|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.986
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.970
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.959
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.954
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.952
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.951
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.949
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.948
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.941
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.938
|
Worm Fly |
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.937
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.935
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.931
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.930
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.928
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.928
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.924
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.920
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.914
|
|
|
|
macroautophagy
|
GO:0016236 |
21 |
0.910
|
Fly |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.910
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.907
|
Fly |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.899
|
|
|
|
negative regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045736 |
9 |
0.899
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.893
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.885
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.885
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.879
|
Worm Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.878
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.874
|
Fly |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.874
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.872
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.863
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.858
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.855
|
|
|
|
positive regulation of transcription by galactose
|
GO:0000411 |
1 |
0.855
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.850
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.850
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
35 |
0.845
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.843
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.840
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.837
|
|
|
|
neurotransmitter transport
|
GO:0006836 |
76 |
0.835
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.832
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.829
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.827
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.820
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.820
|
|
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.811
|
Fly |
|
|
photoreceptor cell morphogenesis
|
GO:0008594 |
3 |
0.811
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.802
|
|
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
3 |
0.792
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.785
|
Mouse |
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.784
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.784
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.782
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.775
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.767
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.764
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.757
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.756
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.753
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.750
|
|
|
|
visual behavior
|
GO:0007632 |
45 |
0.750
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.748
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.747
|
|
|
|
negative regulation of macroautophagy
|
GO:0016242 |
5 |
0.744
|
Fly |
|
|
carbon catabolite activation of transcription
|
GO:0045991 |
4 |
0.733
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.729
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.727
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.724
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.720
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
13 |
0.720
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.717
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.712
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.710
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.706
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.703
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.703
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.700
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.696
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.695
|
|
|
|
negative regulation of organ growth
|
GO:0046621 |
17 |
0.694
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.693
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.690
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.690
|
Fly |
|
|
positive regulation of apoptotic process involved in mammary gland involution
|
GO:0060058 |
4 |
0.681
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.678
|
|
|
|
autophagy
|
GO:0006914 |
45 |
0.677
|
Fly |
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.676
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
13 |
0.675
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.672
|
|
|
|
regulation of transcription by galactose
|
GO:0000409 |
1 |
0.671
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
73 |
0.671
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.666
|
|
|
|
regulation of microtubule polymerization or depolymerization
|
GO:0031110 |
20 |
0.666
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.664
|
|
|
|
positive regulation of ras protein signal transduction
|
GO:0046579 |
13 |
0.663
|
Fly |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.651
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.645
|
Mouse |
