Mus musculus

31 known processes

Zmpste24

zinc metallopeptidase, STE24 homolog (S. cerevisiae)

(Aliases: MADB,D030046F19,STE24,Ste24p,Face-1,FACE1,A530043O15Rik)

Zmpste24 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 323 0.105
amine metabolic process GO:0009308 45 0.080
regulation of cellular amino acid metabolic process GO:0006521 5 0.073
cellular amino acid metabolic process GO:0006520 103 0.073
intracellular protein transport GO:0006886 204 0.071
regulation of cellular amine metabolic process GO:0033238 20 0.069
ion transmembrane transport GO:0034220 361 0.068
negative regulation of molecular function GO:0044092 258 0.067
cation transport GO:0006812 399 0.066
transmembrane transport GO:0055085 412 0.064
positive regulation of cellular amine metabolic process GO:0033240 5 0.062
activation of nf kappab inducing kinase activity GO:0007250 4 0.057
positive regulation of apoptotic process GO:0043065 217 0.056
peptidyl amino acid modification GO:0018193 336 0.056
cytoplasmic transport GO:0016482 234 0.055
regulation of transferase activity GO:0051338 263 0.052
small gtpase mediated signal transduction GO:0007264 97 0.051
cellular ketone metabolic process GO:0042180 84 0.051
skeletal system development GO:0001501 356 0.049
membrane lipid biosynthetic process GO:0046467 32 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
ras protein signal transduction GO:0007265 77 0.046
glycerolipid metabolic process GO:0046486 122 0.045
regulation of intracellular transport GO:0032386 159 0.044
cellular homeostasis GO:0019725 240 0.043
cellular amine metabolic process GO:0044106 44 0.043
regulation of protein kinase activity GO:0045859 232 0.042
regulation of protein localization GO:0032880 231 0.042
regulation of cellular ketone metabolic process GO:0010565 66 0.041
regulation of apoptotic signaling pathway GO:2001233 197 0.041
mapk cascade GO:0000165 281 0.039
metal ion homeostasis GO:0055065 189 0.038
leukocyte differentiation GO:0002521 342 0.037
positive regulation of protein kinase activity GO:0045860 144 0.037
regulation of defense response GO:0031347 233 0.036
apoptotic signaling pathway GO:0097190 306 0.036
positive regulation of protein phosphorylation GO:0001934 242 0.036
sphingolipid biosynthetic process GO:0030148 26 0.036
lipid biosynthetic process GO:0008610 179 0.035
carbohydrate metabolic process GO:0005975 230 0.035
cellular amide metabolic process GO:0043603 58 0.035
cellular ion homeostasis GO:0006873 165 0.034
cation transmembrane transport GO:0098655 266 0.034
cellular response to lipid GO:0071396 145 0.033
cellular chemical homeostasis GO:0055082 215 0.033
protein localization to membrane GO:0072657 108 0.033
sphingolipid metabolic process GO:0006665 45 0.032
dna metabolic process GO:0006259 303 0.032
membrane organization GO:0061024 245 0.031
regulation of mapk cascade GO:0043408 248 0.031
cation homeostasis GO:0055080 212 0.031
organonitrogen compound biosynthetic process GO:1901566 192 0.031
myeloid cell differentiation GO:0030099 233 0.030
protein localization to organelle GO:0033365 185 0.030
divalent metal ion transport GO:0070838 172 0.030
protein targeting GO:0006605 143 0.030
calcium ion transport GO:0006816 159 0.030
cellular metal ion homeostasis GO:0006875 151 0.029
inorganic cation transmembrane transport GO:0098662 207 0.029
negative regulation of cell adhesion mediated by integrin GO:0033629 2 0.029
protein maturation GO:0051604 176 0.029
protein processing GO:0016485 163 0.028
endocytosis GO:0006897 168 0.028
rho protein signal transduction GO:0007266 32 0.028
intrinsic apoptotic signaling pathway GO:0097193 132 0.028
reactive oxygen species metabolic process GO:0072593 84 0.028
striated muscle tissue development GO:0014706 293 0.027
heterocycle catabolic process GO:0046700 280 0.027
lipid transport GO:0006869 98 0.027
inorganic ion transmembrane transport GO:0098660 234 0.027
regulation of ion transport GO:0043269 215 0.027
regulation of protein serine threonine kinase activity GO:0071900 157 0.027
homeostasis of number of cells GO:0048872 210 0.026
nucleobase containing small molecule metabolic process GO:0055086 352 0.026
