly
histone methylation GO:0016571 71 0.158
methylation GO:0032259 134 0.149
chromatin modification GO:0016568 187 0.133
chromatin silencing GO:0006342 15 0.122
spermatogenesis GO:0007283 284 0.120
histone modification GO:0016570 159 0.116
multicellular organism growth GO:0035264 161 0.108
Mouse
covalent chromatin modification GO:0016569 163 0.106
cellular response to dna damage stimulus GO:0006974 207 0.105
olfactory learning GO:0008355 2 0.101
male gamete generation GO:0048232 285 0.097
macromolecule methylation GO:0043414 120 0.092
protein alkylation GO:0008213 81 0.091
positive regulation of growth GO:0045927 104 0.084
t cell differentiation GO:0030217 174 0.082
Mouse
dna metabolic process GO:0006259 303 0.075
response to oxidative stress GO:0006979 123 0.074
development of primary sexual characteristics GO:0045137 143 0.073
muscle tissue development GO:0060537 308 0.073
myeloid cell differentiation GO:0030099 233 0.068
Mouse
protein methylation GO:0006479 81 0.068
negative regulation of protein metabolic process GO:0051248 282 0.068
lymphocyte differentiation GO:0030098 242 0.066
Mouse
chemotaxis GO:0006935 247 0.065
chromatin organization GO:0006325 206 0.065
cellular amino acid metabolic process GO:0006520 103 0.065
regulation of cellular amino acid metabolic process GO:0006521 5 0.063
striated muscle tissue development GO:0014706 293 0.063
translation GO:0006412 93 0.062
epithelial cell development GO:0002064 159 0.062
axon guidance GO:0007411 141 0.061
regulation of translation GO:0006417 71 0.059
negative regulation of molecular function GO:0044092 258 0.058
hindbrain development GO:0030902 128 0.058
camera type eye development GO:0043010 266 0.057
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.056
germ cell development GO:0007281 185 0.055
ossification GO:0001503 216 0.054
Mouse
stem cell differentiation GO:0048863 268 0.054
regulation of organelle organization GO:0033043 289 0.053
nuclear division GO:0000280 158 0.052
posttranscriptional regulation of gene expression GO:0010608 155 0.052
t cell activation GO:0042110 289 0.052
Mouse
leukocyte differentiation GO:0002521 342 0.051
Mouse
regulation of chromosome organization GO:0033044 83 0.051
microtubule cytoskeleton organization GO:0000226 157 0.050
peptidyl amino acid modification GO:0018193 336 0.048
respiratory tube development GO:0030323 167 0.048
Mouse
circadian rhythm GO:0007623 114 0.048
protein ubiquitination GO:0016567 171 0.047
smoothened signaling pathway GO:0007224 105 0.047
embryonic organ morphogenesis GO:0048562 276 0.047
Mouse
protein processing GO:0016485 163 0.047
respiratory system development GO:0060541 190 0.045
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.044
metencephalon development GO:0022037 89 0.043
digestive system development GO:0055123 200 0.042
histone lysine methylation GO:0034968 50 0.041
regulation of secretion GO:0051046 274 0.041
negative regulation of gene expression epigenetic GO:0045814 15 0.041
t cell proliferation GO:0042098 120 0.041
neuron projection guidance GO:0097485 141 0.040
rna interference GO:0016246 2 0.040
regulation of lymphocyte activation GO:0051249 240 0.039
male sex differentiation GO:0046661 109 0.037
cell maturation GO:0048469 127 0.037
macromolecule catabolic process GO:0009057 281 0.036
male gonad development GO:0008584 88 0.036
histone lysine demethylation GO:0070076 13 0.035
muscle cell differentiation GO:0042692 261 0.035
alpha beta t cell activation involved in immune response GO:0002287 31 0.034
regulation of cell activation GO:0050865 289 0.034
mrna metabolic process GO:0016071 84 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.033
gland development GO:0048732 330 0.033
Mouse
circulatory system process GO:0003013 197 0.033
regulation of cell cycle process GO:0010564 160 0.033
aromatic compound catabolic process GO:0019439 286 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.033
regulation of cell cycle GO:0051726 281 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.031
alpha beta t cell activation GO:0046631 91 0.031
stem cell maintenance GO:0019827 130 0.031