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.643
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.634
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.628
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.627
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.625
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.623
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
0.620
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.619
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.617
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.609
|
|
|
|
activation of adenylate cyclase activity
|
GO:0007190 |
4 |
0.590
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.583
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.581
|
Fly |
|
|
regulation of response to drug
|
GO:2001023 |
2 |
0.577
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.575
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.570
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.565
|
|
|
|
cell aging
|
GO:0007569 |
35 |
0.563
|
|
|
|
regulation of rac protein signal transduction
|
GO:0035020 |
19 |
0.559
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.559
|
Fly |
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
51 |
0.558
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
22 |
0.558
|
Mouse |
|
|
cellular response to starvation
|
GO:0009267 |
57 |
0.553
|
Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.552
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.531
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.529
|
|
|
|
stem cell proliferation
|
GO:0072089 |
117 |
0.526
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
81 |
0.520
|
Fly |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.513
|
|
|
|
negative regulation of rho protein signal transduction
|
GO:0035024 |
7 |
0.507
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.506
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.498
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.497
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
44 |
0.497
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.496
|
|
|
|
genetic imprinting
|
GO:0071514 |
27 |
0.494
|
|
|
|
cerebellum development
|
GO:0021549 |
77 |
0.492
|
|
|
|
cell cycle arrest
|
GO:0007050 |
37 |
0.490
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
64 |
0.485
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.478
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.476
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.476
|
Fly |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.476
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.473
|
|
|
|
positive regulation of rac protein signal transduction
|
GO:0035022 |
1 |
0.472
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.472
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.472
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
43 |
0.462
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
64 |
0.461
|
Fly |
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.460
|
|
|
|
formation of radial glial scaffolds
|
GO:0021943 |
4 |
0.456
|
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.453
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.450
|
Mouse Fly |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.443
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.441
|
|
|
|
oocyte axis specification
|
GO:0007309 |
2 |
0.431
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.428
|
|
|
|
regulation of macroautophagy
|
GO:0016241 |
12 |
0.425
|
Fly |
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.425
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
4 |
0.424
|
|
|
|
negative regulation of protein complex disassembly
|
GO:0043242 |
22 |
0.423
|
|
|
|
negative regulation of microtubule depolymerization
|
GO:0007026 |
13 |
0.423
|
|
|
|
microtubule polymerization or depolymerization
|
GO:0031109 |
26 |
0.411
|
|
|
|
camera type eye development
|
GO:0043010 |
266 |
0.408
|
|
|
|
cellular response to radiation
|
GO:0071478 |
28 |
0.406
|
|
|
|
regulation of protein stability
|
GO:0031647 |
52 |
0.404
|
|
|
|
neuron neuron synaptic transmission
|
GO:0007270 |
69 |
0.400
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.395
|
|
|
|
pole plasm assembly
|
GO:0007315 |
2 |
0.394
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.384
|
Fly |
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.381
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.378
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.378
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.375
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
15 |
0.374
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.373
|
Mouse Fly |
|
|
microtubule depolymerization
|
GO:0007019 |
15 |
0.372
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
48 |
0.366
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.365
|
Human |
|
|
cellular senescence
|
GO:0090398 |
11 |
0.364
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.363
|
|
|
|
positive regulation of cell proliferation involved in heart valve morphogenesis
|
GO:0003251 |
1 |
0.362
|
|
|
|
negative regulation of glial cell proliferation
|
GO:0060253 |
4 |
0.358
|
|
|
|
stem cell differentiation
|
GO:0048863 |
268 |
0.351
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.350
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
3 |
0.349
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.345
|
Fly |
|
|
dendritic spine organization
|
GO:0097061 |
26 |
0.344
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
57 |
0.344
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.342
|
Fly |
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.340
|
Worm |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.339
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.336
|
|
|
|
hindbrain development
|
GO:0030902 |
128 |
0.336
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.330
|
|
|
|
metencephalon development
|
GO:0022037 |
89 |
0.328
|
|
|
|
canonical wnt signaling pathway involved in negative regulation of apoptotic process
|
GO:0044336 |
4 |
0.328
|
|
