Mus musculus

51 known processes

Spire2

spire homolog 2 (Drosophila)

(Aliases: MGC31610,Spir2,KIAA1832,BC026502,Spir-2)

Spire2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axon cargo transport GO:0008088 33 0.210
microtubule based movement GO:0007018 84 0.189
cellular amino acid metabolic process GO:0006520 103 0.181
microtubule based transport GO:0010970 50 0.158
male gamete generation GO:0048232 285 0.129
synaptic vesicle localization GO:0097479 59 0.101
membrane organization GO:0061024 245 0.099
cellular component assembly involved in morphogenesis GO:0010927 139 0.086
axonogenesis GO:0007409 274 0.083
establishment of vesicle localization GO:0051650 81 0.079
vesicle localization GO:0051648 86 0.076
cytoskeleton dependent intracellular transport GO:0030705 50 0.070
spermatogenesis GO:0007283 284 0.067
ras protein signal transduction GO:0007265 77 0.066
carbohydrate derivative catabolic process GO:1901136 231 0.060
nucleoside phosphate metabolic process GO:0006753 338 0.059
organelle assembly GO:0070925 177 0.059
purine nucleoside triphosphate metabolic process GO:0009144 226 0.056
regulation of cell motility GO:2000145 236 0.056
exocytosis GO:0006887 121 0.055
nucleotide metabolic process GO:0009117 332 0.055
regulation of hormone levels GO:0010817 211 0.053
regulation of neuron differentiation GO:0045664 281 0.053
microtubule based process GO:0007017 236 0.052
purine nucleoside metabolic process GO:0042278 241 0.052
glycosyl compound metabolic process GO:1901657 246 0.052
cilium morphogenesis GO:0060271 102 0.051
defecation GO:0030421 1 0.050
cellular amine metabolic process GO:0044106 44 0.050
negative regulation of molecular function GO:0044092 258 0.049
dendrite development GO:0016358 115 0.047
fertilization GO:0009566 127 0.045
organic cyclic compound catabolic process GO:1901361 295 0.045
ribose phosphate metabolic process GO:0019693 291 0.045
establishment of synaptic vesicle localization GO:0097480 57 0.044
positive regulation of necrotic cell death GO:0010940 1 0.044
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
purine ribonucleoside catabolic process GO:0046130 205 0.040
organelle localization GO:0051640 179 0.040
spermatid differentiation GO:0048515 115 0.038
ion transmembrane transport GO:0034220 361 0.038
intracellular protein transport GO:0006886 204 0.038
synaptic vesicle transport GO:0048489 57 0.037
cellular nitrogen compound catabolic process GO:0044270 280 0.036
cellular ketone metabolic process GO:0042180 84 0.036
axon transport of mitochondrion GO:0019896 2 0.035
response to oxidative stress GO:0006979 123 0.035
purine nucleotide catabolic process GO:0006195 211 0.034
microtubule cytoskeleton organization GO:0000226 157 0.034
purine ribonucleoside metabolic process GO:0046128 241 0.034
purine ribonucleotide catabolic process GO:0009154 208 0.034
carbohydrate metabolic process GO:0005975 230 0.034
regulation of cellular amino acid metabolic process GO:0006521 5 0.033
nucleoside metabolic process GO:0009116 246 0.033
ribonucleoside metabolic process GO:0009119 245 0.033
actin cytoskeleton organization GO:0030036 220 0.033
peptidyl amino acid modification GO:0018193 336 0.033
nucleoside triphosphate metabolic process GO:0009141 230 0.032
adult behavior GO:0030534 135 0.032
sensory perception GO:0007600 245 0.032
dna metabolic process GO:0006259 303 0.032
nucleoside triphosphate catabolic process GO:0009143 205 0.032
protein modification by small protein conjugation or removal GO:0070647 207 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.031
organonitrogen compound catabolic process GO:1901565 264 0.031
cation transport GO:0006812 399 0.031
cellular response to organonitrogen compound GO:0071417 145 0.031
establishment of organelle localization GO:0051656 122 0.031
reactive oxygen species metabolic process GO:0072593 84 0.030
regulation of cellular amine metabolic process GO:0033238 20 0.029
nitrogen compound transport GO:0071705 271 0.029
regulation of intracellular transport GO:0032386 159 0.029
amine metabolic process GO:0009308 45 0.028
intracellular mrna localization GO:0008298 4 0.028
peptide transport GO:0015833 133 0.028
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
spermatid development GO:0007286 108 0.027
compound eye development GO:0048749 1 0.027
ribonucleoside triphosphate metabolic process GO:0009199 220 0.027
nucleoside catabolic process GO:0009164 206 0.027
oocyte construction GO:0007308 2 0.027
purine nucleotide metabolic process GO:0006163 302 0.026
purine ribonucleotide metabolic process GO:0009150 290 0.026
hindbrain development GO:0030902 128 0.026
cellular homeostasis GO:0019725 240 0.024
regulation of cellular ketone metabolic process GO:0010565 66 0.024
establishment of mitochondrion localization GO:0051654 4 0.024
