Mus musculus

0 known processes

Arfgef1

ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)

(Aliases: D130059B05Rik,BIG1,ARFGEP1,P200,D730028O18Rik)

Arfgef1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleotide metabolic process GO:0009117 332 0.108
Human
small gtpase mediated signal transduction GO:0007264 97 0.083
purine containing compound metabolic process GO:0072521 311 0.083
Human
cation transport GO:0006812 399 0.082
purine nucleoside triphosphate catabolic process GO:0009146 203 0.075
Human
nucleoside triphosphate catabolic process GO:0009143 205 0.075
Human
endomembrane system organization GO:0010256 147 0.074
Human
organic cyclic compound catabolic process GO:1901361 295 0.074
Human
gtp metabolic process GO:0046039 144 0.070
Human
positive regulation of protein modification process GO:0031401 299 0.069
Human
nucleoside phosphate metabolic process GO:0006753 338 0.069
Human
cellular nitrogen compound catabolic process GO:0044270 280 0.067
Human
purine nucleoside metabolic process GO:0042278 241 0.067
Human
positive regulation of protein phosphorylation GO:0001934 242 0.065
organelle localization GO:0051640 179 0.064
nucleoside metabolic process GO:0009116 246 0.063
Human
modification dependent protein catabolic process GO:0019941 133 0.063
positive regulation of cellular catabolic process GO:0031331 148 0.061
Human
synaptic transmission GO:0007268 329 0.060
regulation of ion transport GO:0043269 215 0.060
cation homeostasis GO:0055080 212 0.059
purine ribonucleotide metabolic process GO:0009150 290 0.059
Human
purine nucleoside triphosphate metabolic process GO:0009144 226 0.059
Human
ribonucleoside triphosphate metabolic process GO:0009199 220 0.055
Human
macromolecule catabolic process GO:0009057 281 0.054
heterocycle catabolic process GO:0046700 280 0.053
Human
cell type specific apoptotic process GO:0097285 268 0.051
protein modification by small protein removal GO:0070646 21 0.050
negative regulation of protein metabolic process GO:0051248 282 0.050
protein deubiquitination GO:0016579 19 0.050
guanosine containing compound metabolic process GO:1901068 144 0.050
Human
intracellular protein transport GO:0006886 204 0.050
posttranscriptional regulation of gene expression GO:0010608 155 0.049
membrane organization GO:0061024 245 0.049
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.049
Human
regulation of cellular component size GO:0032535 121 0.049
Human
nucleoside phosphate catabolic process GO:1901292 222 0.048
Human
glycosyl compound metabolic process GO:1901657 246 0.047
Human
cellular protein catabolic process GO:0044257 155 0.046
ras protein signal transduction GO:0007265 77 0.045
lipid localization GO:0010876 126 0.045
divalent metal ion transport GO:0070838 172 0.045
purine containing compound catabolic process GO:0072523 213 0.043
Human
regulation of ion transmembrane transport GO:0034765 119 0.043
establishment of organelle localization GO:0051656 122 0.043
positive regulation of protein kinase activity GO:0045860 144 0.042
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
purine ribonucleotide catabolic process GO:0009154 208 0.042
Human
regulation of purine nucleotide catabolic process GO:0033121 122 0.041
Human
purine nucleotide catabolic process GO:0006195 211 0.041
Human
microtubule cytoskeleton organization GO:0000226 157 0.040
divalent inorganic cation transport GO:0072511 178 0.040
purine ribonucleoside catabolic process GO:0046130 205 0.040
Human
organonitrogen compound catabolic process GO:1901565 264 0.040
Human
nucleoside triphosphate metabolic process GO:0009141 230 0.040
Human
regulation of neuron death GO:1901214 134 0.039
protein modification by small protein conjugation GO:0032446 187 0.039
regulation of vesicle mediated transport GO:0060627 139 0.039
negative regulation of neuron death GO:1901215 98 0.039
regulation of cell motility GO:2000145 236 0.038
regulation of cellular catabolic process GO:0031329 242 0.038
Human
regulation of protein kinase activity GO:0045859 232 0.038
cytoplasmic transport GO:0016482 234 0.038