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.326
|
|
|
|
negative regulation of microtubule polymerization or depolymerization
|
GO:0031111 |
15 |
0.325
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.325
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.324
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.324
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
43 |
0.322
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
47 |
0.320
|
Fly |
|
|
regulation of transforming growth factor beta2 production
|
GO:0032909 |
2 |
0.320
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.310
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.309
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.309
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
58 |
0.309
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.306
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
62 |
0.303
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
7 |
0.303
|
|
|
|
oocyte differentiation
|
GO:0009994 |
35 |
0.301
|
|
|
|
negative regulation of protein depolymerization
|
GO:1901880 |
21 |
0.299
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.296
|
|
|
|
pallium development
|
GO:0021543 |
120 |
0.295
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
3 |
0.292
|
|
|
|
neuroblast fate determination
|
GO:0007400 |
1 |
0.292
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
39 |
0.289
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.288
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
29 |
0.288
|
|
|
|
response to drug
|
GO:0042493 |
75 |
0.288
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.285
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.285
|
|
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
23 |
0.283
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.282
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
31 |
0.282
|
|
|
|
mitotic cell cycle arrest
|
GO:0071850 |
4 |
0.281
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
130 |
0.280
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.280
|
Mouse |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.280
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.278
|
Mouse Fly |
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.275
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.274
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.274
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.272
|
Human |
|
|
gland development
|
GO:0048732 |
330 |
0.271
|
Fly |
|
|
negative regulation of neurotransmitter secretion
|
GO:0046929 |
5 |
0.271
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
16 |
0.265
|
|
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
193 |
0.262
|
|
|
|
atp metabolic process
|
GO:0046034 |
75 |
0.262
|
|
|
|
vesicle localization
|
GO:0051648 |
86 |
0.262
|
|
|
|
regulation of synaptic transmission gabaergic
|
GO:0032228 |
17 |
0.262
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.260
|
Fly |
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.254
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.251
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.248
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.246
|
|
|
|
metanephric glomerular mesangium development
|
GO:0072223 |
3 |
0.245
|
|
|
|
stem cell fate determination
|
GO:0048867 |
2 |
0.245
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.241
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
19 |
0.241
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.240
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.240
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.239
|
|
|
|
lateral mesoderm morphogenesis
|
GO:0048369 |
3 |
0.238
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.237
|
|
|
|
central nervous system neuron differentiation
|
GO:0021953 |
162 |
0.234
|
|
|
|
positive regulation of protein export from nucleus
|
GO:0046827 |
4 |
0.232
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
3 |
0.232
|
|
|
|
negative regulation of synaptic vesicle exocytosis
|
GO:2000301 |
3 |
0.231
|
|
|
|
activation of rac gtpase activity
|
GO:0032863 |
2 |
0.228
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.228
|
|
|
|
regulation of autophagy
|
GO:0010506 |
30 |
0.226
|
Fly |
|
|
photoreceptor cell development
|
GO:0042461 |
40 |
0.226
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.225
|
|
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
3 |
0.224
|
|
|
|
regulation of neurotransmitter levels
|
GO:0001505 |
87 |
0.224
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.224
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.223
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
47 |
0.223
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.223
|
|
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.223
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.223
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.221
|
Mouse |
|
|
stem cell development
|
GO:0048864 |
219 |
0.220
|
|
|
|
regulation of cell size
|
GO:0008361 |
72 |
0.220
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.219
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.218
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.218
|
|
|
|
mitochondrial dna repair
|
GO:0043504 |
3 |
0.217
|
|
|
|
regulation of peptidyl threonine phosphorylation
|
GO:0010799 |
12 |
0.217
|
|
|
|
regulation of protein depolymerization
|
GO:1901879 |
26 |
0.217
|
|
|
|
negative regulation of phosphatidylinositol 3 kinase activity
|
GO:0043553 |
1 |
0.216
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
81 |
0.216
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.216
|
Mouse |
|
|
phagocytosis
|
GO:0006909 |
66 |
0.216
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.215
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.212
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.211
|
Mouse Fly |
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
80 |
0.209
|
|
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
3 |
0.208
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.208
|
|
|
|
negative regulation of fibroblast migration