compound eye development GO:0048749 1 0.031
positive regulation of protein modification process GO:0031401 299 0.030
negative regulation of cellular protein metabolic process GO:0032269 247 0.030
rhythmic process GO:0048511 174 0.030
microtubule based process GO:0007017 236 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
hepaticobiliary system development GO:0061008 67 0.029
Mouse
regulation of cellular response to stress GO:0080135 159 0.029
regulation of viral transcription GO:0046782 3 0.029
mapk cascade GO:0000165 281 0.029
spermatid development GO:0007286 108 0.029
cellular response to lipid GO:0071396 145 0.029
blood circulation GO:0008015 195 0.029
female sex differentiation GO:0046660 84 0.029
cellular response to lipopolysaccharide GO:0071222 77 0.028
positive regulation of histone h3 k9 methylation GO:0051574 4 0.028
cardiac muscle tissue development GO:0048738 130 0.028
histone h3 k9 methylation GO:0051567 17 0.027
gonad development GO:0008406 141 0.027
cellular ketone metabolic process GO:0042180 84 0.027
regulation of apoptotic signaling pathway GO:2001233 197 0.027
heart morphogenesis GO:0003007 178 0.027
segmentation GO:0035282 93 0.027
axonogenesis GO:0007409 274 0.026
central nervous system neuron differentiation GO:0021953 162 0.026
organelle localization GO:0051640 179 0.026
appendage development GO:0048736 166 0.026
Mouse
response to inorganic substance GO:0010035 96 0.026
appendage morphogenesis GO:0035107 149 0.026
Mouse
regulation of kinase activity GO:0043549 249 0.026
somitogenesis GO:0001756 69 0.026
endothelial cell differentiation GO:0045446 41 0.026
organelle assembly GO:0070925 177 0.025
histone h3 k9 trimethylation GO:0036124 6 0.025
cellular response to hormone stimulus GO:0032870 150 0.025
purine nucleotide metabolic process GO:0006163 302 0.025
placenta development GO:0001890 140 0.025
Mouse
cell cycle checkpoint GO:0000075 47 0.025
hematopoietic progenitor cell differentiation GO:0002244 143 0.024
Mouse
response to lipopolysaccharide GO:0032496 128 0.024
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.024
negative regulation of lymphocyte activation GO:0051250 91 0.024
neural tube development GO:0021915 160 0.024
regulation of organ growth GO:0046620 61 0.023
mrna processing GO:0006397 63 0.023
cognition GO:0050890 149 0.023
protein maturation GO:0051604 176 0.023
regulation of transferase activity GO:0051338 263 0.023
negative regulation of nervous system development GO:0051961 156 0.023
positive regulation of cell development GO:0010720 237 0.023
ear morphogenesis GO:0042471 118 0.023
regulation of vesicle mediated transport GO:0060627 139 0.023
amine metabolic process GO:0009308 45 0.022
telencephalon development GO:0021537 186 0.022
forebrain development GO:0030900 302 0.022
pharynx development GO:0060465 1 0.022
skin development GO:0043588 220 0.022
positive regulation of cell activation GO:0050867 158 0.022
regulation of chromatin silencing GO:0031935 2 0.022
regulation of protein serine threonine kinase activity GO:0071900 157 0.021
nuclear transcribed mrna poly a tail shortening GO:0000289 7 0.021
leukocyte proliferation GO:0070661 172 0.021
response to insulin GO:0032868 100 0.021
dna recombination GO:0006310 92 0.021
skeletal muscle organ development GO:0060538 163 0.020
protein polymerization GO:0051258 57 0.020
cell type specific apoptotic process GO:0097285 268 0.020
posttranscriptional gene silencing GO:0016441 10 0.020
meiosis i GO:0007127 60 0.020
regulation of protein maturation GO:1903317 96 0.020
stem cell development GO:0048864 219 0.020
learning or memory GO:0007611 148 0.020
cellular response to molecule of bacterial origin GO:0071219 83 0.020
negative regulation of cell proliferation GO:0008285 296 0.020
cation transport GO:0006812 399 0.020
regulation of secretion by cell GO:1903530 249 0.020
negative regulation of protein maturation GO:1903318 79 0.020
syncytium formation by plasma membrane fusion GO:0000768 42 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
primary neural tube formation GO:0014020 95 0.020
developmental maturation GO:0021700 193 0.020
peptidyl lysine methylation GO:0018022 29 0.019
