Mus musculus

42 known processes

Plekhf1

pleckstrin homology domain containing, family F (with FYVE domain) member 1

(Aliases: 1810013P09Rik,ZFYVE15,PHAFIN1,APPD,LAPF)

Plekhf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.089
regulation of cellular amine metabolic process GO:0033238 20 0.064
cellular ketone metabolic process GO:0042180 84 0.063
regulation of cellular amino acid metabolic process GO:0006521 5 0.058
amine metabolic process GO:0009308 45 0.058
cellular amine metabolic process GO:0044106 44 0.057
oxidation reduction process GO:0055114 342 0.053
nucleotide metabolic process GO:0009117 332 0.052
nucleoside phosphate metabolic process GO:0006753 338 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.045
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
cellular lipid metabolic process GO:0044255 323 0.041
heterocycle catabolic process GO:0046700 280 0.038
negative regulation of protein metabolic process GO:0051248 282 0.037
cation transport GO:0006812 399 0.035
response to organonitrogen compound GO:0010243 246 0.034
transmembrane transport GO:0055085 412 0.034
spermatogenesis GO:0007283 284 0.033
purine nucleotide metabolic process GO:0006163 302 0.033
cation transmembrane transport GO:0098655 266 0.033
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.031
nitrogen compound transport GO:0071705 271 0.031
ion transmembrane transport GO:0034220 361 0.031
peptidyl amino acid modification GO:0018193 336 0.030
aromatic compound catabolic process GO:0019439 286 0.030
purine containing compound metabolic process GO:0072521 311 0.030
small gtpase mediated signal transduction GO:0007264 97 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
negative regulation of cellular amine metabolic process GO:0033239 1 0.029
carbohydrate metabolic process GO:0005975 230 0.029
apoptotic signaling pathway GO:0097190 306 0.029
ribose phosphate metabolic process GO:0019693 291 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
negative regulation of cellular protein metabolic process GO:0032269 247 0.028
membrane organization GO:0061024 245 0.028
Human
organonitrogen compound catabolic process GO:1901565 264 0.028
cellular nitrogen compound catabolic process GO:0044270 280 0.028
regulation of cytokine production GO:0001817 266 0.027
nucleoside metabolic process GO:0009116 246 0.027
actin cytoskeleton organization GO:0030036 220 0.027
cellular response to organonitrogen compound GO:0071417 145 0.027
inorganic cation transmembrane transport GO:0098662 207 0.027
ribonucleoside metabolic process GO:0009119 245 0.026
positive regulation of cell death GO:0010942 224 0.026
organic cyclic compound catabolic process GO:1901361 295 0.026
negative regulation of phosphorylation GO:0042326 166 0.026
glycosyl compound metabolic process GO:1901657 246 0.026
purine ribonucleoside metabolic process GO:0046128 241 0.026
ras protein signal transduction GO:0007265 77 0.026
ribonucleoside triphosphate metabolic process GO:0009199 220 0.026
negative regulation of immune system process GO:0002683 209 0.025
negative regulation of molecular function GO:0044092 258 0.025
regulation of hydrolase activity GO:0051336 246 0.025
rho protein signal transduction GO:0007266 32 0.025
positive regulation of protein modification process GO:0031401 299 0.025
carbohydrate derivative catabolic process GO:1901136 231 0.025
regulation of organelle organization GO:0033043 289 0.025
cofactor metabolic process GO:0051186 80 0.025
inorganic ion transmembrane transport GO:0098660 234 0.025
purine nucleoside triphosphate metabolic process GO:0009144 226 0.025
anion transport GO:0006820 177 0.024
myeloid cell differentiation GO:0030099 233 0.024
intracellular protein transport GO:0006886 204 0.024
regulation of kinase activity GO:0043549 249 0.024
monocarboxylic acid metabolic process GO:0032787 191 0.024
negative regulation of intracellular signal transduction GO:1902532 167 0.024
cellular homeostasis GO:0019725 240 0.024
g protein coupled receptor signaling pathway GO:0007186 243 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.023
purine ribonucleotide metabolic process GO:0009150 290 0.023
leukocyte differentiation GO:0002521 342 0.023
regulation of transferase activity GO:0051338 263 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
cytoplasmic transport GO:0016482 234 0.023
Fly
organophosphate catabolic process GO:0046434 232 0.023
negative regulation of cell proliferation GO:0008285 296 0.023
