Mus musculus

0 known processes

Pdia4

protein disulfide isomerase associated 4

(Aliases: ERp-72,AI987846,Cai,Erp72)

Pdia4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to topologically incorrect protein GO:0035966 25 0.228
Worm
cellular macromolecule catabolic process GO:0044265 206 0.120
protein catabolic process GO:0030163 221 0.103
cellular amino acid metabolic process GO:0006520 103 0.087
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.086
cellular ketone metabolic process GO:0042180 84 0.083
response to organonitrogen compound GO:0010243 246 0.079
cellular amine metabolic process GO:0044106 44 0.071
macromolecule catabolic process GO:0009057 281 0.070
response to extracellular stimulus GO:0009991 127 0.061
transmembrane transport GO:0055085 412 0.061
ubiquitin dependent protein catabolic process GO:0006511 129 0.058
positive regulation of programmed cell death GO:0043068 218 0.057
Mouse
er nucleus signaling pathway GO:0006984 27 0.055
Worm
glycoprotein biosynthetic process GO:0009101 89 0.054
amine metabolic process GO:0009308 45 0.054
regulation of cellular ketone metabolic process GO:0010565 66 0.054
response to unfolded protein GO:0006986 21 0.052
Worm
cellular response to antibiotic GO:0071236 4 0.051
muscle cell differentiation GO:0042692 261 0.050
apoptotic signaling pathway GO:0097190 306 0.050
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.050
proteasomal protein catabolic process GO:0010498 98 0.046
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
modification dependent macromolecule catabolic process GO:0043632 133 0.044
modification dependent protein catabolic process GO:0019941 133 0.044
regulation of cellular amine metabolic process GO:0033238 20 0.044
cellular protein catabolic process GO:0044257 155 0.043
midgut development GO:0007494 4 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.040
positive regulation of hydrolase activity GO:0051345 148 0.039
positive regulation of apoptotic signaling pathway GO:2001235 95 0.037
Mouse
response to organic cyclic compound GO:0014070 198 0.037
cellular response to nutrient levels GO:0031669 64 0.036
synaptic vesicle transport GO:0048489 57 0.036
positive regulation of transferase activity GO:0051347 167 0.035
regulation of organelle organization GO:0033043 289 0.034
positive regulation of protein phosphorylation GO:0001934 242 0.034
regulation of cell migration GO:0030334 219 0.033
response to endoplasmic reticulum stress GO:0034976 53 0.033
Worm
positive regulation of protein modification process GO:0031401 299 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.033
cellular response to interleukin 4 GO:0071353 21 0.032
regulation of kinase activity GO:0043549 249 0.031
cellular lipid metabolic process GO:0044255 323 0.031
positive regulation of kinase activity GO:0033674 155 0.031
spermatogenesis GO:0007283 284 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
cation transport GO:0006812 399 0.031
membrane organization GO:0061024 245 0.030
regulation of cellular catabolic process GO:0031329 242 0.030
peptidyl amino acid modification GO:0018193 336 0.029
regulation of endocytosis GO:0030100 69 0.029
male anatomical structure morphogenesis GO:0090598 4 0.029
maintenance of location GO:0051235 89 0.029
purine nucleoside catabolic process GO:0006152 205 0.029
cellular response to external stimulus GO:0071496 88 0.028
purine nucleoside metabolic process GO:0042278 241 0.028
protein targeting to membrane GO:0006612 20 0.028
protein targeting to er GO:0045047 2 0.028
regulation of cell motility GO:2000145 236 0.028
fertilization GO:0009566 127 0.027
regulation of cell projection organization GO:0031344 206 0.027
regulation of transferase activity GO:0051338 263 0.027
male gamete generation GO:0048232 285 0.027
carbohydrate derivative biosynthetic process GO:1901137 183 0.027
lipid localization GO:0010876 126 0.027
monocarboxylic acid metabolic process GO:0032787 191 0.027
extrinsic apoptotic signaling pathway GO:0097191 126 0.026
Mouse
glycoprotein metabolic process GO:0009100 116 0.026
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.026
regulation of apoptotic signaling pathway GO:2001233 197 0.026
Mouse
muscle tissue development GO:0060537 308 0.025
endocytosis GO:0006897 168 0.025
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.025
regulation of hydrolase activity GO:0051336 246 0.025
establishment of protein localization to membrane GO:0090150 54 0.025
multicellular organism growth GO:0035264 161 0.024
Worm
ribose phosphate metabolic process GO:0019693 291 0.024
glycosyl compound metabolic process GO:1901657 246 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