spermatid differentiation GO:0048515 115 0.019
lymphocyte proliferation GO:0046651 164 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
rna processing GO:0006396 105 0.019
organ growth GO:0035265 117 0.019
response to peptide hormone GO:0043434 127 0.019
leukocyte activation involved in immune response GO:0002366 126 0.019
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.019
negative regulation of synapse assembly GO:0051964 3 0.019
epithelial tube morphogenesis GO:0060562 303 0.019
immune effector process GO:0002252 321 0.019
positive regulation of organelle organization GO:0010638 128 0.019
development of primary male sexual characteristics GO:0046546 88 0.019
positive regulation of nervous system development GO:0051962 221 0.019
digestive tract morphogenesis GO:0048546 147 0.019
nitrogen compound transport GO:0071705 271 0.019
b cell activation GO:0042113 161 0.019
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.019
urogenital system development GO:0001655 261 0.018
cellularization GO:0007349 1 0.018
alpha beta t cell differentiation GO:0046632 69 0.018
cellular macromolecule catabolic process GO:0044265 206 0.018
antigen receptor mediated signaling pathway GO:0050851 64 0.018
positive regulation of dna templated transcription elongation GO:0032786 2 0.018
regulation of histone methylation GO:0031060 30 0.018
sensory perception of sound GO:0007605 97 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
retina development in camera type eye GO:0060041 119 0.018
organelle fission GO:0048285 170 0.018
heterocycle catabolic process GO:0046700 280 0.017
regulation of multi organism process GO:0043900 111 0.017
circadian behavior GO:0048512 13 0.017
renal system development GO:0072001 225 0.017
cellular response to abiotic stimulus GO:0071214 56 0.017
cell activation involved in immune response GO:0002263 126 0.017
mesenchyme development GO:0060485 152 0.017
regulation of chromatin modification GO:1903308 57 0.017
regulation of histone h3 k9 methylation GO:0051570 8 0.017
embryonic placenta development GO:0001892 98 0.017
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.017
regulation of voltage gated calcium channel activity GO:1901385 4 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
canonical wnt signaling pathway GO:0060070 130 0.017
embryonic skeletal system development GO:0048706 120 0.017
Mouse
regulation of lymphocyte differentiation GO:0045619 107 0.017
regulation of mapk cascade GO:0043408 248 0.017
rna catabolic process GO:0006401 29 0.017
regulation of hormone levels GO:0010817 211 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
negative regulation of cell cycle phase transition GO:1901988 48 0.017
sensory perception of mechanical stimulus GO:0050954 107 0.016
negative regulation of organelle organization GO:0010639 90 0.016
synaptic transmission GO:0007268 329 0.016
cell division GO:0051301 120 0.016
positive regulation of histone methylation GO:0031062 16 0.016
mitotic cell cycle GO:0000278 195 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
maintenance of location GO:0051235 89 0.016
organonitrogen compound catabolic process GO:1901565 264 0.016
cardiac muscle cell differentiation GO:0055007 69 0.016
histone h4 k20 methylation GO:0034770 8 0.015
cellular response to steroid hormone stimulus GO:0071383 33 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
cytoplasmic transport GO:0016482 234 0.015
lung development GO:0030324 164 0.015
Mouse
cellular amine metabolic process GO:0044106 44 0.015
regulation of binding GO:0051098 111 0.015
response to acid chemical GO:0001101 111 0.015
blood vessel morphogenesis GO:0048514 285 0.015
lymphocyte mediated immunity GO:0002449 139 0.015
pole plasm assembly GO:0007315 2 0.015
cellular response to organic cyclic compound GO:0071407 87 0.015
genitalia development GO:0048806 37 0.015
negative regulation of cell cycle GO:0045786 123 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.015
response to light stimulus GO:0009416 135 0.015
regulation of histone modification GO:0031056 56 0.015
leukocyte mediated immunity GO:0002443 174 0.015
