Mus musculus

0 known processes

Pole2

polymerase (DNA directed), epsilon 2 (p59 subunit)

Pole2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synapsis GO:0007129 34 0.701
dna metabolic process GO:0006259 303 0.688
meiotic cell cycle process GO:1903046 77 0.656
dna replication GO:0006260 52 0.627
cellular response to dna damage stimulus GO:0006974 207 0.609
dna dependent dna replication GO:0006261 24 0.426
dna repair GO:0006281 107 0.413
microtubule cytoskeleton organization GO:0000226 157 0.410
organic cyclic compound catabolic process GO:1901361 295 0.356
meiosis i GO:0007127 60 0.356
meiotic nuclear division GO:0007126 115 0.340
organelle fission GO:0048285 170 0.332
dna endoreduplication GO:0042023 4 0.307
meiotic cell cycle GO:0051321 122 0.254
chromosome segregation GO:0007059 48 0.253
heterocycle catabolic process GO:0046700 280 0.246
dna conformation change GO:0071103 37 0.244
macromolecule catabolic process GO:0009057 281 0.243
cellular nitrogen compound catabolic process GO:0044270 280 0.226
cellular macromolecule catabolic process GO:0044265 206 0.223
nuclear dna replication GO:0033260 3 0.222
chromosome organization involved in meiosis GO:0070192 39 0.213
dna recombination GO:0006310 92 0.207
double strand break repair GO:0006302 48 0.199
nuclear division GO:0000280 158 0.198
recombinational repair GO:0000725 21 0.191
double strand break repair via homologous recombination GO:0000724 21 0.182
regulation of cell cycle process GO:0010564 160 0.173
regulation of dna dependent dna replication GO:0090329 8 0.169
mitotic centrosome separation GO:0007100 4 0.166
mitotic cell cycle process GO:1903047 159 0.166
regulation of dna replication GO:0006275 17 0.163
chromatin organization GO:0006325 206 0.160
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.158
mitotic cell cycle GO:0000278 195 0.156
purine nucleoside catabolic process GO:0006152 205 0.156
regulation of cell cycle GO:0051726 281 0.144
synaptonemal complex assembly GO:0007130 13 0.135
microtubule based process GO:0007017 236 0.132
purine ribonucleotide metabolic process GO:0009150 290 0.117
organelle assembly GO:0070925 177 0.112
negative regulation of cell cycle GO:0045786 123 0.108
purine nucleoside triphosphate metabolic process GO:0009144 226 0.104
intra s dna damage checkpoint GO:0031573 4 0.103
purine nucleotide metabolic process GO:0006163 302 0.102
sister chromatid cohesion GO:0007062 12 0.102
spindle assembly involved in mitosis GO:0090307 4 0.101
aromatic compound catabolic process GO:0019439 286 0.101
regulation of mitotic cell cycle GO:0007346 126 0.096
cell division GO:0051301 120 0.096
nucleoside phosphate metabolic process GO:0006753 338 0.093
negative regulation of cell cycle process GO:0010948 69 0.093
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.091
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.091
nucleoside metabolic process GO:0009116 246 0.090
female meiosis chromosome segregation GO:0016321 1 0.086
positive regulation of cell cycle GO:0045787 92 0.086
nucleoside triphosphate metabolic process GO:0009141 230 0.084
glycosyl compound catabolic process GO:1901658 206 0.083
histone threonine phosphorylation GO:0035405 1 0.080
nucleobase containing small molecule metabolic process GO:0055086 352 0.078
reciprocal dna recombination GO:0035825 16 0.077
purine nucleoside triphosphate catabolic process GO:0009146 203 0.076
organonitrogen compound catabolic process GO:1901565 264 0.075
ribose phosphate metabolic process GO:0019693 291 0.075
dna packaging GO:0006323 30 0.075
nucleoside phosphate catabolic process GO:1901292 222 0.073
ribonucleoside catabolic process GO:0042454 206 0.072
ribonucleotide catabolic process GO:0009261 208 0.070
regulation of organelle organization GO:0033043 289 0.069
carbohydrate derivative catabolic process GO:1901136 231 0.069
male meiosis GO:0007140 37 0.068
translesion synthesis GO:0019985 1 0.068
covalent chromatin modification GO:0016569 163 0.068
mitotic cytokinesis GO:0000281 4 0.065
mitotic nuclear division GO:0007067 48 0.063
purine containing compound catabolic process GO:0072523 213 0.062
cellular protein catabolic process GO:0044257 155 0.060
cell cycle checkpoint GO:0000075 47 0.059
purine nucleoside metabolic process GO:0042278 241 0.057
reciprocal meiotic recombination GO:0007131 16 0.057
purine ribonucleoside metabolic process GO:0046128 241 0.057
double strand break repair via nonhomologous end joining GO:0006303 10 0.057
cellular ketone metabolic process GO:0042180 84 0.056
regulation of cellular catabolic process GO:0031329 242 0.056
ribonucleoside metabolic process GO:0009119 245 0.055
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.055