male sex differentiation GO:0046661 109 0.023
ribonucleoside metabolic process GO:0009119 245 0.023
regulation of vesicle mediated transport GO:0060627 139 0.023
ribonucleotide metabolic process GO:0009259 291 0.023
ribonucleotide catabolic process GO:0009261 208 0.023
protein ubiquitination GO:0016567 171 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
nucleoside triphosphate catabolic process GO:0009143 205 0.023
heterocycle catabolic process GO:0046700 280 0.023
nucleoside phosphate metabolic process GO:0006753 338 0.023
positive regulation of cell migration GO:0030335 109 0.022
cellular chemical homeostasis GO:0055082 215 0.022
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.022
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
positive regulation of apoptotic process GO:0043065 217 0.022
Mouse
lipid biosynthetic process GO:0008610 179 0.022
regulation of membrane potential GO:0042391 192 0.022
aromatic compound catabolic process GO:0019439 286 0.022
leukocyte differentiation GO:0002521 342 0.022
meiotic nuclear division GO:0007126 115 0.022
protein localization to organelle GO:0033365 185 0.022
regulation of purine nucleotide metabolic process GO:1900542 169 0.021
nucleoside metabolic process GO:0009116 246 0.021
regulation of secretion GO:0051046 274 0.021
response to nutrient levels GO:0031667 109 0.021
neural tube development GO:0021915 160 0.021
cellular response to topologically incorrect protein GO:0035967 25 0.021
Worm
cellular response to extracellular stimulus GO:0031668 81 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
divalent inorganic cation transport GO:0072511 178 0.020
endoplasmic reticulum unfolded protein response GO:0030968 19 0.020
Worm
protein modification by small protein conjugation or removal GO:0070647 207 0.020
organelle localization GO:0051640 179 0.020
regulation of protein kinase activity GO:0045859 232 0.020
regulation of secretion by cell GO:1903530 249 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.020
regulation of cell cycle GO:0051726 281 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.019
chemotaxis GO:0006935 247 0.019
purine ribonucleoside catabolic process GO:0046130 205 0.019
protein localization to membrane GO:0072657 108 0.019
purine nucleoside monophosphate metabolic process GO:0009126 81 0.019
cellular nitrogen compound catabolic process GO:0044270 280 0.019
response to lipopolysaccharide GO:0032496 128 0.019
organelle fission GO:0048285 170 0.019
neural tube formation GO:0001841 108 0.019
response to antibiotic GO:0046677 11 0.019
positive regulation of growth GO:0045927 104 0.019
Worm
regulation of anatomical structure size GO:0090066 178 0.019
embryonic epithelial tube formation GO:0001838 130 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
intracellular protein transport GO:0006886 204 0.019
negative regulation of molecular function GO:0044092 258 0.019
establishment of organelle localization GO:0051656 122 0.019
nucleotide metabolic process GO:0009117 332 0.019
meiotic cell cycle GO:0051321 122 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
cell adhesion GO:0007155 329 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.018
regulation of neuron differentiation GO:0045664 281 0.018
purine containing compound metabolic process GO:0072521 311 0.018
gland development GO:0048732 330 0.018
nucleotide catabolic process GO:0009166 217 0.018
organonitrogen compound biosynthetic process GO:1901566 192 0.018
action potential GO:0001508 78 0.018
dephosphorylation GO:0016311 129 0.018
oxidation reduction process GO:0055114 342 0.018
Yeast
positive regulation of cell death GO:0010942 224 0.018
Mouse
dna metabolic process GO:0006259 303 0.018
cation transmembrane transport GO:0098655 266 0.018
cellular response to biotic stimulus GO:0071216 92 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.017
dna repair GO:0006281 107 0.017
ion transmembrane transport GO:0034220 361 0.017
protein targeting GO:0006605 143 0.017
multi multicellular organism process GO:0044706 109 0.017
anatomical structure homeostasis GO:0060249 145 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
bone development GO:0060348 120 0.017
response to oxygen levels GO:0070482 62 0.017
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.017
maintenance of protein localization in organelle GO:0072595 2 0.017
rna processing GO:0006396 105 0.017
striated muscle tissue development GO:0014706 293 0.017
exocytosis GO:0006887 121 0.016
cellular homeostasis GO:0019725 240 0.016
organophosphate catabolic process GO:0046434 232 0.016
actin cytoskeleton organization GO:0030036 220 0.016
male genitalia morphogenesis GO:0048808 4 0.016
