Mus musculus

505 known processes

Sfrp2

secreted frizzled-related protein 2

(Aliases: AI851596,Sdf5)

Sfrp2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
hematopoietic stem cell proliferation GO:0071425 13 0.996
non canonical wnt signaling pathway GO:0035567 33 0.993
establishment of planar polarity of embryonic epithelium GO:0042249 16 0.990
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.988
chondrocyte development GO:0002063 24 0.985
appendage morphogenesis GO:0035107 149 0.981
regulation of establishment of planar polarity involved in neural tube closure GO:0090178 15 0.980
planar cell polarity pathway involved in axis elongation GO:0003402 4 0.977
axis elongation involved in somitogenesis GO:0090245 4 0.976
Mouse
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.975
embryonic epithelial tube formation GO:0001838 130 0.973
cartilage development GO:0051216 140 0.971
positive regulation of non canonical wnt signaling pathway GO:2000052 6 0.968
negative regulation of gastrulation GO:2000542 3 0.967
positive regulation of catenin import into nucleus GO:0035413 2 0.959
negative regulation of mesoderm development GO:2000381 8 0.958
epithelial tube formation GO:0072175 130 0.957
skeletal system development GO:0001501 356 0.956
embryonic appendage morphogenesis GO:0035113 126 0.955
morphogenesis of embryonic epithelium GO:0016331 159 0.953
neural tube development GO:0021915 160 0.952
neural tube formation GO:0001841 108 0.948
negative regulation of jun kinase activity GO:0043508 9 0.948
regulation of bmp signaling pathway GO:0030510 60 0.943
tube formation GO:0035148 140 0.941
chondrocyte differentiation GO:0002062 72 0.941
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.932
morphogenesis of a polarized epithelium GO:0001738 37 0.931
planar cell polarity pathway involved in neural tube closure GO:0090179 14 0.928
digestive tract morphogenesis GO:0048546 147 0.923
regionalization GO:0003002 337 0.914
bmp signaling pathway GO:0030509 93 0.907
negative regulation of cellular amine metabolic process GO:0033239 1 0.905
extrinsic apoptotic signaling pathway GO:0097191 126 0.903
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 10 0.902
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.901
regulation of establishment of planar polarity GO:0090175 28 0.898
positive regulation of programmed cell death GO:0043068 218 0.898
Human Mouse
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.898
primary neural tube formation GO:0014020 95 0.895
digestive tract development GO:0048565 190 0.889
epithelial tube morphogenesis GO:0060562 303 0.886
stem cell development GO:0048864 219 0.884
Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.879
mesodermal cell fate specification GO:0007501 11 0.878
negative regulation of myeloid cell differentiation GO:0045638 38 0.871
Mouse
negative regulation of ossification GO:0030279 49 0.870
Mouse
cellular ketone metabolic process GO:0042180 84 0.867
positive regulation of apoptotic signaling pathway GO:2001235 95 0.863
Mouse
regulation of epithelial to mesenchymal transition GO:0010717 22 0.862
Human
skeletal system morphogenesis GO:0048705 203 0.861
response to transforming growth factor beta GO:0071559 88 0.859
negative regulation of osteoclast differentiation GO:0045671 12 0.855
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.852
wnt signaling pathway GO:0016055 188 0.841
branching morphogenesis of an epithelial tube GO:0048754 159 0.840
establishment of planar polarity GO:0001736 28 0.828
regulation of cellular amino acid metabolic process GO:0006521 5 0.822
limb morphogenesis GO:0035108 149 0.819
embryonic digit morphogenesis GO:0042733 56 0.818
gland development GO:0048732 330 0.816
Mouse
mesoderm development GO:0007498 100 0.812
limb development GO:0060173 166 0.811
post anal tail morphogenesis GO:0036342 23 0.810
ossification GO:0001503 216 0.809
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.809
Human
positive regulation of cell death GO:0010942 224 0.805