|
GO:0010764 |
2 |
0.208
|
|
|
|
associative learning
|
GO:0008306 |
61 |
0.207
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.206
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.206
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.205
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
42 |
0.204
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.204
|
|
|
|
cognition
|
GO:0050890 |
149 |
0.204
|
|
|
|
apoptotic process involved in mammary gland involution
|
GO:0060057 |
4 |
0.204
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.203
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
36 |
0.203
|
|
|
|
embryonic limb morphogenesis
|
GO:0030326 |
126 |
0.201
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.201
|
Fly |
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.200
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
26 |
0.199
|
|
|
|
protein depolymerization
|
GO:0051261 |
34 |
0.197
|
|
|
|
carbon catabolite regulation of transcription
|
GO:0045990 |
4 |
0.196
|
|
|
|
methylation
|
GO:0032259 |
134 |
0.196
|
|
|
|
granulocyte migration
|
GO:0097530 |
43 |
0.195
|
|
|
|
action potential
|
GO:0001508 |
78 |
0.193
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.192
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
92 |
0.192
|
|
|
|
physiological cardiac muscle hypertrophy
|
GO:0003301 |
3 |
0.189
|
|
|
|
renal system development
|
GO:0072001 |
225 |
0.188
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
87 |
0.188
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.188
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
51 |
0.188
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.187
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.187
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.187
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.185
|
|
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
35 |
0.185
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.184
|
Human |
|
|
regulation of cell division
|
GO:0051302 |
76 |
0.184
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.183
|
|
|
|
lipid storage
|
GO:0019915 |
36 |
0.182
|
|
|
|
notch signaling pathway
|
GO:0007219 |
71 |
0.181
|
|
|
|
endocardial cushion formation
|
GO:0003272 |
13 |
0.177
|
|
|
|
regulation of notch signaling pathway
|
GO:0008593 |
35 |
0.176
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.175
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
77 |
0.175
|
|
|
|
response to sterol
|
GO:0036314 |
4 |
0.170
|
|
|
|
positive regulation of cell division
|
GO:0051781 |
31 |
0.170
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
191 |
0.170
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.169
|
|
|
|
hair follicle morphogenesis
|
GO:0031069 |
29 |
0.169
|
|
|
|
calcium ion transmembrane transport
|
GO:0070588 |
85 |
0.169
|
|
|
|
cellular response to light stimulus
|
GO:0071482 |
19 |
0.168
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.167
|
|
|
|
inner ear receptor cell differentiation
|
GO:0060113 |
61 |
0.167
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
25 |
0.167
|
Human |
|
|
cell growth involved in cardiac muscle cell development
|
GO:0061049 |
3 |
0.166
|
|
|
|
lateral mesodermal cell differentiation
|
GO:0048371 |
3 |
0.165
|
|
|
|
regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0000083 |
3 |
0.164
|
|
|
|
positive regulation of smad protein import into nucleus
|
GO:0060391 |
2 |
0.163
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:0097296 |
2 |
0.162
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.162
|
Mouse |
|
|
protein processing
|
GO:0016485 |
163 |
0.161
|
|
|
|
embryonic hemopoiesis
|
GO:0035162 |
23 |
0.160
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
1 |
0.159
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.158
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.158
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.157
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.156
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.156
|
|
|
|
common partner smad protein phosphorylation
|
GO:0007182 |
2 |
0.155
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.154
|
|
|
|
osteoblast fate commitment
|
GO:0002051 |
4 |
0.154
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
28 |
0.154
|
|
|
|
regulation of engulfment of apoptotic cell
|
GO:1901074 |
2 |
0.153
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
31 |
0.152
|
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.152
|
|
|
|
cell fate specification
|
GO:0001708 |
72 |
0.151
|
Worm |
|
|
axon ensheathment
|
GO:0008366 |
76 |
0.151
|
|
|
|
gonad development
|
GO:0008406 |
141 |
0.151
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.149
|
|
|
|
negative regulation of endothelial cell differentiation
|
GO:0045602 |
2 |
0.149
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.149
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.149
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.149
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.147
|
|
|
|
negative regulation of transcription involved in g1 s transition of mitotic cell cycle
|
GO:0071930 |
1 |
0.147
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.146
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.146
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
143 |
0.145
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.144
|
|
|
|
neuronal action potential
|
GO:0019228 |
54 |
0.144
|
|
|
|
positive regulation of microtubule polymerization or depolymerization
|
GO:0031112 |
3 |
0.143
|
|
|
|
regulation of microtubule polymerization
|
GO:0031113 |
7 |
0.143
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus
|
GO:1901522 |
7 |
0.142
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
31 |
0.141
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
19 |
0.141
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
61 |
0.140
|
|
|
|
organ growth
|
GO:0035265 |
117 |
0.139
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.139
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.138
|
|
|
|
heart morphogenesis
|
GO:0003007 |
178 |
0.137