regulation of cellular response to stress GO:0080135 159 0.022
immune effector process GO:0002252 321 0.022
lipid biosynthetic process GO:0008610 179 0.022
protein processing GO:0016485 163 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.022
mapk cascade GO:0000165 281 0.022
ribonucleotide metabolic process GO:0009259 291 0.022
organic acid transport GO:0015849 101 0.021
regulation of protein kinase activity GO:0045859 232 0.021
positive regulation of programmed cell death GO:0043068 218 0.021
regulation of membrane potential GO:0042391 192 0.021
purine nucleoside catabolic process GO:0006152 205 0.021
t cell activation GO:0042110 289 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
nucleotide catabolic process GO:0009166 217 0.021
purine containing compound catabolic process GO:0072523 213 0.021
response to organic cyclic compound GO:0014070 198 0.021
negative regulation of phosphate metabolic process GO:0045936 184 0.021
urogenital system development GO:0001655 261 0.021
ribonucleotide catabolic process GO:0009261 208 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.020
macromolecule catabolic process GO:0009057 281 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
cell adhesion GO:0007155 329 0.020
purine nucleotide catabolic process GO:0006195 211 0.020
nucleoside catabolic process GO:0009164 206 0.020
muscle tissue development GO:0060537 308 0.020
cytokine production GO:0001816 319 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
protein maturation GO:0051604 176 0.020
endomembrane system organization GO:0010256 147 0.020
Human Fly
dna metabolic process GO:0006259 303 0.020
regulation of secretion GO:0051046 274 0.019
fat cell differentiation GO:0045444 160 0.019
small molecule biosynthetic process GO:0044283 132 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.019
sulfur compound metabolic process GO:0006790 100 0.019
circulatory system process GO:0003013 197 0.019
alpha amino acid metabolic process GO:1901605 59 0.019
regulation of apoptotic signaling pathway GO:2001233 197 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
Human
carboxylic acid transport GO:0046942 100 0.019
cellular response to hormone stimulus GO:0032870 150 0.018
extracellular structure organization GO:0043062 148 0.018
synaptic transmission GO:0007268 329 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
cellular response to lipid GO:0071396 145 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
cellular chemical homeostasis GO:0055082 215 0.018
nucleoside triphosphate catabolic process GO:0009143 205 0.018
glycosyl compound catabolic process GO:1901658 206 0.018
regulation of cell activation GO:0050865 289 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.017
regulation of nucleotide metabolic process GO:0006140 169 0.017
male gamete generation GO:0048232 285 0.017
protein catabolic process GO:0030163 221 0.017
striated muscle tissue development GO:0014706 293 0.017
mitochondrion organization GO:0007005 134 0.017
regulation of mapk cascade GO:0043408 248 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
actin filament organization GO:0007015 113 0.017
homeostasis of number of cells GO:0048872 210 0.017
guanosine containing compound catabolic process GO:1901069 144 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
small molecule catabolic process GO:0044282 71 0.017
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
organic anion transport GO:0015711 137 0.016
ribonucleoside triphosphate catabolic process GO:0009203 199 0.016
response to acid chemical GO:0001101 111 0.016
epithelial cell development GO:0002064 159 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
blood circulation GO:0008015 195 0.016
negative regulation of protein modification process GO:0031400 163 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
organophosphate biosynthetic process GO:0090407 122 0.016
neuronal action potential GO:0019228 54 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
extracellular matrix organization GO:0030198 147 0.016
amide transport GO:0042886 138 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
cellular protein complex assembly GO:0043623 116 0.015
protein ubiquitination GO:0016567 171 0.015
maintenance of location GO:0051235 89 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
regulation of cell migration GO:0030334 219 0.015
lymphocyte differentiation GO:0030098 242 0.015
regulation of hormone levels GO:0010817 211 0.015
response to inorganic substance GO:0010035 96 0.015