regulation of kinase activity GO:0043549 249 0.026
organic hydroxy compound metabolic process GO:1901615 203 0.025
endomembrane system organization GO:0010256 147 0.025
positive regulation of programmed cell death GO:0043068 218 0.025
cellular divalent inorganic cation homeostasis GO:0072503 127 0.025
circulatory system process GO:0003013 197 0.025
mitotic cell cycle process GO:1903047 159 0.025
regulation of cell activation GO:0050865 289 0.025
regulation of body fluid levels GO:0050878 162 0.025
nitrogen compound transport GO:0071705 271 0.025
immune effector process GO:0002252 321 0.025
calcium ion homeostasis GO:0055074 127 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
neuron death GO:0070997 154 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
synaptic transmission GO:0007268 329 0.024
muscle cell differentiation GO:0042692 261 0.024
carboxylic acid biosynthetic process GO:0046394 86 0.023
organophosphate catabolic process GO:0046434 232 0.023
organic hydroxy compound transport GO:0015850 93 0.023
organonitrogen compound catabolic process GO:1901565 264 0.023
nuclear transport GO:0051169 139 0.023
positive regulation of kinase activity GO:0033674 155 0.023
regulation of metal ion transport GO:0010959 106 0.023
positive regulation of transferase activity GO:0051347 167 0.023
t cell activation GO:0042110 289 0.022
divalent inorganic cation homeostasis GO:0072507 138 0.022
ceramide biosynthetic process GO:0046513 20 0.022
cellular response to dna damage stimulus GO:0006974 207 0.022
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.022
divalent inorganic cation transport GO:0072511 178 0.022
sensory perception GO:0007600 245 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
sulfur compound metabolic process GO:0006790 100 0.022
glycoprotein metabolic process GO:0009100 116 0.022
regulation of nucleocytoplasmic transport GO:0046822 73 0.022
protein import into nucleus GO:0006606 95 0.022
monocarboxylic acid metabolic process GO:0032787 191 0.021
peptidyl serine modification GO:0018209 83 0.021
carbohydrate derivative biosynthetic process GO:1901137 183 0.021
positive regulation of protein modification process GO:0031401 299 0.021
dephosphorylation GO:0016311 129 0.021
compound eye development GO:0048749 1 0.021
chromatin organization GO:0006325 206 0.021
positive regulation of map kinase activity GO:0043406 84 0.021
protein import GO:0017038 101 0.021
fatty acid metabolic process GO:0006631 121 0.021
negative regulation of apoptotic signaling pathway GO:2001234 104 0.021
regulation of membrane potential GO:0042391 192 0.021
nucleocytoplasmic transport GO:0006913 139 0.021
regulation of hormone levels GO:0010817 211 0.021
cell adhesion GO:0007155 329 0.020
response to organonitrogen compound GO:0010243 246 0.020
multicellular organismal homeostasis GO:0048871 164 0.020
membrane lipid metabolic process GO:0006643 53 0.020
organelle localization GO:0051640 179 0.020
blood circulation GO:0008015 195 0.020
regulation of cellular response to stress GO:0080135 159 0.020
nucleotide metabolic process GO:0009117 332 0.020
alcohol metabolic process GO:0006066 116 0.020
myeloid leukocyte differentiation GO:0002573 119 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
response to organic cyclic compound GO:0014070 198 0.019
cellular protein complex assembly GO:0043623 116 0.019
gland development GO:0048732 330 0.019
regulation of cell migration GO:0030334 219 0.019
phagocytosis GO:0006909 66 0.019
embryonic organ morphogenesis GO:0048562 276 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
cytokine production GO:0001816 319 0.019
regulation of protein transport GO:0051223 163 0.019
sequestering of calcium ion GO:0051208 18 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
regulation of homeostatic process GO:0032844 182 0.018
gonad morphogenesis GO:0035262 1 0.018
response to insulin GO:0032868 100 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
male gamete generation GO:0048232 285 0.018
regulation of intracellular protein transport GO:0033157 82 0.018
regulation of secretion by cell GO:1903530 249 0.018
regulation of cytokine production GO:0001817 266 0.018