chromatin modification GO:0016568 187 0.054
negative regulation of cell cycle phase transition GO:1901988 48 0.053
spermatogenesis GO:0007283 284 0.053
ribonucleotide metabolic process GO:0009259 291 0.052
peptidyl amino acid modification GO:0018193 336 0.052
glycosyl compound metabolic process GO:1901657 246 0.052
regulation of cell cycle phase transition GO:1901987 77 0.051
nucleoside monophosphate metabolic process GO:0009123 85 0.051
organophosphate catabolic process GO:0046434 232 0.050
purine containing compound metabolic process GO:0072521 311 0.050
negative regulation of mitotic cell cycle GO:0045930 58 0.048
gene silencing GO:0016458 38 0.046
nucleotide metabolic process GO:0009117 332 0.046
regulation of cell division GO:0051302 76 0.046
ribonucleoside triphosphate catabolic process GO:0009203 199 0.045
regulation of cellular ketone metabolic process GO:0010565 66 0.045
nucleoside triphosphate catabolic process GO:0009143 205 0.044
regulation of nuclear cell cycle dna replication GO:0033262 2 0.043
endocytosis GO:0006897 168 0.042
dna integrity checkpoint GO:0031570 28 0.042
purine nucleotide catabolic process GO:0006195 211 0.042
purine ribonucleotide catabolic process GO:0009154 208 0.041
ribonucleoside triphosphate metabolic process GO:0009199 220 0.041
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.041
regulation of cellular amino acid metabolic process GO:0006521 5 0.040
nucleoside catabolic process GO:0009164 206 0.040
amine metabolic process GO:0009308 45 0.039
dna replication independent nucleosome assembly GO:0006336 1 0.039
female meiotic division GO:0007143 21 0.039
mitotic sister chromatid segregation GO:0000070 14 0.038
histone modification GO:0016570 159 0.038
development of primary sexual characteristics GO:0045137 143 0.038
Worm
cytokinetic process GO:0032506 2 0.038
dna catabolic process exonucleolytic GO:0000738 3 0.037
nuclear transport GO:0051169 139 0.037
nucleotide catabolic process GO:0009166 217 0.036
dna catabolic process GO:0006308 19 0.036
establishment of organelle localization GO:0051656 122 0.035
protein catabolic process GO:0030163 221 0.034
response to organic cyclic compound GO:0014070 198 0.033
cellular amino acid metabolic process GO:0006520 103 0.033
organelle localization GO:0051640 179 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.032
meiotic chromosome segregation GO:0045132 19 0.032
dephosphorylation GO:0016311 129 0.032
regulation of kinase activity GO:0043549 249 0.032
dna catabolic process endonucleolytic GO:0000737 15 0.032
purine ribonucleoside catabolic process GO:0046130 205 0.030
regulation of protein localization GO:0032880 231 0.030
regulation of mitotic cell cycle phase transition GO:1901990 73 0.030
negative regulation of phosphate metabolic process GO:0045936 184 0.030
apoptotic signaling pathway GO:0097190 306 0.029
regulation of cytoskeleton organization GO:0051493 122 0.029
mitotic sister chromatid cohesion GO:0007064 1 0.029
fertilization GO:0009566 127 0.027
dna geometric change GO:0032392 7 0.027
regulation of microtubule based process GO:0032886 52 0.027
synaptonemal complex organization GO:0070193 15 0.027
muscle cell differentiation GO:0042692 261 0.027
mitotic chromosome condensation GO:0007076 1 0.026
regulation of transferase activity GO:0051338 263 0.026
histone phosphorylation GO:0016572 9 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
intrinsic apoptotic signaling pathway GO:0097193 132 0.026
gonad development GO:0008406 141 0.025
Worm
response to organonitrogen compound GO:0010243 246 0.025
microtubule organizing center organization GO:0031023 28 0.025
cellular amine metabolic process GO:0044106 44 0.025
positive regulation of hydrolase activity GO:0051345 148 0.025
regulation of hydrolase activity GO:0051336 246 0.024
positive regulation of protein modification process GO:0031401 299 0.024
spindle organization GO:0007051 28 0.024
regulation of establishment of protein localization GO:0070201 181 0.024
centrosome cycle GO:0007098 23 0.024
purine nucleoside monophosphate metabolic process GO:0009126 81 0.024
membrane organization GO:0061024 245 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
response to inorganic substance GO:0010035 96 0.023
positive regulation of cellular catabolic process GO:0031331 148 0.023
oxidation reduction process GO:0055114 342 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.023
cell cycle g1 s phase transition GO:0044843 57 0.023
protein dna complex subunit organization GO:0071824 28 0.022
atp metabolic process GO:0046034 75 0.022
nucleocytoplasmic transport GO:0006913 139 0.022
atp catabolic process GO:0006200 55 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.022