Human Mouse
positive regulation of apoptotic process GO:0043065 217 0.804
Human Mouse
formation of primary germ layer GO:0001704 77 0.791
morphogenesis of a branching epithelium GO:0061138 193 0.791
regulation of canonical wnt signaling pathway GO:0060828 82 0.784
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.782
development of primary female sexual characteristics GO:0046545 73 0.782
Mouse
sclerotome development GO:0061056 4 0.777
regulation of map kinase activity GO:0043405 120 0.776
bone morphogenesis GO:0060349 78 0.775
cellular amine metabolic process GO:0044106 44 0.771
fat cell differentiation GO:0045444 160 0.770
Human
mesoderm formation GO:0001707 62 0.769
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.767
blood vessel morphogenesis GO:0048514 285 0.764
positive regulation of peptidase activity GO:0010952 49 0.762
regulation of embryonic development GO:0045995 71 0.758
appendage development GO:0048736 166 0.746
negative regulation of cell proliferation GO:0008285 296 0.743
Human Mouse
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.738
regulation of mesodermal cell fate specification GO:0042661 5 0.734
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.726
embryonic limb morphogenesis GO:0030326 126 0.726
negative regulation of immune system process GO:0002683 209 0.723
Mouse
regulation of ossification GO:0030278 112 0.715
regulation of morphogenesis of a branching structure GO:0060688 53 0.713
Mouse
somatic stem cell maintenance GO:0035019 47 0.711
Mouse
axis elongation GO:0003401 30 0.707
regulation of stem cell division GO:2000035 4 0.705
negative regulation of osteoblast differentiation GO:0045668 30 0.704
Mouse
prostate gland development GO:0030850 48 0.699
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.689
Human
positive regulation of ossification GO:0045778 47 0.689
regulation of myeloid leukocyte differentiation GO:0002761 58 0.687
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.682
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.677
amine metabolic process GO:0009308 45 0.677
bone development GO:0060348 120 0.675
regulation of b cell differentiation GO:0045577 23 0.673
Mouse
negative regulation of phosphorylation GO:0042326 166 0.668
leukocyte differentiation GO:0002521 342 0.661
Mouse
regulation of mesoderm development GO:2000380 12 0.659
regulation of organ morphogenesis GO:2000027 144 0.655
stem cell proliferation GO:0072089 117 0.654
regulation of cellular ketone metabolic process GO:0010565 66 0.648
prostate gland epithelium morphogenesis GO:0060740 31 0.642
Mouse
lymphocyte differentiation GO:0030098 242 0.637
Mouse
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.630
angiogenesis GO:0001525 201 0.629
neural tube closure GO:0001843 90 0.629
cell fate commitment GO:0045165 210 0.626
regulation of cell adhesion GO:0030155 154 0.625
negative regulation of lymphocyte activation GO:0051250 91 0.625
Mouse
mesoderm morphogenesis GO:0048332 64 0.623
regulation of hormone secretion GO:0046883 88 0.621
negative regulation of bmp signaling pathway GO:0030514 35 0.616
negative regulation of growth GO:0045926 99 0.615
regulation of jnk cascade GO:0046328 62 0.614
bone trabecula morphogenesis GO:0061430 12 0.610
Mouse
canonical wnt signaling pathway GO:0060070 130 0.607
cell fate specification GO:0001708 72 0.605
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.605
response to x ray GO:0010165 11 0.602
regulation of wnt signaling pathway GO:0030111 123 0.591
positive regulation of endopeptidase activity GO:0010950 43 0.590
extracellular structure organization GO:0043062 148 0.589
morphogenesis of a branching structure GO:0001763 203 0.587
regulation of protein serine threonine kinase activity GO:0071900 157 0.585
response to organonitrogen compound GO:0010243 246 0.582
negative regulation of phosphorus metabolic process GO:0010563 184 0.580
axon guidance GO:0007411 141 0.577
stem cell maintenance GO:0019827 130 0.574
Mouse