positive regulation of intracellular transport GO:0032388 70 0.018
phospholipid metabolic process GO:0006644 87 0.018
cellular calcium ion homeostasis GO:0006874 119 0.018
regulation of map kinase activity GO:0043405 120 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
response to oxidative stress GO:0006979 123 0.017
sequestering of metal ion GO:0051238 19 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
ossification GO:0001503 216 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
ribose phosphate metabolic process GO:0019693 291 0.017
regulation of calcium ion transport GO:0051924 69 0.017
regulation of endopeptidase activity GO:0052548 89 0.017
spermatogenesis GO:0007283 284 0.017
neutral lipid metabolic process GO:0006638 57 0.017
peptide secretion GO:0002790 114 0.017
regulation of organelle organization GO:0033043 289 0.017
wound healing GO:0042060 157 0.017
lipid localization GO:0010876 126 0.017
mitotic cell cycle GO:0000278 195 0.017
negative regulation of phosphorylation GO:0042326 166 0.017
organelle assembly GO:0070925 177 0.016
heart morphogenesis GO:0003007 178 0.016
muscle contraction GO:0006936 101 0.016
organic acid biosynthetic process GO:0016053 86 0.016
cellular response to abiotic stimulus GO:0071214 56 0.016
glucose homeostasis GO:0042593 128 0.016
amide transport GO:0042886 138 0.016
glycerophospholipid metabolic process GO:0006650 71 0.016
action potential GO:0001508 78 0.016
nuclear import GO:0051170 95 0.016
cell type specific apoptotic process GO:0097285 268 0.016
multicellular organism growth GO:0035264 161 0.016
glycoprotein biosynthetic process GO:0009101 89 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
oxidation reduction process GO:0055114 342 0.016
small molecule biosynthetic process GO:0044283 132 0.016
muscle tissue development GO:0060537 308 0.016
purine nucleotide metabolic process GO:0006163 302 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
mitochondrion organization GO:0007005 134 0.016
sensory organ morphogenesis GO:0090596 242 0.016
positive regulation of ion transport GO:0043270 65 0.016
regulation of cytoplasmic transport GO:1903649 112 0.015
defense response to bacterium GO:0042742 119 0.015
gonad development GO:0008406 141 0.015
methylation GO:0032259 134 0.015
regulation of protein localization to nucleus GO:1900180 60 0.015
purine containing compound metabolic process GO:0072521 311 0.015
skeletal system morphogenesis GO:0048705 203 0.015
urogenital system development GO:0001655 261 0.015
anion transport GO:0006820 177 0.015
coagulation GO:0050817 78 0.015
regulation of defense response to bacterium GO:1900424 3 0.015
peptidyl tyrosine modification GO:0018212 145 0.015
nucleotide catabolic process GO:0009166 217 0.015
adult behavior GO:0030534 135 0.015
negative regulation of transferase activity GO:0051348 85 0.015
regulation of interleukin 8 production GO:0032677 3 0.015
antimicrobial peptide production GO:0002775 2 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.015
organophosphate biosynthetic process GO:0090407 122 0.014
response to lipopolysaccharide GO:0032496 128 0.014
lateral inhibition GO:0046331 1 0.014
fertilization GO:0009566 127 0.014
regulation of action potential GO:0098900 4 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
antimicrobial peptide biosynthetic process GO:0002777 2 0.014
localization within membrane GO:0051668 4 0.014
stress activated mapk cascade GO:0051403 80 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
plasma membrane organization GO:0007009 90 0.014
positive regulation of cell death GO:0010942 224 0.014
nuclear membrane organization GO:0071763 4 0.014
regulation of peptidase activity GO:0052547 96 0.014
actin cytoskeleton organization GO:0030036 220 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
er nucleus signaling pathway GO:0006984 27 0.014
macromolecule glycosylation GO:0043413 55 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
antibacterial peptide production GO:0002778 2 0.014
chemotaxis GO:0006935 247 0.014
positive regulation of secretion GO:0051047 130 0.014
regulation of secretion GO:0051046 274 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