negative regulation of molecular function GO:0044092 258 0.037
Human
regulation of nucleoside metabolic process GO:0009118 130 0.036
Human
regulation of transmembrane transport GO:0034762 128 0.036
synaptic vesicle localization GO:0097479 59 0.036
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.036
Human
purine nucleotide metabolic process GO:0006163 302 0.036
Human
protein targeting GO:0006605 143 0.035
ion transmembrane transport GO:0034220 361 0.035
guanosine containing compound catabolic process GO:1901069 144 0.035
Human
cellular ketone metabolic process GO:0042180 84 0.035
regulation of cellular ketone metabolic process GO:0010565 66 0.035
calcium ion homeostasis GO:0055074 127 0.035
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
cellular homeostasis GO:0019725 240 0.035
cellular amino acid metabolic process GO:0006520 103 0.035
cellular response to dna damage stimulus GO:0006974 207 0.034
cellular chemical homeostasis GO:0055082 215 0.034
establishment of vesicle localization GO:0051650 81 0.034
apical constriction GO:0003383 4 0.034
regulation of cell migration GO:0030334 219 0.034
calcium ion transport GO:0006816 159 0.033
metal ion homeostasis GO:0055065 189 0.033
synapse organization GO:0050808 125 0.033
ribonucleotide metabolic process GO:0009259 291 0.032
Human
regulation of nucleotide catabolic process GO:0030811 122 0.032
Human
cell adhesion GO:0007155 329 0.032
rho protein signal transduction GO:0007266 32 0.032
centrosome cycle GO:0007098 23 0.032
endocytosis GO:0006897 168 0.032
regulation of metal ion transport GO:0010959 106 0.031
gland development GO:0048732 330 0.031
positive regulation of ras gtpase activity GO:0032320 65 0.031
cell substrate adhesion GO:0031589 130 0.031
cell junction organization GO:0034330 77 0.031
amine metabolic process GO:0009308 45 0.030
glycosyl compound catabolic process GO:1901658 206 0.030
Human
purine nucleoside catabolic process GO:0006152 205 0.030
Human
cellular ion homeostasis GO:0006873 165 0.030
regulation of neuron apoptotic process GO:0043523 122 0.030
regulation of transferase activity GO:0051338 263 0.030
protein localization to nucleus GO:0034504 121 0.030
regulation of neuron differentiation GO:0045664 281 0.030
protein modification by small protein conjugation or removal GO:0070647 207 0.030
organophosphate catabolic process GO:0046434 232 0.030
Human
neuron apoptotic process GO:0051402 142 0.030
ribose phosphate metabolic process GO:0019693 291 0.030
Human
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.029
ribonucleotide catabolic process GO:0009261 208 0.029
Human
regulation of nucleotide metabolic process GO:0006140 169 0.029
Human
regulation of cell projection organization GO:0031344 206 0.029
maintenance of location GO:0051235 89 0.029
ameboidal type cell migration GO:0001667 128 0.028
regulation of organelle organization GO:0033043 289 0.028
Human
gtp catabolic process GO:0006184 143 0.028
Human
response to transforming growth factor beta GO:0071559 88 0.028
positive regulation of kinase activity GO:0033674 155 0.028
dna repair GO:0006281 107 0.028
regulation of hydrolase activity GO:0051336 246 0.027
Human
cellular amine metabolic process GO:0044106 44 0.027
mapk cascade GO:0000165 281 0.027
negative regulation of phosphorylation GO:0042326 166 0.027
ribonucleoside metabolic process GO:0009119 245 0.027
Human
microtubule based process GO:0007017 236 0.026
aromatic compound catabolic process GO:0019439 286 0.026
Human
nucleotide catabolic process GO:0009166 217 0.026
Human
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.026
transmembrane transport GO:0055085 412 0.026
nucleoside catabolic process GO:0009164 206 0.026
Human
positive regulation of nucleoside metabolic process GO:0045979 91 0.026
Human
response to osmotic stress GO:0006970 21 0.026
homeostasis of number of cells GO:0048872 210 0.026
response to growth factor GO:0070848 198 0.026
neuron death GO:0070997 154 0.026
regulation of cellular amine metabolic process GO:0033238 20 0.026