regulation of protein transport GO:0051223 163 0.574
jnk cascade GO:0007254 72 0.571
negative regulation of apoptotic signaling pathway GO:2001234 104 0.570
kidney development GO:0001822 213 0.570
Mouse
male sex differentiation GO:0046661 109 0.565
negative regulation of leukocyte differentiation GO:1902106 51 0.563
Mouse
catenin import into nucleus GO:0035411 6 0.557
regulation of stem cell differentiation GO:2000736 50 0.556
Human
epithelial cell proliferation GO:0050673 174 0.555
Human
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.554
positive regulation of proteolysis GO:0045862 85 0.552
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.552
skin development GO:0043588 220 0.551
cellular response to prostaglandin stimulus GO:0071379 2 0.544
peptide hormone secretion GO:0030072 109 0.534
regulation of protein localization GO:0032880 231 0.533
heart morphogenesis GO:0003007 178 0.531
Human
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.527
negative regulation of phosphate metabolic process GO:0045936 184 0.524
regulation of establishment of protein localization GO:0070201 181 0.521
type b pancreatic cell proliferation GO:0044342 10 0.521
negative regulation of protein metabolic process GO:0051248 282 0.514
muscular septum morphogenesis GO:0003150 4 0.514
osteoclast differentiation GO:0030316 62 0.510
Mouse
single organism nuclear import GO:1902593 95 0.510
peptide transport GO:0015833 133 0.507
cell growth GO:0016049 130 0.505
regulation of branching involved in prostate gland morphogenesis GO:0060687 7 0.505
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.503
cellular response to x ray GO:0071481 2 0.501
positive regulation of protein modification process GO:0031401 299 0.500
cellular response to growth factor stimulus GO:0071363 197 0.494
positive regulation of intracellular transport GO:0032388 70 0.493
regulation of kinase activity GO:0043549 249 0.489
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.485
regulation of epithelial cell proliferation GO:0050678 141 0.482
Human
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.479
negative regulation of protein phosphorylation GO:0001933 126 0.478
positive regulation of wnt signaling pathway GO:0030177 45 0.472
convergent extension involved in axis elongation GO:0060028 7 0.471
regulation of stress activated mapk cascade GO:0032872 69 0.470
negative regulation of intracellular signal transduction GO:1902532 167 0.468
negative regulation of fibroblast apoptotic process GO:2000270 6 0.461
mesenchymal cell development GO:0014031 93 0.459
Human Mouse
cellular response to heparin GO:0071504 1 0.455
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.454
mesenchyme development GO:0060485 152 0.452
female gonad development GO:0008585 71 0.451
Mouse
neural crest cell fate commitment GO:0014034 1 0.449
Mouse
negative regulation of molecular function GO:0044092 258 0.446
regulation of proteolysis GO:0030162 164 0.442
amide transport GO:0042886 138 0.441
trabecula formation GO:0060343 24 0.438
Mouse
negative regulation of wnt signaling pathway GO:0030178 73 0.434
mesodermal cell fate commitment GO:0001710 17 0.431
regulation of osteoblast proliferation GO:0033688 15 0.423
Mouse
cellular response to ionizing radiation GO:0071479 11 0.422
regulation of cellular response to stress GO:0080135 159 0.422
stem cell differentiation GO:0048863 268 0.420
Human Mouse
regulation of protein kinase activity GO:0045859 232 0.418
tissue remodeling GO:0048771 102 0.417
negative regulation of stem cell differentiation GO:2000737 14 0.416
Human
progesterone secretion GO:0042701 1 0.415
response to vitamin d GO:0033280 3 0.402
segmentation GO:0035282 93 0.401
regulation of osteoblast differentiation GO:0045667 67 0.400
response to growth factor GO:0070848 198 0.400
cellular response to prostaglandin e stimulus GO:0071380 1 0.399
urogenital system development GO:0001655 261 0.397
Mouse
prostate glandular acinus development GO:0060525 12 0.395
Mouse