regulation of protein localization GO:0032880 231 0.015
multicellular organismal homeostasis GO:0048871 164 0.015
guanosine containing compound metabolic process GO:1901068 144 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
gtp metabolic process GO:0046039 144 0.015
cell type specific apoptotic process GO:0097285 268 0.015
skeletal muscle organ development GO:0060538 163 0.015
regulation of homeostatic process GO:0032844 182 0.015
respiratory system development GO:0060541 190 0.015
regulation of leukocyte differentiation GO:1902105 159 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
response to oxidative stress GO:0006979 123 0.015
protein localization to organelle GO:0033365 185 0.014
glycerolipid metabolic process GO:0046486 122 0.014
cellular amide metabolic process GO:0043603 58 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
fat soluble vitamin biosynthetic process GO:0042362 4 0.014
cation homeostasis GO:0055080 212 0.014
ossification GO:0001503 216 0.014
innate immune response GO:0045087 157 0.014
protein modification by small protein conjugation GO:0032446 187 0.014
regulation of cell cycle GO:0051726 281 0.014
divalent inorganic cation transport GO:0072511 178 0.014
regulation of defense response GO:0031347 233 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
response to oxygen levels GO:0070482 62 0.014
response to radiation GO:0009314 165 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
regulation of protein serine threonine kinase activity GO:0071900 157 0.014
renal system development GO:0072001 225 0.014
regulation of system process GO:0044057 200 0.014
kidney development GO:0001822 213 0.014
carboxylic acid biosynthetic process GO:0046394 86 0.014
cellular response to acid chemical GO:0071229 68 0.014
gtp catabolic process GO:0006184 143 0.014
inflammatory response GO:0006954 244 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
compound eye development GO:0048749 1 0.014
lateral inhibition GO:0046331 1 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
regulation of cell motility GO:2000145 236 0.013
response to growth factor GO:0070848 198 0.013
cellular ion homeostasis GO:0006873 165 0.013
muscle cell differentiation GO:0042692 261 0.013
microtubule based process GO:0007017 236 0.013
intracellular receptor signaling pathway GO:0030522 74 0.013
coenzyme metabolic process GO:0006732 52 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.013
developmental maturation GO:0021700 193 0.013
skeletal system development GO:0001501 356 0.013
regulation of ion transport GO:0043269 215 0.013
response to light stimulus GO:0009416 135 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
nuclear transport GO:0051169 139 0.013
action potential GO:0001508 78 0.013
lipid transport GO:0006869 98 0.013
lipid localization GO:0010876 126 0.013
cell substrate adhesion GO:0031589 130 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
organic acid biosynthetic process GO:0016053 86 0.013
renal sodium ion transport GO:0003096 2 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
germ cell development GO:0007281 185 0.012
regulation of protein transport GO:0051223 163 0.012
lung development GO:0030324 164 0.012
positive regulation of transferase activity GO:0051347 167 0.012
regulation of transmembrane transport GO:0034762 128 0.012
defense response to other organism GO:0098542 197 0.012
camera type eye development GO:0043010 266 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
cellular modified amino acid metabolic process GO:0006575 63 0.012
response to peptide GO:1901652 136 0.012
tissue homeostasis GO:0001894 115 0.012
mitotic cell cycle GO:0000278 195 0.012
gland development GO:0048732 330 0.012
embryonic organ morphogenesis GO:0048562 276 0.012
fatty acid metabolic process GO:0006631 121 0.012
sodium ion transmembrane transport GO:0035725 49 0.012
regulation of protein maturation GO:1903317 96 0.012
mitochondrion distribution GO:0048311 4 0.012
regulation of t cell activation GO:0050863 170 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
positive regulation of fatty acid oxidation GO:0046321 4 0.012
plasma membrane organization GO:0007009 90 0.012
Human
regulation of anatomical structure size GO:0090066 178 0.012
regulation of proteolysis GO:0030162 164 0.012
protein targeting GO:0006605 143 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
spermatid differentiation GO:0048515 115 0.012
protein localization to membrane GO:0072657 108 0.012
