Mus musculus

54 known processes

Sec63

SEC63-like (S. cerevisiae)

(Aliases: AI649014,5730478J10Rik,AW319215)

Sec63 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule catabolic process GO:0044265 206 0.145
organic cyclic compound catabolic process GO:1901361 295 0.090
proteasomal protein catabolic process GO:0010498 98 0.083
regulation of neuron differentiation GO:0045664 281 0.076
transmembrane transport GO:0055085 412 0.076
cell growth GO:0016049 130 0.074
macromolecule catabolic process GO:0009057 281 0.073
cytoplasmic transport GO:0016482 234 0.072
nucleobase containing small molecule metabolic process GO:0055086 352 0.072
aromatic compound catabolic process GO:0019439 286 0.072
membrane organization GO:0061024 245 0.071
cation homeostasis GO:0055080 212 0.063
gland development GO:0048732 330 0.058
ribose phosphate metabolic process GO:0019693 291 0.056
ubiquitin dependent protein catabolic process GO:0006511 129 0.053
organonitrogen compound catabolic process GO:1901565 264 0.052
intra golgi vesicle mediated transport GO:0006891 1 0.052
compound eye development GO:0048749 1 0.052
regulation of cell projection organization GO:0031344 206 0.050
response to endoplasmic reticulum stress GO:0034976 53 0.050
Zebrafish
regulation of cell motility GO:2000145 236 0.050
purine ribonucleotide metabolic process GO:0009150 290 0.049
nucleoside catabolic process GO:0009164 206 0.046
maintenance of location GO:0051235 89 0.046
lipid localization GO:0010876 126 0.045
glycosyl compound catabolic process GO:1901658 206 0.044
carbohydrate derivative catabolic process GO:1901136 231 0.044
cation transport GO:0006812 399 0.043
protein catabolic process GO:0030163 221 0.043
actin cytoskeleton organization GO:0030036 220 0.042
ribonucleotide metabolic process GO:0009259 291 0.042
cellular protein catabolic process GO:0044257 155 0.042
nucleotide catabolic process GO:0009166 217 0.041
purine containing compound metabolic process GO:0072521 311 0.040
response to organic cyclic compound GO:0014070 198 0.038
axonogenesis GO:0007409 274 0.038
ribonucleoside catabolic process GO:0042454 206 0.038
negative regulation of molecular function GO:0044092 258 0.038
neuron apoptotic process GO:0051402 142 0.038
regulation of intracellular protein transport GO:0033157 82 0.038
posttranscriptional regulation of gene expression GO:0010608 155 0.037
activation of mapk activity involved in innate immune response GO:0035419 2 0.037
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.036
innate immune response GO:0045087 157 0.036
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.035
cellular response to growth factor stimulus GO:0071363 197 0.035
lateral inhibition GO:0046331 1 0.035
renal system development GO:0072001 225 0.035
purine nucleoside catabolic process GO:0006152 205 0.034
regulation of neuron projection development GO:0010975 169 0.034
nucleoside triphosphate catabolic process GO:0009143 205 0.034
response to topologically incorrect protein GO:0035966 25 0.034
Zebrafish
purine nucleoside triphosphate metabolic process GO:0009144 226 0.033
purine nucleotide catabolic process GO:0006195 211 0.033
response to radiation GO:0009314 165 0.033
inorganic cation transmembrane transport GO:0098662 207 0.033
cellular nitrogen compound catabolic process GO:0044270 280 0.031
endocytosis GO:0006897 168 0.031
vacuole organization GO:0007033 38 0.031
regulation of secretion GO:0051046 274 0.031
positive regulation of transferase activity GO:0051347 167 0.030
cytokine production GO:0001816 319 0.030
nucleotide metabolic process GO:0009117 332 0.029
modification dependent protein catabolic process GO:0019941 133 0.029
cation transmembrane transport GO:0098655 266 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
purine ribonucleoside metabolic process GO:0046128 241 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
negative regulation of protein metabolic process GO:0051248 282 0.028
nucleoside phosphate metabolic process GO:0006753 338 0.028
regulation of hydrolase activity GO:0051336 246 0.028
cellular ketone metabolic process GO:0042180 84 0.028
skeletal system development GO:0001501 356 0.028
inorganic ion transmembrane transport GO:0098660 234 0.028
ribonucleoside metabolic process GO:0009119 245 0.028
cellular amino acid metabolic process GO:0006520 103 0.028
metencephalon development GO:0022037 89 0.028
digestive tract development GO:0048565 190 0.027
camera type eye development GO:0043010 266 0.027
developmental growth involved in morphogenesis GO:0060560 138 0.027
cellular response to biotic stimulus GO:0071216 92 0.027
regulation of protein localization GO:0032880 231 0.027
regulation of cell adhesion GO:0030155 154 0.027
hindbrain development GO:0030902 128 0.027