nitrogen compound transport GO:0071705 271 0.016
substantia nigra development GO:0021762 2 0.016
ossification GO:0001503 216 0.016
synaptic transmission GO:0007268 329 0.016
skeletal system development GO:0001501 356 0.016
cellular response to organonitrogen compound GO:0071417 145 0.016
actin filament organization GO:0007015 113 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.016
mapk cascade GO:0000165 281 0.016
regulation of body fluid levels GO:0050878 162 0.016
positive regulation of cell activation GO:0050867 158 0.016
digestive tract development GO:0048565 190 0.016
cytoplasmic transport GO:0016482 234 0.016
sensory perception GO:0007600 245 0.016
multicellular organismal homeostasis GO:0048871 164 0.015
regulation of cell adhesion GO:0030155 154 0.015
positive regulation of apoptotic cell clearance GO:2000427 3 0.015
regulation of mapk cascade GO:0043408 248 0.015
response to light stimulus GO:0009416 135 0.015
multicellular organismal signaling GO:0035637 91 0.015
nucleoside triphosphate metabolic process GO:0009141 230 0.015
response to testosterone GO:0033574 3 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
wound healing GO:0042060 157 0.015
forebrain development GO:0030900 302 0.015
hindbrain development GO:0030902 128 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
protein modification by small protein conjugation GO:0032446 187 0.015
transmission of nerve impulse GO:0019226 76 0.015
regulation of neurotransmitter levels GO:0001505 87 0.015
germ cell development GO:0007281 185 0.015
tube formation GO:0035148 140 0.014
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
regulation of hormone levels GO:0010817 211 0.014
positive regulation of phagocytosis GO:0050766 26 0.014
actin filament polymerization GO:0030041 44 0.014
organic cyclic compound catabolic process GO:1901361 295 0.014
glycosyl compound catabolic process GO:1901658 206 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
cerebellar purkinje cell layer development GO:0021680 26 0.014
positive regulation of cell motility GO:2000147 116 0.014
single organism cell adhesion GO:0098602 156 0.014
response to radiation GO:0009314 165 0.014
positive regulation of atpase activity GO:0032781 3 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
t cell activation GO:0042110 289 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
atp metabolic process GO:0046034 75 0.014
neural tube closure GO:0001843 90 0.014
regulation of mrna processing GO:0050684 41 0.014
immune effector process GO:0002252 321 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
response to acid chemical GO:0001101 111 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
regulation of cellular response to stress GO:0080135 159 0.014
epithelial tube formation GO:0072175 130 0.013
cation homeostasis GO:0055080 212 0.013
regulation of cell substrate adhesion GO:0010810 73 0.013
nucleoside catabolic process GO:0009164 206 0.013
negative regulation of nucleoside metabolic process GO:0045978 11 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
regulation of ion transport GO:0043269 215 0.013
lymphocyte differentiation GO:0030098 242 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
fatty acid metabolic process GO:0006631 121 0.013
regulation of cellular response to growth factor stimulus GO:0090287 82 0.013
positive regulation of endocytosis GO:0045807 42 0.013
regulation of phagocytosis GO:0050764 33 0.013
striated muscle myosin thick filament assembly GO:0071688 1 0.013
defecation GO:0030421 1 0.013
organic acid transport GO:0015849 101 0.013
establishment of synaptic vesicle localization GO:0097480 57 0.013
synaptic vesicle localization GO:0097479 59 0.013
response to interleukin 4 GO:0070670 23 0.013
endodermal digestive tract morphogenesis GO:0061031 4 0.013
vesicle localization GO:0051648 86 0.013
cerebellar cortex development GO:0021695 48 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
mrna metabolic process GO:0016071 84 0.013
atp catabolic process GO:0006200 55 0.013
cellular protein complex assembly GO:0043623 116 0.013
lateral inhibition GO:0046331 1 0.013
positive regulation of cell substrate adhesion GO:0010811 47 0.012
regulation of proteolysis GO:0030162 164 0.012
glycosylation GO:0070085 62 0.012
regulation of endopeptidase activity GO:0052548 89 0.012
myosin filament organization GO:0031033 3 0.012
cellular response to lipid GO:0071396 145 0.012
interspecies interaction between organisms GO:0044419 83 0.012
spermatid differentiation GO:0048515 115 0.012
blood vessel morphogenesis GO:0048514 285 0.012
translation GO:0006412 93 0.012
negative regulation of cell development GO:0010721 169 0.012