establishment of synaptic vesicle localization GO:0097480 57 0.025
apoptotic signaling pathway GO:0097190 306 0.025
regulation of protein localization GO:0032880 231 0.025
blood vessel morphogenesis GO:0048514 285 0.025
morphogenesis of embryonic epithelium GO:0016331 159 0.025
carbohydrate derivative catabolic process GO:1901136 231 0.024
Human
mesodermal cell migration GO:0008078 4 0.024
regulation of kinase activity GO:0043549 249 0.024
regulation of cytoskeleton organization GO:0051493 122 0.024
Human
negative regulation of intracellular signal transduction GO:1902532 167 0.024
regulation of endocytosis GO:0030100 69 0.024
sequestering of calcium ion GO:0051208 18 0.024
plasma membrane organization GO:0007009 90 0.024
lipid homeostasis GO:0055088 63 0.023
cellular response to growth factor stimulus GO:0071363 197 0.023
regulation of cellular amino acid metabolic process GO:0006521 5 0.023
actin filament polymerization GO:0030041 44 0.023
Human
tube formation GO:0035148 140 0.023
neural tube development GO:0021915 160 0.023
vesicle coating GO:0006901 2 0.023
regulation of cellular response to stress GO:0080135 159 0.023
intermediate filament based process GO:0045103 27 0.023
positive regulation of hydrolase activity GO:0051345 148 0.022
Human
regulation of peptidase activity GO:0052547 96 0.022
response to radiation GO:0009314 165 0.022
stress activated protein kinase signaling cascade GO:0031098 81 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
synaptic vesicle transport GO:0048489 57 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.022
sensory organ morphogenesis GO:0090596 242 0.022
protein ubiquitination GO:0016567 171 0.022
embryonic epithelial tube formation GO:0001838 130 0.022
cell division GO:0051301 120 0.021
actin cytoskeleton organization GO:0030036 220 0.021
Human
inorganic ion transmembrane transport GO:0098660 234 0.021
positive regulation of transferase activity GO:0051347 167 0.021
positive regulation of organelle organization GO:0010638 128 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.021
centrosome duplication GO:0051298 16 0.021
chemotaxis GO:0006935 247 0.021
locomotory behavior GO:0007626 195 0.021
exocytosis GO:0006887 121 0.021
stress activated mapk cascade GO:0051403 80 0.020
positive regulation of ion transport GO:0043270 65 0.020
cell junction assembly GO:0034329 52 0.020
negative regulation of immune system process GO:0002683 209 0.020
amide transport GO:0042886 138 0.020
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.020
neural tube formation GO:0001841 108 0.020
dendrite development GO:0016358 115 0.020
cytokine production GO:0001816 319 0.020
response to oxidative stress GO:0006979 123 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
Human
intermediate filament cytoskeleton organization GO:0045104 26 0.019
peptide transport GO:0015833 133 0.019
regulation of cellular component biogenesis GO:0044087 181 0.019
Human
ribonucleoside catabolic process GO:0042454 206 0.019
Human
muscle system process GO:0003012 141 0.019
covalent chromatin modification GO:0016569 163 0.019
divalent inorganic cation homeostasis GO:0072507 138 0.018
regulation of cell shape GO:0008360 39 0.018
golgi to endosome transport GO:0006895 3 0.018
lipid biosynthetic process GO:0008610 179 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.018
response to uv GO:0009411 44 0.018
regulation of calcium ion transport GO:0051924 69 0.018
regulation of proteolysis GO:0030162 164 0.018
cellular metal ion homeostasis GO:0006875 151 0.018
positive regulation of gtpase activity GO:0043547 85 0.018
Human
regulation of apoptotic signaling pathway GO:2001233 197 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
vesicle localization GO:0051648 86 0.018
response to peptide GO:1901652 136 0.018
response to organic cyclic compound GO:0014070 198 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
Human
lipid transport GO:0006869 98 0.017
regulation of mapk cascade GO:0043408 248 0.017
granulocyte migration GO:0097530 43 0.017