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.022
maintenance of location GO:0051235 89 0.021
cellular response to organonitrogen compound GO:0071417 145 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.021
germ cell development GO:0007281 185 0.021
negative regulation of cellular component organization GO:0051129 194 0.021
positive regulation of organelle organization GO:0010638 128 0.021
mitotic cell cycle checkpoint GO:0007093 31 0.020
ribonucleoside monophosphate catabolic process GO:0009158 57 0.020
male gamete generation GO:0048232 285 0.020
response to uv GO:0009411 44 0.020
regulation of microtubule cytoskeleton organization GO:0070507 37 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.020
dna biosynthetic process GO:0071897 22 0.019
protein secretion GO:0009306 111 0.019
ras protein signal transduction GO:0007265 77 0.019
regulation of cytoplasmic transport GO:1903649 112 0.018
regulation of cell motility GO:2000145 236 0.018
microtubule based movement GO:0007018 84 0.018
mitochondrion organization GO:0007005 134 0.018
cell type specific apoptotic process GO:0097285 268 0.018
single fertilization GO:0007338 82 0.018
neuron migration GO:0001764 122 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.018
spindle assembly GO:0051225 13 0.018
asymmetric stem cell division GO:0098722 3 0.018
dna replication initiation GO:0006270 5 0.018
mapk cascade GO:0000165 281 0.017
protein import GO:0017038 101 0.017
receptor mediated endocytosis GO:0006898 51 0.017
cellular lipid metabolic process GO:0044255 323 0.017
intracellular protein transport GO:0006886 204 0.017
positive regulation of kinase activity GO:0033674 155 0.017
striated muscle myosin thick filament assembly GO:0071688 1 0.017
cell fate commitment GO:0045165 210 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
cellular response to organic cyclic compound GO:0071407 87 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
mrna processing GO:0006397 63 0.017
male meiosis i GO:0007141 16 0.017
response to light stimulus GO:0009416 135 0.017
purine nucleoside monophosphate catabolic process GO:0009128 58 0.017
negative regulation of dna replication GO:0008156 4 0.017
regulation of mitosis GO:0007088 29 0.017
positive regulation of cell death GO:0010942 224 0.016
centrosome separation GO:0051299 4 0.016
chromosome separation GO:0051304 14 0.016
cellular response to abiotic stimulus GO:0071214 56 0.016
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.016
cation transport GO:0006812 399 0.016
regulation of response to wounding GO:1903034 189 0.016
regulation of nucleoside metabolic process GO:0009118 130 0.016
nucleoside monophosphate catabolic process GO:0009125 59 0.016
rna processing GO:0006396 105 0.016
centrosome organization GO:0051297 26 0.016
regulation of histone modification GO:0031056 56 0.016
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
positive regulation of meiotic cell cycle GO:0051446 15 0.015
dendrite development GO:0016358 115 0.015
striated muscle cell development GO:0055002 125 0.015
cellular response to lipid GO:0071396 145 0.015
metaphase plate congression GO:0051310 2 0.015
negative regulation of organelle organization GO:0010639 90 0.015
cell adhesion GO:0007155 329 0.015
endomembrane system organization GO:0010256 147 0.015
regulation of cell migration GO:0030334 219 0.015
citrate metabolic process GO:0006101 3 0.015
regulation of protein transport GO:0051223 163 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
regulation of chromosome organization GO:0033044 83 0.014
cellularization GO:0007349 1 0.014
peptidyl serine modification GO:0018209 83 0.014
gland development GO:0048732 330 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
positive regulation of cell cycle process GO:0090068 61 0.014
peptidyl threonine phosphorylation GO:0018107 31 0.014
protein targeting GO:0006605 143 0.014
wnt signaling pathway GO:0016055 188 0.014
leukocyte apoptotic process GO:0071887 71 0.014
positive regulation of nervous system development GO:0051962 221 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
response to ionizing radiation GO:0010212 42 0.014
response to metal ion GO:0010038 47 0.014
regulation of secretion GO:0051046 274 0.014
regulation of protein kinase activity GO:0045859 232 0.014
nuclear import GO:0051170 95 0.014
chromatin assembly or disassembly GO:0006333 16 0.014
axonogenesis GO:0007409 274 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
negative regulation of dna dependent dna replication GO:2000104 1 0.014
protein localization to nucleus GO:0034504 121 0.014
regulation of secretion by cell GO:1903530 249 0.013
homeostasis of number of cells GO:0048872 210 0.013