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.137
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.137
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
4 |
0.137
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
50 |
0.136
|
|
|
|
positive regulation of bmp signaling pathway
|
GO:0030513 |
23 |
0.136
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.136
|
|
|
|
cellular response to drug
|
GO:0035690 |
15 |
0.136
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.134
|
|
|
|
regulation of microtubule cytoskeleton organization
|
GO:0070507 |
37 |
0.132
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
40 |
0.131
|
|
|
|
negative regulation of rac protein signal transduction
|
GO:0035021 |
4 |
0.130
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.129
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation
|
GO:2000721 |
2 |
0.129
|
|
|
|
positive regulation of mitotic sister chromatid separation
|
GO:1901970 |
2 |
0.128
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.128
|
|
|
|
activation of ras gtpase activity
|
GO:0032856 |
11 |
0.127
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.127
|
|
|
|
appendage development
|
GO:0048736 |
166 |
0.126
|
Fly |
|
|
cell matrix adhesion
|
GO:0007160 |
68 |
0.126
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.124
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
122 |
0.124
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
28 |
0.124
|
Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.124
|
|
|
|
regulation of cyclase activity
|
GO:0031279 |
13 |
0.124
|
|
|
|
tor signaling
|
GO:0031929 |
21 |
0.123
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902042 |
11 |
0.123
|
Mouse |
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.122
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.122
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
85 |
0.121
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.120
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
87 |
0.119
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
98 |
0.119
|
|
|
|
rap protein signal transduction
|
GO:0032486 |
3 |
0.119
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.119
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.118
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
14 |
0.116
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.115
|
Fly |
|
|
cell adhesion
|
GO:0007155 |
329 |
0.115
|
|
|
|
limb development
|
GO:0060173 |
166 |
0.114
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.114
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.114
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
62 |
0.112
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.112
|
|
|
|
regulation of adenylate cyclase activity
|
GO:0045761 |
10 |
0.112
|
|
|
|
dna methylation
|
GO:0006306 |
43 |
0.112
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.111
|
Human |
|
|
maternal process involved in female pregnancy
|
GO:0060135 |
32 |
0.111
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.111
|
|
|
|
negative regulation of stem cell proliferation
|
GO:2000647 |
12 |
0.111
|
|
|
|
regulation of anoikis
|
GO:2000209 |
2 |
0.111
|
|
|
|
positive regulation of nitric oxide synthase activity
|
GO:0051000 |
2 |
0.111
|
|
|
|
regulation of organ growth
|
GO:0046620 |
61 |
0.109
|
|
|
|
keratinocyte differentiation
|
GO:0030216 |
48 |
0.109
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.109
|
|
|
|
canonical wnt signaling pathway involved in positive regulation of apoptotic process
|
GO:0044337 |
3 |
0.108
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.108
|
|
|
|
regulation of myelination
|
GO:0031641 |
20 |
0.108
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.107
|
|
|
|
negative regulation of osteoblast proliferation
|
GO:0033689 |
4 |
0.107
|
|
|
|
positive regulation of striated muscle cell apoptotic process
|
GO:0010663 |
3 |
0.106
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.106
|
|
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
41 |
0.106
|
|
|
|
regulation of b cell tolerance induction
|
GO:0002661 |
2 |
0.105
|
|
|
|
regulation of photoreceptor cell differentiation
|
GO:0046532 |
4 |
0.105
|
Fly |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.105
|
|
|
|
negative regulation of neurotransmitter transport
|
GO:0051589 |
7 |
0.104
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
31 |
0.104
|
|
|
|
response to cholesterol
|
GO:0070723 |
4 |
0.102
|
|
|
|
membrane fusion
|
GO:0061025 |
38 |
0.101
|
|
|
|
antral ovarian follicle growth
|
GO:0001547 |
5 |
0.101
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.101
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.100
|
|
|
|
positive regulation of synaptic growth at neuromuscular junction
|
GO:0045887 |
1 |
0.100
|
|
|
|
negative regulation of protein tyrosine kinase activity
|
GO:0061099 |
3 |
0.100
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.099
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
65 |
0.097
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.097
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.097
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
56 |
0.096
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.096
|
|
|
|
developmental cell growth
|
GO:0048588 |
84 |
0.095
|
|
|
|
negative regulation of cell cycle arrest
|
GO:0071157 |
1 |
0.095
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.095
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.095
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.094
|
|
|
|
regulation of epithelial cell proliferation involved in prostate gland development
|
GO:0060768 |
10 |
0.094
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
17 |
0.094
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.093
|
|
|
|
cardiac endothelial cell differentiation
|
GO:0003348 |
4 |
0.093
|
|
|
|
pigmentation
|
GO:0043473 |
71 |
0.093
|
|
|
|
negative regulation of anoikis
|
GO:2000811 |
2 |
0.093
|
|
|
|
positive regulation of insulin like growth factor receptor signaling pathway
|
GO:0043568 |
8 |
0.092
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.092
|
|