peptidyl amino acid modification GO:0018193 336 0.017
protein polymerization GO:0051258 57 0.017
Human
mitotic cytokinesis GO:0000281 4 0.017
phosphatidylethanolamine metabolic process GO:0046337 2 0.017
epithelial cell development GO:0002064 159 0.017
nitrogen compound transport GO:0071705 271 0.017
chromatin organization GO:0006325 206 0.017
regulation of cell substrate adhesion GO:0010810 73 0.017
cellular calcium ion homeostasis GO:0006874 119 0.017
nucleobase containing small molecule metabolic process GO:0055086 352 0.017
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.017
epithelial tube formation GO:0072175 130 0.017
cell cell junction organization GO:0045216 72 0.017
protein catabolic process GO:0030163 221 0.017
adult behavior GO:0030534 135 0.017
compound eye development GO:0048749 1 0.016
establishment of protein localization to membrane GO:0090150 54 0.016
neural tube closure GO:0001843 90 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
regulation of actin filament based process GO:0032970 99 0.015
Human
regulation of anatomical structure size GO:0090066 178 0.015
Human
rac protein signal transduction GO:0016601 13 0.015
asymmetric stem cell division GO:0098722 3 0.015
methylation GO:0032259 134 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
sequestering of metal ion GO:0051238 19 0.015
regulation of microtubule cytoskeleton organization GO:0070507 37 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
cation transmembrane transport GO:0098655 266 0.015
extrinsic apoptotic signaling pathway GO:0097191 126 0.015
regulation of secretion GO:0051046 274 0.015
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
Human
negative regulation of transferase activity GO:0051348 85 0.015
modification dependent macromolecule catabolic process GO:0043632 133 0.014
regulation of gtp catabolic process GO:0033124 113 0.014
Human
regulation of hormone levels GO:0010817 211 0.014
epithelium migration GO:0090132 63 0.014
monoubiquitinated protein deubiquitination GO:0035520 2 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
Human
chromatin modification GO:0016568 187 0.014
regulation of cell activation GO:0050865 289 0.014
jnk cascade GO:0007254 72 0.014
immune effector process GO:0002252 321 0.014
axonogenesis GO:0007409 274 0.014
mitotic cell cycle process GO:1903047 159 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.014
synapsis GO:0007129 34 0.013
response to organonitrogen compound GO:0010243 246 0.013
neuronal action potential GO:0019228 54 0.013
negative regulation of mapk cascade GO:0043409 65 0.013
actin filament based movement GO:0030048 23 0.013
cellular lipid metabolic process GO:0044255 323 0.013
actin mediated cell contraction GO:0070252 15 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.013
Human
phagocytosis GO:0006909 66 0.013
cellular protein complex assembly GO:0043623 116 0.013
Human
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
peptide secretion GO:0002790 114 0.013
tissue homeostasis GO:0001894 115 0.013
positive regulation of ion transmembrane transport GO:0034767 24 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
neurofilament cytoskeleton organization GO:0060052 10 0.013
glycerolipid biosynthetic process GO:0045017 50 0.013
lymphocyte proliferation GO:0046651 164 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
protein localization to organelle GO:0033365 185 0.013
macromolecule methylation GO:0043414 120 0.013
protein localization to membrane GO:0072657 108 0.013
transmission of nerve impulse GO:0019226 76 0.013
regulation of intracellular transport GO:0032386 159 0.013
adherens junction organization GO:0034332 28 0.012
regulation of androgen receptor signaling pathway GO:0060765 3 0.012
angiogenesis GO:0001525 201 0.012
regulation of cell cycle process GO:0010564 160 0.012
carbohydrate metabolic process GO:0005975 230 0.012
Human
mitotic cell cycle GO:0000278 195 0.012
dephosphorylation GO:0016311 129 0.012
positive regulation of transmembrane transport GO:0034764 29 0.012
protein autophosphorylation GO:0046777 61 0.012