regulation of cellular component size GO:0032535 121 0.012
negative regulation of cell cycle GO:0045786 123 0.012
myeloid cell differentiation GO:0030099 233 0.012
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.012
Mouse
mitotic cell cycle process GO:1903047 159 0.012
inflammatory response GO:0006954 244 0.012
regulation of systemic arterial blood pressure GO:0003073 61 0.012
protein folding GO:0006457 28 0.012
Yeast Rat
regulation of cytokine production GO:0001817 266 0.012
response to steroid hormone GO:0048545 56 0.012
positive regulation of protein ubiquitination GO:0031398 27 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
positive regulation of cell development GO:0010720 237 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
rho protein signal transduction GO:0007266 32 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
nuclear division GO:0000280 158 0.012
cell type specific apoptotic process GO:0097285 268 0.012
cerebellum morphogenesis GO:0021587 42 0.012
tissue homeostasis GO:0001894 115 0.012
glucose metabolic process GO:0006006 92 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.011
digestive system development GO:0055123 200 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
microtubule based process GO:0007017 236 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
regulation of response to wounding GO:1903034 189 0.011
hindbrain morphogenesis GO:0021575 46 0.011
myosin filament assembly GO:0031034 2 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
cellular response to starvation GO:0009267 57 0.011
carbohydrate homeostasis GO:0033500 128 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
striated muscle cell development GO:0055002 125 0.011
small molecule biosynthetic process GO:0044283 132 0.011
plasma membrane organization GO:0007009 90 0.011
compound eye development GO:0048749 1 0.011
regulation of homeostatic process GO:0032844 182 0.011
circulatory system process GO:0003013 197 0.011
sensory organ morphogenesis GO:0090596 242 0.011
glucose homeostasis GO:0042593 128 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
primary neural tube formation GO:0014020 95 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
regulation of actin cytoskeleton organization GO:0032956 84 0.011
nuclear transport GO:0051169 139 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
placenta development GO:0001890 140 0.011
ear development GO:0043583 200 0.011
actin polymerization or depolymerization GO:0008154 54 0.011
protein maturation GO:0051604 176 0.011
negative regulation of immune system process GO:0002683 209 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
divalent metal ion transport GO:0070838 172 0.011
carbohydrate metabolic process GO:0005975 230 0.011
cerebellum development GO:0021549 77 0.011
purine containing compound catabolic process GO:0072523 213 0.011
tube closure GO:0060606 91 0.011
cell junction organization GO:0034330 77 0.011
response to growth factor GO:0070848 198 0.010
negative regulation of organelle organization GO:0010639 90 0.010
digestive tract morphogenesis GO:0048546 147 0.010
immunoglobulin production GO:0002377 73 0.010
negative regulation of nervous system development GO:0051961 156 0.010
heart morphogenesis GO:0003007 178 0.010
retina homeostasis GO:0001895 23 0.010
hexose metabolic process GO:0019318 98 0.010
mitochondrion distribution GO:0048311 4 0.010
canonical wnt signaling pathway GO:0060070 130 0.010
peptide transport GO:0015833 133 0.010
innate immune response GO:0045087 157 0.010
angiogenesis GO:0001525 201 0.010
skeletal muscle organ development GO:0060538 163 0.010
neural nucleus development GO:0048857 22 0.010
cognition GO:0050890 149 0.010
kidney development GO:0001822 213 0.010
protein oligomerization GO:0051259 67 0.010
posttranslational protein targeting to membrane GO:0006620 2 0.010
morphogenesis of a branching structure GO:0001763 203 0.010

Pdia4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
nervous system disease DOID:863 0 0.043
musculoskeletal system disease DOID:17 0 0.030
connective tissue disease DOID:65 0 0.030
central nervous system disease DOID:331 0 0.028
bone disease DOID:0080001 0 0.025
disease of cellular proliferation DOID:14566 0 0.022
cancer DOID:162 0 0.021
organ system cancer DOID:0050686 0 0.021
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.018
bone development disease DOID:0080006 0 0.018
immune system disease DOID:2914 0 0.018
immune system cancer DOID:0060083 0 0.016
hematologic cancer DOID:2531 0 0.016
sensory system disease DOID:0050155 0 0.015
neurodegenerative disease DOID:1289 0 0.013
osteochondrodysplasia DOID:2256 0 0.012
thoracic cancer DOID:5093 0 0.010