bone remodeling GO:0046849 53 0.391
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.390
negative regulation of osteoblast proliferation GO:0033689 4 0.387
Mouse
peptide secretion GO:0002790 114 0.384
bone trabecula formation GO:0060346 9 0.383
Mouse
positive regulation of cytoplasmic transport GO:1903651 40 0.381
regulation of b cell activation GO:0050864 81 0.375
Mouse
peptidyl amino acid modification GO:0018193 336 0.374
response to heparin GO:0071503 1 0.370
stress activated protein kinase signaling cascade GO:0031098 81 0.365
ureteric bud development GO:0001657 94 0.363
Mouse
positive regulation of protein import into nucleus GO:0042307 26 0.361
metencephalon development GO:0022037 89 0.359
regulation of peptidase activity GO:0052547 96 0.358
regulation of tissue remodeling GO:0034103 38 0.357
negative regulation of cellular protein metabolic process GO:0032269 247 0.356
extracellular matrix organization GO:0030198 147 0.355
myeloid cell differentiation GO:0030099 233 0.353
Mouse
mapk cascade GO:0000165 281 0.353
regulation of cell cycle GO:0051726 281 0.352
positive regulation of growth GO:0045927 104 0.352
cardiac chamber morphogenesis GO:0003206 93 0.348
Human
regulation of myeloid cell differentiation GO:0045637 96 0.341
Mouse
peptidyl tyrosine modification GO:0018212 145 0.341
neural crest cell differentiation GO:0014033 54 0.340
Mouse
b cell activation GO:0042113 161 0.340
Mouse
hematopoietic stem cell differentiation GO:0060218 8 0.339
cellular response to bmp stimulus GO:0071773 14 0.338
negative regulation of cell development GO:0010721 169 0.338
Human
regulation of osteoclast differentiation GO:0045670 36 0.337
Mouse
inner ear morphogenesis GO:0042472 101 0.336
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 7 0.335
Mouse
cell division GO:0051301 120 0.331
cellular amino acid metabolic process GO:0006520 103 0.328
negative regulation of hydrolase activity GO:0051346 71 0.322
regulation of cell motility GO:2000145 236 0.320
regulation of cysteine type endopeptidase activity GO:2000116 65 0.319
nitrogen compound transport GO:0071705 271 0.314
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.314
Human
mesonephric tubule development GO:0072164 94 0.314
Mouse
cytoplasmic transport GO:0016482 234 0.311
pallium development GO:0021543 120 0.310
kidney epithelium development GO:0072073 121 0.305
Mouse
negative regulation of cell growth GO:0030308 44 0.304
Human
stem cell division GO:0017145 30 0.302
stress activated mapk cascade GO:0051403 80 0.302
regulation of neuron differentiation GO:0045664 281 0.298
regulation of gastrulation GO:0010470 16 0.297
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.295
response to extracellular stimulus GO:0009991 127 0.294
negative regulation of cellular component organization GO:0051129 194 0.293
Human
regulation of cellular amine metabolic process GO:0033238 20 0.292
positive regulation of cellular amine metabolic process GO:0033240 5 0.289
gastrulation GO:0007369 116 0.288
regulation of vasculature development GO:1901342 88 0.286
positive regulation of osteoblast differentiation GO:0045669 34 0.286
peptidyl serine modification GO:0018209 83 0.285
mesonephric duct morphogenesis GO:0072180 4 0.280
positive regulation of protein phosphorylation GO:0001934 242 0.276
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.276
cerebellum development GO:0021549 77 0.273
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.273
cellular response to abiotic stimulus GO:0071214 56 0.268
cellular response to radiation GO:0071478 28 0.267
regulation of cell migration GO:0030334 219 0.265
regulation of protein targeting GO:1903533 61 0.263
embryonic skeletal system development GO:0048706 120 0.259
intracellular receptor signaling pathway GO:0030522 74 0.259
regulation of peptide hormone secretion GO:0090276 75 0.258
regulation of intracellular transport GO:0032386 159 0.258
protein maturation GO:0051604 176 0.257
hormone secretion GO:0046879 128 0.256