endomembrane system organization GO:0010256 147 0.024
aromatic compound catabolic process GO:0019439 286 0.024
purine nucleoside monophosphate metabolic process GO:0009126 81 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.024
macromolecule catabolic process GO:0009057 281 0.023
germ cell development GO:0007281 185 0.023
purine containing compound metabolic process GO:0072521 311 0.023
organophosphate catabolic process GO:0046434 232 0.023
axon guidance GO:0007411 141 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
neuronal action potential GO:0019228 54 0.022
protein localization to organelle GO:0033365 185 0.022
protein ubiquitination GO:0016567 171 0.022
gtp catabolic process GO:0006184 143 0.022
ribonucleotide metabolic process GO:0009259 291 0.022
positive regulation of protein modification process GO:0031401 299 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
regulation of hydrolase activity GO:0051336 246 0.022
neurotransmitter secretion GO:0007269 62 0.022
glycerolipid metabolic process GO:0046486 122 0.021
positive regulation of nervous system development GO:0051962 221 0.021
cilium assembly GO:0042384 81 0.021
cellular carbohydrate metabolic process GO:0044262 119 0.021
oocyte axis specification GO:0007309 2 0.021
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.021
protein targeting GO:0006605 143 0.021
small gtpase mediated signal transduction GO:0007264 97 0.021
multicellular organismal signaling GO:0035637 91 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
cell adhesion GO:0007155 329 0.020
guanosine containing compound metabolic process GO:1901068 144 0.020
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.020
purine containing compound catabolic process GO:0072523 213 0.020
cation transmembrane transport GO:0098655 266 0.019
nucleotide catabolic process GO:0009166 217 0.019
nuclear division GO:0000280 158 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
regulation of receptor activity GO:0010469 41 0.019
camera type eye development GO:0043010 266 0.019
insulin secretion GO:0030073 89 0.019
cellularization GO:0007349 1 0.019
negative regulation of cell development GO:0010721 169 0.019
meiotic cell cycle process GO:1903046 77 0.019
meiotic cell cycle GO:0051321 122 0.019
response to nutrient levels GO:0031667 109 0.019
cell junction maintenance GO:0034331 4 0.019
cytoplasmic transport GO:0016482 234 0.019
synapse organization GO:0050808 125 0.018
peptide secretion GO:0002790 114 0.018
protein localization to membrane GO:0072657 108 0.018
regulation of reactive oxygen species metabolic process GO:2000377 40 0.018
positive regulation of cell development GO:0010720 237 0.018
modification dependent macromolecule catabolic process GO:0043632 133 0.018
regulation of metal ion transport GO:0010959 106 0.018
negative regulation of synapse assembly GO:0051964 3 0.018
negative regulation of nervous system development GO:0051961 156 0.018
developmental maturation GO:0021700 193 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
peptidyl serine modification GO:0018209 83 0.018
positive regulation of cell projection organization GO:0031346 95 0.017
divalent metal ion transport GO:0070838 172 0.017
cellular protein catabolic process GO:0044257 155 0.017
heterocycle catabolic process GO:0046700 280 0.017
chemotaxis GO:0006935 247 0.017
membrane lipid metabolic process GO:0006643 53 0.017
organelle fission GO:0048285 170 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
positive regulation of neuron differentiation GO:0045666 141 0.016
central nervous system neuron differentiation GO:0021953 162 0.016
response to organonitrogen compound GO:0010243 246 0.016
regulation of synaptic plasticity GO:0048167 87 0.016
transmission of nerve impulse GO:0019226 76 0.016
regulation of feeding behavior GO:0060259 3 0.016
urogenital system development GO:0001655 261 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
regulation of ras protein signal transduction GO:0046578 114 0.016
regulation of cytoskeleton organization GO:0051493 122 0.015
peptidyl serine phosphorylation GO:0018105 74 0.015
plasma membrane organization GO:0007009 90 0.015
negative regulation of neuron differentiation GO:0045665 101 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
phospholipid metabolic process GO:0006644 87 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
neurotransmitter transport GO:0006836 76 0.015
vesicle organization GO:0016050 60 0.015
purine nucleoside catabolic process GO:0006152 205 0.015
maintenance of location GO:0051235 89 0.015
locomotory behavior GO:0007626 195 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.015
calcium ion dependent exocytosis GO:0017156 35 0.015
regulation of transmembrane transport GO:0034762 128 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