histone modification GO:0016570 159 0.014
response to epidermal growth factor GO:0070849 4 0.014
leukocyte proliferation GO:0070661 172 0.014
camera type eye development GO:0043010 266 0.014
single fertilization GO:0007338 82 0.014
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
forebrain development GO:0030900 302 0.013
carbohydrate homeostasis GO:0033500 128 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
cellular modified amino acid metabolic process GO:0006575 63 0.013
regulation of proteolysis GO:0030162 164 0.013
lymphocyte proliferation GO:0046651 164 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
single organism nuclear import GO:1902593 95 0.013
protein localization to nucleus GO:0034504 121 0.013
hormone secretion GO:0046879 128 0.013
regulation of cellular catabolic process GO:0031329 242 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
stress activated protein kinase signaling cascade GO:0031098 81 0.013
establishment of organelle localization GO:0051656 122 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
limb development GO:0060173 166 0.013
myotube differentiation GO:0014902 105 0.013
regulation of hydrolase activity GO:0051336 246 0.013
skeletal muscle organ development GO:0060538 163 0.013
negative regulation of cytokine production GO:0001818 84 0.013
regulation of system process GO:0044057 200 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
regulation of anatomical structure size GO:0090066 178 0.013
cell growth GO:0016049 130 0.013
hemostasis GO:0007599 78 0.013
i kappab kinase nf kappab signaling GO:0007249 85 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
lymphocyte differentiation GO:0030098 242 0.013
sterol transmembrane transport GO:0035382 2 0.012
monocarboxylic acid biosynthetic process GO:0072330 61 0.012
negative regulation of immune system process GO:0002683 209 0.012
peptide transport GO:0015833 133 0.012
ceramide metabolic process GO:0006672 31 0.012
multicellular organismal signaling GO:0035637 91 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
blood coagulation GO:0007596 76 0.012
inflammatory response GO:0006954 244 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
regulation of blood pressure GO:0008217 93 0.012
cytosolic calcium ion transport GO:0060401 48 0.012
angiogenesis GO:0001525 201 0.012
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
ear development GO:0043583 200 0.012
positive regulation of growth GO:0045927 104 0.012
muscle cell development GO:0055001 133 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
response to steroid hormone GO:0048545 56 0.012
blood vessel morphogenesis GO:0048514 285 0.012
anatomical structure homeostasis GO:0060249 145 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
organelle fission GO:0048285 170 0.012
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.012
negative regulation of sterol transport GO:0032372 4 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
neuron apoptotic process GO:0051402 142 0.012
histone h4 k16 acetylation GO:0043984 3 0.012
aromatic compound catabolic process GO:0019439 286 0.012
regulation of neuron death GO:1901214 134 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
calcium mediated signaling GO:0019722 46 0.012
insulin secretion GO:0030073 89 0.012
antibacterial peptide biosynthetic process GO:0002780 2 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
regulation of chromatin silencing GO:0031935 2 0.012
respiratory system development GO:0060541 190 0.012
organ regeneration GO:0031100 2 0.012
calcium ion transport into cytosol GO:0060402 48 0.012
myosin filament assembly GO:0031034 2 0.012
canonical wnt signaling pathway GO:0060070 130 0.012
locomotory behavior GO:0007626 195 0.011
peptide metabolic process GO:0006518 46 0.011
fat cell differentiation GO:0045444 160 0.011
telencephalon development GO:0021537 186 0.011
positive regulation of defense response GO:0031349 124 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
maintenance of location GO:0051235 89 0.011
serine phosphorylation of stat protein GO:0042501 3 0.011
ribonucleoside metabolic process GO:0009119 245 0.011