female sex differentiation GO:0046660 84 0.256
Mouse
response to radiation GO:0009314 165 0.255
muscle tissue development GO:0060537 308 0.252
regulation of receptor activity GO:0010469 41 0.251
protein localization to nucleus GO:0034504 121 0.251
convergent extension GO:0060026 14 0.250
neural precursor cell proliferation GO:0061351 121 0.248
apoptotic signaling pathway GO:0097190 306 0.248
cellular response to acid chemical GO:0071229 68 0.247
positive regulation of protein localization to nucleus GO:1900182 30 0.246
regulation of endopeptidase activity GO:0052548 89 0.245
negative regulation of lymphocyte differentiation GO:0045620 32 0.245
Mouse
prostate gland morphogenesis GO:0060512 32 0.244
Mouse
insulin secretion GO:0030073 89 0.243
establishment of protein localization to organelle GO:0072594 118 0.241
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.240
regulation of protein import into nucleus GO:0042306 52 0.234
regulation of mapk cascade GO:0043408 248 0.233
striated muscle cell apoptotic process GO:0010658 12 0.232
cellular response to organic cyclic compound GO:0071407 87 0.232
Mouse
positive regulation of smoothened signaling pathway GO:0045880 23 0.232
muscle cell apoptotic process GO:0010657 18 0.230
digestive system development GO:0055123 200 0.228
cellular chemical homeostasis GO:0055082 215 0.227
single organism cell adhesion GO:0098602 156 0.226
regulation of lymphocyte activation GO:0051249 240 0.226
Mouse
protein import GO:0017038 101 0.223
hematopoietic progenitor cell differentiation GO:0002244 143 0.222
negative regulation of b cell activation GO:0050869 27 0.222
Mouse
response to bmp GO:0071772 14 0.221
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.220
regulation of lymphocyte differentiation GO:0045619 107 0.220
Mouse
cellular response to external stimulus GO:0071496 88 0.214
peptidyl tyrosine phosphorylation GO:0018108 143 0.214
regulation of androgen receptor signaling pathway GO:0060765 3 0.214
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.213
regulation of hormone levels GO:0010817 211 0.211
negative regulation of protein processing GO:0010955 79 0.210
actin cytoskeleton organization GO:0030036 220 0.207
maintenance of cell number GO:0098727 3 0.205
hair follicle development GO:0001942 85 0.205
regulation of cell cycle process GO:0010564 160 0.203
regulation of neuron projection development GO:0010975 169 0.201
t cell differentiation GO:0030217 174 0.200
multicellular organismal homeostasis GO:0048871 164 0.198
regulation of peptide transport GO:0090087 91 0.198
regulation of peptide secretion GO:0002791 77 0.193
skeletal muscle organ development GO:0060538 163 0.190
regulation of protein localization to nucleus GO:1900180 60 0.189
mesenchymal cell differentiation GO:0048762 107 0.188
Human Mouse
regulation of muscle cell apoptotic process GO:0010660 17 0.188
myeloid leukocyte differentiation GO:0002573 119 0.183
Mouse
response to ionizing radiation GO:0010212 42 0.182
regulation of cell activation GO:0050865 289 0.181
Mouse
negative regulation of endopeptidase activity GO:0010951 44 0.180
regulation of cartilage development GO:0061035 44 0.179
hepaticobiliary system development GO:0061008 67 0.179
nuclear import GO:0051170 95 0.177
intracellular protein transport GO:0006886 204 0.176
regulation of peptidyl serine phosphorylation GO:0033135 39 0.176
negative regulation of epithelial to mesenchymal transition GO:0010719 6 0.176
Human
protein processing GO:0016485 163 0.175
cellular response to organonitrogen compound GO:0071417 145 0.173
sensory organ morphogenesis GO:0090596 242 0.172
response to acid chemical GO:0001101 111 0.171
neuron projection extension GO:1990138 64 0.168
regulation of cell fate specification GO:0042659 10 0.168
trachea cartilage morphogenesis GO:0060535 4 0.168
cellular response to vitamin GO:0071295 2 0.167
endochondral bone morphogenesis GO:0060350 50 0.166
regulation of hydrolase activity GO:0051336 246 0.163
camera type eye development GO:0043010 266 0.161