oxidation reduction process GO:0055114 342 0.015
negative regulation of protein processing GO:0010955 79 0.015
cation transmembrane transport GO:0098655 266 0.015
response to organonitrogen compound GO:0010243 246 0.015
morphogenesis of embryonic epithelium GO:0016331 159 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 12 0.015
response to peptide GO:1901652 136 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.014
negative regulation of protein modification process GO:0031400 163 0.014
response to organic cyclic compound GO:0014070 198 0.014
mitotic cell cycle process GO:1903047 159 0.014
cd4 positive alpha beta t cell activation GO:0035710 45 0.014
regulation of protein processing GO:0070613 96 0.014
habituation GO:0046959 3 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
cellular homeostasis GO:0019725 240 0.014
multi organism behavior GO:0051705 62 0.014
macromolecule deacylation GO:0098732 37 0.014
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.014
regulation of neuron projection development GO:0010975 169 0.014
ribonucleoprotein complex subunit organization GO:0071826 28 0.014
protein deacetylation GO:0006476 32 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
cytoplasmic mrna processing body assembly GO:0033962 6 0.014
cellular protein catabolic process GO:0044257 155 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
ear development GO:0043583 200 0.014
amide transport GO:0042886 138 0.014
sensory perception GO:0007600 245 0.014
cellular response to peptide hormone stimulus GO:0071375 92 0.014
viral gene expression GO:0019080 3 0.014
nucleoside triphosphate metabolic process GO:0009141 230 0.014
negative regulation of translation GO:0017148 22 0.014
transdifferentiation GO:0060290 1 0.013
regulation of leukocyte proliferation GO:0070663 121 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
regulation of adaptive immune response GO:0002819 90 0.013
carbohydrate metabolic process GO:0005975 230 0.013
embryonic appendage morphogenesis GO:0035113 126 0.013
Mouse
regulation of b cell activation GO:0050864 81 0.013
positive regulation of chromosome organization GO:2001252 33 0.013
gene silencing by rna GO:0031047 19 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
cellular response to peptide GO:1901653 92 0.013
carbohydrate homeostasis GO:0033500 128 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
neural precursor cell proliferation GO:0061351 121 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
viral transcription GO:0019083 3 0.013
chromatin assembly or disassembly GO:0006333 16 0.013
activation of immune response GO:0002253 138 0.013
endocytosis GO:0006897 168 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
Mouse
transmembrane transport GO:0055085 412 0.013
cellular response to oxidative stress GO:0034599 76 0.013
immune response activating signal transduction GO:0002757 116 0.013
ventricular cardiac myofibril assembly GO:0055005 3 0.013
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.013
limb development GO:0060173 166 0.013
Mouse
histone deacetylation GO:0016575 26 0.013
regulation of t cell activation GO:0050863 170 0.013
organic cyclic compound catabolic process GO:1901361 295 0.013
actin cytoskeleton organization GO:0030036 220 0.012
thymus development GO:0048538 41 0.012
digestive tract development GO:0048565 190 0.012
regulation of neuron differentiation GO:0045664 281 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
cerebellum morphogenesis GO:0021587 42 0.012
connective tissue development GO:0061448 179 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
endothelium development GO:0003158 45 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
lipid localization GO:0010876 126 0.012
response to radiation GO:0009314 165 0.012
adaptive immune response GO:0002250 155 0.012
positive regulation of cell cycle GO:0045787 92 0.012
sensory organ morphogenesis GO:0090596 242 0.012
Mouse
nucleoside catabolic process GO:0009164 206 0.012
epithelial cell proliferation GO:0050673 174 0.012
histone demethylation GO:0016577 13 0.012
nucleotide metabolic process GO:0009117 332 0.012