molting cycle GO:0042303 90 0.014
dephosphorylation GO:0016311 129 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.014
negative regulation of protein metabolic process GO:0051248 282 0.014
regulation of cellular component size GO:0032535 121 0.014
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
divalent inorganic cation transport GO:0072511 178 0.014
rna processing GO:0006396 105 0.014
hormone secretion GO:0046879 128 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
calcium ion homeostasis GO:0055074 127 0.014
cellular lipid metabolic process GO:0044255 323 0.014
regulation of organelle organization GO:0033043 289 0.014
carbohydrate biosynthetic process GO:0016051 74 0.014
sperm motility GO:0030317 47 0.013
cellular response to peptide GO:1901653 92 0.013
adult locomotory behavior GO:0008344 91 0.013
regulation of membrane potential GO:0042391 192 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
single organismal cell cell adhesion GO:0016337 131 0.013
extracellular structure organization GO:0043062 148 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
transition metal ion transport GO:0000041 38 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
cellular modified amino acid metabolic process GO:0006575 63 0.013
renal system development GO:0072001 225 0.013
gliogenesis GO:0042063 141 0.013
peptide hormone secretion GO:0030072 109 0.013
transmembrane transport GO:0055085 412 0.013
cell chemotaxis GO:0060326 81 0.013
cellular response to dna damage stimulus GO:0006974 207 0.012
rac protein signal transduction GO:0016601 13 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
establishment of protein localization to membrane GO:0090150 54 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
regulation of cell cycle process GO:0010564 160 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
mrna metabolic process GO:0016071 84 0.012
lipid biosynthetic process GO:0008610 179 0.012
regulation of cell projection organization GO:0031344 206 0.012
ubiquitin dependent protein catabolic process GO:0006511 129 0.012
cerebellum morphogenesis GO:0021587 42 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
regulation of proteolysis GO:0030162 164 0.012
development of primary sexual characteristics GO:0045137 143 0.012
atp metabolic process GO:0046034 75 0.012
regulation of ion transport GO:0043269 215 0.012
regionalization GO:0003002 337 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
protein catabolic process GO:0030163 221 0.011
amide transport GO:0042886 138 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
positive regulation of cell death GO:0010942 224 0.011
lateral inhibition GO:0046331 1 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
calcium ion transport GO:0006816 159 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
cellular chemical homeostasis GO:0055082 215 0.011
gtp metabolic process GO:0046039 144 0.011
protein maturation GO:0051604 176 0.011
regulation of protein catabolic process GO:0042176 108 0.011
regulation of peptidase activity GO:0052547 96 0.011
rho protein signal transduction GO:0007266 32 0.011
maternal determination of anterior posterior axis embryo GO:0008358 2 0.011
negative regulation of protein modification process GO:0031400 163 0.011
alcohol metabolic process GO:0006066 116 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
rap protein signal transduction GO:0032486 3 0.011
regulation of neuron projection development GO:0010975 169 0.011
regulation of microtubule based process GO:0032886 52 0.011
mitotic cell cycle GO:0000278 195 0.011
regulation of protein targeting GO:1903533 61 0.011
cation homeostasis GO:0055080 212 0.011
cellular protein complex assembly GO:0043623 116 0.010
positive regulation of neuron projection development GO:0010976 79 0.010
reactive nitrogen species metabolic process GO:2001057 0 0.010
synapse assembly GO:0007416 56 0.010
response to extracellular stimulus GO:0009991 127 0.010
regulation of apoptotic signaling pathway GO:2001233 197 0.010
neuromuscular process GO:0050905 99 0.010
regulation of neurotransmitter levels GO:0001505 87 0.010
organic hydroxy compound metabolic process GO:1901615 203 0.010
regulation of cell migration GO:0030334 219 0.010
regulation of protein kinase activity GO:0045859 232 0.010
oxidation reduction process GO:0055114 342 0.010
regulation of nucleocytoplasmic transport GO:0046822 73 0.010
nuclear transport GO:0051169 139 0.010
meiosis i GO:0007127 60 0.010
male sex differentiation GO:0046661 109 0.010
response to monosaccharide GO:0034284 67 0.010

Spire2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.020
disease of anatomical entity DOID:7 0 0.020
disease of cellular proliferation DOID:14566 0 0.012
disease of metabolism DOID:0014667 0 0.011