positive regulation of nervous system development GO:0051962 221 0.161
response to nutrient levels GO:0031667 109 0.161
small gtpase mediated signal transduction GO:0007264 97 0.160
cellular response to steroid hormone stimulus GO:0071383 33 0.158
Mouse
response to fibroblast growth factor GO:0071774 47 0.157
nucleocytoplasmic transport GO:0006913 139 0.155
negative regulation of striated muscle cell apoptotic process GO:0010664 8 0.155
nuclear transport GO:0051169 139 0.154
rho protein signal transduction GO:0007266 32 0.153
chemotaxis GO:0006935 247 0.152
ribonucleotide metabolic process GO:0009259 291 0.151
regulation of organelle organization GO:0033043 289 0.149
negative regulation of cell migration GO:0030336 59 0.148
regulation of cardiac muscle cell apoptotic process GO:0010665 9 0.147
muscle tissue morphogenesis GO:0060415 53 0.147
prostate glandular acinus morphogenesis GO:0060526 7 0.145
Mouse
regulation of secretion by cell GO:1903530 249 0.145
polarity specification of proximal distal axis GO:0010085 2 0.145
regulation of secretion GO:0051046 274 0.145
regulation of intracellular protein transport GO:0033157 82 0.144
regulation of non canonical wnt signaling pathway GO:2000050 12 0.143
regulation of protein maturation GO:1903317 96 0.141
cerebellum vasculature development GO:0061300 1 0.140
negative regulation of kinase activity GO:0033673 81 0.139
apoptotic process involved in morphogenesis GO:0060561 25 0.137
bone mineralization GO:0030282 54 0.136
regulation of bone remodeling GO:0046850 28 0.135
peptidyl serine phosphorylation GO:0018105 74 0.134
regulation of reproductive process GO:2000241 66 0.134
Mouse
positive regulation of map kinase activity GO:0043406 84 0.134
regulation of execution phase of apoptosis GO:1900117 9 0.133
negative regulation of secretion GO:0051048 61 0.132
striated muscle tissue development GO:0014706 293 0.132
positive regulation of epithelial cell proliferation GO:0050679 68 0.132
positive regulation of cell development GO:0010720 237 0.131
renal system development GO:0072001 225 0.131
Mouse
intestinal epithelial structure maintenance GO:0060729 4 0.130
cellular response to vitamin d GO:0071305 2 0.130
syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 2 0.129
positive regulation of bmp signaling pathway GO:0030513 23 0.129
skin morphogenesis GO:0043589 38 0.128
lung development GO:0030324 164 0.127
somite development GO:0061053 81 0.126
regulation of jun kinase activity GO:0043506 40 0.123
ear morphogenesis GO:0042471 118 0.123
connective tissue development GO:0061448 179 0.122
trabecula morphogenesis GO:0061383 40 0.121
Mouse
regulation of chorionic trophoblast cell proliferation GO:1901382 1 0.121
cerebellum vasculature morphogenesis GO:0061301 1 0.120
cellular response to ketone GO:1901655 12 0.119
cell type specific apoptotic process GO:0097285 268 0.119
metal ion homeostasis GO:0055065 189 0.119
cellular response to estrogen stimulus GO:0071391 12 0.119
Mouse
negative regulation of mapk cascade GO:0043409 65 0.117
purine nucleotide metabolic process GO:0006163 302 0.117
response to organic cyclic compound GO:0014070 198 0.116
Mouse
lung alveolus development GO:0048286 45 0.115
palate development GO:0060021 76 0.113
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.113
negative regulation of insulin secretion GO:0046676 14 0.112
negative regulation of mesodermal cell fate specification GO:0042662 3 0.111
glucose homeostasis GO:0042593 128 0.110
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.110
response to starvation GO:0042594 65 0.110
hypophysis morphogenesis GO:0048850 3 0.109
negative regulation of protein modification process GO:0031400 163 0.109
protein catabolic process GO:0030163 221 0.108
cellular response to starvation GO:0009267 57 0.108
nucleoside triphosphate metabolic process GO:0009141 230 0.108
regulation of tube size GO:0035150 57 0.107
labyrinthine layer development GO:0060711 49 0.107
cerebellum morphogenesis GO:0021587 42 0.106