regulation of cytokine production GO:0001817 266 0.026
transition metal ion transport GO:0000041 38 0.026
posttranslational protein targeting to membrane GO:0006620 2 0.026
protein localization to organelle GO:0033365 185 0.026
locomotory behavior GO:0007626 195 0.026
organelle disassembly GO:1903008 2 0.026
urogenital system development GO:0001655 261 0.025
carbohydrate metabolic process GO:0005975 230 0.025
purine nucleotide metabolic process GO:0006163 302 0.025
liver development GO:0001889 66 0.024
regulation of kinase activity GO:0043549 249 0.024
positive regulation of apoptotic process GO:0043065 217 0.024
action potential GO:0001508 78 0.024
Zebrafish
response to extracellular stimulus GO:0009991 127 0.024
regulation of cell migration GO:0030334 219 0.024
negative regulation of cytokine production GO:0001818 84 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.024
ribonucleoside triphosphate metabolic process GO:0009199 220 0.024
forebrain development GO:0030900 302 0.024
positive regulation of cell motility GO:2000147 116 0.024
positive regulation of glial cell proliferation GO:0060252 4 0.023
metal ion homeostasis GO:0055065 189 0.023
neuron death GO:0070997 154 0.023
neuronal action potential GO:0019228 54 0.023
Zebrafish
translation GO:0006412 93 0.023
regulation of organelle organization GO:0033043 289 0.023
cell substrate adhesion GO:0031589 130 0.023
purine containing compound catabolic process GO:0072523 213 0.023
establishment of vesicle localization GO:0051650 81 0.022
thymocyte migration GO:0072679 2 0.022
ion transmembrane transport GO:0034220 361 0.022
cerebellum development GO:0021549 77 0.022
ribonucleotide catabolic process GO:0009261 208 0.022
er nucleus signaling pathway GO:0006984 27 0.022
Zebrafish
positive regulation of hydrolase activity GO:0051345 148 0.022
kidney development GO:0001822 213 0.022
regionalization GO:0003002 337 0.022
regulation of mapk cascade GO:0043408 248 0.022
regulation of establishment of protein localization GO:0070201 181 0.021
epithelial tube formation GO:0072175 130 0.021
endoplasmic reticulum unfolded protein response GO:0030968 19 0.021
Zebrafish
cerebellar cortex development GO:0021695 48 0.021
midgut development GO:0007494 4 0.021
negative regulation of nervous system development GO:0051961 156 0.020
organophosphate catabolic process GO:0046434 232 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
inflammatory response GO:0006954 244 0.020
positive regulation of nervous system development GO:0051962 221 0.020
lipid transport GO:0006869 98 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.020
modification dependent macromolecule catabolic process GO:0043632 133 0.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.019
positive regulation of cell migration GO:0030335 109 0.019
cellular metal ion homeostasis GO:0006875 151 0.019
regulation of protein kinase activity GO:0045859 232 0.019
response to transforming growth factor beta GO:0071559 88 0.019
circulatory system process GO:0003013 197 0.019
response to unfolded protein GO:0006986 21 0.019
Zebrafish
regulation of thymocyte migration GO:2000410 2 0.019
connective tissue development GO:0061448 179 0.019
negative regulation of growth GO:0045926 99 0.019
positive regulation of growth GO:0045927 104 0.019
cellular response to lipid GO:0071396 145 0.019
regulation of membrane potential GO:0042391 192 0.018
Zebrafish
regulation of transferase activity GO:0051338 263 0.018
positive regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000309 1 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
cellular ion homeostasis GO:0006873 165 0.018
striated muscle tissue development GO:0014706 293 0.018
negative regulation of phosphorus metabolic process GO:0010563 184 0.018
developmental maturation GO:0021700 193 0.018
regulation of proteolysis GO:0030162 164 0.018
anion transport GO:0006820 177 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
regulation of cell growth GO:0001558 91 0.018
positive regulation of cell growth GO:0030307 33 0.018
cellular protein complex assembly GO:0043623 116 0.018
muscle cell differentiation GO:0042692 261 0.018
lipid biosynthetic process GO:0008610 179 0.017
ribonucleoprotein complex disassembly GO:0032988 3 0.017
protein oligomerization GO:0051259 67 0.017
adult locomotory behavior GO:0008344 91 0.017
ensheathment of neurons GO:0007272 76 0.017
Zebrafish
regulation of eosinophil migration GO:2000416 2 0.017
muscle tissue development GO:0060537 308 0.017
cellular homeostasis GO:0019725 240 0.017
skin development GO:0043588 220 0.017
cellular amine metabolic process GO:0044106 44 0.017
cell type specific apoptotic process GO:0097285 268 0.017
mapk cascade GO:0000165 281 0.017
regulation of hormone levels GO:0010817 211 0.017
epidermis development GO:0008544 187 0.017