bmp signaling pathway GO:0030509 93 0.012
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.012
positive regulation of homeostatic process GO:0032846 64 0.012
ectoderm formation GO:0001705 3 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.012
regulation of cell cycle phase transition GO:1901987 77 0.012
vagus nerve development GO:0021564 3 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
rna splicing via transesterification reactions GO:0000375 43 0.012
t cell activation involved in immune response GO:0002286 43 0.012
cardiocyte differentiation GO:0035051 87 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
sensory system development GO:0048880 3 0.012
protein dealkylation GO:0008214 13 0.012
angiogenesis GO:0001525 201 0.012
somite development GO:0061053 81 0.012
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.012
mesenchymal cell differentiation GO:0048762 107 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
oocyte construction GO:0007308 2 0.011
negative regulation of proteolysis GO:0045861 74 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
cell differentiation in spinal cord GO:0021515 53 0.011
regulation of defense response GO:0031347 233 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.011
regulation of protein complex assembly GO:0043254 83 0.011
ribonucleoside metabolic process GO:0009119 245 0.011
cerebellum development GO:0021549 77 0.011
telomere maintenance GO:0000723 19 0.011
regulation of cell motility GO:2000145 236 0.011
ovarian follicle development GO:0001541 40 0.011
peptide hormone secretion GO:0030072 109 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
myeloid cell homeostasis GO:0002262 114 0.011
Mouse
positive regulation of stem cell proliferation GO:2000648 59 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
positive regulation of transferase activity GO:0051347 167 0.011
regulation of protein binding GO:0043393 60 0.011
dna methylation GO:0006306 43 0.011
regulation of cell division GO:0051302 76 0.011
protein demethylation GO:0006482 13 0.011
wound healing GO:0042060 157 0.011
g1 s transition of mitotic cell cycle GO:0000082 57 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.011
posttranscriptional gene silencing by rna GO:0035194 10 0.011
negative regulation of t cell activation GO:0050868 65 0.011
oocyte axis specification GO:0007309 2 0.011
limb morphogenesis GO:0035108 149 0.011
Mouse
pancreas development GO:0031016 57 0.011
meiotic nuclear division GO:0007126 115 0.011
palate development GO:0060021 76 0.011
protein localization to organelle GO:0033365 185 0.011
peptidyl lysine modification GO:0018205 77 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
inner ear morphogenesis GO:0042472 101 0.010
chromatin remodeling GO:0006338 32 0.010
locomotory behavior GO:0007626 195 0.010
regulation of muscle tissue development GO:1901861 97 0.010
negative regulation of cell activation GO:0050866 111 0.010
histone h3 k4 methylation GO:0051568 23 0.010
organic hydroxy compound metabolic process GO:1901615 203 0.010
regulation of transcription by chromatin organization GO:0034401 0 0.010
wnt signaling pathway GO:0016055 188 0.010
male courtship behavior GO:0008049 2 0.010
cellular chemical homeostasis GO:0055082 215 0.010
regulation of mitotic cell cycle phase transition GO:1901990 73 0.010
negative regulation of chromosome organization GO:2001251 30 0.010
regulation of stem cell proliferation GO:0072091 78 0.010
regulation of circadian rhythm GO:0042752 58 0.010
intracellular receptor signaling pathway GO:0030522 74 0.010
labyrinthine layer development GO:0060711 49 0.010
female gamete generation GO:0007292 74 0.010
his purkinje system cell differentiation GO:0060932 2 0.010
cellular response to external stimulus GO:0071496 88 0.010
protein modification by small protein conjugation GO:0032446 187 0.010
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
rna 3 end processing GO:0031123 20 0.010
neuron migration GO:0001764 122 0.010

Sp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
central nervous system disease DOID:331 0 0.011