regulation of protein processing GO:0070613 96 0.105
midbrain development GO:0030901 35 0.104
negative regulation of b cell differentiation GO:0045578 4 0.103
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.103
fibroblast proliferation GO:0048144 35 0.103
cardiac muscle cell apoptotic process GO:0010659 10 0.102
negative regulation of synapse assembly GO:0051964 3 0.101
anatomical structure homeostasis GO:0060249 145 0.100
hindbrain development GO:0030902 128 0.100
wound healing GO:0042060 157 0.100
negative regulation of hepatocyte differentiation GO:0070367 1 0.100
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.099
negative regulation of nervous system development GO:0051961 156 0.099
cellular response to nutrient levels GO:0031669 64 0.099
regulation of cell growth GO:0001558 91 0.098
asymmetric neuroblast division GO:0055059 1 0.098
nucleobase containing small molecule metabolic process GO:0055086 352 0.097
positive regulation of mapk cascade GO:0043410 170 0.097
male germ line sex determination GO:0019100 2 0.097
organ growth GO:0035265 117 0.096
ribonucleoside metabolic process GO:0009119 245 0.096
neuron migration GO:0001764 122 0.095
somatic sex determination GO:0018993 2 0.095
ribonucleoside triphosphate catabolic process GO:0009203 199 0.094
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.093
somitogenesis GO:0001756 69 0.093
mesonephric epithelium development GO:0072163 94 0.093
Mouse
negative regulation of fibroblast proliferation GO:0048147 14 0.093
regulation of fibroblast proliferation GO:0048145 34 0.093
cellular response to lipid GO:0071396 145 0.093
Mouse
tube closure GO:0060606 91 0.091
glycosyl compound metabolic process GO:1901657 246 0.091
cardiac septum morphogenesis GO:0060411 46 0.091
regulation of cellular component biogenesis GO:0044087 181 0.090
face morphogenesis GO:0060325 29 0.090
astrocyte fate commitment GO:0060018 4 0.090
axonogenesis GO:0007409 274 0.089
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.088
chorionic trophoblast cell proliferation GO:0097360 1 0.087
regulation of nucleotide metabolic process GO:0006140 169 0.087
artery development GO:0060840 53 0.086
tissue regeneration GO:0042246 22 0.086
negative regulation of execution phase of apoptosis GO:1900118 4 0.085
homeostasis of number of cells GO:0048872 210 0.085
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.085
epithelial to mesenchymal transition GO:0001837 47 0.085
Human Mouse
ameboidal type cell migration GO:0001667 128 0.085
embryonic nail plate morphogenesis GO:0035880 3 0.084
negative regulation of protein maturation GO:1903318 79 0.082
regulation of actin filament based process GO:0032970 99 0.082
compound eye development GO:0048749 1 0.081
regulation of cellular response to growth factor stimulus GO:0090287 82 0.081
motor neuron axon guidance GO:0008045 26 0.081
nucleotide metabolic process GO:0009117 332 0.081
protein import into nucleus GO:0006606 95 0.081
macromolecule catabolic process GO:0009057 281 0.080
positive regulation of homeostatic process GO:0032846 64 0.079
response to estrogen GO:0043627 24 0.079
Mouse
regulation of cytokine production GO:0001817 266 0.079
endoderm development GO:0007492 45 0.078
peripheral nervous system neuron axonogenesis GO:0048936 3 0.077
regulation of cellular catabolic process GO:0031329 242 0.077
cellular response to alcohol GO:0097306 23 0.077
neural crest formation GO:0014029 2 0.077
Mouse
embryonic heart tube morphogenesis GO:0003143 51 0.077
ear development GO:0043583 200 0.076
salivary gland morphogenesis GO:0007435 33 0.076
regulation of muscle tissue development GO:1901861 97 0.076
establishment of tissue polarity GO:0007164 28 0.076
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.075

Sfrp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.081
bone disease DOID:0080001 0 0.081
disease of anatomical entity DOID:7 0 0.081
musculoskeletal system disease DOID:17 0 0.081
connective tissue disease DOID:65 0 0.081