organelle fission GO:0048285 170 0.012
actin filament bundle assembly GO:0051017 40 0.012
leukocyte differentiation GO:0002521 342 0.012
insulin secretion GO:0030073 89 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
nuclear import GO:0051170 95 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
protein localization to plasma membrane GO:0072659 57 0.012
regulation of ras gtpase activity GO:0032318 88 0.012
Human
calcium mediated signaling GO:0019722 46 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
primary neural tube formation GO:0014020 95 0.012
protein maturation GO:0051604 176 0.012
positive regulation of cytoskeleton organization GO:0051495 49 0.012
dna metabolic process GO:0006259 303 0.012
positive regulation of actin filament bundle assembly GO:0032233 11 0.012
positive regulation of protein complex assembly GO:0031334 45 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
Human
receptor mediated endocytosis GO:0006898 51 0.012
respiratory system development GO:0060541 190 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
learning or memory GO:0007611 148 0.011
regulation of neuron projection development GO:0010975 169 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
respiratory tube development GO:0030323 167 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
negative regulation of cellular protein metabolic process GO:0032269 247 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
positive regulation of cell motility GO:2000147 116 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
Human
epidermis development GO:0008544 187 0.011
positive regulation of cell adhesion GO:0045785 80 0.011
regulation of angiogenesis GO:0045765 81 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.011
establishment of tissue polarity GO:0007164 28 0.011
actin filament organization GO:0007015 113 0.011
Human
leukocyte mediated immunity GO:0002443 174 0.011
regulation of rho protein signal transduction GO:0035023 71 0.011
Human
regulation of cell cycle GO:0051726 281 0.011
cognition GO:0050890 149 0.011
cell activation involved in immune response GO:0002263 126 0.011
cellular response to radiation GO:0071478 28 0.011
protein polyubiquitination GO:0000209 33 0.011
cofactor biosynthetic process GO:0051188 41 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
sensory perception of sound GO:0007605 97 0.011
glucose homeostasis GO:0042593 128 0.011
histone modification GO:0016570 159 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
non canonical wnt signaling pathway GO:0035567 33 0.011
protein import into nucleus GO:0006606 95 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
Human
response to calcium ion GO:0051592 20 0.011
maintenance of apical basal cell polarity GO:0035090 3 0.010
multicellular organismal signaling GO:0035637 91 0.010
centrosome organization GO:0051297 26 0.010
germ cell development GO:0007281 185 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
negative regulation of protein phosphorylation GO:0001933 126 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
Human
single organism cell adhesion GO:0098602 156 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
protein glycosylation GO:0006486 55 0.010
Human
cofactor metabolic process GO:0051186 80 0.010
positive regulation of proteolysis GO:0045862 85 0.010
rhythmic process GO:0048511 174 0.010
leukocyte migration GO:0050900 124 0.010
regulation of innate immune response GO:0045088 91 0.010
bmp signaling pathway GO:0030509 93 0.010
small molecule biosynthetic process GO:0044283 132 0.010
epithelial cell morphogenesis GO:0003382 41 0.010
cell chemotaxis GO:0060326 81 0.010

Arfgef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.049
disease of cellular proliferation DOID:14566 0 0.049
organ system cancer DOID:0050686 0 0.046
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.018
bone disease DOID:0080001 0 0.017
bone development disease DOID:0080006 0 0.014
osteochondrodysplasia DOID:2256 0 0.013
integumentary system disease DOID:16 0 0.010