spindle assembly involved in female meiosis GO:0007056 3 0.013
protein import into nucleus GO:0006606 95 0.013
guanosine containing compound metabolic process GO:1901068 144 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
regulation of cell projection organization GO:0031344 206 0.013
regulation of proteasomal protein catabolic process GO:0061136 46 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
leukocyte proliferation GO:0070661 172 0.013
neural tube development GO:0021915 160 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
positive regulation of nucleoside metabolic process GO:0045979 91 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
heterochromatin organization GO:0070828 4 0.012
lymphocyte proliferation GO:0046651 164 0.012
chromatin remodeling GO:0006338 32 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
regulation of cell activation GO:0050865 289 0.012
sister chromatid segregation GO:0000819 20 0.012
mitotic spindle organization GO:0007052 10 0.012
positive regulation of cell activation GO:0050867 158 0.012
spindle midzone assembly GO:0051255 1 0.012
positive regulation of nucleotide catabolic process GO:0030813 88 0.012
myosin filament assembly GO:0031034 2 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
mitotic g2 dna damage checkpoint GO:0007095 8 0.012
neural tube formation GO:0001841 108 0.012
regulation of inflammatory response GO:0050727 147 0.012
cellular chemical homeostasis GO:0055082 215 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
positive regulation of cell division GO:0051781 31 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
tube formation GO:0035148 140 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
neural precursor cell proliferation GO:0061351 121 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
blastocyst development GO:0001824 80 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
regulation of mapk cascade GO:0043408 248 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
regulation of leukocyte apoptotic process GO:2000106 56 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
cleavage furrow formation GO:0036089 2 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
rho protein signal transduction GO:0007266 32 0.012
cellular response to biotic stimulus GO:0071216 92 0.011
dna damage checkpoint GO:0000077 26 0.011
lymphocyte differentiation GO:0030098 242 0.011
b cell activation GO:0042113 161 0.011
multicellular organism growth GO:0035264 161 0.011
cytoplasmic transport GO:0016482 234 0.011
response to radiation GO:0009314 165 0.011
peptidyl threonine modification GO:0018210 31 0.011
protein oligomerization GO:0051259 67 0.011
regulation of meiosis i GO:0060631 7 0.011
regulation of binding GO:0051098 111 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
anion transport GO:0006820 177 0.011
regulation of spindle organization GO:0090224 2 0.011
sensory perception GO:0007600 245 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
response to hypoxia GO:0001666 58 0.011
mitotic recombination GO:0006312 3 0.011
response to oxygen levels GO:0070482 62 0.011
cellular response to inorganic substance GO:0071241 37 0.011
camera type eye development GO:0043010 266 0.011
myeloid cell differentiation GO:0030099 233 0.011
positive regulation of cell development GO:0010720 237 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
regulation of neuron projection development GO:0010975 169 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
forebrain development GO:0030900 302 0.011
digestive system development GO:0055123 200 0.011
regulation of wnt signaling pathway GO:0030111 123 0.010
negative regulation of cellular protein metabolic process GO:0032269 247 0.010
anatomical structure homeostasis GO:0060249 145 0.010
multi multicellular organism process GO:0044706 109 0.010
lipid biosynthetic process GO:0008610 179 0.010
cell activation involved in immune response GO:0002263 126 0.010
response to acid chemical GO:0001101 111 0.010
negative regulation of molecular function GO:0044092 258 0.010
establishment of protein localization to organelle GO:0072594 118 0.010
muscle cell development GO:0055001 133 0.010
regulation of transcription by chromatin organization GO:0034401 0 0.010
stem cell differentiation GO:0048863 268 0.010
positive regulation of protein transport GO:0051222 93 0.010
protein maturation GO:0051604 176 0.010
gtp metabolic process GO:0046039 144 0.010
alpha beta t cell activation GO:0046631 91 0.010
centrosome duplication GO:0051298 16 0.010

Pole2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.037
cancer DOID:162 0 0.028
organ system cancer DOID:0050686 0 0.023