Human
regulation of protein processing GO:0070613 96 0.012
sensory perception GO:0007600 245 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.012
negative regulation of cell cycle GO:0045786 123 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
chemotaxis GO:0006935 247 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.012
anion transmembrane transport GO:0098656 71 0.012
regulation of blood pressure GO:0008217 93 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
regulation of body fluid levels GO:0050878 162 0.012
negative regulation of cell development GO:0010721 169 0.012
regulation of secretion by cell GO:1903530 249 0.012
endocytosis GO:0006897 168 0.012
Fly
response to lipopolysaccharide GO:0032496 128 0.012
rhythmic process GO:0048511 174 0.012
protein hydroxylation GO:0018126 4 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
regulation of ossification GO:0030278 112 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
carboxylic acid catabolic process GO:0046395 51 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
sensory organ morphogenesis GO:0090596 242 0.011
alcohol metabolic process GO:0006066 116 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
t cell differentiation GO:0030217 174 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
Human
localization within membrane GO:0051668 4 0.011
sodium ion transport GO:0006814 73 0.011
mitotic cell cycle process GO:1903047 159 0.011
cellular protein catabolic process GO:0044257 155 0.011
acetate metabolic process GO:0006083 1 0.011
mitochondrion degradation GO:0000422 3 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
carbohydrate homeostasis GO:0033500 128 0.011
positive regulation of kinase activity GO:0033674 155 0.011
leukocyte migration GO:0050900 124 0.011
interleukin 8 production GO:0032637 4 0.011
peptide transport GO:0015833 133 0.011
respiratory tube development GO:0030323 167 0.011
anatomical structure homeostasis GO:0060249 145 0.011
protein polymerization GO:0051258 57 0.011
regulation of fat cell differentiation GO:0045598 81 0.011
chromatin modification GO:0016568 187 0.011
organic hydroxy compound transport GO:0015850 93 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
regulation of chloride transport GO:2001225 2 0.011
positive regulation of cytokine production GO:0001819 174 0.011
defense response to bacterium GO:0042742 119 0.011
glucose homeostasis GO:0042593 128 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
regulation of neuron differentiation GO:0045664 281 0.011
body fluid secretion GO:0007589 53 0.011
response to peptide hormone GO:0043434 127 0.010
regulation of cell adhesion GO:0030155 154 0.010
membrane tubulation GO:0097320 4 0.010
transmission of nerve impulse GO:0019226 76 0.010
chromatin organization GO:0006325 206 0.010
regulation of cell projection organization GO:0031344 206 0.010
regulation of response to wounding GO:1903034 189 0.010
neuron death GO:0070997 154 0.010
regulation of intracellular transport GO:0032386 159 0.010
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
metal ion homeostasis GO:0055065 189 0.010
regulation of ion transmembrane transport GO:0034765 119 0.010
myeloid cell homeostasis GO:0002262 114 0.010
glycerolipid biosynthetic process GO:0045017 50 0.010
negative regulation of protein processing GO:0010955 79 0.010
multicellular organism growth GO:0035264 161 0.010
response to amino acid GO:0043200 37 0.010
regulation of actin filament based process GO:0032970 99 0.010
amino acid transport GO:0006865 61 0.010
regulation of lipid metabolic process GO:0019216 118 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
regulation of myeloid cell differentiation GO:0045637 96 0.010
connective tissue development GO:0061448 179 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
locomotory behavior GO:0007626 195 0.010
positive regulation of cellular ph reduction GO:0032849 2 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010

Plekhf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.031
immune system disease DOID:2914 0 0.022
central nervous system disease DOID:331 0 0.018
disease of metabolism DOID:0014667 0 0.017
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
hematopoietic system disease DOID:74 0 0.015
bone disease DOID:0080001 0 0.014
eye disease DOID:5614 0 0.014
inherited metabolic disorder DOID:655 0 0.012
neurodegenerative disease DOID:1289 0 0.011
neuromuscular disease DOID:440 0 0.011
neuropathy DOID:870 0 0.011