male gamete generation GO:0048232 285 0.017
purine ribonucleotide catabolic process GO:0009154 208 0.017
glycoprotein metabolic process GO:0009100 116 0.016
regulation of defense response GO:0031347 233 0.016
golgi vesicle transport GO:0048193 30 0.016
apoptotic signaling pathway GO:0097190 306 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
gliogenesis GO:0042063 141 0.016
fibronectin dependent thymocyte migration GO:0072681 1 0.016
cell division GO:0051301 120 0.016
positive regulation of cell death GO:0010942 224 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
adult behavior GO:0030534 135 0.016
regulation of ion transport GO:0043269 215 0.016
cellular component assembly involved in morphogenesis GO:0010927 139 0.016
morphogenesis of a branching epithelium GO:0061138 193 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
regulation of actin filament based process GO:0032970 99 0.016
mrna metabolic process GO:0016071 84 0.016
heterocycle catabolic process GO:0046700 280 0.016
regulation of protein transport GO:0051223 163 0.016
rna interference GO:0016246 2 0.016
regulation of cellular response to stress GO:0080135 159 0.016
guanosine containing compound metabolic process GO:1901068 144 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of intracellular transport GO:0032386 159 0.015
transmission of nerve impulse GO:0019226 76 0.015
Zebrafish
retina morphogenesis in camera type eye GO:0060042 45 0.015
positive regulation of cell activation GO:0050867 158 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
establishment of protein localization to membrane GO:0090150 54 0.015
bmp signaling pathway GO:0030509 93 0.015
nucleoside triphosphate metabolic process GO:0009141 230 0.015
retina development in camera type eye GO:0060041 119 0.015
cartilage development GO:0051216 140 0.015
positive regulation of thymocyte migration GO:2000412 2 0.015
gtp catabolic process GO:0006184 143 0.015
extracellular structure organization GO:0043062 148 0.014
immune effector process GO:0002252 321 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
myelination GO:0042552 74 0.014
Zebrafish
positive regulation of eosinophil migration GO:2000418 2 0.014
bone development GO:0060348 120 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
lung development GO:0030324 164 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
regulation of neuron death GO:1901214 134 0.014
regulation of ossification GO:0030278 112 0.014
fertilization GO:0009566 127 0.014
ear development GO:0043583 200 0.014
neural tube formation GO:0001841 108 0.014
regulation of cellular component size GO:0032535 121 0.014
regulation of bmp signaling pathway GO:0030510 60 0.014
response to growth factor GO:0070848 198 0.014
phagocytosis GO:0006909 66 0.014
activation of adenylate cyclase activity GO:0007190 4 0.014
extrinsic apoptotic signaling pathway GO:0097191 126 0.014
axon ensheathment GO:0008366 76 0.014
Zebrafish
cellular chemical homeostasis GO:0055082 215 0.013
prevention of polyspermy GO:0060468 4 0.013
regulation of anatomical structure size GO:0090066 178 0.013
angiogenesis GO:0001525 201 0.013
regulation of protein localization to nucleus GO:1900180 60 0.013
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.013
nephron development GO:0072006 109 0.013
response to organonitrogen compound GO:0010243 246 0.013
nucleoside metabolic process GO:0009116 246 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.013
endomembrane system organization GO:0010256 147 0.013
positive regulation of cell development GO:0010720 237 0.013
schwann cell differentiation GO:0014037 26 0.013
stress activated mapk cascade GO:0051403 80 0.013
heart morphogenesis GO:0003007 178 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
fat cell differentiation GO:0045444 160 0.013
multicellular organismal signaling GO:0035637 91 0.013
Zebrafish
guanosine containing compound catabolic process GO:1901069 144 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
amine metabolic process GO:0009308 45 0.013
establishment of endothelial blood brain barrier GO:0014045 3 0.013
protein import GO:0017038 101 0.013
positive regulation of neuron differentiation GO:0045666 141 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
cellular lipid metabolic process GO:0044255 323 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
positive regulation of secretion GO:0051047 130 0.013
embryonic digit morphogenesis GO:0042733 56 0.012
response to nutrient levels GO:0031667 109 0.012
regulation of secretion by cell GO:1903530 249 0.012
skeletal system morphogenesis GO:0048705 203 0.012
regulation of metal ion transport GO:0010959 106 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
morphogenesis of embryonic epithelium GO:0016331 159 0.012