cellular response to insulin stimulus GO:0032869 78 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
response to endoplasmic reticulum stress GO:0034976 53 0.011
response to acid chemical GO:0001101 111 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
purine ribonucleoside catabolic process GO:0046130 205 0.011
immune response activating signal transduction GO:0002757 116 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
regulation of exit from mitosis GO:0007096 1 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
cytosolic calcium ion homeostasis GO:0051480 70 0.011
positive regulation of protein transport GO:0051222 93 0.011
regulation of feeding behavior GO:0060259 3 0.011
adult locomotory behavior GO:0008344 91 0.011
response to extracellular stimulus GO:0009991 127 0.011
regulation of striated muscle cell differentiation GO:0051153 81 0.011
actin filament based movement GO:0030048 23 0.011
transmission of nerve impulse GO:0019226 76 0.011
negative regulation of protein modification process GO:0031400 163 0.011
lactation GO:0007595 25 0.011
regulation of protein import into nucleus translocation GO:0033158 2 0.011
tissue remodeling GO:0048771 102 0.011
activation of mapk activity GO:0000187 59 0.011
regulation of cell cycle GO:0051726 281 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
positive regulation of glucose transport GO:0010828 16 0.011
regulation of multi organism process GO:0043900 111 0.011
covalent chromatin modification GO:0016569 163 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
regulation of t cell activation GO:0050863 170 0.011
triglyceride metabolic process GO:0006641 51 0.011
regulation of cell projection organization GO:0031344 206 0.011
epithelial cell development GO:0002064 159 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cell activation involved in immune response GO:0002263 126 0.011
regulation of cell motility GO:2000145 236 0.011
protein kinase b signaling GO:0043491 74 0.010
interleukin 8 production GO:0032637 4 0.010
establishment of vesicle localization GO:0051650 81 0.010
macromolecule catabolic process GO:0009057 281 0.010
organic anion transport GO:0015711 137 0.010
positive regulation of cell motility GO:2000147 116 0.010
positive regulation of cell development GO:0010720 237 0.010
small molecule catabolic process GO:0044282 71 0.010
carbohydrate derivative catabolic process GO:1901136 231 0.010
myosin filament organization GO:0031033 3 0.010
sulfur compound biosynthetic process GO:0044272 37 0.010
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
positive regulation of cell migration GO:0030335 109 0.010
positive regulation of secretion by cell GO:1903532 114 0.010
retrograde transport endosome to golgi GO:0042147 2 0.010
response to peptide hormone GO:0043434 127 0.010
cellular response to steroid hormone stimulus GO:0071383 33 0.010
response to peptide GO:1901652 136 0.010
cellular response to peptide GO:1901653 92 0.010
translation GO:0006412 93 0.010
cellular macromolecule catabolic process GO:0044265 206 0.010
positive regulation of innate immune response GO:0045089 80 0.010
jak stat cascade GO:0007259 42 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
regulation of lipid metabolic process GO:0019216 118 0.010

Zmpste24 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.040
musculoskeletal system disease DOID:17 0 0.031
immune system cancer DOID:0060083 0 0.031
disease of cellular proliferation DOID:14566 0 0.031
cancer DOID:162 0 0.031
organ system cancer DOID:0050686 0 0.031
hematologic cancer DOID:2531 0 0.031
integumentary system disease DOID:16 0 0.029
inherited metabolic disorder DOID:655 0 0.027
disease of metabolism DOID:0014667 0 0.027
connective tissue disease DOID:65 0 0.026
osteochondrodysplasia DOID:2256 0 0.026
bone development disease DOID:0080006 0 0.026
bone disease DOID:0080001 0 0.026
neuropathy DOID:870 0 0.022
thoracic cancer DOID:5093 0 0.016
sensory system disease DOID:0050155 0 0.014
immune system disease DOID:2914 0 0.014
cardiovascular system disease DOID:1287 0 0.011
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010
lipid metabolism disorder DOID:3146 0 0.010