male anatomical structure morphogenesis GO:0090598 4 0.012
male sex differentiation GO:0046661 109 0.012
positive regulation of cytokine production GO:0001819 174 0.012
actin filament organization GO:0007015 113 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
p38mapk cascade GO:0038066 4 0.012
retrograde vesicle mediated transport golgi to er GO:0006890 1 0.012
ameboidal type cell migration GO:0001667 128 0.012
hormone secretion GO:0046879 128 0.012
regulation of multi organism process GO:0043900 111 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
developmental cell growth GO:0048588 84 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
germinal center formation GO:0002467 16 0.012
leukocyte differentiation GO:0002521 342 0.012
calcium ion homeostasis GO:0055074 127 0.012
response to light stimulus GO:0009416 135 0.012
limb morphogenesis GO:0035108 149 0.012
cellular response to external stimulus GO:0071496 88 0.012
zinc ion transport GO:0006829 12 0.012
actin cytoskeleton reorganization GO:0031532 21 0.012
extracellular matrix organization GO:0030198 147 0.012
organelle localization GO:0051640 179 0.011
neural tube development GO:0021915 160 0.011
actin modification GO:0030047 1 0.011
eosinophil migration GO:0072677 3 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
organ growth GO:0035265 117 0.011
divalent inorganic cation transport GO:0072511 178 0.011
determination of left right symmetry GO:0007368 80 0.011
cellular response to radiation GO:0071478 28 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
positive regulation of phospholipase activity GO:0010518 3 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
epithelial cell development GO:0002064 159 0.011
anatomical structure maturation GO:0071695 49 0.011
regulation of actin cytoskeleton organization GO:0032956 84 0.011
cell chemotaxis GO:0060326 81 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
cerebellar purkinje cell layer development GO:0021680 26 0.011
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.011
endodermal digestive tract morphogenesis GO:0061031 4 0.011
positive regulation of protein modification process GO:0031401 299 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.011
negative regulation of neuron death GO:1901215 98 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
mesoderm development GO:0007498 100 0.011
regulation of cell activation GO:0050865 289 0.011
stress activated protein kinase signaling cascade GO:0031098 81 0.011
protein processing GO:0016485 163 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.011
respiratory system development GO:0060541 190 0.011
regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000307 1 0.011
dephosphorylation GO:0016311 129 0.011
positive regulation of defense response GO:0031349 124 0.011
positive regulation of innate immune response GO:0045089 80 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
rna processing GO:0006396 105 0.011
morphogenesis of a branching structure GO:0001763 203 0.010
regulation of cellular amino acid metabolic process GO:0006521 5 0.010
interleukin 8 production GO:0032637 4 0.010
asymmetric stem cell division GO:0098722 3 0.010
positive regulation of t cell activation GO:0050870 101 0.010
protein targeting GO:0006605 143 0.010
regulation of transmembrane transport GO:0034762 128 0.010
lipid storage GO:0019915 36 0.010
regulation of homeostatic process GO:0032844 182 0.010
regulation of inflammatory response GO:0050727 147 0.010
single organism cell adhesion GO:0098602 156 0.010
multi multicellular organism process GO:0044706 109 0.010
cellular response to abiotic stimulus GO:0071214 56 0.010
macromolecule methylation GO:0043414 120 0.010
ossification GO:0001503 216 0.010
methylation GO:0032259 134 0.010
regulation of vacuole organization GO:0044088 4 0.010

Sec63 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.057
retinal degeneration DOID:8466 0 0.057
sensory system disease DOID:0050155 0 0.057
disease of anatomical entity DOID:7 0 0.057
eye and adnexa disease DOID:1492 0 0.057
nervous system disease DOID:863 0 0.057
eye disease DOID:5614 0 0.057
disease of metabolism DOID:0014667 0 0.032
inherited metabolic disorder DOID:655 0 0.032
disease of cellular proliferation DOID:14566 0 0.018
nephritis DOID:10952 0 0.017
glomerulonephritis DOID:2921 0 0.017
focal segmental glomerulosclerosis DOID:1312 0 0.017
kidney disease DOID:557 0 0.017
urinary system disease DOID:18 0 0.017
glomerulosclerosis DOID:0050851 0 0.017
non syndromic intellectual disability DOID:0050889 0 0.016
disease of mental health DOID:150 0 0.016
developmental disorder of mental health DOID:0060037 0 0.016
specific developmental disorder DOID:0060038 0 0.016
intellectual disability DOID:1059 0 0.016